Impact of physical activity on inflammation: Effects on cardiovascular disease risk and other inflammatory conditions

Archives of Medical Science

Volumn 8, Issue 5, 2012, Pages 794-804

  Ertek, Sibel ^a   Cicero, Arrigo ^b  

^a UFUK UNIVERSITY   (Turkey)

^b UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Adipokines; Atherosclerosis; Inflammation; Insulin resistance; Metabolic syndrome; Myokines; Obesity; Physical activity

Indexed keywords

ADIPONECTIN; ANGIOTENSIN 1 RECEPTOR; GHRELIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 15; INTERLEUKIN 19; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; OBESTATIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; REACTIVE OXYGEN METABOLITE; RESISTIN; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR;

ACUTE HEART INFARCTION; ADIPOSE TISSUE; AEROBIC EXERCISE; AGE; ANTIINFLAMMATORY ACTIVITY; ATHEROSCLEROSIS; BODY COMPOSITION; BREAST CANCER; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CHRONIC KIDNEY FAILURE; CHRONIC OBSTRUCTIVE LUNG DISEASE; COLON CANCER; CORONARY ARTERY DISEASE; CYCLING; DIET THERAPY; DISEASE ACTIVITY; ERGOMETER; EXERCISE; GENDER; HEART FAILURE; HUMAN; HYPERCHOLESTEROLEMIA; IMMUNE SYSTEM; IMPAIRED GLUCOSE TOLERANCE; INFLAMMATION; INTERMITTENT CLAUDICATION; LUNG CANCER; LUNG DISEASE; MARATHON RUNNER; METABOLIC SYNDROME X; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PERIPHERAL OCCLUSIVE ARTERY DISEASE; PHYSICAL ACTIVITY; RACE; RESISTANCE TRAINING; REVIEW; RHEUMATIC DISEASE; RHEUMATOID ARTHRITIS; RUNNING; SITTING; TISSUE METABOLISM; TREADMILL EXERCISE; WALKING; WELLBEING;

EID: 84869998324     PISSN: 17341922     EISSN: None     Source Type: Journal    
DOI: 10.5114/aoms.2012.31614     Document Type: Review

References (130)

