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Volumn 55, Issue 1, 2016, Pages 1-18

How Does Exercise Reduce the Rate of Age-Associated Cognitive Decline? A Review of Potential Mechanisms

Author keywords

BDNF; cognition; cognitive aging; exercise; inflammation; insulin; stress; vascular

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; INSULIN;

EID: 84994568502     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-160665     Document Type: Review
Times cited : (140)

References (250)
  • 1
    • 33748532898 scopus 로고    scopus 로고
    • Revenge of the Sit": How lifestyle impacts neuronal and cognitive health through molecular systems that interface energy metabolism with neuronal plasticity
    • Vaynman S, Gomez-Pinilla F (2006) Revenge of the "Sit": How lifestyle impacts neuronal and cognitive health through molecular systems that interface energy metabolism with neuronal plasticity. J Neurosci Res 84, 699-715.
    • (2006) J Neurosci Res , vol.84 , pp. 699-715
    • Vaynman, S.1    Gomez-Pinilla, F.2
  • 4
    • 0031462248 scopus 로고    scopus 로고
    • Exercise and its role in the prevention and rehabilitation of cardiovascular disease
    • Miller TD, Balady GJ, Fletcher GF (1997) Exercise and its role in the prevention and rehabilitation of cardiovascular disease. Ann Behav Med 19, 220-229.
    • (1997) Ann Behav Med , vol.19 , pp. 220-229
    • Miller, T.D.1    Balady, G.J.2    Fletcher, G.F.3
  • 6
    • 84877805496 scopus 로고    scopus 로고
    • Lifestyle predictors of healthy ageing in men
    • SödergrenM(2013) Lifestyle predictors of healthy ageing in men. Maturitas 75, 113-117.
    • (2013) Maturitas , vol.75 , pp. 113-117
    • Södergren, M.1
  • 7
    • 84930735699 scopus 로고    scopus 로고
    • Effect of moderate to vigorous physical activity on all-cause mortality in middle-aged and older Australians
    • Gebel K, Ding D, Chey T, Stamatakis E, Brown WJ, Bauman AE (2015) Effect of moderate to vigorous physical activity on all-cause mortality in middle-aged and older Australians. JAMA Intern Med 175, 970-977.
    • (2015) JAMA Intern Med , vol.175 , pp. 970-977
    • Gebel, K.1    Ding, D.2    Chey, T.3    Stamatakis, E.4    Brown, W.J.5    Bauman, A.E.6
  • 12
    • 33745925273 scopus 로고    scopus 로고
    • A meta-regression to examine the relationship between aerobic fitness and cognitive performance
    • Etnier JL, Nowell PM, Landers DM, Sibley BA (2006) A meta-regression to examine the relationship between aerobic fitness and cognitive performance. Brain Res Rev 52, 119-130.
    • (2006) Brain Res Rev , vol.52 , pp. 119-130
    • Etnier, J.L.1    Nowell, P.M.2    Landers, D.M.3    Sibley, B.A.4
  • 13
    • 59849089967 scopus 로고    scopus 로고
    • The effects of exercise on cognition in older adults with and without cognitive decline: A systematic review
    • van Uffelen JGZ, Chin A, Paw MJM, Hopman-Rock M, van MechelenW(2008) The effects of exercise on cognition in older adults with and without cognitive decline: A systematic review. Clin J Sport Med 18, 486-500.
    • (2008) Clin J Sport Med , vol.18 , pp. 486-500
    • Van Uffelen, J.G.Z.1    Chin, A.2    Paw, M.J.M.3    Hopman-Rock, M.4    Van Mechelen, W.5
  • 14
    • 84901823628 scopus 로고    scopus 로고
    • The impact of exercise on the cognitive functioning of healthy older adults: A systematic review and meta-analysis
    • Kelly ME, Loughrey D, Lawlor BA, Robertson IH, Walsh C, Brennan S (2014) The impact of exercise on the cognitive functioning of healthy older adults: A systematic review and meta-analysis. Ageing Res Rev 16, 12-31.
    • (2014) Ageing Res Rev , vol.16 , pp. 12-31
    • Kelly, M.E.1    Loughrey, D.2    Lawlor, B.A.3    Robertson, I.H.4    Walsh, C.5    Brennan, S.6
  • 15
    • 0036602967 scopus 로고    scopus 로고
    • Exercise: A behavioral intervention to enhance brain health and plasticity
    • CotmanCW, Berchtold NC (2002) Exercise: A behavioral intervention to enhance brain health and plasticity. Trends Neurosci 25, 295-301.
    • (2002) Trends Neurosci , vol.25 , pp. 295-301
    • Cotman, C.W.1    Berchtold, N.C.2
  • 16
    • 9644270414 scopus 로고    scopus 로고
    • Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition
    • Vaynman S, Ying Z, Gomez-Pinilla F (2004) Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition. Eur J Neurosci 20, 2580-2590.
    • (2004) Eur J Neurosci , vol.20 , pp. 2580-2590
    • Vaynman, S.1    Ying, Z.2    Gomez-Pinilla, F.3
  • 17
    • 56749180855 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor functions as a metabotrophin to mediate the effects of exercise on cognition
    • Gomez-Pinilla F, Vaynman S, YingZ(2008) Brain-derived neurotrophic factor functions as a metabotrophin to mediate the effects of exercise on cognition. Eur J Neurosci 28, 2278-2287.
    • (2008) Eur J Neurosci , vol.28 , pp. 2278-2287
    • Gomez-Pinilla, F.1    Vaynman, S.2    Ying, Z.3
  • 19
    • 84883312203 scopus 로고    scopus 로고
    • Endothelium-dependent control of cerebrovascular functions through age: Exercise for healthy cerebrovascular aging
    • Bolduc V, Thorin-Trescases N, Thorin E (2013) Endothelium-dependent control of cerebrovascular functions through age: Exercise for healthy cerebrovascular aging. Am J Physiol Heart Circ Physiol 305, H620-H633.
    • (2013) Am J Physiol Heart Circ Physiol , vol.305 , pp. H620-H633
    • Bolduc, V.1    Thorin-Trescases, N.2    Thorin, E.3
  • 20
    • 84888088025 scopus 로고    scopus 로고
    • Central artery stiffness, neuropsychological function, cerebral perfusion in sedentary and endurance-trained middle-aged adults
    • Tarumi T, Gonzales MM, Fallow B, Nualnim N, Pyron M, Tanaka H, Haley AP (2013) Central artery stiffness, neuropsychological function, cerebral perfusion in sedentary and endurance-trained middle-aged adults. J Hypertens 31, 2400-2409.
    • (2013) J Hypertens , vol.31 , pp. 2400-2409
    • Tarumi, T.1    Gonzales, M.M.2    Fallow, B.3    Nualnim, N.4    Pyron, M.5    Tanaka, H.6    Haley, A.P.7
  • 22
    • 33845649334 scopus 로고    scopus 로고
    • The protective role of exercise on stress system dysregulation and comorbidities
    • Tsatsoulis A, Fountoulakis S (2006) The protective role of exercise on stress system dysregulation and comorbidities. Ann N Y Acad Sci 1083, 196-213.
    • (2006) Ann N y Acad Sci , vol.1083 , pp. 196-213
    • Tsatsoulis, A.1    Fountoulakis, S.2
  • 23
    • 84863331154 scopus 로고    scopus 로고
    • The moderating role of exercise on stress-related effects on the hippocampus and memory in later adulthood
    • Head D, Singh T, Bugg JM (2012) The moderating role of exercise on stress-related effects on the hippocampus and memory in later adulthood. Neuropsychology 26, 133-143.
    • (2012) Neuropsychology , vol.26 , pp. 133-143
    • Head, D.1    Singh, T.2    Bugg, J.M.3
  • 25
    • 77957970723 scopus 로고    scopus 로고
    • Does exercise protect from cognitive decline by altering brain cytokine and apoptotic protein levels?Asystematic review of the literature
    • Packer N, Pervaiz N, Hoffman-Goetz L (2010) Does exercise protect from cognitive decline by altering brain cytokine and apoptotic protein levels?Asystematic review of the literature. Exerc Immunol Rev 16, 138-162.
    • (2010) Exerc Immunol Rev , vol.16 , pp. 138-162
    • Packer, N.1    Pervaiz, N.2    Hoffman-Goetz, L.3
  • 26
    • 84936941104 scopus 로고    scopus 로고
    • Effects of physical exercise on neuroinflammation, neuroplasticity, neurodegeneration, behavior: What we can learn from animal models in clinical settings
    • Svensson M, Lexell J, Deierborg T (2015) Effects of physical exercise on neuroinflammation, neuroplasticity, neurodegeneration, behavior: What we can learn from animal models in clinical settings. Neurorehabil Neural Repair 29, 577-589.
    • (2015) Neurorehabil Neural Repair , vol.29 , pp. 577-589
    • Svensson, M.1    Lexell, J.2    Deierborg, T.3
  • 27
    • 84951832271 scopus 로고    scopus 로고
    • Neuroinflammation negatively affects adult hippocampal neurogenesis and cognition: Can exercise compensate
    • Ryan SM, Nolan YM (2016) Neuroinflammation negatively affects adult hippocampal neurogenesis and cognition: Can exercise compensate Neurosci Biobehav Rev 61, 121-131.
    • (2016) Neurosci Biobehav Rev , vol.61 , pp. 121-131
    • Ryan, S.M.1    Nolan, Y.M.2
  • 29
    • 81355151398 scopus 로고    scopus 로고
    • Insulin resistance and pathological brain ageing
    • Cholerton B, Baker LD, Craft S (2011) Insulin resistance and pathological brain ageing. Diabet Med 28, 1463-1475.
    • (2011) Diabet Med , vol.28 , pp. 1463-1475
    • Cholerton, B.1    Baker, L.D.2    Craft, S.3
  • 30
    • 84877996641 scopus 로고    scopus 로고
    • Insulin and Alzheimer's disease: Untangling the web
    • Craft S, Cholerton B, Baker LD (2013) Insulin and Alzheimer's disease: Untangling the web. J Alzheimers Dis 33, S263-S275.
    • (2013) J Alzheimers Dis , vol.33 , pp. S263-S275
    • Craft, S.1    Cholerton, B.2    Baker, L.D.3
  • 31
    • 0038050784 scopus 로고    scopus 로고
    • Fitness effects on the cognitive function of older adults a meta-analytic study
    • Colcombe S, KramerA(2003) Fitness effects on the cognitive function of older adults a meta-analytic study. Psychol Sci 14, 125-130.
