Cooperative antitumor effects of vitamin D3 derivatives and rosemary preparations in a mouse model of myeloid leukemia

International Journal of Cancer

Volumn 118, Issue 12, 2006, Pages 3012-3021

  Sharabani, Hagar ^a   Izumchenko, Eugene ^a   Wang, Qing ^b   Kreinin, Rita ^a   Steiner, Michael ^a   Barvish, Zeev ^a   Kafka, Michael ^c   Sharoni, Yoav ^a   Levy, Joseph ^a   Uskokovic, Milan ^d   Studzinski, George P ^b   Danilenko, Michael ^a  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^b RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^c BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^d Bioxell Inc   (United States)

Author keywords

Carnosic acid; Cell cycle; Differentiation; Myeloid leukemia; Vitamin D3

Indexed keywords

1,25 DIHYDROXY 16 ENE 5,6 COLECALCIFEROL; 1,25 DIHYDROXY 16,23 DIENE 20 EPI 26,27 HEXAFLUORO 19 NORCOLECALCIFEROL; ALCOHOL; CALCIUM ION; CARNOSIC ACID; COLECALCIFEROL DERIVATIVE; POLYPHENOL; RO 254020; RO 263884; ROSMARINUS OFFICINALIS EXTRACT; SUPEROXIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL CYCLE; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL DIFFERENTIATION; CONTROLLED STUDY; DRUG POTENTIATION; HUMAN; HUMAN CELL; HYPERCALCEMIA; IN VIVO STUDY; MOUSE; MYELOID LEUKEMIA; MYELOMONOCYTIC LEUKEMIA; NONHUMAN; PRIORITY JOURNAL; TUMOR VOLUME;

ANIMALS; ANTICARCINOGENIC AGENTS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CALCIUM; CHOLECALCIFEROL; DITERPENES, ABIETANE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; FLAVONOIDS; LEUKEMIA, EXPERIMENTAL; LEUKEMIA, MYELOID; LEUKEMIA, MYELOMONOCYTIC, ACUTE; MICE; MICE, INBRED BALB C; PHENOLS; PLANT EXTRACTS; PLANT PREPARATIONS; ROSMARINUS; TUMOR CELLS, CULTURED;

EID: 33646421969     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.21736     Document Type: Article

References (72)