1. Mayerl C, Lukasser M, Sedivy R, et al. Atherosclerosis research from past to present on the tract of two pathologists with opposing views, Carl von Rokitanski and Rudolf Wirchow. Virch Arch 2006; 449: 96-103.
2. Lamon BD, Hajjar DP. Inflammation at the molecular interface of atherogenesis. An anthropological journey. Am J Pathology 2008; 173: 1253-64.
3. Libby P. Inflammation and the cardiovascular disease mechanisms. Am J Nutr 2006; 83 (Suppl.): 456S-60S.
4. Ertek S, Akgül E, Cicero AF, et al. 25-Hydroxy vitamin D levels and endothelial vasodilator function in normotensive women. Arch Med Sci 2012; 8: 47-52.
5. Ertek S, Francesco Cicero A, Erdoǧan G. The relationship between calcium metabolism, insulin-like growth factor-1 and pulse pressure in normotensive, normolipidaemic and non-diabetic patients. Arch Med Sci 2011; 7: 776-80.
6. Pickard RR, Libby P. Inflammation in atherosclerosis: from vascular biology to biomarker discovery and risk prediction. Clin Chem 2008; 54: 2438.
7. Schuster DP. Obesity and the development of type 2 diabetes: the effects of fatty tissue inflammation. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 2010; 3: 253-62.
8. Paoletti R, Bolego C, Poli A, Cignarella A. Metabolic syndrome, inflammation and atherosclerosis. Vasc Health Risk Manag 2006; 2: 145-52.
9. Derosa G, Cicero AF, Scalise F, et al. Metalloproteinase-2 and -9 in diabetic and nondiabetic subjects during acute coronary syndromes. Endothelium 2007; 14: 45-51.
10. Derosa G, D'Angelo A, Scalise F, et al. Comparison between metalloproteinases-2 and -9 in healthy subjects, diabetics, and subjects with acute coronary syndrome. Heart Vessels 2007; 22: 361-70.
11. Haffner SM. Abdominal adiposity and cardiometabolic risk: do we have all the answers? Am J Med 2007; 120: S10-6.
12. Bays HE. "Sick fat", metabolic disease and atherosclerosis. Am J Med 2009; 122: S26-37.
13. Nocon N, Hiermann T, Muller-Riemenschineider F, Thalau F, Roll S, Willich SN. Association of physical activity with all-cause and ardiovascular mortality: a systemic review and meta-analysis. Eur J Cardiovasc Prev Rehab 2008; 15: 239-46.
14. Tuomiletho J, Lindstrom J, Eriksson JL, et al. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with mpaired glucose tolerance. N Eng J Med 2001; 344: 1343-50.
15. Wolin KY, Yan Y, Colditz GA, Lee IM. Physical activity and colon cancer prevention: a meta-analysis. Br J Cancer 2009; 100: 611-6.
16. Pedersen BK. The diseasome of physical inactivity and the role of myokines in muscle-fat cross-talk. J Physiol 2009; 587: 5559-68.
17. Simeunovic S, Milincic Z, Nikolic D, et al. Physical activity evaluation in Yugoslav Study of the Precursors of Atherosclerosis in School Children - YUSAD study. Arch Med Sci 2010; 6: 874-8.
18. Esch T, Stefano GB. Endogenous reward mechanisms and their importance in stress reduction, exercise and the brain. Arch Med Sci 2010; 6: 447-55.
19. Fletcher GF, Balady G, Blair SN, et al. Statement on exercise: benefits and recommendations for physical activity programs for all Americans. Circulation 1996; 94: 857-62.
20. Lee IM, Sesso HD, Oquma Y, Paffenbarger RS Jr. The "weekend- warrior" and risk of mortality. Am J Epidemiol 2004; 160: 636-41.
21. Williams PT. Physical fitness and activity as separate heart disease risk factors. Med Sci Sports Exerc 2001; 33: 754-61.
22. Fischer CP. Interleukin-6 in acute exercise and training: what is the biological relevance? Exercise Immunol Rev 2006; 12 :6-33.
23. Pedersen BK, Febbraio MA. Muscle as an endocrine organ: focus on muscle derived interleukin-6. Physiol Rev 2008; 88: 1379-406.
24. Kamiński KA, Jasiewicz M, Knapp M, et al. Short period of exercise causes rapid increase of serum interleukin 6 with no effect on its soluble receptor. Arch Med Sci 2009; 5: 364-70.
25. Wojtaszewski JF, Hansen BF, Gade Kiens B, et al. Insulin signalling and insulin sensitivity after exercise in human skeletal muscle. Diabetes 2000; 49: 325-31.
26. Hotlamisligil GS, Murray DL, Choy LN, Spiegelman BM. Tumor necrosis factor alpha inhibits signalling from the insulin receptor. Proc Natl Acad Sci USA 1994; 91: 4854-8.
27. Ostrowski K, Schjerling P, Pedersen BK. Physical activity and plasma IL-6 levels in humans: effect of intensity of exercise. Eur J Appl Physiol 2000; 83: 512-5.