    • (2003) Psychol Sci , vol.14 , pp. 125-130
    • Colcombe, S.1    Kramer, A.2
  • 33
    • 84879458170 scopus 로고    scopus 로고
    • The influence of exercise on cognitive abilities
    • Gomez-Pinilla F, Hillman C (2013) The influence of exercise on cognitive abilities. Compr Physiol 3, 403-428.
    • (2013) Compr Physiol , vol.3 , pp. 403-428
    • Gomez-Pinilla, F.1    Hillman, C.2
  • 34
    • 34147111339 scopus 로고    scopus 로고
    • Physical activity and the maintenance of cognitive function
    • Rockwood K, Middleton L (2007) Physical activity and the maintenance of cognitive function. Alzheimers Dement 3, S38-S44.
    • (2007) Alzheimers Dement , vol.3 , pp. S38-S44
    • Rockwood, K.1    Middleton, L.2
  • 37
    • 84903268968 scopus 로고    scopus 로고
    • Does physical activity prevent cognitive decline and dementia: A systematic review and meta-analysis of longitudinal studies
    • Blondell SJ, Hammersley-Mather R, Veerman JL (2014) Does physical activity prevent cognitive decline and dementia?: A systematic review and meta-analysis of longitudinal studies. BMC Public Health 14, 510.
    • (2014) BMC Public Health , vol.14 , pp. 510
    • Blondell, S.J.1    Hammersley-Mather, R.2    Veerman, J.L.3
  • 42
    • 5344237365 scopus 로고    scopus 로고
    • The effects of exercise training on elderly persons with cognitive impairment and dementia: A meta-analysis
    • Heyn P, Abreu BC, Ottenbacher KJ (2004) The effects of exercise training on elderly persons with cognitive impairment and dementia: A meta-analysis. Arch Phys Med Rehabil 85, 1694-1704.
    • (2004) Arch Phys Med Rehabil , vol.85 , pp. 1694-1704
    • Heyn, P.1    Abreu, B.C.2    Ottenbacher, K.J.3
  • 43
    • 77956289055 scopus 로고    scopus 로고
    • Physical activity and mild cognitive impairment and Alzheimer's disease
    • Lautenschlager NT, Cox K, Kurz AF (2010) Physical activity and mild cognitive impairment and Alzheimer's disease. Curr Neurol Neurosci Rep 10, 352-358.
    • (2010) Curr Neurol Neurosci Rep , vol.10 , pp. 352-358
    • Lautenschlager, N.T.1    Cox, K.2    Kurz, A.F.3
  • 45
    • 84906638920 scopus 로고    scopus 로고
    • Effect of physical exercise on cognitive performance in older adults with mild cognitive impairment or dementia: A systematic review
    • Ohman H, Savikko N, Strandberg TE, Pitkälä KH (2014) Effect of physical exercise on cognitive performance in older adults with mild cognitive impairment or dementia: A systematic review. Dement Geriatr Cogn Disord 38, 347-365.
    • (2014) Dement Geriatr Cogn Disord , vol.38 , pp. 347-365
    • Ohman, H.1    Savikko, N.2    Strandberg, T.E.3    Pitkälä, K.H.4
  • 47
    • 84959087182 scopus 로고    scopus 로고
    • Physical activity and neurocognitive functioning in aging-A condensed updated review
    • Gajewski PD, Falkenstein M (2016) Physical activity and neurocognitive functioning in aging-a condensed updated review. Eur Rev Aging Phys Act 13, 1.
    • (2016) Eur Rev Aging Phys Act , vol.13 , pp. 1
    • Gajewski, P.D.1    Falkenstein, M.2
  • 48
    • 1842528400 scopus 로고    scopus 로고
    • Convergence of atherosclerosis and Alzheimer's disease: Inflammation, cholesterol, misfolded proteins
    • Casserly I, Topol E (2004) Convergence of atherosclerosis and Alzheimer's disease: Inflammation, cholesterol, misfolded proteins. Lancet 363, 1139-1146.
    • (2004) Lancet , vol.363 , pp. 1139-1146
    • Casserly, I.1    Topol, E.2
  • 49
    • 0036218738 scopus 로고    scopus 로고
    • Alzheimer disease as a vascular disorder: Nosological evidence
    • de la Torre JC (2002) Alzheimer disease as a vascular disorder: Nosological evidence. Stroke 33, 1152-1162.
    • (2002) Stroke , vol.33 , pp. 1152-1162
    • Dela Torre, J.C.1
  • 50
    • 1242331823 scopus 로고    scopus 로고
    • Is Alzheimer's disease a neurodegenerative or a vascular disorder Data, dogma, dialectics
    • de la Torre JC (2004) Is Alzheimer's disease a neurodegenerative or a vascular disorder Data, dogma, dialectics. Lancet Neurol 3, 184-190.
    • (2004) Lancet Neurol , vol.3 , pp. 184-190
    • Dela Torre, J.C.1
  • 52
    • 2442566380 scopus 로고    scopus 로고
    • Review: An active and socially integrated lifestyle in late life might protect against dementia
    • Fratiglioni L, Paillard-borg S, Winblad B (2004) Review: An active and socially integrated lifestyle in late life might protect against dementia. Lancet Neurol 3, 343-353.
    • (2004) Lancet Neurol , vol.3 , pp. 343-353
    • Fratiglioni, L.1    Paillard-Borg, S.2    Winblad, B.3
  • 53
    • 84902549545 scopus 로고    scopus 로고
    • Cognitive impairment and cardiovascular disease: So near, so far
    • Picano E, Bruno RM, Ferrari GF, Bonuccelli U (2014) Cognitive impairment and cardiovascular disease: So near, so far. Int J Cardiol 175, 21-29.
    • (2014) Int J Cardiol , vol.175 , pp. 21-29
    • Picano, E.1    Bruno, R.M.2    Ferrari, G.F.3    Bonuccelli, U.4
  • 55
    • 84921454500 scopus 로고    scopus 로고
    • The mechanical cause of age-related dementia (Alzheimer's disease): The brain is destroyed by the pulse
    • Stone J, Johnstone DM, Mitrofanis J, Rourke MO (2015) The mechanical cause of age-related dementia (Alzheimer's disease): The brain is destroyed by the pulse. J Alzheimers Dis 44, 355-373.
    • (2015) J Alzheimers Dis , vol.44 , pp. 355-373
    • Stone, J.1    Johnstone, D.M.2    Mitrofanis, J.3    Rourke, M.O.4
  • 56
    • 20044392868 scopus 로고    scopus 로고
    • Structural and genetic bases of arterial stiffness
    • Laurent S, Boutouyrie P, Lacolley P (2005) Structural and genetic bases of arterial stiffness. Hypertension 45, 1050-1055.
    • (2005) Hypertension , vol.45 , pp. 1050-1055
    • Laurent, S.1    Boutouyrie, P.2    Lacolley, P.3
  • 57
    • 84865833424 scopus 로고    scopus 로고
    • Arteriosclerosis: Inevitable or self-inflicted
    • Wilkinson IB, McEniery CM (2012) Arteriosclerosis: Inevitable or self-inflicted Hypertension 60, 3-5.
    • (2012) Hypertension , vol.60 , pp. 3-5
    • Wilkinson, I.B.1    McEniery, C.M.2
  • 58
    • 25444523801 scopus 로고    scopus 로고
    • Arterial aging: Is it an immutable cardiovascular risk factor
    • Najjar SS, Scuteri A, Lakatta EG (2005) Arterial aging: Is it an immutable cardiovascular risk factor Hypertension 46, 454-462.
    • (2005) Hypertension , vol.46 , pp. 454-462
    • Najjar, S.S.1    Scuteri, A.2    Lakatta, E.G.3
  • 59
    • 57049128826 scopus 로고    scopus 로고
    • Effects of central arterial aging on the structure and function of the peripheral vasculature: Implications for end-organ damage
    • Mitchell GF (2008) Effects of central arterial aging on the structure and function of the peripheral vasculature: Implications for end-organ damage. J Appl Physiol 105, 1652-1660.
    • (2008) J Appl Physiol , vol.105 , pp. 1652-1660
    • Mitchell, G.F.1
  • 60
    • 21744459081 scopus 로고    scopus 로고
    • Relationship between aortic stiffening and microvascular disease in brain and kidney: Cause and logic of therapy
    • O'Rourke MF, Safar ME (2005) Relationship between aortic stiffening and microvascular disease in brain and kidney: Cause and logic of therapy. Hypertension 46, 200-204.
    • (2005) Hypertension , vol.46 , pp. 200-204
    • O'Rourke, M.F.1    Safar, M.E.2
  • 61
    • 84865838017 scopus 로고    scopus 로고
    • Arterial stiffness: Basic concepts and measurement techniques
    • Chirinos JA (2012) Arterial stiffness: Basic concepts and measurement techniques. J Cardiovasc Transl Res 5, 243-255.
    • (2012) J Cardiovasc Transl Res , vol.5 , pp. 243-255
    • Chirinos, J.A.1
  • 62
    • 84872257634 scopus 로고    scopus 로고
    • Arterial stiffness: Detection and consequences in cognitive impairment and dementia of the elderly
    • Rabkin SW (2012) Arterial stiffness: Detection and consequences in cognitive impairment and dementia of the elderly. J Alzheimers Dis 32, 541-549.
    • (2012) J Alzheimers Dis , vol.32 , pp. 541-549
    • Rabkin, S.W.1
  • 63
    • 84927644444 scopus 로고    scopus 로고
    • Association between arterial stiffness, cerebral small vessel disease and cognitive impairment: A systematic review and meta-analysis
    • van Sloten TT, Protogerou AD, Henry RMA, Schram MT, Launer LJ, Stehouwer CDA (2015) Association between arterial stiffness, cerebral small vessel disease and cognitive impairment: A systematic review and meta-analysis. Neurosci Biobehav Rev 53, 121-130.
    • (2015) Neurosci Biobehav Rev , vol.53 , pp. 121-130
    • Van Sloten, T.T.1    Protogerou, A.D.2    Henry, R.M.A.3    Schram, M.T.4    Launer, L.J.5    Stehouwer, C.D.A.6
  • 65
    • 38449115868 scopus 로고    scopus 로고
    • Arterial aging: Pathophysiological principles
    • O'Rourke MF (2007) Arterial aging: Pathophysiological principles. Vasc Med 12, 329-341.
    • (2007) Vasc Med , vol.12 , pp. 329-341
    • O'Rourke, M.F.1
  • 67
    • 77954862582 scopus 로고    scopus 로고
    • Yearlong physical activity and regional stiffness of arteries in older adults: The Nakanojo Study
    • AoyagiY, Park H, KakiyamaT, Park S, Yoshiuchi K, Shephard RJ (2010) Yearlong physical activity and regional stiffness of arteries in older adults: The Nakanojo Study. Eur J Appl Physiol 109, 455-464.
