Carnosic acid inhibits the proliferation and migration capacity of human colorectal cancer cells

Oncology Reports

Volumn 27, Issue 4, 2012, Pages 1041-1048

  Barni, M V ^a   Carlini, M J ^b   Cafferata, E G ^a   Puricelli, L ^b   Moreno, Silva ^a  

^a FUNDACIÓN INSTITUTO LELOIR   (Argentina)

^b Instituto de Oncologia Angel H Roffo   (Argentina)

Author keywords

Antitumor; Carnosic acid; Colorectal cancer; Cyclooxygenase 2; Migration

Indexed keywords

CARNOSIC ACID; CYCLOOXYGENASE 2; MATRIX METALLOPROTEINASE; UROKINASE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CELL MIGRATION; CELL PROLIFERATION; CELL VIABILITY; COLORECTAL CANCER; CONTROLLED STUDY; DOWN REGULATION; DRUG STRUCTURE; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; ZYMOGRAPHY;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CACO-2 CELLS; CELL ADHESION; CELL MOVEMENT; CELL PROLIFERATION; CELL SURVIVAL; COLORECTAL NEOPLASMS; CYCLOOXYGENASE 2; DITERPENES, ABIETANE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; HT29 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; PLANT EXTRACTS; PROTEASE INHIBITORS; RNA, MESSENGER; TIME FACTORS; UROKINASE-TYPE PLASMINOGEN ACTIVATOR;

EID: 84856582005     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2012.1630     Document Type: Article

References (31)

