Greater glucocorticoid receptor activation in hippocampus of aged rats sensitizes microglia

Neurobiology of Aging

Volumn 36, Issue 3, 2015, Pages 1483-1495

  Barrientos, Ruth M ^a   Thompson, Vanessa M ^a   Kitt, Meagan M ^a   Amat, Jose ^a   Hale, Matthew W ^a,b   Frank, Matthew G ^a   Crysdale, Nicole Y ^a   Stamper, Christopher E ^a   Hennessey, Patrick A ^a   Watkins, Linda R ^a   Spencer, Robert L ^a   Lowry, Christopher A ^a   Maier, Steven F ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b LA TROBE UNIVERSITY   (Australia)

Author keywords

Automated blood sampling; GR activation; Invivo microdialysis; Memory impairments; Microglial immunophenotype; Microglial sensitization; Mifepristone; Normal aging; Voluntary exercise

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1; CORTICOSTERONE; CORTICOSTERONE BINDING GLOBULIN; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; MIFEPRISTONE; THYROXINE BINDING GLOBULIN; UNCLASSIFIED DRUG;

ADULT; AGED; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN LEVEL; BRAIN TISSUE; CIRCADIAN RHYTHM; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; ENZYME ACTIVITY; ESCHERICHIA COLI; EX VIVO STUDY; EXERCISE; HIPPOCAMPUS; HORMONE SYNTHESIS; IMMUNE RESPONSE; IMMUNOSTIMULATION; IN VIVO STUDY; MALE; MEMORY DISORDER; MICROGLIA; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR UPREGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENSITIZATION; YOUNG ADULT; ANIMAL; ANTAGONISTS AND INHIBITORS; CATALYSIS; CELL CULTURE; FISCHER 344 RAT; IMMUNOLOGY; INFLAMMATION; MEMORY; MEMORY DISORDERS; METABOLISM; PHYSIOLOGY;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; AGING; ANIMALS; CATALYSIS; CELLS, CULTURED; CORTICOSTERONE; HIPPOCAMPUS; INFLAMMATION; MALE; MEMORY; MEMORY DISORDERS; MICROGLIA; MIFEPRISTONE; PHYSICAL CONDITIONING, ANIMAL; RATS, INBRED F344; RECEPTORS, GLUCOCORTICOID;

EID: 84923587472     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2014.12.003     Document Type: Article

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