    • (2010) Eur J Appl Physiol , vol.109 , pp. 455-464
    • Aoyagi, Y.1    Park, H.2    Kakiyamat Park, S.3    Yoshiuchi, K.4    Shephard, R.J.5
  • 68
    • 33947206736 scopus 로고    scopus 로고
    • Arterial stiffness and baroreflex sensitivity following bouts of aerobic and resistance exercise
    • Heffernan KS, Collier SR, Kelly EE, Jae SY, Fernhall B (2007) Arterial stiffness and baroreflex sensitivity following bouts of aerobic and resistance exercise. Int J Sports Med 28, 197-203.
    • (2007) Int J Sports Med , vol.28 , pp. 197-203
    • Heffernan, K.S.1    Collier, S.R.2    Kelly, E.E.3    Jae, S.Y.4    Fernhall, B.5
  • 70
    • 0035797864 scopus 로고    scopus 로고
    • Central arterial compliance is associated with ageand habitual exercise-related differences in cardiovagal baroreflex sensitivity
    • Monahan KD, Tanaka H, Dinenno FA, Seals DR (2001) Central arterial compliance is associated with ageand habitual exercise-related differences in cardiovagal baroreflex sensitivity. Circulation 104, 1627-1632.
    • (2001) Circulation , vol.104 , pp. 1627-1632
    • Monahan, K.D.1    Tanaka, H.2    Dinenno, F.A.3    Seals, D.R.4
  • 71
    • 0031975620 scopus 로고    scopus 로고
    • Absence of agerelated increase in central arterial stiffness in physically active women
    • Tanaka H, DeSouza CA, Seals DR (1998) Absence of agerelated increase in central arterial stiffness in physically active women. Arterioscler Thromb Vasc Biol 18, 127-132.
    • (1998) Arterioscler Thromb Vasc Biol , vol.18 , pp. 127-132
    • Tanaka, H.1    Desouza, C.A.2    Seals, D.R.3
  • 72
    • 33745161871 scopus 로고    scopus 로고
    • Resistance exercise training: Its role in the prevention of cardiovascular disease
    • Braith RW, Stewart KJ (2006) Resistance exercise training: Its role in the prevention of cardiovascular disease. Circulation 113, 2642-2650.
    • (2006) Circulation , vol.113 , pp. 2642-2650
    • Braith, R.W.1    Stewart, K.J.2
  • 74
    • 2342614850 scopus 로고    scopus 로고
    • Neurovascular regulation in the normal brain and in Alzheimer's disease
    • Iadecola C (2004) Neurovascular regulation in the normal brain and in Alzheimer's disease. Nat Rev Neurosci 5, 347-360.
    • (2004) Nat Rev Neurosci , vol.5 , pp. 347-360
    • Iadecola, C.1
  • 75
    • 48849101520 scopus 로고    scopus 로고
    • Electrophysiology of cerebral ischemia
    • Krnjevíc K (2008) Electrophysiology of cerebral ischemia. Neuropharmacology 55, 319-333.
    • (2008) Neuropharmacology , vol.55 , pp. 319-333
    • Krnjevíc, K.1
  • 77
    • 84950170726 scopus 로고    scopus 로고
    • Mental health benefits of omega-3 fatty acids may be mediated by improvements in cerebral vascular function
    • Sinn N, Howe P (2008) Mental health benefits of omega-3 fatty acids may be mediated by improvements in cerebral vascular function. Biosci Hypotheses 1, 103-108.
    • (2008) Biosci Hypotheses , vol.1 , pp. 103-108
    • Sinn, N.1    Howe, P.2
  • 78
    • 0031893415 scopus 로고    scopus 로고
    • Regulation of the cerebral circulation: Role of endothelium and potassium channels
    • Faraci FM, Heistad DD (1998) Regulation of the cerebral circulation: Role of endothelium and potassium channels. Physiol Rev 78, 53-97.
    • (1998) Physiol Rev , vol.78 , pp. 53-97
    • Faraci, F.M.1    Heistad, D.D.2
  • 79
    • 11044230424 scopus 로고    scopus 로고
    • Delayed cerebral vasospasm and nitric oxide: Review, new hypo thesis proposed treatment
    • Pluta RM (2005) Delayed cerebral vasospasm and nitric oxide: Review, new hypothesis, proposed treatment. Pharmacol Ther 105, 23-56.
    • (2005) Pharmacol Ther , vol.105 , pp. 23-56
    • Pluta, R.M.1
  • 80
    • 29244463365 scopus 로고    scopus 로고
    • Astrocyteendothelial interactions at the blood-brain barrier
    • Abbott NJ, Rönnbäck L, Hansson E (2006) Astrocyteendothelial interactions at the blood-brain barrier. Nat Rev Neurosci 7, 41-53.
    • (2006) Nat Rev Neurosci , vol.7 , pp. 41-53
    • Abbott, N.J.1    Rönnbäck, L.2    Hansson, E.3
  • 81
    • 84856468202 scopus 로고    scopus 로고
    • Age-related changes in endothelial function and blood flow regulation
    • TodaN(2012) Age-related changes in endothelial function and blood flow regulation. Pharmacol Ther 133, 159-176.
    • (2012) Pharmacol Ther , vol.133 , pp. 159-176
    • Toda, N.1
  • 82
    • 77955920784 scopus 로고    scopus 로고
    • Endothelial dysfunction and vascular disease in later life
    • Virdis A, Ghiadoni L, Giannarelli C, Taddei S (2010) Endothelial dysfunction and vascular disease in later life. Maturitas 67, 20-24.
    • (2010) Maturitas , vol.67 , pp. 20-24
    • Virdis, A.1    Ghiadoni, L.2    Giannarelli, C.3    Taddei, S.4
  • 83
    • 84957434718 scopus 로고    scopus 로고
    • Flowmediated dilation and neurocognition: Systematic review and future directions
    • Naiberg MR, Newton DF, Goldstein BI (2016) Flowmediated dilation and neurocognition: Systematic review and future directions. Psychosom Med 78, 192-207.
    • (2016) Psychosom Med , vol.78 , pp. 192-207
    • Naiberg, M.R.1    Newton, D.F.2    Goldstein, B.I.3
  • 84
    • 84898849858 scopus 로고    scopus 로고
    • Endothelial nitric oxide: Protector of a healthy mind
    • Katusic ZS, Austin SA (2014) Endothelial nitric oxide: Protector of a healthy mind. Eur Heart J 35, 888-894.
    • (2014) Eur Heart J , vol.35 , pp. 888-894
    • Katusic, Z.S.1    Austin, S.A.2
  • 85
    • 0034687139 scopus 로고    scopus 로고
    • Regular aerobic exercise prevents and restores age-related declines in endothelium-dependent vasodilation in healthy men
    • DeSouza CA, Shapiro LF, Clevenger CM, Dinenno FA, Monahan KD, Tanaka H, Seals DR (2000) Regular aerobic exercise prevents and restores age-related declines in endothelium-dependent vasodilation in healthy men. Circulation 102, 1351-1357.
    • (2000) Circulation , vol.102 , pp. 1351-1357
    • Desouza, C.A.1    Shapiro, L.F.2    Clevenger, C.M.3    Dinenno, F.A.4    Monahan, K.D.5    Tanaka, H.6    Seals, D.R.7
  • 86
    • 84929155130 scopus 로고    scopus 로고
    • Exercise modalities and endothelial function: A systematic review and dose-response meta-analysis of randomized controlled trials
    • Ashor AW, Lara J, Siervo M, Celis-Morales C, Oggioni C, Jakovljevic DG, Mathers JC (2015) Exercise modalities and endothelial function: A systematic review and dose-response meta-analysis of randomized controlled trials. Sport Med 45, 279-296.
    • (2015) Sport Med , vol.45 , pp. 279-296
    • Ashor, A.W.1    Lara, J.2    Siervo, M.3    Celis-Morales, C.4    Oggioni, C.5    Jakovljevic, D.G.6    Mathers, J.C.7
  • 87
    • 84873539239 scopus 로고    scopus 로고
    • Exercise training and endothelial function
    • Rauramaa R, Hassinen M (2011) Exercise training and endothelial function. Curr Cardiovasc Risk Rep 5, 323-330.
    • (2011) Curr Cardiovasc Risk Rep , vol.5 , pp. 323-330
    • Rauramaa, R.1    Hassinen, M.2
  • 88
    • 84938857208 scopus 로고    scopus 로고
    • The association of cardiorespiratory fitness with endothelial or smooth muscle vasodilator function
    • Montero D (2015) The association of cardiorespiratory fitness with endothelial or smooth muscle vasodilator function. Eur J Prev Cardiol 22, 1200-1211.
    • (2015) Eur J Prev Cardiol , vol.22 , pp. 1200-1211
    • Montero, D.1
  • 90
    • 84949895045 scopus 로고    scopus 로고
    • Vascular ageing and exercise: Focus on cellular reparative processes
    • Ross MD, Malone E, Florida-James G (2015) Vascular ageing and exercise: Focus on cellular reparative processes. Oxid Med Cell Longev 2016, 18-20.
    • (2015) Oxid Med Cell Longev , vol.2016 , pp. 18-20
    • Ross, M.D.1    Malone, E.2    Florida-James, G.3
  • 91
    • 58149296292 scopus 로고    scopus 로고
    • Exercise is brain food: The effects of physical activity on cognitive function
    • PloughmanM(2008) Exercise is brain food: The effects of physical activity on cognitive function. Dev Neurorehabil 11, 236-240.
    • (2008) Dev Neurorehabil , vol.11 , pp. 236-240
    • Ploughman, M.1
  • 92
    • 0031789814 scopus 로고    scopus 로고
    • Neurogenesis in the adult human hippocampus
    • Jolla L (1998) Neurogenesis in the adult human hippocampus. Nat Med 4, 1313-1317.
    • (1998) Nat Med , vol.4 , pp. 1313-1317
    • Jolla, L.1
  • 93
  • 94
    • 84949217867 scopus 로고    scopus 로고
    • Acute exercise improves prefrontal cortex but not hippocampal function in healthy adults
    • Basso JC, Shang A, Elman M, Karmouta R, Suzuki WA (2015) Acute exercise improves prefrontal cortex but not hippocampal function in healthy adults. J Int Neuropsychol Soc 21, 791-801.
    • (2015) J Int Neuropsychol Soc , vol.21 , pp. 791-801
    • Basso, J.C.1    Shang, A.2    Elman, M.3    Karmouta, R.4    Suzuki, W.A.5
  • 95
    • 84884502539 scopus 로고    scopus 로고
    • Bridging animal and human models of exercise-induced brain plasticity
    • VossMW, Vivar C, Kramer AF, van PraagH(2013) Bridging animal and human models of exercise-induced brain plasticity. Trends Cogn Sci 17, 525-544.
