Growth inhibitory and apoptosis inducing effect of Perilla frutescens extract on human hepatoma HepG2 cells

Journal of Ethnopharmacology

Volumn 112, Issue 3, 2007, Pages 557-567

  Lin, Chih Sheng ^a   Kuo, Chao Lin ^b   Wang, Jui Ping ^a   Cheng, Ju Sang ^a   Huang, Zheng Wen ^a   Chen, Chi Fei ^a  

^a NATIONAL CHIAO TUNG UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Apoptosis; cDNA microarray; Hepatocellular carcinoma; Perilla frutescens; Rosmarinic acid

Indexed keywords

COMPLEMENTARY DNA; PERILLA FRUTESCENS EXTRACT; PLANT EXTRACT; ROSMARINIC ACID; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL PROLIFERATION; CELL STRAIN HEPG2; CONTROLLED STUDY; CULTURE MEDIUM; DNA MICROARRAY; DRUG EFFECT; DRUG MECHANISM; FLOW CYTOMETRY; GENE CONTROL; GENE EXPRESSION PROFILING; GROWTH INHIBITION; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; NUCLEOTIDE SEQUENCE; PERILLA FRUTESCENS;

4-1BB LIGAND; APOPTOSIS; CAFFEIC ACIDS; CARCINOMA, HEPATOCELLULAR; CASPASE 8; CELL LINE, TUMOR; CELL PROLIFERATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CINNAMATES; CLUSTER ANALYSIS; DEPSIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LIVER NEOPLASMS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PERILLA FRUTESCENS; PLANT EXTRACTS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-BCL-2; PROTO-ONCOGENE PROTEINS C-JUN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TIME FACTORS;

LAMIACEAE; PERILLA FRUTESCENS;

EID: 34347327216     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2007.05.008     Document Type: Article

References (34)

