An intrinsically labile α-helix abutting the BCL9-binding site of β-catenin is required for its inhibition by carnosic acid

Nature Communications

Volumn 3, Issue , 2012, Pages

  De La Roche, Marc ^a   Rutherford, Trevor J ^a   Gupta, Deepti ^a   Veprintsev, Dmitry B ^a,c   Saxty, Barbara ^b   Freund, Stefan M ^a   Bienz, Mariann ^a  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^b Centre for Therapeutics Discovery   (United Kingdom)

^c PAUL SCHERRER INSTITUTE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; BETA CATENIN; CARNOSIC ACID; CARNOSOL; PROTEASOME; PROTEIN BCL 9; PROTEIN INHIBITOR; TOTAROL; UNCLASSIFIED DRUG; WNT PROTEIN; ABIETANE DERIVATIVE; BCL9 PROTEIN, HUMAN; PLANT EXTRACT; SALVIN; TUMOR PROTEIN;

ALPHA HELIX; AMINO TERMINAL SEQUENCE; ARTICLE; CANCER CELL; CARCINOGENESIS; CARCINOGENICITY; COLORECTAL CANCER; CONTROLLED STUDY; DRUG BINDING SITE; DRUG PROTEIN BINDING; DRUG TARGETING; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN STRUCTURE; REGULATORY MECHANISM; ROSEMARY; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS; TRANSCRIPTION REGULATION; ULTRACENTRIFUGATION; BINDING SITE; CELL STRAIN HEK293; CHEMISTRY; COLORECTAL TUMOR; DRUG ANTAGONISM; HELA CELL; METABOLISM; NUCLEAR MAGNETIC RESONANCE; PROTEIN STABILITY; ROSMARINUS; TUMOR CELL LINE; X RAY CRYSTALLOGRAPHY;

ROSMARINUS OFFICINALIS;

BETA CATENIN; BINDING SITES; CELL LINE, TUMOR; COLORECTAL NEOPLASMS; CRYSTALLOGRAPHY, X-RAY; DITERPENES, ABIETANE; HEK293 CELLS; HELA CELLS; HUMANS; NEOPLASM PROTEINS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PLANT EXTRACTS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN STABILITY; ROSMARINUS; SIGNAL TRANSDUCTION; WNT PROTEINS;

EID: 84857724447     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms1680     Document Type: Article

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