    • (2013) Trends Cogn Sci , vol.17 , pp. 525-544
    • Voss, M.W.1    Vivar, C.2    Kramer, A.F.3    Van Praag, H.4
  • 96
    • 84865802076 scopus 로고    scopus 로고
    • Nutrition, adult hippocampal neurogenesis and mental health
    • Zainuddin MSA, Thuret S (2012) Nutrition, adult hippocampal neurogenesis and mental health. Br Med Bull 103, 89-114.
    • (2012) Br Med Bull , vol.103 , pp. 89-114
    • Zainuddin, M.S.A.1    Thuret, S.2
  • 97
    • 84898663474 scopus 로고    scopus 로고
    • Physical activity and cognitive function in individuals over 60 years of age: A systematic review
    • Carvalho A, Rea IM, Parimon T, Cusack BJ (2014) Physical activity and cognitive function in individuals over 60 years of age: A systematic review. Clin Interv Aging 9, 661-682.
    • (2014) Clin Interv Aging , vol.9 , pp. 661-682
    • Carvalho, A.1    Rea, I.M.2    Parimon, T.3    Cusack, B.J.4
  • 98
    • 28244464412 scopus 로고    scopus 로고
    • License to run: Exercise impacts functional plasticity in the intact and injured central nervous system by using neurotrophins
    • Vaynman S, Gomez-Pinilla F (2005) License to run: Exercise impacts functional plasticity in the intact and injured central nervous system by using neurotrophins. Neurorehabil Neural Repair 19, 283-295.
    • (2005) Neurorehabil Neural Repair , vol.19 , pp. 283-295
    • Vaynman, S.1    Gomez-Pinilla, F.2
  • 99
    • 53949111613 scopus 로고    scopus 로고
    • New insights into brain BDNF function in normal aging and Alzheimer disease
    • Tapia-Arancibia L, Aliaga E, Silhol M, Arancibia S (2008) New insights into brain BDNF function in normal aging and Alzheimer disease. Brain Res Rev 59, 201-220.
    • (2008) Brain Res Rev , vol.59 , pp. 201-220
    • Tapia-Arancibia, L.1    Aliaga, E.2    Silhol, M.3    Arancibia, S.4
  • 101
    • 70349179900 scopus 로고    scopus 로고
    • Enrichment effects on adult cognitive development: Can the functional capacity of older adults be preserved and enhanced
    • Hertzog C, KramerAF, Wilson RS, LindenbergerU(2009) Enrichment effects on adult cognitive development: Can the functional capacity of older adults be preserved and enhanced Psychol Sci Public Interest 9, 1-66.
    • (2009) Psychol Sci Public Interest , vol.9 , pp. 1-66
    • Hertzog, C.1    Kramer, A.F.2    Wilson, R.S.3    Lindenberger, U.4
  • 102
    • 84942770349 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor in Alzheimer's disease: Risk, mechanisms, therapy
    • Song J-H, Yu J-T, TanL(2014) Brain-derived neurotrophic factor in Alzheimer's disease: Risk, mechanisms, therapy. Mol Neurobiol 52, 1477-1493.
    • (2014) Mol Neurobiol , vol.52 , pp. 1477-1493
    • Song, J.-H.1    Yu, J.-T.2    Tan, L.3
  • 103
    • 84900530338 scopus 로고    scopus 로고
    • BDNF and synaptic plasticity, cognitive function, dysfunction
    • Lu B, Nagappan G, Lu Y (2014) BDNF and synaptic plasticity, cognitive function, dysfunction. Handb Exp Pharmacol 220, 223-250.
    • (2014) Handb Exp Pharmacol , vol.220 , pp. 223-250
    • Lu, B.1    Nagappan, G.2    Lu, Y.3
  • 104
    • 0029021177 scopus 로고
    • Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor
    • Korte M, Carroll P, Wolf E, Brem G, Thoenen H, Bonhoeffer T (1995) Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor. Proc Natl Acad Sci USA 92, 8856-8860.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 8856-8860
    • Korte, M.1    Carroll, P.2    Wolf, E.3    Brem, G.4    Thoenen, H.5    Bonhoeffer, T.6
  • 105
    • 0030176079 scopus 로고    scopus 로고
    • Recombinant BDNF rescues deficits in basal synaptic transmission and hippocampal LTP in BDNF knockout mice
    • Patterson SL, Abel T, Deuel TAS, Martin KC, Rose JC, Kandel ER (1996) Recombinant BDNF rescues deficits in basal synaptic transmission and hippocampal LTP in BDNF knockout mice. Neuron 16, 1137-1145.
    • (1996) Neuron , vol.16 , pp. 1137-1145
    • Patterson, S.L.1    Abel, T.2    Deuel, T.A.S.3    Martin, K.C.4    Rose, J.C.5    Kandel, E.R.6
  • 106
    • 0030967828 scopus 로고    scopus 로고
    • Neurotrophins and time: Different roles for TrkB signaling in hippocampal long-term potentiation
    • Kang H, Welcher AA, Shelton D, Schuman EM (1997) Neurotrophins and time: Different roles for TrkB signaling in hippocampal long-term potentiation. Neuron 19, 653-664.
    • (1997) Neuron , vol.19 , pp. 653-664
    • Kang, H.1    Welcher, A.A.2    Shelton, D.3    Schuman, E.M.4
  • 107
    • 0033568871 scopus 로고    scopus 로고
    • Relative contribution of endogenous neurotrophins in hippocampal long-term potentiation
    • Chen G, Kolbeck R, Barde YA, Bonhoeffer T, Kossel A (1999) Relative contribution of endogenous neurotrophins in hippocampal long-term potentiation. J Neurosci 19, 7983-7990.
    • (1999) J Neurosci , vol.19 , pp. 7983-7990
    • Chen, G.1    Kolbeck, R.2    Barde, Y.A.3    Bonhoeffer, T.4    Kossel, A.5
  • 109
    • 84919389649 scopus 로고    scopus 로고
    • Ameta-analytic review of the effects of exercise on brain-derived neurotrophic factor
    • Szuhany KL, Bugatti M, OttoMW(2015)Ameta-analytic review of the effects of exercise on brain-derived neurotrophic factor. J Psychiatr Res 60, 56-64.
    • (2015) J Psychiatr Res , vol.60 , pp. 56-64
    • Szuhany, K.L.1    Bugatti, M.2    Otto, M.W.3
  • 110
    • 49849105703 scopus 로고    scopus 로고
    • Neurogenesis and exercise: Past and future directions
    • Van Praag H (2008) Neurogenesis and exercise: Past and future directions. NeuroMolecular Med 10, 128-140.
    • (2008) NeuroMolecular Med , vol.10 , pp. 128-140
    • Van Praag, H.1
  • 111
    • 0035239020 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor in the control human brain, in Alzheimer's disease and Parkinson's disease
    • Murer M, Yan Q, Raisman-Vozari R (2001) Brain-derived neurotrophic factor in the control human brain, in Alzheimer's disease and Parkinson's disease. Prog Neurobiol 63, 71-124.
    • (2001) Prog Neurobiol , vol.63 , pp. 71-124
    • Murer, M.1    Yan, Q.2    Raisman-Vozari, R.3
  • 113
    • 33750049661 scopus 로고    scopus 로고
    • Serum BDNF TNF-and and IL-1-levels in dementia patients: Comparison between Alzheimer's disease and vascular dementia
    • Yasutake C, Kuroda K, Yanagawa T, Okamura T, Yoneda H (2006) Serum BDNF, TNF-and and IL-1-levels in dementia patients: Comparison between Alzheimer's disease and vascular dementia. Eur Arch Psychiatry Clin Neurosci 256, 402-406.
    • (2006) Eur Arch Psychiatry Clin Neurosci , vol.256 , pp. 402-406
    • Yasutake, C.1    Kuroda, K.2    Yanagawa, T.3    Okamura, T.4    Yoneda, H.5
  • 114
    • 84865610733 scopus 로고    scopus 로고
    • The brain-derived neurotrophic factor val66met polymorphism is associated with reduced hippocampus perfusion in frontotemporal lobar degeneration
    • Borroni B, Bianchi M, Premi E, Alberici A, Archetti S, Paghera B, Cerini C, Papetti A, Padovani A (2012) The brain-derived neurotrophic factor val66met polymorphism is associated with reduced hippocampus perfusion in frontotemporal lobar degeneration. J Alzheimers Dis 31, 243-251.
    • (2012) J Alzheimers Dis , vol.31 , pp. 243-251
    • Borroni, B.1    Bianchi, M.2    Premi, E.3    Alberici, A.4    Archetti, S.5    Paghera, B.6    Cerini, C.7    Papetti, A.8    Padovani, A.9
  • 117
    • 84888020120 scopus 로고    scopus 로고
    • Effect of BDNF Val66Met polymorphism on regional white matter hyperintensities and cognitive function in elderly males without dementia
    • Huang CC, Liu ME, Chou KH, Yang AC, Hung CC, Hong CJ, Tsai SJ, Lin CP (2014) Effect of BDNF Val66Met polymorphism on regional white matter hyperintensities and cognitive function in elderly males without dementia. Psychoneuroendocrinology 39, 94-103.
    • (2014) Psychoneuroendocrinology , vol.39 , pp. 94-103
    • Huang, C.C.1    Liu, M.E.2    Chou, K.H.3    Yang, A.C.4    Hung, C.C.5    Hong, C.J.6    Tsai, S.J.7    Lin, C.P.8
  • 120
    • 80054800740 scopus 로고    scopus 로고
    • BDNF polymorphism predicts the rate of decline in skilled task performance and hippocampal volume in healthy individuals
    • Sanchez MM, Das D, Taylor JL, Noda A, Yesavage JA, Salehi A (2011) BDNF polymorphism predicts the rate of decline in skilled task performance and hippocampal volume in healthy individuals. Transl Psychiatry 1, e51.
    • (2011) Transl Psychiatry , vol.1 , pp. e51
    • Sanchez, M.M.1    Das, D.2    Taylor, J.L.3    Noda, A.4    Yesavage, J.A.5    Salehi, A.6
  • 121
    • 33644768186 scopus 로고    scopus 로고
    • The Val66Met polymorphism of the brain-derived neurotrophic factor gene affects agerelated brain morphology
    • Nemoto K, Ohnishi T, Mori T, MoriguchiY, Hashimoto R, Asada T, Kunugi H (2006) The Val66Met polymorphism of the brain-derived neurotrophic factor gene affects agerelated brain morphology. Neurosci Lett 397, 25-29.
