Association between arterial stiffness, cerebral small vessel disease and cognitive impairment: A systematic review and meta-analysis

Neuroscience and Biobehavioral Reviews

Volumn 53, Issue , 2015, Pages 121-130

  van Sloten, Thomas T ^a   Protogerou, Athanase D ^a   Henry, Ronald M A ^a   Schram, Miranda T ^a   Launer, Lenore J ^b   Stehouwer, Coen D A ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Arterial stiffness; Cerebral infarcts; Cerebral microbleeds; Cerebral small vessel disease; Cognitive impairment; Dementia; Meta analysis; Systematic review; White matter hyperintensities

Indexed keywords

ADULT; AGED; ANKLE; ARTERIAL STIFFNESS; BRAIN DISEASE; CAROTID ARTERY; CEREBROVASCULAR DISEASE; COGNITIVE DEFECT; CROSS-SECTIONAL STUDY; DISEASE ASSOCIATION; FEMORAL ARTERY; HUMAN; LACUNAR STROKE; LONGITUDINAL STUDY; META ANALYSIS; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PULSE PRESSURE; PULSE WAVE; REVIEW; SYSTEMATIC REVIEW; TRANSIENT ISCHEMIC ATTACK; BLOOD PRESSURE; CEREBRAL SMALL VESSEL DISEASES; COGNITION DISORDERS; PATHOPHYSIOLOGY; PSYCHOLOGY; RISK FACTOR;

BLOOD PRESSURE; CEREBRAL SMALL VESSEL DISEASES; COGNITION DISORDERS; HUMANS; RISK FACTORS; VASCULAR STIFFNESS;

EID: 84927644444     PISSN: 01497634     EISSN: 18737528     Source Type: Journal    
DOI: 10.1016/j.neubiorev.2015.03.011     Document Type: Review

References (81)

1. Aribisala B.S., Morris Z., Eadie E., Thomas A., Gow A., Valdes Hernandez M.C., Royle N.A., Bastin M.E., Starr J., Deary I.J., Wardlaw J.M. Blood pressure, internal carotid artery flow parameters, and age-related white matter hyperintensities. Hypertension 2014, 63:1011-1018.
2. Benetos A., Watfa G., Hanon O., Salvi P., Fantin F., Toulza O., Manckoundia P., Agnoletti D., Labat C., Gautier S. Pulse wave velocity is associated with 1-year cognitive decline in the elderly older than 80 years: the PARTAGE study. J. Am. Med. Dir. Assoc. 2012, 13:239-243.
3. Brisset M., Boutouyrie P., Pico F., Zhu Y., Zureik M., Schilling S., Dufouil C., Mazoyer B., Laurent S., Tzourio C., Debette S. Large-vessel correlates of cerebral small-vessel disease. Neurology 2013, 80:662-669.
4. Chrysohoou C., Psaltopoulou T., Panagiotakos D., Pitsavos C., Lazaros G., Skoumas J., Oikonomou E., Poulidakis E., Striggou M., Stefanadis C. Aortic elastic properties and cognitive function in elderly individuals: the Ikaria study. Maturitas 2012, (Epub ahead of print).
5. Coutinho T., Turner S.T., Kullo I.J. Aortic pulse wave velocity is associated with measures of subclinical target organ damage. JACC Cardiovasc. Imaging 2011, 4:754-761.
6. Davis R.N., Massman P.J., Doody R.S. Effects of blood pressure on neuropsychological functioning in Alzheimer's disease. Arch. Clin. Neuropsychol. 2003, 18:19-32.
7. DeCarli C., Fletcher E., Ramey V., Harvey D., Jagust W.J. Anatomical mapping of white matter hyperintensities (WMH): exploring the relationships between periventricular WMH, deep WMH, and total WMH burden. Stroke 2005, 36:50-55.
8. De Leeuw F.E., Barkhof F., Scheltens P. Alzheimer's disease - one clinical syndrome, two radiological expressions: a study on blood pressure. J. Neurol. Neurosurg. Psychiatry 2004, 75:1270-1274.
