AMP-activated protein kinase-a1 as an activating kinase of TGF-b-activated kinase 1 has a key role in inflammatory signals

Cell Death and Disease

Volumn 3, Issue 7, 2012, Pages

  Kim, S Y ^a   Jeong, S ^a   Jung, E ^a   Baik, K H ^a   Chang, M H ^a   Kim, S A ^a   Shim, J H ^b   Chun, E ^b   Lee, K Y ^a  

^a Sungkyunkwan University School of Medicine   (South Korea)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

AMP activated protein kinase a1; NF kB; TGF b activated kinase 1; TNF a induced apoptosis; Toll like receptor 4

Indexed keywords

AMP ACTIVATED PROTEIN KINASE ALPHA1; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; TOLL LIKE RECEPTOR 4; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; LIPOPOLYSACCHARIDE; MAP KINASE KINASE KINASE 7; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; PRKAA1 PROTEIN, HUMAN; SMALL INTERFERING RNA;

ARTICLE; CYTOKINE PRODUCTION; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; APOPTOSIS; CELL LINE; CELL STRAIN HEK293; DRUG ANTAGONISM; GENETIC TRANSFECTION; GENETICS; INFLAMMATION; METABOLISM; MICROARRAY ANALYSIS; PATHOLOGY; RNA INTERFERENCE;

AMP-ACTIVATED PROTEIN KINASES; APOPTOSIS; CELL LINE; HEK293 CELLS; HUMANS; INFLAMMATION; INTERLEUKIN-1BETA; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MAP KINASE KINASE KINASES; MICROARRAY ANALYSIS; NF-KAPPA B; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4; TRANSFECTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84864867582     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2012.95     Document Type: Article

References (37)