1. Tenen DG. Disruption of differentiation in human cancer: AML shows the way. Nat Rev Cancer 2003;3:89-101.
2. Lowenberg B, Downing JR, Burnett A. Acute myeloid leukemia. N Engl J Med 1999;341:1051-62.
3. Smith M, Barnett M, Bassan R, Gatta G, Tondini C, Kern W. Adult acute myeloid leukaemia. Crit Rev Oncol Hematol 2004;50:197-222.
4. Tallman MS. Acute promyelocytic leukemia as a paradigm for targeted therapy. Semin Hematol 2004;41:27-32.
5. Schlenk RF, Frohling S, Hartmann F, Fischer JT, Glasmacher A, del Valle F, Grimminger W, Gotze K, Waterhouse C, Schoch R, Pralle H, Mergenthaler HG, et al. Phase III study of all-trans retinoic acid in previously untreated patients 61 years or older with acute myeloid leukemia. Leukemia 2004;18:1798-803.
6. Raffoux E, Chaibi P, Dombret H, Degos L. Valproic acid and all-trans retinoic acid for the treatment of elderly patients with acute myeloid leukemia. Haematologica 2005;90:986-8.
7. 3 metabolites. Cancer Res 1983;43: 4443-7.
8. Colston KW, Chander SK, Mackay AG, Coombes RC. Effects of synthetic vitamin D analogues on breast cancer cell proliferation in vivo and in vitro. Biochem Pharmacol 1992;44:693-702.
9. 3 receptors and actions in human prostate cancer cell lines. Endocrinology 1993;132:1952-60.
10. Studzinski GP, Moore DC. Vitamin D and retardation of cancer progression. In: Watson RR, Mufti SI, eds. Nutrition and cancer prevention. Boca Raton: CRC Press, 1996.257-82.
11. 3-resistant variant can be sensitized by TPA. J Steroid Biochem Mol Biol 2003;84:199-209.
12. Trump DL, Hershberger PA, Bernardi RJ, Ahmed S, Muindi J, Fakih M, Yu WD, Johnson CS. Anti-tumor activity of calcitriol: pre-clinical and clinical studies. J Steroid Biochem Mol Biol 2004;89/90:519-26.
13. 3 and its analogs. Exp Cell Res 2004;298:339-58.
14. Studzinski GP, Bhandal AK, Brelvi ZS. A system for monocytic differentiation of leukemic cells HL 60 by a short exposure to 1,25-dihydroxycholecalciferol. Proc Soc Exp Biol Med 1985;179:288-95.
15. 3 prolongs survival time of leukemic mice. Proc Natl Acad Sci USA 1990;87:3929-32.
16. 3 and retinoic acid. Exp Cell Res 1999;249:279-90.
17. 3: a new class of potent inhibitors of proliferation of prostate, breast, and myeloid leukemic cells. Cancer Res 1999; 59:4023-9.
18. 3 in HL60 cells. Cancer Res 1996;56:264-67.
19. 3 leads to the induced differentiation of the myelomonocytic cell line U937. Genes Dev 1996;10:142-53.
20. 3 reverses the G1 block but not differentiation of HL60 cells. Leukemia 1998;12:1256-65.
21. Studzinski GP, Moore DC. Sunlight-can it prevent as well as cause cancer? Cancer Res 1995;55:4014-22.
22. Giovannucci E. The epidemiology of vitamin D and cancer incidence and mortality: a review (United States). Cancer Causes Control 2005; 16:83-95.
23. 2 metabolite, inhibits growth of breast cancer cells and tumors. Anticancer Res 2005;25:235-41.
24. Smith DC, Johnson CS, Freeman CC, Muindi J, Wilson JW, Trump DL. A Phase I trial of calcitriol (1,25-dihydroxycholecalciferol) in patients with advanced malignancy. Clin Cancer Res 1999;5:1339-45.
25. Beer TM, Munar M, Henner WD. A Phase I trial of pulse calcitriol in patients with refractory malignancies: pulse dosing permits substantial dose escalation. Cancer 2001;91:2431-9.
26. Evans TR, Colston KW, Lofts FJ, Cunningham D, Anthoney DA, Gogas H, de Bono JS, Hamberg KJ, Skov T, Mansi JL. A phase II trial of the vitamin D analogue Seocalcitol (EB1089) in patients with inoperable pancreatic cancer. Br J Cancer 2002;86:680-5.
27. 2 in the treatment of advanced androgen-independent prostate cancer. Clin Cancer Res 2003;9:4077-83.
28. 3 analogue, in a phase I study of patients with advanced malignancies. Invest New Drugs 2003;21:445-52.
29. Luong QT, Koeffler HP. Vitamin D compounds in leukemia. J Steroid Biochem Mol Biol 2005;97:195-202.
30. Beer TM, Myrthue A. Calcitriol in cancer treatment: from the lab to the clinic. Mol Cancer Ther 2004;3:373-81.
31. Sharoni Y, Stahl W, Danilenko M, Levy J. The anticancer activity of carotenoids: from human studies to cellular processes and gene regulation. In: Krinsky NI, Mayne ST, Sies H, eds. Carotenoids in health and disease. New York: Marcel Dekker, 2003.165-96.
32. Chung FL, Schwartz J, Herzog CR, Yang YM. Tea and cancer prevention: studies in animals and humans. J Nutr 2003;133:32685-745.
33. Arts IC, Hollman PC. Polyphenols and disease risk in epidemiologic studies. Am J Clin Nutr 2005;81:317S-25S.
34. 3. Oncol Res 1997;9:31-39.
35. 3-induced differentiation in human promyelocytic leukemia HL-60 cells. Oncol Res 1997;9:19-29.
36. Danilenko M, Wang X, Studzinski GP. Carnosic acid and promotion of monocytic differentiation of HL60-G cells initiated by other agents. J Natl Cancer Inst 2001;93:1224-33.
37. Kang SN, Lee MH, Kim KM, Cho D, Kim TS. Induction of human promyelocytic leukemia HL-60 cell differentiation into monocytes by silibinin: involvement of protein kinase C. Biochem Pharmacol 2001; 61:1487-95.
38. 3 in induction of leukemia HL60 cell differentiation through the JNK/AP-1/Egr-1 pathway. J Cell Physiol 2005;204:964-74.
39. 3 that resist metabolism through C-24 oxidation and C-3 epimerization pathways. Steroids 2001;66:463-71.
40. 3 and retinoic acid. Nutr Cancer 2001;41:135-44.
