A systems study reveals concurrent activation of AMPK and mTOR by amino acids

Nature Communications

Volumn 7, Issue , 2016, Pages

  Pezze, Piero Dalle ^a,b   Ruf, Stefanie ^c,d   Sonntag, Annika G ^c   Langelaar Makkinje, Miriam ^d   Hall, Philip ^a   Heberle, Alexander M ^d   Navas, Patricia Razquin ^d,e   Van Eunen, Karen ^d   Tölle, Regine C ^c   Schwarz, Jennifer J ^c   Wiese, Heike ^c,f   Warscheid, Bettina ^c   Deitersen, Jana ^g   Stork, Björn ^g   Fäßler, Erik ^h   Schäuble, Sascha ^h   Hahn, Udo ^h   Horvatovich, Peter ⁱ   Shanley, Daryl P ^g   Thedieck, Kathrin ^d,e  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b BABRAHAM INSTITUTE   (United Kingdom)

^c UNIVERSITY OF FREIBURG   (Germany)

^d UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^e UNIVERSITY OF OLDENBURG   (Germany)

^f UNIVERSITY OF ULM   (Germany)

^g HEINRICH HEINE UNIVERSITY   (Germany)

^h FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

ⁱ UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE KINASE BETA; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PHOSPHOTRANSFERASE; PROTEIN C JUN; PROTEIN SERINE THREONINE KINASE; S6 KINASE; UNC 51 LIKE KINASE 1; UNCLASSIFIED DRUG; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE KINASE; MTOR PROTEIN, HUMAN; PROTEIN KINASE B; SERINE THREONINE PROTEIN KINASE ULK1; SIGNAL PEPTIDE; TARGET OF RAPAMYCIN KINASE; ULK1 PROTEIN, HUMAN;

AMINO ACID; ENZYME ACTIVITY; EXPERIMENTAL STUDY; GENETIC ANALYSIS; METABOLITE; PHYSIOLOGY; PROTEIN; PROTEOMICS;

ANIMAL CELL; ARTICLE; AUTOPHAGY; COMPUTER MODEL; CONTROLLED STUDY; DATA MINING; EMBRYO; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FEMALE; HUMAN; HUMAN CELL; MATHEMATICAL MODEL; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PROTEOMICS; QUANTITATIVE ANALYSIS; BIOLOGICAL MODEL; CELL LINE; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; METABOLISM;

MAMMALIA;

AMINO ACIDS; AMP-ACTIVATED PROTEIN KINASES; AUTOPHAGY-RELATED PROTEIN-1 HOMOLOG; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE KINASE; CELL LINE; GENE EXPRESSION REGULATION; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 2; MODELS, BIOLOGICAL; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; TOR SERINE-THREONINE KINASES;

EID: 84995944908     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms13254     Document Type: Article

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