28. Mizuhara H, O'Neill E, Seki N, et al. T-cell activation associated hepatic injury, mediation tumor necrosis factors and protection by interleukin-6. J Exp Med 1994; 179: 1529-37.
29. van der Poll T, Coyle SM, Barbosa K, Braxton CC, Lowry SF. Epinephrine inhibits tumor necrosis factor-alpha and potentiates interleukin-10 production during human endotoxemia. J Clin Invest 1996; 97: 713-9.
30. Szostak J, Laurant P. The forgotton face of regular physical exercise: a natural antiatherogenic activity. Clin Sci (Lond) 2011; 121: 91-106.
31. Pinto A, Di Raimondo D, Tuttolomondo A, Buttà C, Milio G, Licata G. Effects of physical exercise on inflammatory markers of atherosclerosis. Curr Pharm Des 2012 Feb 29 [Epub ahead of print].
32. Quinn LS, Strait-Bodey L, Anderson BG, Argiles JM, Havel PJ. Intereukin-15 stimulates adiponectin secretion by 3T3-L1 adipoctyes: evidence for a skeletal muscle to fat signalling pathway. Cell Biol Int 2005; 29: 449-57.
33. Frydelund-Larsen, Penkowa M, Akerstrom T, Zankari A, Nielsen S, Pedersen BK. Exercise induces interleukin-8 receptor (CXCR2) expression in human skeletal muscle. Exp Physiol 2007; 92: 233-40.
34. Rubin DA, Hackney AC. Inflammatory cytokines and metabolic risk factors during growth and maturation: influence of physical activity. Med Sport Sci 2010; 55: 43-55.
35. Ahonen TM, Saltevo JT, Kautiainen HJ, Kumpusalo EA, Vanhala MJ. The association of adiponectin and low-grade inflammation with the course of metabolic syndrome. Nutr Metab Cardiovasc Dis 2012; 22: 285-91.
36. Alibegovic AC, Sonne MP, Højbjerre L, et al. Insulin resistance induced by physical inactivity is associated with multiple transcriptional changes in skeletal muscle in young men. Am J Physiol Endocrinol Metab 2010; 299: E752-63.
37. Alvarez-Guardia D, Palomer X, Coll T, et al. PPARbeta/delta activation blocks lipid-induced inflammatory pathways in mouse heart and human cardiac cells. Biochim Biophys Acta 2011; 1811: 59-67.
38. Handschin C. PGC-1alpha in muscle links metabolism to inflammation. Clin Exp Pharmacol Physiol 2009; 36: 1139-43.
39. Balagopal PB, Gidding SS, Buckloh LM, et al. Changes in circulating satiety hormones in obese children: randomized controlled physical activity - based intervention study. Obesity 2010; 18: 1747-53.
40. Ata SM, Vaishnav U, Puglisi M, et al. Macronutrient composition and increased physical activity modulate plasma adipokines and appetite hormones during a weight loss intervention. J Womens Health 2010; 19: 139-45.
41. Oliviera AG, Carvalho BM, Tobar N, et al. Physical exercise reduces circulating lipopolysaccharide and TLR4 activation and improves insulin signalling in tissues of DIO rats. Diabetes 2011; 60: 784-96.
42. Da Silva AS, Pauli JR, Ropelle ER, et al. Exercise intensity, inflammatory signalling, and insulin resistance in obese rats. Med Sci Sports Exerc 2010; 42: 2180-8.
43. Király MA, Campbell J, Park E, et al. Exercise maintains euglycemia in association with decreased activation of c-Jun NH2-terminal kinase and serine phosphorylation of IRS-1 in the liver of ZDF rats. Am J Physiol Endocrinol Metab 2010; 298: E671-81.
44. de Lemos ET, Reis F, Baptista S, et al. Exercise training is associated with improved levels of C-reactive protein and adiponectin in ZDF (type 2 ) diabetic rats. Med Sci Monit 2007; 13: BR 168-74.
45. Asghar M, George L, Lokhandwala MF. Exercise decreases oxidative stress and inflammation and restores renal dopamine D1 receptor function in old rats. Am J Physiol Renal Physiol 2007; 293: F914-9.
46. Huang CC, Lin WT, Hsu FL, Tsai PW, Hou CC. Metabolomics investigation of exercise modulated changes in metabolism in rat liver after exhaustive and endurance exercises. Eur J Applied Phys 2010; 108: 557-66.
47. Bradley RL, Jeon JY, Liu FF, Maratos-Flier E. Voluntary exercise improves insulin sensitivity and adipose tissue inflammation in diet-induced obese mice. Am J Physiol Endocrinol Metab 2008; 295: E586-94.
48. Lira FS, Rosa JC, Pimenel GD, et al. Inflammation and adipose tissue :effects of progressive load training in rats. Lipids Health Dis 2010; 9: 109.
49. Kim HJ, Jamart C, Deldicque L, et al. Endoplasmic reticulum stress markers and ubiquitin-proteasome pathway activity in response to a 200 km run. Med Sci Sport Exerc 2011; 43: 18-25.