9. Elias M.F., Robbins M.A., Budge M.M., Abhayaratna W.P., Dore G.A., Elias P.K. Arterial pulse wave velocity and cognition with advancing age. Hypertension 2009, 53:668-673.
10. Freitag M.H., Peila R., Masaki K., Petrovitch H., Ross G.W., White L.R., Launer L.J. Midlife pulse pressure and incidence of dementia: the Honolulu-Asia Aging Study. Stroke 2006, 37:33-37.
11. Fisher C.M. Capsular infarcts: the underlying vascular lesions. Arch. Neurol. 1979, 36:65-73.
12. Fujiwara Y., Chaves P.H., Takahashi R., Amano H., Yoshida H., Kumagai S., Fujita K., Wang D.G., Shinkai S. Arterial pulse wave velocity as a marker of poor cognitive function in an elderly community-dwelling population. J. Gerontol. A. Biol. Sci. Med. Sci. 2005, 60:607-612.
13. Fukuhara M., Matsumura K., Ansai T., Takata Y., Sonoki K., Akifusa S., Wakisaka M., Hamasaki T., Fujisawa K., Yoshida A., Fujii K., Iida M., Takehara T. Prediction of cognitive function by arterial stiffness in the very elderly. Circ. J. 2006, 70:756-761.
14. Giang L.M., Tighiouart H., Lou K.V., Agganis B., Drew D.A., Shaffi K., Scott T., Weiner D.E., Sarnak M.J. Measures of blood pressure and cognition in dialysis patients. Hemodial. Int. 2013, 17:24-31.
15. Gorelick P.B., Scuteri A., Black S.E., Decarli C., Greenberg S.M., Iadecola C., Launer L.J., Laurent S., Lopez O.L., Nyenhuis D., Petersen R.C., Schneider J.A., Tzourio C., Arnett D.K., Bennett D.A., Chui H.C., Higashida R.T., Lindquist R., Nilsson P.M., Roman G.C., Sellke F.W., Seshadri S. Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 2011, 42:2672-2713.
16. Hanon O., Haulon S., Lenoir H., Seux M.L., Rigaud A.S., Safar M., Girerd X., Forette F. Relationship between arterial stiffness and cognitive function in elderly subjects with complaints of memory loss. Stroke 2005, 36:2193-2197.
17. Hashimoto J., Aikawa T., Imai Y. Large artery stiffening as a link between cerebral lacunar infarction and renal albuminuria. Am. J. Hypertens. 2008, 21:1304-1309.
18. Henskens L.H., Kroon A.A., van Oostenbrugge R.J., Gronenschild E.H., Fuss-Lejeune M.M., Hofman P.A., Lodder J., de Leeuw P.W. Increased aortic pulse wave velocity is associated with silent cerebral small-vessel disease in hypertensive patients. Hypertension 2008, 52:1120-1126.
19. Kalaitzidis R.G., Karasavvidou D., Tatsioni A., Balafa O., Pappas K., Spanos G., Pelidou S.H., Siamopoulos K.C. Risk factors for cognitive dysfunction in CKD and hypertensive subjects. Int. Urol. Nephrol. 2013, 45:1637-1646.
20. Kearney-Schwartz A., Rossignol P., Bracard S., Felblinger J., Fay R., Boivin J.M., Lecompte T., Lacolley P., Benetos A., Zannad F. Vascular structure and function is correlated to cognitive performance and white matter hyperintensities in older hypertensive patients with subjective memory complaints. Stroke 2009, 40:1229-1236.
21. Kim C.K., Lee S.H., Kim B.J., Ryu W.S., Yoon B.W. Age-independent association of pulse pressure with cerebral white matter lesions in asymptomatic elderly individuals. J. Hypertens. 2011, 29:325-329.
22. Kim S.H., Shim J.Y., Lee H.R., Na H.Y., Lee Y.J. The relationship between pulse pressure and leukoaraiosis in the elderly. Arch. Gerontol. Geriatr. 2012, 54:206-209.
