Carnosic acid inhibits proliferation and augments differentiation of human leukemic cells induced by 1,25-dihydroxyvitamin D3 and retinoic acid

Nutrition and Cancer

Volumn 41, Issue 1-2, 2001, Pages 135-144

  Steiner, Michael ^a   Priel, Irene ^a   Giat, Judith ^a   Levy, Joseph ^a   Sharoni, Yoav ^a   Danilenko, Michael ^a  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; ANTIOXIDANT; CALCITRIOL; CARNOSIC ACID; CD11B ANTIGEN; CD14 ANTIGEN; FORMYLMETHIONYLLEUCYLPHENYLALANINE; PROTEIN P21; PROTEIN P27; RETINOIC ACID; UNCLASSIFIED DRUG; ABIETANE DERIVATIVE; CDKN1A PROTEIN, HUMAN; CELL CYCLE PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYCLINE; DITERPENE; PLANT EXTRACT; SALVIN; TUMOR SUPPRESSOR PROTEIN;

ANTIGEN EXPRESSION; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE G1 PHASE; CELL DIFFERENTIATION; CELL PROLIFERATION; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; GROWTH INHIBITION; HUMAN; HUMAN CELL; IC 50; INHIBITION KINETICS; LEUKEMIA CELL; MUTAGENESIS; PROTEIN BLOOD LEVEL; WESTERN BLOTTING; CELL CULTURE; CELL CYCLE; CELL DIVISION; CELL STRAIN HL 60; CELL STRAIN U937; CHEMISTRY; DRUG EFFECT; DRUG INTERACTION; FLOW CYTOMETRY; LEUKEMIA; METABOLISM; MYELOID LEUKEMIA; PATHOLOGY; ROSEMARY;

ANIMALIA; ROSMARINUS OFFICINALIS;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CALCITRIOL; CELL CYCLE; CELL CYCLE PROTEINS; CELL DIFFERENTIATION; CELL DIVISION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLINS; DITERPENES; DITERPENES, ABIETANE; DRUG INTERACTIONS; FLOW CYTOMETRY; G1 PHASE; HL-60 CELLS; HUMANS; LEUKEMIA; LEUKEMIA, MYELOID; PLANT EXTRACTS; ROSMARINUS; TRETINOIN; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEINS; U937 CELLS;

EID: 0035527494     PISSN: 01635581     EISSN: None     Source Type: Journal    
DOI: 10.1207/s15327914nc41-1&2_19     Document Type: Article

References (43)

1. Antioxidant and pro-oxidant properties of active rosemary constituents: Carnosol and carnosic acid
2. Dietary ortho phenols that induce glutathione S-transferase and increase the resistance of cells to hydrogen peroxide are potential cancer chemopreventives that act by two mechanisms: The alleviation of oxidative stress and the detoxication of mutagenic xenobiotics
3. Antioxidant activity of a rosemary extract and its constituents, carnosic acid, carnosol, and rosmarinic acid, in bulk oil and oil-in-water emulsion
4. Inhibition of lipid peroxidation and superoxide generation by diterpenoids from Rosmarinus officinalis
5. Chemiluminescence determination of the in vivo and in vitro antioxidant activity of RoseOx and carnosic acid
6. Inhibition of endothelial cell-mediated oxidation of low-density lipoprotein by rosemary and plant phenolics
7. Natural antioxidants as inhibitors of oxygen species-induced mutagenicity
8. Inhibition of skin tumorigenesis by rosemary and its constituents carnosol and ursolic acid
9. Inhibition by rosemary and carnosol of 7,12-dimethylbenz[a]anthracene (DMBA)-induced rat mammary tumorigenesis and in vivo DMBA-DNA adduct formation
10. Mechanisms involved in the chemoprotective effects of rosemary extract studied in human liver and bronchial cells
11. Rosemary components inhibit benzo[a]pyrene-induced genotoxicity in human bronchial cells
12. Development of in vitro models for cellular and molecular studies in toxicology and chemoprevention
13. 3 cooperate in the inhibition of cell cycle progression and induction of differentiation in HL-60 leukemic cells
14. 3, lipopolysaccharide, or lipoteichoic acid on the expression of NADPH oxidase components in cultured human monocytes
15. A combination of a T cell-derived lymphokine differentiation-inducing activity and a physiologic concentration of retinoic acid induces HL-60 to differentiate to cells with functional chemotactic peptide receptors
16. Cleavage of automodified poly(ADP-ribose) polymerase during apoptosis: Evidence for involvement of caspase-7
17. Curcumin, an antioxidant and antitumor promoter, induces apoptosis in human leukemia cells
18. Chemopreventive agent resveratrol, a natural product derived from grapes, triggers CD95 signaling-dependent apoptosis in human tumor cells
19. Analysis of apoptotic cells by flow and laser scanning cytometry
20. 3: Possible relationship to NF-κB
21. 3
22. 3-induced differentiation in human promyelocytic leukemia HL-60 cells
23. 3 in HL60 cells
24. 1 block but not differentiation of HL 60 cells
25. Leukemia cell differentiation: Cellular and molecular interactions of retinoids and vitamin D
26. Molecular mechanisms of chemopreventive effects of selected dietary and medicinal phenolic substances
27. Cell cycle regulatory protein expression in fresh acute myeloid leukemia cells and after drug exposure
28. 1 that is preceded by a transient proliferative burst and an increase in cyclin expression
29. 3
30. Proanthocyanidins from barley bran potentiate retinoic acid-induced granulocytic and sodium butyrate-induced monocytic differentiation of HL60 cells
31. 3- and all-trans retinoic acid-induced differentiation of human promyelocytic leukemia HL-60 cells
32. Carnosic acid and promotion of monocytic differentiation of HL60-G cells initiated by other agents
33. Inhibition of the cytochrome P-450 modulates all-trans-retinoic acid-induced differentiation and apoptosis of HL- 60 cells
34. Activation of transcription factor NF-κB is suppressed by curcumin (diferulolylmethane)
35. Redox regulation of transcriptional activators
36. Oxidative stress and nuclear factor-κB activation: A reassessment of the evidence in the light of recent discoveries
37. 3
38. Cell cycle dysregulation by green tea polyphenol epigallocatechin-3-gallate
39. 1 cell cycle arrest and apoptosis in prostate cancer cells
40. Kip1
41. 3 leads to the induced differentiation of the myelomonocytic cell line U 937
42. WAF1/CIP1 gene by retinoic acid receptor: Correlation with retinoid induction of U 937 cell differentiation
43. KIP1