50. Wilund KR. Is the anti-inflammatory effect of regular exercise responsible for reduced cardiovascular disease? Clin Sci (Lond) 2007; 112: 543-55.
51. Fukao K, Shimada K, Naito H, et al. Voluntary exercise ameliorates the progression of atherosclerotic lesion formation via anti-inflammatory effects in apoprotein E-deficient mice. J Atheroscler Thromb 2010; 17: 1226-36.
52. Degerstrøm J, Østerud B. Increased inflammatory response of blood cells to repeated bout of exercise. Med Sci Sports Exerc 2006; 38: 1297-303.
53. Suzuki K, Nakaji S, Yamada M, et al. Impact of competitive marathon race on systemic cytokine and neutrophil responses. Med Sci Sports Exerc 2003; 35: 348-55.
54. Suzuki K, Totsuka M, Nakaji S, et al. Endurance exercise causes interaction among stress hormones, cytokines, neutrophil dynamics and muscle damage. J Appl Physiol 1999; 87: 1360-7.
55. Pizza FX, Davis BH, Henrickson SD, et al. Adaptation to eccentric exercise: effect on CD64 and CD11b/CD18 expression. J Appl Physiol 1996; 80: 47-55.
56. Plaisance EP, Grandjean PW. Physical activity and high sensitive C-reactive protein. Sports Med 2006; 36: 443-58.
57. Kasapis C, Thompson PD. The effects of physical activity on serum CRP and inflammatory markers: a systematic review. J Am Coll Cardiol 2005; 45: 1563-9.
58. Ford ES. Does exercise reduce inflammation? Physical activity and C-reactive protein among US adults. Epidemiology 2002; 13: 561-8.
59. Wannamethee SG, Lowe GD, Whincup PH, Rumley A, Walker M, Lennon L. Physical activity and hemostatic and inflammatory variables in elderly men. Circulation 2002; 105: 1785-90.
60. Borodulin K, Laatikainen T, Salomaa V, Jousilahti P. Associations of leisure time physical activity, self-rated physical fitness and estimated aerobic fitness with serum C-reactive protein among 3,803 adults. Atherosclerosis 2006; 185: 381-7.
61. Boekholdt SM, Sandhu MS, Day NE, et al. Physical activity, C-reactive protein levels and the risk of future coronary artery disease in apparently healthy men and women : the EPIC-Norfolk prospective population study. Eur J Cardiovasc Prev Rehab 2006; 13: 970-6.
62. Autenrieth C, Schneider A, Döring A, et al. Association between different domains of physical activity and markers of inflammation. Med Sci Sports Exerc 2009; 41: 1706-13.
63. Jankord R, Jemiolo B. Influence of physical activity on serum IL-10 and IL-6 levels in healthy older men. Med Sci Sports Exerc 2004; 36: 960-4.
64. Reuben DB, Judd-Hamilton L, Harris TB, Seeman TE; MacArthur Studies of Successful Aging. The associations between physical activity and inflammatory markers in high-functioning older persons: MacArthur Studies of Successful Aging. J Am Geriatr Soc 2003; 51: 1125-30.
65. Geffken DF, Cushman M, Burke GL, Polak JF, Sakkinen PA, Tracy RP. Association between physical activity and markers of inflammation in healthy elderly population. Am J Epidemiol 2001; 153: 242-50.
66. Majka DS, Chang RW, Vu TH, et al. Physical activity and high sensitivity C-reactive protein: the multi-ethnic study of atherosclerosis. Am J Prev Med 2009; 36: 56-62.
67. Harmse B, Kruger HS. Significant differences between serum CRP levels in children in different categories of physical activity. Cardiovasc J Afr 2010; 21: 316-22.
68. Villegas R, Xiang YB, Cai H, et al. Lifestyle determinants of C-reactive protein in middle aged urban Chinese men. Nurt Metab Cardiovasc Dis 2012; 22: 223-30.
69. Pitsavos C, Panagiotakos DB, Chrysohoou C, Kavouras S, Stefanadis C. The associations between physical activity, inflammation and coagulation markers, in people with metabolic syndrome. Eur J Cardiovasc Prev Rehab 2005; 12: 151-8.
70. Oberbach A, Tönjes A, Klöting N, et al. Effect of a 4-week physical training program on plasma concentrations of inflammatory markers in patients with abnormal glucose tolerance. Eur J Endocrinol 2006; 154: 577-85.
71. Lavoie ME, Rabasa-Lhoret R, Doucet E, et al. Association between physical activity, energy expenditure and inflammatory markers in sedentary overweight and obese women. Int J Obes 2010; 34: 1387-95.
72. Cicero AF, Derosa G, Bove M, Di Gregori V, Gaddi AV, Borghi C. Effect of sequential training programme on inflammatory, prothrombic and vascular remodelling biomarkers in hypertensive overweight patients with or without metabolic syndrome . Eur J Cardiovasc Prev Rehab 2009; 16: 698-704.