23. Kim Y.S., Kim D.H., Choi B.H., Sohn E.H., Lee A.Y. Relationship between brachial-ankle pulse wave velocity and cognitive function in an elderly community-dwelling population with metabolic syndrome. Arch. Gerontol. Geriatr. 2009, 49:176-179.
24. Kwon H.S., Lim Y.H., Kim H.Y., Kim H.T., Kwon H.M., Lim J.S., Lee Y.J., Kim J.Y., Kim Y.S. Association of ambulatory blood pressure and heart rate with advanced white matter lessions in ischemic stroke patients. Am. J. Hypertens. 2014, 27:177-183.
25. Laugesen E., Hoyem P., Stausbol-Gron B., Mikkelsen A., Thrysoe S., Erlandsen M., Christiansen J.S., Knudsen S.T., Hansen K.W., Kim W.Y., Hansen T.K., Poulsen P.L. Carotid-femoral pulse wave velocity is associated with cerebral white matter lesions in type 2 diabetes. Diabetes Care 2013, 36:722-728.
26. Lee A.T., Chan W.C., Chiu H.F., Richards M., Ng S.P., Hui L.Y., Chan W.M., Lam L.C. Widened pulse pressure is a potential risk factor for significant cognitive impairment among community-dwelling Chinese younger old people. J. Alzheimers Dis. 2013, 35:687-696.
27. Liao D., Cooper L., Cai J., Toole J., Bryan N., Burke G., Shahar E., Nieto J., Mosley T., Heiss G. The prevalence and severity of white matter lesions, their relationship with age, ethnicity, gender, and cardiovascular disease risk factors: the ARIC Study. Neuroepidemiology 1997, 16:149-162.
28. Matsumoto M., Inoue K., Moriki A. Associations of brachial-ankle pulse wave velocity and carotid atherosclerotic lesions with silent cerebral lesions. Hypertens. Res. 2007, 30:767-773.
29. McFall G.P., Wiebe S.A., Vergrote D., Jhamandas J., Westaway D., Dixon R.A. IDE (rs6583817) polymorphism and pulse pressure are independently and interactively associated with level and change in executive function in older adults. Psychol. Aging 2014, 29:418-430.
30. Mitchell G.F. Effects of central arterial aging on the structure and function of the peripheral vasculature: implications for end-organ damage. J. Appl. Physiol. (1985) 2008, 105:1652-1660.
31. Mitchell G.F., van Buchem M.A., Sigurdsson S., Gotal J.D., Jonsdottir M.K., Kjartansson O., Garcia M., Aspelund T., Harris T.B., Gudnason V., Launer L.J. Arterial stiffness, pressure and flow pulsatility and brain structure and function: the Age, Gene/Environment Susceptibility - Reykjavik study. Brain 2011, 134:3398-3407.
32. Moher D., Liberati A., Tetzlaff J., Altman D.G. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann. Intern. Med. 2009, 151:264-269. W264.
33. Molander L., Gustafson Y., Lovheim H. Low blood pressure is associated with cognitive impairment in very old people. Dement. Geriatr. Cogn. Disord. 2010, 29:335-341.
34. Morris M.C., Scherr P.A., Hebert L.E., Glynn R.J., Bennett D.A., Evans D.A. Association of incident Alzheimer disease and blood pressure measured from 13 years before to 2 years after diagnosis in a large community study. Arch. Neurol. 2001, 58:1640-1646.
35. Muller M., Grobbee D.E., Aleman A., Bots M., van der Schouw Y.T. Cardiovascular disease and cognitive performance in middle-aged and elderly men. Atherosclerosis 2007, 190:143-149.
36. Muller M., Smulders Y.M., de Leeuw P.W., Stehouwer C.D. Treatment of hypertension in the oldest old: a critical role for frailty?. Hypertension 2014, 63:433-441.
37. Naganuma T., Takemoto Y., Yamasaki T., Shima H., Shoji T., Ishimura E., Nishizawa Y., Morino M., Okamura M., Nakatani T. Factors associated with silent cerebral microbleeds in hemodialysis patients. Clin. Nephrol. 2011, 75:346-355.