1. Banno N., Akihisa T., Tokuda H., Yasukawa K., Higashihara H., Ukiya M., Watanabe K., Kimura Y., Hasegawa J., and Nishino H. Triterpene acids from the leaves of Perilla frutescens and their anti-inflammatory and antitumor-promoting effects. Bioscience, Biotechnology, and Biochemistry 68 (2004) 85-90
2. Campos A.H., Zhao Y., Pollman M.J., and Gibbons G.H. DNA microarray profiling to identify angiotensin-responsive genes in vascular smooth muscle cells: potential mediators of vascular disease. Circulation Research 92 (2003) 111-118
3. Chor S.Y., Hui A.Y., To K.F., Chan K.K., Go Y.Y., Chan H.L., Leung W.K., and Sung J.J. Anti-proliferative and pro-apoptotic effects of herbal medicine on hepatic stellate cell. Journal of Ethnopharmacology 100 (2005) 180-186
4. Cory S., and Adams J.M. The Bcl2 family: regulators of the cellular life-or-death switch. Nature Review Cancer 2 (2002) 647-656
5. Davis D.W., Buchholz T.A., Hess K.R., Sahin A.A., Valero V., and McConkey D.J. Automated quantification of apoptosis after neoadjuvant chemotherapy for breast cancer: early assessment predicts clinical response. Clinical Cancer Research 9 (2003) 955-960
6. Hsieh T.C., and Wu J.M. Differential control of growth, cell cycle progression, and gene expression in human estrogen receptor positive MCF-7 breast cancer cells by extracts derived from polysaccharopeptide I'm-Yunity and Danshen and their combination. International Journal of Oncology 29 (2006) 1215-1222
7. Huang H., Park C.K., Ryu J.Y., Chang E.J., Lee Y., Kang S.S., and Kim H.H. Expression profiling of lipopolysaccharide target genes in RAW264.7 cells by oligonucleotide microarray analyses. Archives of Pharmacal Research 29 (2006) 890-897
8. Hur Y.G., Suh C.H., Kim S., and Won J. Rosmarinic acid induces apoptosis of activated T cells from rheumatoid arthritis patients via mitochondrial pathway. Journal of Clinical Immunology 27 (2007) 36-45
9. lck-dependent apoptosis in Jurkat and peripheral T cells via mitochondrial pathway independent from Fas/Fas ligand interaction. Journal of Immunology 172 (2004) 79-87
10. Kang J.X., Liu J., Wang J., He C., and Li F.P. The extract of huanglian, a medicinal herb, induces cell growth arrest and apoptosis by up-regulation of interferon-β and TNF-α in human breast cancer cells. Carcinogenesis 26 (2005) 1934-1939
11. Kang T.H., Pae H.O., Yoo J.C., Kim N.Y., Kim Y.C., Ko G.I., and Chung H.T. Antiproliferative effects of alkaloids from Sedum sarmentosum on murine and human hepatoma cell lines. Journal of Ethnopharmacology 70 (2000) 177-182
12. Kawahata T., Otake T., Mori H., Kojima Y., Oishi I., Oka S., Fukumori Y., and Sano K. A novel substance purified from Perilla frutescens Britton inhibits an early stage of HIV-1 replication without blocking viral adsorption. Antiviral Chemistry & Chemotherapy 13 (2002) 283-288
13. Kim D.S., Kim H.R., Woo E.R., Hong S.T., Chae H.J., and Chae S.W. Inhibitory effects of rosmarinic acid on adriamycin-induced apoptosis in H9c2 cardiac muscle cells by inhibiting reactive oxygen species and the activations of c-jun N-terminal kinase and extracellular signal-regulated kinase. Biochemical Pharmacology 70 (2005) 1066-1078
14. Kolettas E., Thomas C., Leneti E., Skoufos I., Mbatsi C., Sisoula C., Manos G., and Evangelou A. Rosmarinic acid failed to suppress hydrogen peroxide-mediated apoptosis but induced apoptosis of Jurkat cells which was suppressed by Bcl-2. Molecular and Cellular Biochemistry 285 (2006) 111-120
15. Kuo K.W., Hsu S.H., Li Y.P., Lin W.L., Liu L.F., Chang L.C., Lin C.C., Lin C.N., and Sheu H.M. Anticancer activity evaluation of the solanum glycoalkaloid solamargine: triggering apoptosis in human hepatoma cells. Biochemical Pharmacology 60 (2000) 1865-1873
16. Kyprianou N. Doxazosin and terazosin suppress prostate growth by inducing apoptosis: clinical significance. Journal of Urology 169 (2003) 1520-1525
17. Lee J., Jung E., Kim Y., Lee J., Park J., Hong S., Hyun C.G., Park D., and Kim Y.S. Rosmarinic acid as a downstream inhibitor of IKK-beta in TNF-alpha-induced upregulation of CCL11 and CCR3. British Journal of Pharmacology 148 (2006) 366-375
18. Lee S.P., Jun G., Yoon E.J., Park S., and Yang C.H. Inhibitory effect of methyl caffeate on Fos-Jun-DNA complex formation and suppression of cancer cell growth. Bulletin of the Korean Chemical Society 22 (2001) 1131-1135
19. Lim do Y., Jeong Y., Tyner A.L., and Park J.H. Induction of cell cycle arrest and apoptosis in HT-29 human colon cancer cells by the dietary compound luteolin. American Journal of Physiology: Gastrointestinal and Liver Physiology 292 (2007) G66-G75
20. Lin C.S., and Hsu C.W. Differentially transcribed genes in skeletal muscle of Duroc and Taoyuan pigs. Journal of Animal Science 83 (2005) 2075-2086
21. Luo X., Budihardjo I., Zou H., Slaughter C., and Wang X. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell 94 (1998) 481-490
22. Makino T., Furuta Y., Wakushima H., Fujii H., Saito K., and Kano Y. Anti-allergic effect of Perilla frutescens and its active constituents. Phytotherapy Research 17 (2003) 240-243
23. Osakabe N., Yasuda A., Natsume M., and Yoshikawa T. Rosmarinic acid inhibits epidermal inflammatory responses: anticarcinogenic effect of Perilla frutescens extract in the murine two-stage skin model. Carcinogenesis 25 (2004) 549-557
24. Peng Y., Ye J., and Kong J. Determination of phenolic compounds in Perilla frutescens L. by capillary electrophoresis with electrochemical detection. Journal of Agricultural and Food Chemistry 53 (2005) 8141-8147
25. Salimei P.S., Marfe G., Di Renzo L., Di Stefano C., Giganti M.G., Filomeni G., and Ciriolo M.R. The interference of rosmarinic acid in the DNA fragmentation induced by osmotic shock. Frontiers in Bioscience 12 (2007) 1308-1317
26. Selvendiran K., Koga H., Ueno T., Yoshida T., Maeyama M., Torimura T., Yano H., Kojiro M., and Sata M. Luteolin promotes degradation in signal transducer and activator of transcription 3 in human hepatoma cells: an implication for the antitumor potential of flavonoids. Cancer Research 66 (2006) 4826-4834
27. Stennicke H.R., Jurgensmeier J.M., Shin H., Deveraux Q., Wolf B.B., Yang X., Zhou Q., Ellerby H.M., Ellerby L.M., Bredesen D., Green D.R., Reed J.C., Froelich C.J., and Salvesen G.S. Pro-caspase-3 is a major physiologic target of caspase-8. Journal of Biological Chemistry 273 (1998) 27084-27090
28. Takano H., Osakabe N., Sanbongi C., Yanagisawa R., Inoue K., Yasuda A., Natsume M., Baba S., Ichiishi E., and Yoshikawa T. Extract of Perilla frutescens enriched for rosmarinic acid, a polyphenolic phytochemical, inhibits seasonal allergic rhinoconjunctivitis in humans. Experimental Biology and Medicine (Maywood) 229 (2004) 247-254
29. Takeda H., Tsuji M., Matumiya T., and Kubo M. Identification of rosmarinic acid as a novel antidepressive substance in the leaves of Perilla frutescens Britton var. acuta Kudo (Perillae Herba). Japanese Journal of Psychopharmacology 22 (2002) 15-22
30. Ueda H., Yamazaki C., and Yamazaki M. Luteolin as an anti-inflammatory and anti-allergic constituent of Perilla frutescens. Biological & Pharmaceutical Bulletin 25 (2002) 1197-1202
31. Ueda H., Yamazaki C., and Yamazaki M. Inhibitory effect of Perilla leaf extract and luteolin on mouse skin tumor promotion. Biological & Pharmaceutical Bulletin 26 (2003) 560-563
32. Wang Q.F., Chen J.C., Hsieh S.J., Cheng C.C., and Hsu S.L. Regulation of Bcl-2 family molecules and activation of caspase cascade involved in gypenosides-induced apoptosis in human hepatoma cells. Cancer Letters 183 (2002) 169-178
33. Yang N.S., Shyur L.F., Chen C.H., Wang S.Y., and Tzeng C.M. Medicinal herb extract and a single-compound drug confer similar complex pharmacogenomic activities in mcf-7 cells. Journal of Biomedical Science 11 (2004) 418-422
34. Yoo S.M., Oh S.H., Lee S.J., Lee B.W., Ko W.G., Moon C.K., and Lee B.H. Inhibition of proliferation and induction of apoptosis by tetraandrine in HepG2 cells. Journal of Ethnopharmacology 81 (2002) 225-229