73. Balducci S, Zanuso S, Nicolucci A, et al. Anti-inflammatory effect of exercise training in subjects with type 2 diabetes and the metabolic syndrome is dependent on exercise modalities and independent of weight loss. Nurt Metab Cardiovasc Dis 2010; 20: 608-17.
74. Rothenbacher D, Hoffmeister A, Brenner H, Koenig W. Physical activity, coronary heart disease, and inflammatory response. Arch Intern Med 2003; 163: 1200-5.
75. Craft LL, Guralnik JM, Ferrucci L, et al. Physical activity during daily life and circulating biomarker levels in patients with peripheral arterial disease. Am J Cardiol 2008; 102: 1263-8.
76. Bruun JM, Helge JW, Richelsen B, Stallknecht B. Diet and exercise reduce low grade inflammation and macrophage infiltration in adipose tissue but not in skeletal muscle in severely obese subjects Am J Physiol Endocrinol Metab 2006; 290: E961-7.
77. Sabiston CM, Castonguay A, Low NC, et al. Vigorous physical activity and low grade systemic inflammation in adolescent boys and girls. Int J Pediatr Obes 2010; 5: 509-15.
78. Andersson J, Jansson JH, Hellsten G, Nilsson TK, Hallmans G, Boman K. Effects of heavy endurance physical exercise on inflammatory markers in non-athletes. Atherosclerosis 2010; 209; 601-5.
79. Uchida MC, Nosaka K, Ugrinowitsch C, et al. Effect of bench press exercise intensity on muscle soreness and inflammatory mediators. J Sports Sci 2009; 27: 499-507.
80. Goussetis E, Spiropoulos A, Tsironi M, et al. Spartathlon, a 246 km foot race: effects of acute inflammation induced by prolonged exercise on circulating progenitor reparative cells. Blood Cells Mol Dis 2009; 42: 294-9.
81. Kim HJ, Lee YH, Kim CK. Changes in serum cartilage oligomeric matrix protein (COMP), plasma CPK and plasma hs-CRP in relation to running distance in a marathon (42.195 km) and an ultra-marathon race. Eur J Applied Physiol 2009; 105: 765-70.
82. Suzuki K, Peake J, Nosaka K, et al. Changes in markers of muscle damage, nflammation and HSP 70 after an Ironman Triathlon race. Eur J Applied Physiol 2006; 98: 525-34.
83. Gomez-Merino D, Drogou C, Guezennec CY, et al. Comparison of systemic cytokine responses after a long distance triathlon and a 100 km-run: relationship to metabolic and inflammatory processes. Eur Cytokine Netw 2006; 17: 117-24.
84. Yates T, Davies MJ, Gorely T, et al. The effect of increased ambulatory activity on markers of chronic low-grade inflammation, evidence from PREPARE programme randomized controlled trial. Diabet Med 2010; 27: 1256-63.
85. Sjögren P, Cederholm T, Heimburger M, et al. Simple advice on lifestyle habits and longterm changes in biomarkers of inflammation and vascular adhesion in healthy middle-aged men. Eur J Clin Nutr 2010; 64: 1450-6.
86. Baevers KM, Hsu FC, Isom S, et al. Long term physical activity and inflammatory biomarkers in odler adults. Med Sci Sports Exerc 2010; 42: 2189-96.
87. Martinez-Gomez D, Eisenmann JC, Wärnberg J, et al. Associations of physical activity, cardiorespiratory fitness, and fatness with low-grade inflammation in adolescents: the AFINOS study. Int J Obes (Lond) 2010; 34: 1501-7.
88. Ruiz JR, Ortega FB, Warnberg J, Sjöström M. Associations of low grade inflammation with physical activity, fitness, and fatness in prepubertal children, European Young Heart Study. Int J Obes 2007; 31: 1545-51.
89. Church TS, Earnest CP, Thompson AM, et al. Exercise without weight loss does not reduce C-reactive protein: the INFLAME study. Med Sci Sports 2010; 42: 708-16.
90. Lin CY, Chen PC, Kuo HK, Lin LY, Lin JW, Hwang JJ. Effects of obesity, physical activity, and cardiorespiratory fitness on blood pressure, inflammation, and insulin resistance in National Health and Nutrition Survey 1999-2002. Nurt Metab Cardiovasc Dis 2010; 20: 713-9.
91. Verdaet D, Dendale P, De Bacquer D, Delanghe J, Block P, De Backer G. Association between leisure time physical activity and markers of chronic inflammation related to coronary heart disease. Atherosclerosis 2004; 176: 303-10.
92. Colbert LH, Visser M, Simonsick EM, et al. Physical activity, exercise and inflammatory markers in older adults, findings from the Health, Ageing and Body Composition Study. J Am Geriatr Soc 2004; 52: 1098-104.