    • (2006) Neurosci Lett , vol.397 , pp. 25-29
    • Nemoto, K.1    Ohnishi, T.2    Mori, T.3    Moriguchi, Y.4    Hashimoto, R.5    Asada, T.6    Kunugi, H.7
  • 122
    • 0043135252 scopus 로고    scopus 로고
    • Brainderived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance
    • Hariri AR, Goldberg TE, Mattay VS, Kolachana BS, Callicott JH, Egan MF, Weinberger DR (2003) Brainderived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance. J Neurosci 23, 6690-6694.
    • (2003) J Neurosci , vol.23 , pp. 6690-6694
    • Hariri, A.R.1    Goldberg, T.E.2    Mattay, V.S.3    Kolachana, B.S.4    Callicott, J.H.5    Egan, M.F.6    Weinberger, D.R.7
  • 125
    • 0032404127 scopus 로고    scopus 로고
    • Transport of brain-derived neurotrophic factor across the blood-brain barrier
    • PanW, BanksWA, Fasold MB, Bluth J, Kastin AJ (1998) Transport of brain-derived neurotrophic factor across the blood-brain barrier. Neuropharmacology 37, 1553-1561.
    • (1998) Neuropharmacology , vol.37 , pp. 1553-1561
    • Pan, W.1    Banks, W.A.2    Fasold, M.B.3    Bluth, J.4    Kastin, A.J.5
  • 129
    • 77955948750 scopus 로고    scopus 로고
    • Neuroplasticity-exercise-induced response of peripheral brain-derived neurotrophic factor: A systematic review of experimental studies in human subjects
    • Knaepen K, Goekint M, Heyman EM, Meeusen R (2010) Neuroplasticity-exercise-induced response of peripheral brain-derived neurotrophic factor: A systematic review of experimental studies in human subjects. Sports Med 40, 765-801.
    • (2010) Sports Med , vol.40 , pp. 765-801
    • Knaepen, K.1    Goekint, M.2    Heyman, E.M.3    Meeusen, R.4
  • 130
    • 84892879964 scopus 로고    scopus 로고
    • The effects of physical activity and exercise on brain-derived neurotrophic factor in healthy humans: A review
    • Huang T, Larsen KT, Ried-Larsen M, Møller NC, ersen LB (2014) The effects of physical activity and exercise on brain-derived neurotrophic factor in healthy humans: A review. Scand J Med Sci Sports 24, 1-10.
    • (2014) Scand J Med Sci Sports , vol.24 , pp. 1-10
    • Huang, T.1    Larsen, K.T.2    Ried-Larsen, M.3    Møller, N.C.4    Andersen, L.B.5
  • 132
    • 35748961429 scopus 로고    scopus 로고
    • The effects of stress and stress hormones on human cognition: Implications for the field of brain and cognition
    • Lupien SJ, Maheu F, Tu M, Fiocco A, Schramek TE (2007) The effects of stress and stress hormones on human cognition: Implications for the field of brain and cognition. Brain Cogn 65, 209-237.
    • (2007) Brain Cogn , vol.65 , pp. 209-237
    • Lupien, S.J.1    Maheu, F.2    Tu, M.3    Fiocco, A.4    Schramek, T.E.5
  • 133
    • 0036530044 scopus 로고    scopus 로고
    • Role of adrenal stress hormones in forming lasting memories in the brain
    • McGaugh JL, Roozendaal B (2002) Role of adrenal stress hormones in forming lasting memories in the brain. Curr Opin Neurobiol 12, 205-210.
    • (2002) Curr Opin Neurobiol , vol.12 , pp. 205-210
    • McGaugh, J.L.1    Roozendaal, B.2
  • 135
    • 0033215376 scopus 로고    scopus 로고
    • Stress and cognition: Are corticosteroids good or bad guys
    • De Kloet ER, Oitzl MS, Joëls M (1999) Stress and cognition: Are corticosteroids good or bad guys Trends Neurosci 22, 422-426.
    • (1999) Trends Neurosci , vol.22 , pp. 422-426
    • De Kloet, E.R.1    Oitzl, M.S.2    Joëls, M.3
  • 136
    • 77249114755 scopus 로고    scopus 로고
    • Central role of the brain in stress and adaptation: Links to socioeconomic status, health, disease
    • McEwen BS, Gianaros PJ (2010) Central role of the brain in stress and adaptation: Links to socioeconomic status, health, disease. Ann N Y Acad Sci 1186, 190-222.
    • (2010) Ann N y Acad Sci , vol.1186 , pp. 190-222
    • McEwen, B.S.1    Gianaros, P.J.2
  • 137
    • 84907483716 scopus 로고    scopus 로고
    • The current state of the neurogenic theory of depression and anxiety
    • Miller BR, Hen R (2015) The current state of the neurogenic theory of depression and anxiety. Curr Opin Neurobiol 30, 51-58.
    • (2015) Curr Opin Neurobiol , vol.30 , pp. 51-58
    • Miller, B.R.1    Hen, R.2
  • 138
    • 60849109938 scopus 로고    scopus 로고
    • Chronic stress-induced hippocampal vulnerability: The glucocorticoid vulnerability hypothesis
    • Conrad CD (2008) Chronic stress-induced hippocampal vulnerability: The glucocorticoid vulnerability hypothesis. Rev Neurosci 19, 395-411.
    • (2008) Rev Neurosci , vol.19 , pp. 395-411
    • Conrad, C.D.1
  • 139
    • 0142103727 scopus 로고    scopus 로고
    • Long-term treatment with paroxetine increases verbal declarative memory and hippocampal volume in posttraumatic stress disorder
    • Vermetten E, Vythilingam M, Southwick SM, Charney DS, Bremner JD (2003) Long-term treatment with paroxetine increases verbal declarative memory and hippocampal volume in posttraumatic stress disorder. Biol Psychiatry 54, 693-702.
    • (2003) Biol Psychiatry , vol.54 , pp. 693-702
    • Vermetten, E.1    Vythilingam, M.2    Southwick, S.M.3    Charney, D.S.4    Bremner, J.D.5
  • 142
    • 84888286622 scopus 로고    scopus 로고
    • Electroconvulsive therapy increases hippocampal and amygdala volume in therapy refractory depression: A longitudinal pilot study
    • Tendolkar I, van Beek M, van Oostrom I, Mulder M, Janzing J, Voshaar RO, van Eijndhoven P (2013) Electroconvulsive therapy increases hippocampal and amygdala volume in therapy refractory depression: A longitudinal pilot study. Psychiatry Res 214, 197-203.
    • (2013) Psychiatry Res , vol.214 , pp. 197-203
    • Tendolkar, I.1    Van Beek, M.2    Van Oostrom, I.3    Mulder, M.4    Janzing, J.5    Voshaar, R.O.6    Van Eijndhoven, P.7
  • 143
    • 0030818130 scopus 로고    scopus 로고
    • Stress, anxiety and depression
    • Wheatley D (1997) Stress, anxiety and depression. Stress Med 13, 173-177.
    • (1997) Stress Med , vol.13 , pp. 173-177
    • Wheatley, D.1
  • 144
    • 84884289864 scopus 로고    scopus 로고
    • Stress anxiety dendritic spines: What are the connections
    • Leuner B, Shors TJ (2013) Stress, anxiety, dendritic spines: What are the connections Neuroscience 251, 108-119.
    • (2013) Neuroscience , vol.251 , pp. 108-119
    • Leuner, B.1    Shors, T.J.2
  • 145
    • 66549116678 scopus 로고    scopus 로고
    • The association of anxiety and depressive symptoms with cognitive performance in community-dwelling older adults
    • Beaudreau SA, O'Hara R (2009) The association of anxiety and depressive symptoms with cognitive performance in community-dwelling older adults. Psychol Aging 24, 507-512.
    • (2009) Psychol Aging , vol.24 , pp. 507-512
    • Beaudreau, S.A.1    O'Hara, R.2
  • 146
    • 80052775244 scopus 로고    scopus 로고
    • Anxiety disorders, depressive episodes and cognitive impairment no dementia in community-dwelling older men and women
    • Potvin O, Hudon C, Dion M, Grenier S, Préville M (2011) Anxiety disorders, depressive episodes and cognitive impairment no dementia in community-dwelling older men and women. Int J Geriatr Psychiatry 26, 1080-1088.
    • (2011) Int J Geriatr Psychiatry , vol.26 , pp. 1080-1088
    • Potvin, O.1    Hudon, C.2    Dion, M.3    Grenier, S.4    Préville, M.5
  • 147
    • 84884351651 scopus 로고    scopus 로고
    • Late life anxiety is associated with decreased memory and executive functioning in community dwelling older adults
    • Yochim BP, Mueller AE, Segal DL (2013) Late life anxiety is associated with decreased memory and executive functioning in community dwelling older adults. J Anxiety Disord 27, 567-575.
    • (2013) J Anxiety Disord , vol.27 , pp. 567-575
    • Yochim, B.P.1    Mueller, A.E.2    Segal, D.L.3
  • 150
    • 0028088167 scopus 로고
    • Effects of rehabilitation exercise programmes on anxiety and depression in coronary patients: A meta-analysis
    • Kugler J, Seelbach H, Kruskemper GM (1994) Effects of rehabilitation exercise programmes on anxiety and depression in coronary patients: A meta-analysis. Br J Clin Psychol 33, 401-410.
    • (1994) Br J Clin Psychol , vol.33 , pp. 401-410
    • Kugler, J.1    Seelbach, H.2    Kruskemper, G.M.3
  • 151
    • 84862271676 scopus 로고    scopus 로고
    • The protective effects of voluntary exercise against the behavioral consequences of uncontrollable stress persist despite an increase in anxiety following forced cessation of exercise
    • Greenwood BN, Loughridge AB, Sadaoui N, Christianson JP, Fleshner M (2012) The protective effects of voluntary exercise against the behavioral consequences of uncontrollable stress persist despite an increase in anxiety following forced cessation of exercise. Behav Brain Res 233, 314-321.
    • (2012) Behav Brain Res , vol.233 , pp. 314-321
    • Greenwood, B.N.1    Loughridge, A.B.2    Sadaoui, N.3    Christianson, J.P.4    Fleshner, M.5
  • 152
    • 0025967423 scopus 로고
    • Ameta-analysis on the anxiety-reducing effects of acute and chronic exercise: Outcomes and mechanisms
    • Petruzzello SJ, Landers DM, Hatfield BD, Kubitz KA, SalazarW(1991)Ameta-analysis on the anxiety-reducing effects of acute and chronic exercise: Outcomes and mechanisms. Sport Med 11, 143-182.