38. Nomura K., Hamamoto Y., Takahara S., Kikuchi O., Honjo S., Ikeda H., Wada Y., Nabe K., Okumra R., Koshiyama H. Relationship between carotid intima-media thickness and silent cerebral infarction in Japanese subjects with type 2 diabetes. Diabetes Care 2010, 33:168-170.
39. Obisesan T.O., Obisesan O.A., Martins S., Alamgir L., Bond V., Maxwell C., Gillum R.F. High blood pressure, hypertension, and high pulse pressure are associated with poorer cognitive function in persons aged 60 and older: the Third National Health and Nutrition Examination Survey. J. Am. Geriatr. Soc. 2008, 56:501-509.
40. Ochi N., Kohara K., Tabara Y., Nagai T., Kido T., Uetani E., Ochi M., Igase M., Miki T. Association of central systolic blood pressure with intracerebral small vessel disease in Japanese. Am. J. Hypertens. 2010, 23:889-894.
41. Ogunniyi A., Lane K.A., Baiyewu O., Gao S., Gureje O., Unverzagt F.W., Murrell J.R., Smith-Gamble V., Hall K.S., Hendrie H.C. Hypertension and incident dementia in community-dwelling elderly Yoruba Nigerians. Acta Neurol. Scand. 2011, 124:396-402.
42. O'Rourke M.F., Safar M.E. Relationship between aortic stiffening and microvascular disease in brain and kidney: cause and logic of therapy. Hypertension 2005, 46:200-204.
43. Pase M.P., Herbert A., Grima N.A., Pipingas A., O'Rourke M.F. Arterial stiffness as a cause of cognitive decline and dementia: a systematic review and meta-analysis. Intern. Med. J. 2012, 42:808-815.
44. Pase M.P., Stough C., Grima N.A., Harris E., Macpherson H., Scholey A.B., Pipingas A. Blood pressure and cognitive function: the role of central aortic and brachial pressures. Psychol. Sci. 2013, 24:2173-2181.
45. Peters R., Beckett N., Fagard R., Thijs L., Wang J.G., Forette F., Pereira L., Fletcher A., Bulpitt C. Increased pulse pressure linked to dementia: further results from the Hypertension in the Very Elderly Trial - HYVET. J. Hypertens. 2013, 31:1868-1875.
46. Poels M.M., van Oijen M., Mattace-Raso F.U., Hofman A., Koudstaal P.J., Witteman J.C., Breteler M.M. Arterial stiffness, cognitive decline, and risk of dementia: the Rotterdam study. Stroke 2007, 38:888-892.
47. Poels M.M., Vernooij M.W., Ikram M.A., Hofman A., Krestin G.P., van der Lugt A., Breteler M.M. Prevalence and risk factors of cerebral microbleeds: an update of the Rotterdam scan study. Stroke 2010, 41:S103-S106.
48. Poels M.M., Zaccai K., Verwoert G.C., Vernooij M.W., Hofman A., van der Lugt A., Witteman J.C., Breteler M.M., Mattace-Raso F.U., Ikram M.A. Arterial stiffness and cerebral small vessel disease: the Rotterdam Scan Study. Stroke 2012, 43:2637-2642.
49. Review Manager (RevMan) [Computer program]. Version 5.2 2012, The Nordic Cochrane Centre, The Cochrane Collaboration, Copenhagen.
50. Qiu C., Winblad B., Viitanen M., Fratiglioni L. Pulse pressure and risk of Alzheimer disease in persons aged 75 years and older: a community-based, longitudinal study. Stroke 2003, 34:594-599.
51. Rabkin S.W., Jarvie G. Comparison of vascular stiffness in vascular dementia, Alzheimer dementia and cognitive impairment. Blood Press. 2011, 20:274-283.
52. Raz N., Dahle C.L., Rodrigue K.M., Kennedy K.M., Land S. Effects of age, genes, and pulse pressure on executive functions in healthy adults. Neurobiol. Aging 2011, 32:1124-1137.
53. Robbins M.A., Elias M.F., Elias P.K., Budge M.M. Blood pressure and cognitive function in an African-American and a Caucasian-American sample: the Maine-Syracuse Study. Psychosom. Med. 2005, 67:707-714.