1. Bruce WR, Giacca A and Medline A: Possible mechanisms relating diet and risk of colon cancer. Cancer Epidemiol Biomarkers Prev 9: 1271-1279, 2000. (Pubitemid 32044794)
2. Storz P: Reactive oxygen species in tumor progression. Front Biosci 10: 1881-1896, 2005.
3. Kundu JK and Surh YJ: Epigallocatechin gallate inhibits phorbol ester-induced activation of NF-κB and CREB in mouse skin. Ann NY Acad Sci 1095: 504-512, 2007. (Pubitemid 47092481)
4. Kellof GJ, Crowell JA, Steele VE, Lubert RA, Malone WA, Boone CW, Koplovich L, Hawk ET, Liberman R, Lawrence JA, Ali I, Viner JL and Sigman CC: Progress in cancer chemoprevention: development of diet-derived chemopreventive agents. J Nutr 130: S467-S471, 2000.
5. Friedl P and Wolf K: Tumor-cell invasion and migration: diversity and escape mechanisms. Nat Rev Cancer 3: 362-374, 2003. (Pubitemid 37328856)
6. Lai KC, Huang AC, Hsu SC, Kuo CL, Yang JS, Wu SH and Chung JG: Benzyl Isothiocyanate (BITC) Inhibits migration and invasion of human colon cancer HT29 cells by inhibiting matrix metalloproteinase-2/-9 and urokinase plasminogen (uPA) through PKC and MAPK signaling pathway. J Agric Food Chem 58: 2935-2942, 2010.
7. Cao Y and Prescott SM: Many actions of cyclooxygenase-2 in cellular dynamics and in cancer. J Cell Physiol 190: 279-286, 2002. (Pubitemid 34111968)
8. Philip M, Rowley DA and Schreiber H: Inflammation as a tumor promoter in cancer induction. Semin Cancer Biol 14: 433-439, 2004. (Pubitemid 39360991)
9. Tsujii M, Kawano S and Dubois RN: Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential. Proc Natl Acad Sci USA 94: 3336-3340, 1997. (Pubitemid 27157312)
10. Lee KW, Bode AM and Dong Z: Molecular targets of phytochemicals for cancer prevention. Nat Rev Cancer 11: 211-218, 2011.
11. Aggarwal BB and Shisodia S: Suppression of the nuclear factor-kappaB activation pathway by spice-derived phytochemicals: reasoning for seasoning. Ann N Y Acad Sci 1030: 434-441, 2004. (Pubitemid 40378943)
12. Cheung S and Tai J: Anti-proliferative and antioxidant properties of rosemary Rosmarinus officinalis. Oncol Rep 17: 1525-1531, 2007.
13. Mengoni ES, Vichera G, Rigano LA, Rodriguez Puebla ML, Galliano SR, Cafferata EE, Pivetta OH, Moreno S and Vojnov AA: Suppression of COX-2, IL-1β and TNF-α expression and leukocyte infiltration in inflamed skin by bioactive compounds from Rosmarinus officinalis L. Fitoterapia 8: 414-421, 2011.
14. Steiner M, Priel I, Giat J, Levy J, Sharoni Y and Danilenko M: Carnosic acid inhibits proliferation and augments differentiation of human leukemic cells induced by 1,25-dihydroxyvitamin D3 and retinoic acid. Nutr Cancer 41: 135-144, 2001. (Pubitemid 34666233)
15. Danilenko M, Wang X and Studzinski GP: Carnosic acid and promotion of monocytic differentiation of HL60-G cell initiated by other agents. J Natl Cancer Inst 93: 1224-1233, 2001. (Pubitemid 32816197)
16. 3 in leukemia cells but does not promote elevation of basal levels of intracellular calcium. Cancer Res 63: 1325-1332, 2003.
17. Yu YM, Lin CH, Chan HC and Tsai HD: Carnosic acid reduces cytokine-induced adhesion molecules expression and monocyte adhesion to endothelial cells. Eur J Nutr 48: 101-106, 2009.
18. Yu YM, Lin HC and Chang WC: Carnosic acid prevents the migration of human aortic smooth muscle cells by inhibiting the activation and expression of matrix metalloproteinase-9. Br J Nutr 100: 731-738, 2008.
19. Moreno S, Scheyer T, Romano CS and Vojnov A: Antimicrobial and antioxidant activities of Argentinean Rosmarinus officinalis L. extracts. Free Radic Res 40: 223-231, 2006. (Pubitemid 43050885)
20. Romano CS, Abadi K, Repetto V, Vojnov A and Moreno S: Synergistic antioxidant and antibacterial activity of rosemary plus butylated derivatives. Food Chem 115: 456-461, 2008.
21. Barni MV, Fontanals A and Moreno S: Study of the antibiotic Efficacy of an ethanolic extract from Rosmarinus officinalis against Staphylococcus aureus in two skin infection models in mice. BLACPMA 8: 219-223, 2009.
22. He J, Xiao Y, Casiano CA and Zhang L: Role of mitochondrial cytochrome c in cocaine-induced apoptosis in coronary artery endothelial cells. J Pharmacol Exp Ther 295: 896-903, 2000.
23. Huang SS and Zheng RL: Rosmarinic acid inhibits angiogenesis and its mechanism of action in vitro. Cancer Lett 239: 271-280, 2006.
24. Aguirre Ghiso JA, Farías EF, Alonso DF and Bal de Kier Joffé E: Secretion of urokinase and metalloproteinase-9 induced by staurosporine is dependent on tyrosine kinase pathway in mammary tumor cells. Int J Cancer 76: 362-367, 1998. (Pubitemid 28282935)
25. Visanji JM, Thompson DG and Padfield PJ: Induction of G2/M phase cell cycle arrest by carnosol and carnosic acid is associated with alteration of cyclin A and cyclin B1 levels. Cancer Lett 237: 130-136, 2006. (Pubitemid 44262316)
26. Pesakhov S, Khanin M, Studzinski GP and Danilenko M: Distinct combinatorial effects of the plant polyphenols curcumin, carnosic acid and silibinin on proliferation and apoptosis in acute myeloid leukemia cells. Nutr Cancer 62: 811-824, 2010.
27. Limab YC, Park HY, Hwang HS, Kang SU, Pyunc JH, Lee MH, Choi EC and Kimc C: (-)-Epigallocatechin-3-gallate (EGCG) inhibits HGF-induced invasion and metastasis in hypopharyngeal carcinoma cells. Cancer Lett 271: 140-152, 2008.
28. Park C, Moon DO and Choi IW: Curcumin induces apoptosis and inhibits prostaglandin E2 productionin synovial fibroblasts of patients with rheumatoid arthritis. Int J Mol Med 20: 365-372, 2007.
29. Gupta RA and DuBois RN: Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2. Nat Rev Cancer 1: 11-21, 2001. (Pubitemid 33741877)
30. Sobolewski C, Cerella C, Dicato M, Ghibelli M and Miederich M: The role of cyclooxygenase-2 in cell proliferation and cell death in human malignancies. Int J Cell Biol 2010: 1-21, 2010.
31. Leung E, McArthur D, Morris A and Williams N: Cyclo-oxygenase-2 inhibition prevents migration of colorectal cancer cells to extracellular matrix by down-regulation of matrix metalloproteinase-2 expression. Dis Colon Rectum 51: 342-347, 2007.