    • (1991) Sport Med , vol.11 , pp. 143-182
    • Petruzzello, S.J.1    Landers, D.M.2    Hatfield, B.D.3    Kubitz, K.A.4    Salazar, W.5
  • 153
    • 85075680860 scopus 로고    scopus 로고
    • Physical activity, anxiety, stress
    • Biddle SJH, Fox KR, Boutcher SH, eds, Routledge, London
    • Taylor AH (2000) Physical activity, anxiety, stress. In Physical Activity and Psychological Well-Being, Biddle SJH, Fox KR, Boutcher SH, eds. Routledge, London, pp. 10-45.
    • (2000) Physical Activity and Psychological Well-Being , pp. 10-45
    • Taylor, A.H.1
  • 154
    • 53349120913 scopus 로고    scopus 로고
    • The anxiolytic effects of exercise: A meta-analysis of randomized trials and dose-response analysis
    • Wipfli BBM, Rethorst CDC, Landers DDM (2008) The anxiolytic effects of exercise: A meta-analysis of randomized trials and dose-response analysis. J Sport Exerc Psychol 30, 392-410.
    • (2008) J Sport Exerc Psychol , vol.30 , pp. 392-410
    • Wipfli, B.B.M.1    Rethorst, C.D.C.2    Landers, D.D.M.3
  • 155
    • 84877705276 scopus 로고    scopus 로고
    • Effects of exercise and physical activity on anxiety
    • Anderson E, Shivakumar G (2013) Effects of exercise and physical activity on anxiety. Front Psychiatry 4, 10-13.
    • (2013) Front Psychiatry , vol.4 , pp. 10-13
    • Anderson, E.1    Shivakumar, G.2
  • 156
    • 84865560845 scopus 로고    scopus 로고
    • Exercise offers anxiolytic potential: A role for stress and brain noradrenergicgalaninergic mechanisms
    • Sciolino NR, Holmes PV (2012) Exercise offers anxiolytic potential: A role for stress and brain noradrenergicgalaninergic mechanisms. Neurosci Biobehav Rev 36, 1965-1984.
    • (2012) Neurosci Biobehav Rev , vol.36 , pp. 1965-1984
    • Sciolino, N.R.1    Holmes, P.V.2
  • 157
    • 84877126337 scopus 로고    scopus 로고
    • Physical exercise prevents stress-induced activation of granule neurons and enhances local inhibitory mechansims in the dentate gyrus
    • Schoenfeld TJ, Rada P, Pieruzzini PR, Hsueh B, Gould E (2013) Physical exercise prevents stress-induced activation of granule neurons and enhances local inhibitory mechansims in the dentate gyrus. J Neurosci 33, 7770-7777.
    • (2013) J Neurosci , vol.33 , pp. 7770-7777
    • Schoenfeld, T.J.1    Rada, P.2    Pieruzzini, P.R.3    Hsueh, B.4    Gould, E.5
  • 159
    • 0037180771 scopus 로고    scopus 로고
    • Inflammation in atherosclerosis
    • Libby P (2002) Inflammation in atherosclerosis. Arterioscler Thromb Vasc Biol 420, 868.
    • (2002) Arterioscler Thromb Vasc Biol , vol.420 , pp. 868
    • Libby, P.1
  • 161
    • 84869998324 scopus 로고    scopus 로고
    • Impact of physical activity on inflammation: Effects on cardiovascular disease risk and other inflammatory conditions
    • Ertek S, Cicero A (2012) Impact of physical activity on inflammation: Effects on cardiovascular disease risk and other inflammatory conditions. Arch Med Sci 8, 794-804.
    • (2012) Arch Med Sci , vol.8 , pp. 794-804
    • Ertek, S.1    Cicero, A.2
  • 163
    • 0036901234 scopus 로고    scopus 로고
    • Cytokines and cognition-The case for a head-to-toe inflammatory paradigm
    • Wilson CJ, Finch CE, Cohen HJ (2002) Cytokines and cognition-The case for a head-to-toe inflammatory paradigm. J Am Geriatr Soc 50, 2041-2056.
    • (2002) J Am Geriatr Soc , vol.50 , pp. 2041-2056
    • Wilson, C.J.1    Finch, C.E.2    Cohen, H.J.3
  • 165
    • 17844379486 scopus 로고    scopus 로고
    • Central nervous system injury triggers hepatic CC and CXC chemokine expression that is associated with leukocyte mobilization and recruitment to both the central nervous system and the liver
    • Campbell SJ, Perry VH, Pitossi FJ, Butchart AG, Chertoff M, Waters S, Dempster R, Anthony DC (2005) Central nervous system injury triggers hepatic CC and CXC chemokine expression that is associated with leukocyte mobilization and recruitment to both the central nervous system and the liver. Am J Pathol 166, 1487-1497.
    • (2005) Am J Pathol , vol.166 , pp. 1487-1497
    • Campbell, S.J.1    Perry, V.H.2    Pitossi, F.J.3    Butchart, A.G.4    Chertoff, M.5    Waters, S.6    Dempster, R.7    Anthony, D.C.8
  • 166
    • 70449526190 scopus 로고    scopus 로고
    • Heterogeneity of microglial activation in the innate immune response in the brain
    • Colton CA (2009) Heterogeneity of microglial activation in the innate immune response in the brain. J Neuroimmune Pharmacol 4, 399-418.
    • (2009) J Neuroimmune Pharmacol , vol.4 , pp. 399-418
    • Colton, C.A.1
  • 167
    • 0030222037 scopus 로고    scopus 로고
    • Microglia: A sensor for pathological events in the CNS
    • Kreutzberg GW(1996) Microglia: A sensor for pathological events in the CNS. Trends Neurosci 19, 312-318.
    • (1996) Trends Neurosci , vol.19 , pp. 312-318
    • Kreutzberg, G.W.1
  • 168
    • 77956338790 scopus 로고    scopus 로고
    • Aging sensitizes rapidly isolated hippocampal microglia to LPS ex vivo
    • Frank MG, Barrientos RM, Watkins LR, Maier SF (2010) Aging sensitizes rapidly isolated hippocampal microglia to LPS ex vivo. J Neuroimmunol 226, 181-184.
    • (2010) J Neuroimmunol , vol.226 , pp. 181-184
    • Frank, M.G.1    Barrientos, R.M.2    Watkins, L.R.3    Maier, S.F.4
  • 172
    • 0345189366 scopus 로고    scopus 로고
    • Inflammatory blockade restores adult hippocampal neurogenesis
    • Monje ML, Toda H, Palmer TD (2003) Inflammatory blockade restores adult hippocampal neurogenesis. Science 302, 1760-1765.
    • (2003) Science , vol.302 , pp. 1760-1765
    • Monje, M.L.1    Toda, H.2    Palmer, T.D.3
  • 173
    • 22544482956 scopus 로고    scopus 로고
    • Physiological and behavioral responses to interleukin-1-and LPS in vagotomized mice
    • Wieczorek M, Swiergiel AH, Pournajafi-Nazarloo H, Dunn AJ (2005) Physiological and behavioral responses to interleukin-1-and LPS in vagotomized mice. Physiol Behav 85, 500-511.
    • (2005) Physiol Behav , vol.85 , pp. 500-511
    • Wieczorek, M.1    Swiergiel, A.H.2    Pournajafi-Nazarloo, H.3    Dunn, A.J.4
  • 177
    • 0037072285 scopus 로고    scopus 로고
    • Interleukin-6 and risk of cognitive decline: MacArthur studies of successful aging
    • Weaver JD, Huang M-H, Albert M, Harris T, Rowe JW, Seeman TE (2002) Interleukin-6 and risk of cognitive decline: MacArthur studies of successful aging. Neurology 59, 371-378.
    • (2002) Neurology , vol.59 , pp. 371-378
    • Weaver, J.D.1    Huang, M.-H.2    Albert, M.3    Harris, T.4    Rowe, J.W.5    Seeman, T.E.6
  • 178
    • 33646775663 scopus 로고    scopus 로고
    • High-sensitivity C-reactive protein and cognitive function in older women
    • Weuve J, Ridker PM, Cook NR, Buring JE, Grodstein F (2006) High-sensitivity C-reactive protein and cognitive function in older women. Epidemiology 17, 183-189.
    • (2006) Epidemiology , vol.17 , pp. 183-189
    • Weuve, J.1    Ridker, P.M.2    Cook, N.R.3    Buring, J.E.4    Grodstein, F.5
  • 180
    • 0036321773 scopus 로고    scopus 로고
    • Early inflammation and dementia: A 25-year follow-up of the Honolulu-Asia Aging Study
    • Schmidt R, Schmidt H, Curb JD, Masaki K, White LR, Launer LJ (2002) Early inflammation and dementia: A 25-year follow-up of the Honolulu-Asia Aging Study. Ann Neurol 52, 168-174.
    • (2002) Ann Neurol , vol.52 , pp. 168-174
    • Schmidt, R.1    Schmidt, H.2    Curb, J.D.3    Masaki, K.4    White, L.R.5    Launer, L.J.6
  • 181
    • 0032914896 scopus 로고    scopus 로고
    • A genetic variation of the inflammatory cytokine interleukin-6 delays the intial onset and reduces the risk for sporadic Alzheimer's disease
    • Papassotiropoulos A, Bagali M, Jessen F, Bayer TA, Maier W, Rao M, Heun R (1999) A genetic variation of the inflammatory cytokine interleukin-6 delays the intial onset and reduces the risk for sporadic Alzheimer's disease. Ann Neurol 45, 666-668.
    • (1999) Ann Neurol , vol.45 , pp. 666-668
    • Papassotiropoulos, A.1    Bagali, M.2    Jessen, F.3    Bayer, T.A.4    Maier, W.5    Rao, M.6    Heun, R.7
  • 182
    • 77954865635 scopus 로고    scopus 로고
    • Systemic inflammatory cells fight off neurodegenerative disease
    • Schwartz M, Shechter R (2010) Systemic inflammatory cells fight off neurodegenerative disease. Nat Rev Neurol 6, 405-410.
    • (2010) Nat Rev Neurol , vol.6 , pp. 405-410
    • Schwartz, M.1    Shechter, R.2
  • 183
    • 59549102756 scopus 로고    scopus 로고
    • Exercise as a mean to control low-grade systemic inflammation
    • Mathur N, Pedersen BK (2008) Exercise as a mean to control low-grade systemic inflammation. Mediators Inflamm 2008, 1-6.
    • (2008) Mediators Inflamm , vol.2008 , pp. 1-6
    • Mathur, N.1    Pedersen, B.K.2
  • 185
    • 0034473259 scopus 로고    scopus 로고
    • Cross-sectional and prospective relationships of interleukin-6 and C-reactive protein with physical performance in elderly persons: MacArthur studies of successful aging
    • Taaffe DR, Harris TB, Ferrucci L, Rowe J, Seeman TE (2000) Cross-sectional and prospective relationships of interleukin-6 and C-reactive protein with physical performance in elderly persons: MacArthur studies of successful aging. J Gerontol A Biol Sci Med Sci 55, M709-M715.