54. Rosano C., Watson N., Chang Y., Newman A.B., Aizenstein H.J., Du Y., Venkatraman V., Harris T.B., Barinas-Mitchell E., Sutton-Tyrrell K. Aortic pulse wave velocity predicts focal white matter hyperintensities in a biracial cohort of older adults. Hypertension 2013, 61:160-165.
55. Sabayan B., Oleksik A.M., Maier A.B., van Buchem M.A., Poortvliet R.K., de Ruijter W., Gussekloo J., de Craen A.J., Westendorp R.G. High blood pressure and resilience to physical and cognitive decline in the oldest old: the Leiden 85-plus Study. J. Am. Geriatr. Soc. 2012, 60:2014-2019.
56. Safar M.E., O'Rourke M.F. Arterial stiffness in hypertension 2006, Elsevier, Amsterdam.
57. Saji N., Kimura K., Shimizu H., Kita Y. Association between silent brain infarct and arterial stiffness indicated by brachial-ankle pulse wave velocity. Intern. Med. 2012, 51:1003-1008.
58. Saji N., Shimizu H., Kawarai T., Tadano M., Kita Y., Yokono K. Increased brachial-ankle pulse wave velocity is independently associated with white matter hyperintensities. Neuroepidemiology 2011, 36:252-257.
59. Scuteri A., Tesauro M., Guglini L., Lauro D., Fini M., Di Daniele N. Aortic stiffness and hypotension episodes are associated with impaired cognitive function in older subjects with subjective complaints of memory loss. Int. J. Cardiol. 2013, 169:371-377.
60. Seo W.K., Lee J.M., Park M.H., Park K.W., Lee D.H. Cerebral microbleeds are independently associated with arterial stiffness in stroke patients. Cerebrovasc. Dis. 2008, 26:618-623.
61. Singer J., Trollor J.N., Baune B.T., Sachdev P.S., Smith E. Arterial stiffness, the brain and cognition: a systematic review. Ageing Res. Rev. 2014, 15:16-27.
62. Singer J., Trollor J.N., Crawford J., O'Rourke M.F., Baune B.T., Brodaty H., Samaras K., Kochan N.A., Campbell L., Sachdev P.S., Smith E. The association between pulse wave velocity and cognitive function: the Sydney Memory and Ageing Study. PloS One 2013, 8:e61855.
63. Song T.J., Kim J., Kim Y.D., Nam H.S., Lee H.S., Nam C.M., Heo J.H. The distribution of cerebral microbleeds determines their association with arterial stiffness in non-cardioembolic acute stroke patients. Eur. J. Neurol. 2013, 21:463-469.
64. Sugawara N., Yasui-Furukori N., Umeda T., Kaneda A., Sato Y., Takahashi I., Matsuzaka M., Danjo K., Nakaji S., Kaneko S. Comparison of ankle-brachial pressure index and pulse wave velocity as markers of cognitive function in a community-dwelling population. BMC Psychiatry 2010, 10:46.
65. Taylor C., Tillin T., Chaturvedi N., Dewey M., Ferri C.P., Hughes A., Prince M., Richards M., Shah A., Stewart R. Midlife hypertensive status and cognitive function 20 years later: the Southall and Brent revisited study. J. Am. Geriatr. Soc. 2013, 61:1489-1498.
66. Tsao C.W., Seshadri S., Beiser A.S., Westwood A.J., Decarli C., Au R., Himali J.J., Hamburg N.M., Vita J.A., Levy D., Larson M.G., Benjamin E.J., Wolf P.A., Vasan R.S., Mitchell G.F. Relations of arterial stiffness and endothelial function to brain aging in the community. Neurology 2013, 10:984-991.
67. Tsivgoulis G., Alexandrov A.V., Wadley V.G., Unverzagt F.W., Go R.C., Moy C.S., Kissela B., Howard G. Association of higher diastolic blood pressure levels with cognitive impairment. Neurology 2009, 73:589-595.
68. Tzourio C., Laurent S., Debette S. Is hypertension associated with an accelerated aging of the brain?. Hypertension 2014, 63:894-903.
