Terpinolene, a component of herbal sage, downregulates AKT1 expression in K562 cells

Oncology Letters

Volumn 3, Issue 2, 2012, Pages 321-324

  Okumura, Naoko ^a   Yoshida, Hitomi ^a   Nishimura, Yuri ^a   Kitagishi, Yasuko ^a   Matsuda, Satoru ^a  

^a NARA WOMEN'S UNIVERSITY   (Japan)

Author keywords

AKT; Apoptosis; Cancer; Cell growth; Rosemary; Sage; Terpinolene

Indexed keywords

BRCA1 PROTEIN; BRCA2 PROTEIN; GINGER EXTRACT; GREEN TEA EXTRACT; MITOGEN ACTIVATED PROTEIN KINASE 1; PROTEIN KINASE AKT1; PROTEIN SERINE THREONINE KINASE; ROSMARINUS OFFICINALIS EXTRACT; TERPINOLENE; UNCLASSIFIED DRUG;

ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; DRUG ISOLATION; GENE EXPRESSION; HUMAN; HUMAN CELL; PERILLA FRUTESCENS; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SWEET PEPPER;

EID: 84855220716     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2011.491     Document Type: Article

References (10)

1. Castaneda CA, Cortes-Funes H, Gomez HL and Ciruelos EM: The phosphatidyl inositol 3-kinase/AKT signaling pathway in breast cancer. Cancer Metastasis Rev 29: 751-759, 2010.
2. Martelli AM, Evangelisti C, Chiarini F, et al: The emerging role of the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin signaling network in normal myelopoiesis and leukemogenesis. Biochim Biophys Acta 1803: 991-1002, 2010.
3. Pal SK, Reckamp K, Yu H and Figurelin RA: Akt inhibitors in clinical development for the treatment of cancer. Expert Opin Investig Drugs 19: 1355-1366, 2010.
4. Abad MJ, Bedoya LM and Bermejo P: An update on drug interactions with the herbal medicine Ginkgo biloba. Curr Drug Metab 11: 171-181, 2010.
5. Johnson JJ: Carnosol: a promising anti-cancer and anti-inflammatory agent. Cancer Lett 305: 1-7, 2011.
6. Liu CP, Tsai WJ, Lin YL, Liao JF, Chen CF and Kuo YC: The extracts from Nelumbo Nucifera suppress cell cycle progression, cytokine genes expression, and cell proliferation in human peripheral blood mononuclear cells. Life Sci 75: 699-716, 2004.
7. Nishimura Y, Kitagishi Y, Yoshida H, Okumura N and Matsuda S: Ethanol extracts of black pepper or turmeric down-regulated SIRT1 protein expression in Daudi culture cells. Mol Med Report 4: 727-730, 2011.
8. Plo I, Laulier C, Gauthier L, Lebrun F, Calvo F and Lopez BS: AKT1 inhibits homologous recombination by inducing cytoplasmic retention of BRCA1 and RAD51. Cancer Res 68: 9404-9412, 2008.
9. Cherng JM, Shieh DE, Chiang W, Chang MY and Chiang LC: Chemopreventive effects of minor dietary constituents in common foods on human cancer cells. Biosci Biotechnol Biochem 71: 1500-1504, 2007.
10. Yoshida N, Takada T, Yamamura Y, Adachi I, Suzuki H and Kawakami J: Inhibitory effects of terpenoids on multidrug resistance-associated protein 2- and breast cancer resistance protein-mediated transport. Drug Metab Dispos 36: 1206-1211, 2008.