    • (2000) J Gerontol A Biol Sci Med Sci , vol.55 , pp. M709-M715
    • Taaffe, D.R.1    Harris, T.B.2    Ferrucci, L.3    Rowe, J.4    Seeman, T.E.5
  • 186
    • 0035242622 scopus 로고    scopus 로고
    • Association between physical activity and markers of inflammation in a healthy elderly population
    • Geffken DF, Cushman M, Burke GL, Polak JF, Sakkinen PA, Tracy RP (2001) Association between physical activity and markers of inflammation in a healthy elderly population. Am J Epidemiol 153, 242-250.
    • (2001) Am J Epidemiol , vol.153 , pp. 242-250
    • Geffken, D.F.1    Cushman, M.2    Burke, G.L.3    Polak, J.F.4    Sakkinen, P.A.5    Tracy, R.P.6
  • 187
    • 0036716772 scopus 로고    scopus 로고
    • Does exercise reduce inflammation Physical activity and C-reactive protein among U
    • Ford ES (2002) Does exercise reduce inflammation Physical activity and C-reactive protein among U. S. adults. Epidemiology 13, 561-568.
    • (2002) S. Adults. Epidemiology , vol.13 , pp. 561-568
    • Ford, E.S.1
  • 188
    • 21144432015 scopus 로고    scopus 로고
    • Association between physical activity, physical performance, inflammatory biomarkers in an elderly population: The InCHIANTI study
    • Elosua R, Bartali B, Ordovas JM, Corsi AM, Lauretani F, Ferrucci L (2005) Association between physical activity, physical performance, inflammatory biomarkers in an elderly population: The InCHIANTI study. J Gerontol A Biol Sci Med Sci 60A, 760-767.
    • (2005) J Gerontol A Biol Sci Med Sci , vol.60 , Issue.A , pp. 760-767
    • Elosua, R.1    Bartali, B.2    Ordovas, J.M.3    Corsi, A.M.4    Lauretani, F.5    Ferrucci, L.6
  • 189
    • 33644502498 scopus 로고    scopus 로고
    • Associations of leisure time physical activity, self-rated physical fitness, estimated aerobic fitness with serum C-reactive protein among 3803 adults
    • Borodulin K, Tiina L, Veikko S, Pekka J (2006) Associations of leisure time physical activity, self-rated physical fitness, estimated aerobic fitness with serum C-reactive protein among 3803 adults. Atherosclerosis 185, 381-387.
    • (2006) Atherosclerosis , vol.185 , pp. 381-387
    • Borodulin, K.1    Tiina, L.2    Veikko, S.3    Pekka, J.4
  • 190
    • 50949096419 scopus 로고    scopus 로고
    • Relation of cardiorespiratory fitness to inflammatory markers, fibrinolytic factors, lipoprotein(a) in patients with type 2 diabetes mellitus
    • Jae SY, Heffernan KS, Lee MK, Fernhall B, Park WH (2008) Relation of cardiorespiratory fitness to inflammatory markers, fibrinolytic factors, lipoprotein(a) in patients with type 2 diabetes mellitus. Am J Cardiol 102, 700-703.
    • (2008) Am J Cardiol , vol.102 , pp. 700-703
    • Jae, S.Y.1    Heffernan, K.S.2    Lee, M.K.3    Fernhall, B.4    Park, W.H.5
  • 191
    • 34249732099 scopus 로고    scopus 로고
    • Changes in inflammatory biomarkers following one-year of moderate resistance training in overweight women
    • Olson TP, Dengel DR, Leon AS, Schmitz KH (2007) Changes in inflammatory biomarkers following one-year of moderate resistance training in overweight women. Int J Obes 31, 996-1003.
    • (2007) Int J Obes , vol.31 , pp. 996-1003
    • Olson, T.P.1    Dengel, D.R.2    Leon, A.S.3    Schmitz, K.H.4
  • 193
    • 77954192215 scopus 로고    scopus 로고
    • Effect of exercise training on chronic inflammation
    • Beavers KM, Brinkley TE, Nicklas BJ (2010) Effect of exercise training on chronic inflammation. Clin Chim Acta 411, 785-793.
    • (2010) Clin Chim Acta , vol.411 , pp. 785-793
    • Beavers, K.M.1    Brinkley, T.E.2    Nicklas, B.J.3
  • 194
    • 33947529793 scopus 로고    scopus 로고
    • Interleukin-6 in acute exercise and training: What is the biological relevance
    • Fischer CP (2006) Interleukin-6 in acute exercise and training: What is the biological relevance Exerc Immunol Rev 12, 6-33.
    • (2006) Exerc Immunol Rev , vol.12 , pp. 6-33
    • Fischer, C.P.1
  • 197
    • 0347444022 scopus 로고
    • Effect of insulin administered intracisternally in dogs on the glucose level of the blood and the cerebrospinal fluid
    • Chowers I, Lavy S, Halpern L (1961) Effect of insulin administered intracisternally in dogs on the glucose level of the blood and the cerebrospinal fluid. Exp Neurol 3, 197-205.
    • (1961) Exp Neurol , vol.3 , pp. 197-205
    • Chowers, I.1    Lavy, S.2    Halpern, L.3
  • 198
    • 0013882754 scopus 로고
    • Effect of insulin administered intracisternally on the glucose level of the blood and the cerebrospinal fluid in vagotomized dogs
    • Chowers I, Lavy S, Halpern L (1966) Effect of insulin administered intracisternally on the glucose level of the blood and the cerebrospinal fluid in vagotomized dogs. Exp Neurol 14, 383-389.
    • (1966) Exp Neurol , vol.14 , pp. 383-389
    • Chowers, I.1    Lavy, S.2    Halpern, L.3
  • 199
    • 0032562694 scopus 로고    scopus 로고
    • Tracking insulin to the mind
    • Wickelgren I (1998) Tracking insulin to the mind. Science 280, 517-520.
    • (1998) Science , vol.280 , pp. 517-520
    • Wickelgren, I.1
  • 200
    • 0033664539 scopus 로고    scopus 로고
    • Insulin receptors and insulin action in the brain: Review and clinical implications
    • Schulingkamp RJ, Pagano TC, Hung D, Raffa RB (2000) Insulin receptors and insulin action in the brain: Review and clinical implications. Neurosci Biobehav Rev 24, 855-872.
    • (2000) Neurosci Biobehav Rev , vol.24 , pp. 855-872
    • Schulingkamp, R.J.1    Pagano, T.C.2    Hung, D.3    Raffa, R.B.4
  • 201
    • 1842633872 scopus 로고    scopus 로고
    • Insulin and the insulin receptor in experimental models of learning and memory
    • Zhao W-Q, Chen H, Quon MJ, Alkon DL (2004) Insulin and the insulin receptor in experimental models of learning and memory. Eur J Pharmacol 490, 71-81.
    • (2004) Eur J Pharmacol , vol.490 , pp. 71-81
    • Zhao, W.-Q.1    Chen, H.2    Quon, M.J.3    Alkon, D.L.4
  • 202
    • 0025847968 scopus 로고
    • Insulin receptors in the central nervous system: Localization, signalling mechanisms and functional aspects
    • Unger JW, Livingston JN, MossAM(1991) Insulin receptors in the central nervous system: Localization, signalling mechanisms and functional aspects. Prog Neurobiol 36, 343-362.
    • (1991) Prog Neurobiol , vol.36 , pp. 343-362
    • Unger, J.W.1    Livingston, J.N.2    Moss, A.M.3
  • 203
    • 0028890116 scopus 로고
    • Hypothalamic GLUT 4 expression: A glucose-and insulin-sensing mechanism
    • Livingstone C, Lyall H, Gould GW (1995) Hypothalamic GLUT 4 expression: A glucose-and insulin-sensing mechanism Mol Cell Endocrinol 107, 67-70.
    • (1995) Mol Cell Endocrinol , vol.107 , pp. 67-70
    • Livingstone, C.1    Lyall, H.2    Gould, G.W.3
  • 204
    • 0032487335 scopus 로고    scopus 로고
    • Immunocytochemical localization of the insulin-responsive glucose transporter 4 (Glut4) in the rat central nervous system
    • El Messari S, Leloup C, Quignon M, Brisorgueil MJ, Penicaud L, Arluison M (1998) Immunocytochemical localization of the insulin-responsive glucose transporter 4 (Glut4) in the rat central nervous system. J Comp Neurol 399, 492-512.
    • (1998) J Comp Neurol , vol.399 , pp. 492-512
    • El Messari, S.1    Leloup, C.2    Quignon, M.3    Brisorgueil, M.J.4    Penicaud, L.5    Arluison, M.6
  • 205
    • 0033199378 scopus 로고    scopus 로고
    • Insulin-sensitive GLUT4glucose transporters are colocalized with GLUT3-expressing cells and demonstrate a chemically distinct neuron-specific localization in rat brain
    • Apelt J, Mehlhorn G, Schliebs R (1999) Insulin-sensitive GLUT4glucose transporters are colocalized with GLUT3-expressing cells and demonstrate a chemically distinct neuron-specific localization in rat brain. J Neurosci Res 57, 693-705.
    • (1999) J Neurosci Res , vol.57 , pp. 693-705
    • Apelt, J.1    Mehlhorn, G.2    Schliebs, R.3
  • 206
    • 0034681328 scopus 로고    scopus 로고
    • GLUTX1, a novel mammalian glucose transporter expressed in the central nervous system and insulin-sensitive tissues
    • Ibberson M, Uldry M, ThorensB(2000) GLUTX1, a novel mammalian glucose transporter expressed in the central nervous system and insulin-sensitive tissues. J Biol Chem 275, 4607-4612.
    • (2000) J Biol Chem , vol.275 , pp. 4607-4612
    • Ibberson, M.1    Uldry, M.2    Thorens, B.3
  • 208
    • 0024347261 scopus 로고
    • Insulin-like growth factor 1 (IGF-1) receptors in the human brain: Quantitative autoradiographic localization
    • Adem A, Jossan SS, D'Argy R, Gillberg PG, Nordberg A, Winblad B, Sara V (1989) Insulin-like growth factor 1 (IGF-1) receptors in the human brain: Quantitative autoradiographic localization. Brain Res 503, 299-303.