1. Yamaguchi K, Shirakabe K, Shibuya H, Irie K, Oishi I, Ueno N et al. Identification of a member of the MAPKKK family as a potential mediator of TGF-b signal transduction. Science 1995; 270: 2008-2011.
2. Wang C, Deng L, Hong M, Akkaraju GR, Inoue J, Chen Z.J. TAK1 is ubiquitin-dependent kinase of MKK and IKK. Nature 2001; 412: 346-351.
3. Shim JH, Xiao C, Paschal AE, Bailey ST, Rao P, Hayden MS et al. TAK1 but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo. Genes Dev 2005; 19: 2668-2681.
4. Kim SY, Shim JH, Chun E, Lee K.Y. Reciprocal Inhibition between the transforming growth factor-b-activated kinase 1 (TAK1) and apoptosis signal-regulating kinase 1 (ASK1) mitogen-activated protein kinase kinase kinases and its suppression by TAK1- binding protein 2 (TAB2), an adapter protein for TAK1. J Biol Chem 2012; 287: 3381-3391.
5. Skaug B, Jiang X, Chen Z.J. The role of ubiquitin in NF-kappaB regulatory pathways. Annu Rev Biochem 2009; 78: 769-796.
6. Liu S, Chen Z.J. Expanding role of ubiquitination in NF-kB signaling. Cell Res 2011; 21: 6-21.
7. Hayden MS, Ghosh S. Signaling to NF-kappaB. Genes Dev 2004; 18: 2195-2224.
8. West AP, Koblansky AA, Ghosh S. Recognition and signaling by toll-like receptors. Annu Rev Cell Dev Biol 2006; 22: 409-437.
9. Viollet B, Horman S, Leclerc J, Lantier L, Foretz M, Billaud M et al. AMPK inhibition in health and disease. Crit Rev Biochem Mol Biol 2010; 45: 276-295.
10. Carling D, Mayer FV, Sanders MJ, Gamblin S.J. AMP-activated protein kinase: nature's energy sensor. Nat Chem Biol 2011; 7: 512-518.
11. Corton JM, Gillespie JG, Hardie D.G. Role of the AMP-activated protein kinase in the cellular stress response. Curr Biol 1994; 4: 315-324.
12. Hardie DG, Carling D. The AMP-activated protein kinase-fuel gauge of the mammalian cell? Eur J Biochem 1997; 246: 259-273.
13. Witczak CA, Sharoff CG, Goodyear L.J. AMP-activated protein kinase in skeletal muscle: from structure and localization to its role as a master regulator of cellular metabolism. Cell Mol Life Sci 2008; 65: 3737-3755.
14. Salt I, Celler JW, Hawley SA, Prescott A, Woods A, Carling D et al. AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the alpha2 isoform. Biochem J 1998; 334(Part 1): 177-187.
15. Tamás P, Hawley SA, Clarke RG, Mustard KJ, Green K, Hardie DG et al. Regulation of the energy sensor AMP-activated protein kinase by antigen receptor and Ca2 in T lymphocytes. J Exp Med 2006; 203: 1665-1670.
16. Sag D, Carling D, Stout RD, Suttles J. Adenosine 5'-monophosphate- activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype. J Immunol 2008; 181: 8633-8641.
17. Momcilovic M, Hong SP, Carlson M. Mammalian TAK1 activates Snf1 protein kinase in yeast and phosphorylates AMP-activated protein kinase in vitro. J Biol Chem 2006; 281: 25336-25343.
18. Xie M, Zhang D, Dyck JR, Li Y, Zhang H, Morishima M et al. A pivotal role for endogenous TGF-beta-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway. Proc Natl Acad Sci USA 2006; 103: 17378-17383.
19. Herrero-Mart?́n G, Høyer-Hansen M, Garc?́a-Garc? ́a C, Fumarola C, Farkas T, López-Rivas A et al. TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells. EMBO J 2009; 28: 677-685.
20. Scholz R, Sidler CL, Thali RF, Winssinger N, Cheung PC, Neumann D. Autoactivation of transforming growth factor beta-activated kinase 1 is a sequential bimolecular process. J Biol Chem 2010; 285: 25753-25766.
21. Vucicevic L, Misirkic M, Janjetovic K, Vilimanovich U, Sudar E, Isenovic E et al. Compound C induces protective autophagy in cancer cells through AMPK inhibition-independent blockade of Akt/mTOR pathway. Autophagy 2011; 7: 40-50.
22. Li J, Miller EJ, Ninomiya-Tsuji J, Russell RR 3rd, Young L.H. AMP-activated protein kinase activates p38 mitogen-activated protein kinase by increasing recruitment of p38 MAPK to TAB1 in the ischemic heart. Circ Res 2005; 97: 872-879.
23. Kefas BA, Cai Y, Ling Z, Heimberg H, Hue L, Pipeleers D et al. AMP-activated protein kinase can induce apoptosis of insulin-producing MIN6 cells through stimulation of c-Jun- N-terminal kinase. J Mol Endocrinol 2003; 30: 151-161.
24. Leclerc GM, Leclerc GJ, Fu G, Barredo J.C. AMPK-induced activation of Akt by AICAR is mediated by IGF-1R dependent and independent mechanisms in acute lymphoblastic leukemia. J Mol Signal 2010; 5: 15.
25. Kewalramani G, Puthanveetil P, Wang F, Kim MS, Deppe S, Abrahani A et al. AMPactivated protein kinase confers protection against TNF-{alpha}-induced cardiac cell death. Cardiovasc Res 2009; 84: 42-53.
26. Hsu H, Xiong J, Goeddel D.V. The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation. Cell 1999; 81: 495-504.
27. Hsu H, Shu HB, Pan MG, Goeddel D.V. TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways. Cell 1996; 84: 299-308.
28. Vasudevan KM, Gurumurthy S, Rangnekar V.M. Suppression of PTEN expression by NF-kappa B prevents apoptosis. Mol Cell Biol 2004; 24: 1007-1021.
29. Koul D, Takada Y, Shen R, Aggarwal BB, Yung W.K. PTEN enhances TNF-induced apoptosis through modulation of nuclear factor-kappaB signaling pathway in human glioma cells. Biochem Biophys Res Commun 2006; 350: 463-471.
30. Littler DR, Walker JR, Davis T, Wybenga-Groot LE, Finerty PJ Jr, Newman E et al. A conserved mechanism of autoinhibition for the AMPK kinase domain: ATP-binding site and catalytic loop refolding as a means of regulation. Acta Crystallogr Sect F Struct Biol Cryst Commun 2010; 66(Pt 2): 143-151.
31. Li M, Wang H, Huang T, Wang J, Ding Y, Li Z et al. TAB2 scaffolds TAK1 and NLK in repressing canonical Wnt signaling. J Biol Chem 2010; 285: 13397-13404.
32. Winkel A, Stricker S, Tylzanowski P, Seiffart V, Mundlos S, Gross G et al. Wnt-liganddependent interaction of TAK1 (TGF-beta-activated kinase-1) with the receptor tyrosine kinase Ror2 modulates canonical Wnt-signalling. Cell Signal 2008; 20: 2134-2144.
33. Kim SY, Chun E, Lee K.Y. Phospholipase A(2) of peroxiredoxin 6 has a critical role in tumor necrosis factor-induced apoptosis. Cell Death Differ 2011; 18: 1573-1583.
34. Fraser DA, Arora M, Bohlson SS, Lozano E, Tenner A.J. Generation of inhibitory NFkappaB complexes and phosphorylated cAMP response element-binding protein correlates with the anti-inflammatory activity of complement protein C1q in human monocytes. J Biol Chem 2007; 282: 7360-7367.
35. Lee YG, Lee SW, Sin HS, Kim EJ, Um S.J. Kinase activity-independent suppression of p73 alpha by AMP-activated kinase alpha (AMPKalpha). Oncogene 2009; 28: 1040-10452.
36. Kim SY, Kim TJ, Lee K.Y. A novel function of peroxiredoxin 1 (Prx-1) in apoptosis signal-regulating kinase 1 (ASK1)-mediated signaling pathway. FEBS Lett 2008; 582: 1913-1918.
37. Kim SY, Jo HY, Kim MH, Cha YY, Choi SW, Shim JH et al. H2O2-dependent hyperoxidation of peroxiredoxin 6 (Prdx6) plays a role in cellular toxicity via up-regulation of iPLA2 activity. J Biol Chem 2008; 283: 33563-33568.