Synergism between carnosic acid and arsenic trioxide on induction of acute myeloid leukemia cell apoptosis is associated with modulation of PTEN/Akt signaling pathway

Chinese Journal of Integrative Medicine

Volumn 18, Issue 12, 2012, Pages 934-941

  Wang, Ran ^a   Cong, Wei Hong ^b   Guo, Gang ^a   Li, Xiang Xin ^a   Chen, Xue Liang ^a   Yu, Xiao Ning ^a   Li, Hao ^a  

^a SHANDONG UNIVERSITY   (China)

^b INSTITUTE OF CHINESE MATERIA MEDICA   (China)

Author keywords

acute myeloid leukemia; apoptosis; carnosic acid; combination therapy; PTEN Akt signaling pathway

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ARSENIC TRIOXIDE; CARNOSIC ACID; CASPASE 9; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN BAD; PROTEIN KINASE B; PROTEIN P27;

ACUTE GRANULOCYTIC LEUKEMIA; APOPTOSIS; ARTICLE; CELL ASSAY; CELL CYCLE; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DRUG POTENTIATION; FLOW CYTOMETRY; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; INDUCTION CHEMOTHERAPY; INTRACELLULAR SIGNALING; LEUKEMIA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RECEPTOR UPREGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

APOPTOSIS; ARSENICALS; BASE SEQUENCE; BLOTTING, WESTERN; CELL CYCLE; DITERPENES, ABIETANE; DNA PRIMERS; DRUG SYNERGISM; HL-60 CELLS; HUMANS; LEUKEMIA, MYELOID, ACUTE; OXIDES; PLANT EXTRACTS; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

EID: 84874485141     PISSN: 16720415     EISSN: 19930402     Source Type: Journal    
DOI: 10.1007/s11655-012-1297-z     Document Type: Article

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