    • (1989) Brain Res , vol.503 , pp. 299-303
    • Adem, A.1    Jossan, S.S.2    D'Argy, R.3    Gillberg, P.G.4    Nordberg, A.5    Winblad, B.6    Sara, V.7
  • 209
    • 0037303635 scopus 로고    scopus 로고
    • Brain insulin: Regulation, mechanisms of action and functions
    • Gerozissis K, Kyriaki G (2003) Brain insulin: Regulation, mechanisms of action and functions. Cell Mol Neurobiol 23, 1-25.
    • (2003) Cell Mol Neurobiol , vol.23 , pp. 1-25
    • Gerozissis, K.1    Kyriaki, G.2
  • 210
    • 64249129005 scopus 로고    scopus 로고
    • Insulin resistance and amyloidogenesis as common molecular foundation for type 2 diabetes and Alzheimer's disease
    • Zhao W-Q, Townsend M (2009) Insulin resistance and amyloidogenesis as common molecular foundation for type 2 diabetes and Alzheimer's disease. Biochim Biophys Acta 1792, 482-496.
    • (2009) Biochim Biophys Acta , vol.1792 , pp. 482-496
    • Zhao, W.-Q.1    Townsend, M.2
  • 211
    • 0035947044 scopus 로고    scopus 로고
    • Role of insulin and insulin receptor in learning and memory
    • Zhao W-Q, Alkon DL (2001) Role of insulin and insulin receptor in learning and memory. Mol Cell Endocrinol 177, 125-134.
    • (2001) Mol Cell Endocrinol , vol.177 , pp. 125-134
    • Zhao, W.-Q.1    Alkon, D.L.2
  • 212
    • 84858631674 scopus 로고    scopus 로고
    • The many faces of insulin-like peptide signalling in the brain
    • Fernandez AM, Torres-Alemán I (2012) The many faces of insulin-like peptide signalling in the brain. Nat Rev Neurosci 13, 225-239.
    • (2012) Nat Rev Neurosci , vol.13 , pp. 225-239
    • Fernandez, A.M.1    Torres-Alemán, I.2
  • 214
    • 0021136096 scopus 로고
    • Effects of insulin, insulinlike growth factor-II and nerve growth factor on neurite outgrowth in cultured human neuroblastoma cells
    • Recio-Pinto E, Ishii DN (1984) Effects of insulin, insulinlike growth factor-II and nerve growth factor on neurite outgrowth in cultured human neuroblastoma cells. Brain Res 302, 323-334.
    • (1984) Brain Res , vol.302 , pp. 323-334
    • Recio-Pinto, E.1    Ishii, D.N.2
  • 215
    • 0038024467 scopus 로고    scopus 로고
    • Wiring the brain with insulin
    • Dickson BJ (2003) Wiring the brain with insulin. Science 300, 440-441.
    • (2003) Science , vol.300 , pp. 440-441
    • Dickson, B.J.1
  • 216
    • 0037453461 scopus 로고    scopus 로고
    • Axons guided by insulin receptor in drosophila visual system
    • Song J, Wu L, Chen Z, Kohanski RA, Pick L (2003) Axons guided by insulin receptor in drosophila visual system. Science 300, 502-505.
    • (2003) Science , vol.300 , pp. 502-505
    • Song, J.1    Wu, L.2    Chen, Z.3    Kohanski, R.A.4    Pick, L.5
  • 220
    • 0030583645 scopus 로고    scopus 로고
    • Preproinsulin i and II mRNAs and insulin electron microscopic immunoreaction are present within the rat fetal nervous system
    • Schechter R, Beju D, Gaffney T, Schaefer F, Whetsell L (1996) Preproinsulin I and II mRNAs and insulin electron microscopic immunoreaction are present within the rat fetal nervous system. Brain Res 736, 16-27.
    • (1996) Brain Res , vol.736 , pp. 16-27
    • Schechter, R.1    Beju, D.2    Gaffney, T.3    Schaefer, F.4    Whetsell, L.5
  • 221
    • 0032547885 scopus 로고    scopus 로고
    • Effects of brain endogenous insulin on neurofilament and MAPK in fetal rat neuron cell cultures
    • Schechter R, Yanovitch T, Abboud M, Johnson G, Gaskins J (1998) Effects of brain endogenous insulin on neurofilament and MAPK in fetal rat neuron cell cultures. Brain Res 808, 270-278.
    • (1998) Brain Res , vol.808 , pp. 270-278
    • Schechter, R.1    Yanovitch, T.2    Abboud, M.3    Johnson, G.4    Gaskins, J.5
  • 222
    • 0034938160 scopus 로고    scopus 로고
    • Cognitive effects of insulin in the central nervous system
    • Park C (2001) Cognitive effects of insulin in the central nervous system. Neurosci Biobehav Rev 25, 311-323.
    • (2001) Neurosci Biobehav Rev , vol.25 , pp. 311-323
    • Park, C.1
  • 223
    • 1842734659 scopus 로고    scopus 로고
    • The source of cerebral insulin
    • Banks WA (2004) The source of cerebral insulin. Eur J Pharmacol 490, 5-12.
    • (2004) Eur J Pharmacol , vol.490 , pp. 5-12
    • Banks, W.A.1
  • 224
  • 225
    • 0030664286 scopus 로고    scopus 로고
    • Transport of insulin across the blood-brain barrier: Saturability at euglycemic doses of insulin
    • BanksWA, Jaspan JB, HuangW, Kastin AJ (1997) Transport of insulin across the blood-brain barrier: Saturability at euglycemic doses of insulin. Peptides 18, 1423-1429.
    • (1997) Peptides , vol.18 , pp. 1423-1429
    • Banks, W.A.1    Jaspan, J.B.2    Huang, W.3    Kastin, A.J.4
  • 226
    • 0031456345 scopus 로고    scopus 로고
    • Selective, physiological transport of insulin across the blood-brain barrier Novel demonstration by species-specific radioimmunoassays
    • BanksWA, Jaspan JB, Kastin AJ (1997) Selective, physiological transport of insulin across the blood-brain barrier. Novel demonstration by species-specific radioimmunoassays. Peptides 18, 1257-1262.
    • (1997) Peptides , vol.18 , pp. 1257-1262
    • Banks, W.A.1    Jaspan, J.B.2    Kastin, A.J.3
  • 228
    • 1842684432 scopus 로고    scopus 로고
    • Glucose improvement of memory: A review
    • Messier C (2004) Glucose improvement of memory: A review. Eur J Pharmacol 490, 33-57.
    • (2004) Eur J Pharmacol , vol.490 , pp. 33-57
    • Messier, C.1
  • 230
    • 0025279593 scopus 로고
    • Insulin binding to brain capillaries is reduced in genetically obese, hyperinsulinemic Zucker rats
    • Schwartz MW, Figlewicz DF, Kahn SE, Baskin DG, Greenwood MRC, Porte D (1990) Insulin binding to brain capillaries is reduced in genetically obese, hyperinsulinemic Zucker rats. Peptides 11, 467-472.
    • (1990) Peptides , vol.11 , pp. 467-472
    • Schwartz, M.W.1    Figlewicz, D.F.2    Kahn, S.E.3    Baskin, D.G.4    Greenwood, M.R.C.5    Porte, D.6
  • 231
    • 28444459842 scopus 로고    scopus 로고
    • Insulin resistance syndrome and Alzheimer's disease: Age-and obesity-related effects on memory, amyloid, inflammation
    • Craft S (2005) Insulin resistance syndrome and Alzheimer's disease: Age-and obesity-related effects on memory, amyloid, inflammation. Neurobiol Aging 26, 65-69.
    • (2005) Neurobiol Aging , vol.26 , pp. 65-69
    • Craft, S.1
  • 233
  • 236
    • 3042589342 scopus 로고    scopus 로고
    • Change in cognitive function by glucose tolerance status in older adults
    • Kanaya AM, Barrett-Connor E, Gildengorin G, Yaffe K (2004) Change in cognitive function by glucose tolerance status in older adults. Arch Intern Med 164, 1327-1333.
    • (2004) Arch Intern Med , vol.164 , pp. 1327-1333
    • Kanaya, A.M.1    Barrett-Connor, E.2    Gildengorin, G.3    Yaffe, K.4
  • 237
    • 1542373533 scopus 로고    scopus 로고
    • Prospective study of type 2 diabetes and cognitive decline in women aged 70-81 years
    • Logroscino G, Kang JH, Grodstein F (2004) Prospective study of type 2 diabetes and cognitive decline in women aged 70-81 years. BMJ 328, 548.
    • (2004) BMJ , vol.328 , pp. 548
    • Logroscino, G.1    Kang, J.H.2    Grodstein, F.3
  • 239
    • 0037452760 scopus 로고    scopus 로고
    • Reduced glucose tolerance is associated with poor memory performance and hippocampal atrophy among normal elderly
    • Convit A, Wolf OT, Tarshish C, de Leon MJ (2003) Reduced glucose tolerance is associated with poor memory performance and hippocampal atrophy among normal elderly. Proc Natl Acad Sci USA 100, 2019-2022.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 2019-2022
    • Convit, A.1    Wolf, O.T.2    Tarshish, C.3    De Leon, M.J.4
  • 244
    • 84940975339 scopus 로고    scopus 로고
    • Biochemical markers of physical exercise on mild cognitive impairment and dementia: Systematic review and perspectives
    • Jensen CS, Hasselbalch SG, Waldemar G, Simonsen AH (2015) Biochemical markers of physical exercise on mild cognitive impairment and dementia: Systematic review and perspectives. Front Neurol 6, 1-10.
    • (2015) Front Neurol , vol.6 , pp. 1-10
    • Jensen, C.S.1    Hasselbalch, S.G.2    Waldemar, G.3    Simonsen, A.H.4
  • 247
    • 0033967003 scopus 로고    scopus 로고
    • Exercise and insulin sensitivity: A review
    • Borghouts LB, Keizer HA (2000) Exercise and insulin sensitivity: A review. Int J Sports Med 21, 1-12.
    • (2000) Int J Sports Med , vol.21 , pp. 1-12
    • Borghouts, L.B.1    Keizer, H.A.2
  • 249
    • 0034142298 scopus 로고    scopus 로고
    • Allostasis and allostatic load: Implications for neuropsychopharmacology
    • McEwenBS(2000) Allostasis and allostatic load: Implications for neuropsychopharmacology. Neuropharmacology 22, 108-124.
    • (2000) Neuropharmacology , vol.22 , pp. 108-124
    • McEwen, B.S.1
  • 250
    • 84893021363 scopus 로고    scopus 로고
    • BDNF mediates adaptive brain and body responses to energetic challenges
    • Marosi K, Mattson MP (2014) BDNF mediates adaptive brain and body responses to energetic challenges. Trends Endocrinol Metab 25, 89-98.
    • (2014) Trends Endocrinol Metab , vol.25 , pp. 89-98
    • Marosi, K.1    Mattson, M.P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.