69. van Bruchem-Visser R.L., Mattace-Raso F.U., van der Cammen T.J. High systolic and pulse pressure levels are associated with better cognitive performance in patients with probable Alzheimer's disease: a cross-sectional observational study in a geriatric outpatient population. Dement. Geriatr. Cogn. Disord. 2009, 28:320-324.
70. Van Dooren M., Staals J., De Leeuw P.W., Kroon A.A., Henskens L.H., Van Oostenbrugge R.J. Progression of brain microbleeds in essential hypertensive patients: a 2-year follow-up study. Am. J. Hypertens. 2014, (Epub ahead of print).
71. Verhaaren B.F., Vernooij M.W., de Boer R., Hofman A., Niessen W.J., van der Lugt A., Ikram M.A. High blood pressure and cerebral white matter lesion progression in the general population. Hypertension 2013, 61:1354-1359.
72. Waldstein S.R., Rice S.C., Thayer J.F., Najjar S.S., Scuteri A., Zonderman A.B. Pulse pressure and pulse wave velocity are related to cognitive decline in the Baltimore Longitudinal Study of Aging. Hypertension 2008, 51:99-104.
73. Wardlaw J.M., Smith C., Dichgans M. Mechanisms of sporadic cerebral small vessel disease: insights from neuroimaging. Lancet Neurol. 2013, 12:483-497.
74. Wardlaw J.M., Smith E.E., Biessels G.J., Cordonnier C., Fazekas F., Frayne R., Lindley R.I., O'Brien J.T., Barkhof F., Benavente O.R., Black S.E., Brayne C., Breteler M., Chabriat H., Decarli C., de Leeuw F.E., Doubal F., Duering M., Fox N.C., Greenberg S., Hachinski V., Kilimann I., Mok V., Oostenbrugge R., Pantoni L., Speck O., Stephan B.C., Teipel S., Viswanathan A., Werring D., Chen C., Smith C., van Buchem M., Norrving B., Gorelick P.B., Dichgans M. Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration. Lancet Neurol. 2013, 822-838.
75. Watson N.L., Sutton-Tyrrell K., Rosano C., Boudreau R.M., Hardy S.E., Simonsick E.M., Najjar S.S., Launer L.J., Yaffe K., Atkinson H.H., Satterfield S., Newman A.B. Arterial stiffness and cognitive decline in well-functioning older adults. J. Gerontol. A: Biol. Sci. Med. Sci. 2011, 66:1336-1342.
76. Wells, G.A., Shea, B., O'Connell, D., Peterson, J., Welch, V., Losos, M., Tugwell, P. The Newcastle-Ottawa Scale (NOS) for assessing the quality if nonrandomized studies in meta-analyses. Available from: URL: http://www.ohri.ca/programs/clinical_epidemiology/oxford.htm.
77. Yang Y.H., Roe C.M., Morris J.C. Relationship between late-life hypertension, blood pressure, and Alzheimer's disease. Am. J. Alzheimers Dis. Other Demen. 2011, 26:457-462.
78. Yasar S., Ko J.Y., Nothelle S., Mielke M.M., Carlson M.C. Evaluation of the effect of systolic blood pressure and pulse pressure on cognitive function: the Women's Health and Aging Study II. PLoS ONE 2011, 6:e27976.
79. Young V.G., Halliday G.M., Kril J.J. Neuropathologic correlates of white matter hyperintensities. Neurology 2008, 71:804-811.
80. Zeki Al Hazzouri A., Newman A.B., Simonsick E., Sink K.M., Sutton Tyrrell K., Watson N., Satterfield S., Harris T., Yaffe K. Pulse wave velocity and cognitive decline in elders: the Health, Aging, and Body Composition study. Stroke 2013, 44:388-393.
81. Zhong W., Cruickshanks K.J., Schubert C.R., Carlsson C.M., Chappell R.J., Klein B.E., Klein R., Acher C.W. Pulse wave velocity and cognitive function in older adults. Alzheimer Dis. Assoc. Disord. 2013, 28:44-49.