41. 3 in leukemia cells but does not promote elevation of basal levels of intracellular calcium. Cancer Res 2003;63: 1325-32.
42. Swami S, Zhao XY, Sarabia S, Siu-Caldera ML, Uskokovic M, Reddy SG, Feldman D. A low-calcemic vitamin D analog (Ro 25-4020) inhibits the growth of LNCaP human prostate cancer cells with increased potency by producing an active 24-oxo metabolite (Ro29-9970). Recent Results Cancer Res 2003;164:349-52.
43. 3 analogues: disassociation of their prominent antileukemic effects from their lack of calcium modulation. Cancer Res 2001;61:3361-8.
44. 3 correlates with reduced rate of maturation of DNA replication intermediates. Cancer Res 1991;51:3451-55.
45. Finch RA, Li J, Chou TC, Sartorelli AC. Maintenance of retinoic acid receptor alpha pools by granulocyte colony-stimulating factor and lithium chloride in all-trans retinoic acid-treated WEHI-3B leukemia cells: relevance to the synergistic induction of terminal differentiation. Blood 2000;96:2262-8.
46. Austyn JM, Gordon S. F4/80, a monoclonal antibody directed specifically against the mouse macrophage. Eur J Immunol 1981;11:805-15.
47. 3. J Cell Biochem 2003;89: 1087-101.
48. 3 analogs to mice. J Endocrinol 2000;165: 163-72.
49. 3 reduces their tumorigenicity: a model for cancer chemoprevention. Proc Soc Exp Biol Med 1997;215:399-404.
50. Singh RP, Dhanalakshmi S, Tyagi AK, Chan DC, Agarwal C, Agarwal R. Dietary feeding of silibinin inhibits advance human prostate carcinoma growth in athymic nude mice and increases plasma insulin-like growth factor-binding protein-3 levels. Cancer Res 2002;62:3063-9.
51. Bettens F, Schlick E, Farrar W, Ruscetti F. 1,25- Dihydroxycholecalciferol-induced differentiation of myelomonocytic leukemic cells unresponsive to colony stimulating factors and phorbol esters. J Cell Physiol 1986;129:295-302.
52. Schlick E, Ruscetti FW. In vivo induction of terminal differentiation of malignant myelopoietic progenitor cells by CSF-inducing biological response modifiers. Blood 1986;67:980-7.
53. 3 exerts dose-dependent dual effects on APL cells. Blood 1997;89:3345-53.
54. Studzinski GP, Harrison LE. Differentiation-related changes in the cell cycle traverse. Int Rev Cytol 1999;189:1-58.
55. Warner NL, Moore MA, Metcalf D. A transplantable myelomonocytic leukemia in BALB-c mice: cytology, karyotype, and muramidase content. J Natl Cancer Inst 1969;43:963-82.
56. Singletary K, MacDonald C, Wallig M. Inhibition by rosemary and carnosol of 7,12-dimethylbenz(a)anthracene (DMBA)-induced rat mammary tumorigenesis and in vivo DMBA-DNA adduct formation. Cancer Lett 1996;104:43-48.
57. Amagase H, Sakamoto K, Segal ER, Milner JA. Dietary rosemary suppresses 7,12-dimethylbenz(a)anthracene binding to rat mammary cell DNA. J Nutr 1996;126:1475-80.
58. Debersac P, Heydel JM, Amiot MJ, Goudonnet H, Artur Y, Suschetet M, Siess MH. Induction of cytochrome P450 and/or detoxication enzymes by various extracts of rosemary: description of specific patterns. Food Chem Toxicol 2001;39:907-18.
59. Zhu BT, Loder DP, Cai MX, Ho CT, Huang MT, Conney AH. Dietary administration of an extract from rosemary leaves enhances the liver microsomal metabolism of endogenous estrogens and decreases their uterotropic action in CD-1 mice. Carcinogenesis 1998;19:1821-27.
60. Gius D, Bolero A, Shah S, Curry HA. Intracellular oxidation/reduction status in the regulation of transcription factors NF-kB and AP-1 Toxicol Lett 1999;106:93-106.
61. Gius D. Redox-sensitive signaling factors and antioxidants: how tumor cells respond to ionizing radiation. J Nutr 2004;134:3213S-14S.
62. 3: possible relationship to NF-κB. Leukemia 1997;11:1546-53.
63. 3. Cancer Lett 1998;125: 157-64.
64. Caltagirone S, Rossi C, Poggi A, Ranelletti FO, Natali PG, Brunetti M, Aiello FB, Piantelli M. Flavonoids apigenin and quercetin inhibit melanoma growth and metastatic potential. Int J Cancer 2000;87:595-600.
65. Singh RP, Mallikarjuna GU, Sharma G, Dhanalakshmi S, Tyagi AK, Chan DC, Agarwal C, Agarwal R. Oral silibinin inhibits lung tumor growth in athymic nude mice and forms a novel chemocombination with doxorubicin targeting nuclear factor κB-mediated inducible chemoresistance. Clin Cancer Res 2004;10:8641-7.
66. Nakazato T, Ito K, Miyakawa Y, Kinjo K, Yamada T, Hozumi N, Ikeda Y, Kizaki M. Catechin, a green tea component, rapidly induces apoptosis of myeloid leukemic cells via modulation of reactive oxygen species production in vitro and inhibits tumor growth in vivo. Haematologica 2005;90:317-25.
67. 3 inhibits phorbol ester-dependent chemical carcinogenesis in mouse skin. Biochem Biophys Res Commun 1983; 116:605-11.
68. 5. J Natl Cancer Inst 2000;92:1836-40.
69. 3 in N,N′-dimethylhydrazine-induced rat colon carcinogenesis. Carcinogenesis 2000;21:173-8.
70. 3 activate three MAPK pathways and upregulate pRb expression in differentiating HL60 Cells. Cell Cycle 2002;1:410-5.
71. Fahim FA, Esmat AY, Fadel HM, Hassan KF. Allied studies on the effect of Rosmarinus officinalis L. on experimental hepatotoxicity and mutagenesis. Int J Food Sci Nutr 1999;50:413-27.
72. Amin A, Hamza AA. Hepatoprotective effects of Hibiscus, Rosmarinus and Salvia on azathioprine-induced toxicity in rats. Life Sci 2005;77: 266-78.