93. Rawson ES, Freedson PS, Osganian SK, Matthews CE, Reed G, Ockene IS. Body mass index, but not physical activity, is associated with C-reactive protein. Med Sci Sports Exerc 2003; 35: 1160-6.
94. Rauramaa R, Halonen P, Väisänen SB, et al. Effects of aerobic physical exercise on inflammationand atherosclerosis in men, the DNASCO study: a six year randomized, controlled trial. Ann Int Med 2004; 140: 1007-14.
95. Pischon T, Hankinson SE, Hotamisligil GS, Rifai N, Rimm EB. Leisure time physical activity and reduced plasma levels of obesity-related inflammatory markers. Obes Res 2003; 11: 1055-64.
96. Beavers KM, Brinkley TE, Nicklas BJ. Effect of exercise training on chronic inflammation. Clin Chim Acta 2010; 411: 785-93.
97. King DE, Carek P, Mainous AG 3rd, Pearson WS. Inflammatory markers and exercise: differences related to exercise type. Med Sci Sports Exerc 2003; 35: 575-81.
98. Ploeger HE, Takken T, de Greef MH, Timmons BW. The effects of acute and chronic exercise on inflammatory markers in children and adults with a chronic systemic diseases: a systematic review. Exerc Immunol Rev 2009; 15: 6-41.
99. Nader GA, Lundberg E. Exercise as an anti-inflammatory intervention to combat inflammatory diseases of muscle. Curr Opin Rheumatol 2009; 21: 599-603.
100. Shephard RJ, Shek PN. Autoimmune disorders, physical activity, and training with particular reference to rheumatoid arthritis. Exerc Immunol Rev 1997; 3: 53-67.
101. Metsios GS, Stavropoulos-Kalinoglou A, Sandoo A, et al. Vascular function and inflammation in rheumatoid arthritis: the role of physical activity. Open Cardiovasc Med J 2010; 4: 89-96.
102. Onur E, Kabaroglu C, Gunay O, et al. The beneficial effect of physical exercise on anti-oxidant status in asthmatic children. Allergol Immunopathol (Madr) 2011; 39: 90-5.
103. Mendes FA, Almeida FM, Cukier A, et al. Effects of aerobic training on airway inflammation in asthmatic patients. Med Sci Sports 2011; 43: 197-203.
104. Mercken EM, Gosker HR, Rutten EP, et al. Systemic and pulmonary oxidative stress after single leg exercise in COPD. Chest 2009; 136: 1291-300.
105. Watz H, Waschki B, Kirsten A, et al. The metabolic syndrome in patients with chronic bronchitis and COPD: frequency and associated consequences for systemic inflammation and physical inactivity. Chest 2009; 136: 1039-46.
106. Juvonen R, Bloigu A, Peitso A, et al. Training improves physical fitness and decreases CRP also in asthmatic conscripts. J Asthma 2008; 45: 237-42.
107. Waschki B, Kirsten A, Holz O, et al. hysical activity ist he strongest predictor of all cause mortality in patients with COPD; a prospective cohort study. Chest 2011; 140; 331-42.
108. Mussi RK, Camargo EA, Ferreira T, et al. Exercise training reduces pulmonary ischemia - reperfusion induced inflammatory responses. Eur Resp J 2008; 31: 645-9.
109. Giovannucci E. Metabolic syndrome, hyperinsulinemia, and colon cancer: a review. Am J Clin Nutr 2007; 86: S836-42.
110. Xue F, Michels KB. Diabetes, metabolic syndrome, and breast cancer: a review of the current evidence. Am J Clin Nutr 2007; S823-35.
111. Neilson HK, Friedenreich CM, Brockton NT, Millikan RC. Physical activity and postmenopausal breast cancer: proposed biologic mechanisms and areas for future research. Cancer Epidemiol Biomarkers Prev 2009; 18: 11-27.
112. Winzer BM, Whiteman DC, Reeves MM, Paratz JD. Physical activity and cancer prevention: a systematic review of the clinical trials. Cancer Causes Control 2011; 22: 811-26.
113. Walsh NP, Gleeson M, Shephard RJ, et al. Position statement. Part 1: Immune function and exercise. Exerc Immunol Rev 2011; 17: 6-63.
114. Friedenreich CM. Physical activity and breast cancer: review of the epidemiologic evidence and biologic mechanisms. Recent Results Cancer Res 2011; 188: 125-39.
115. Emaus A, Thune I. Physical acxtivity and lung cancer prevention. Recent Results Cancer Res 2011; 186: 101-33.
116. Hauret KG, Bostick RM, Matthews CE, et al. Physical activity and reduced risk of incident sporadic colorectal adenomas: observational support for mechanisms involving energy balance and inflammation modulation. Am J Epidemiol 2004; 159: 983-92.
117. Hung AM, Chertow GM, Young BS, Carey S, Johansen KL. Inflammatory markers are unrelated to physical activity, performance and functioning in hemodialysis. Adv Ren Replace 2003; 10: 232-40.
118. Afshar R, Shegarfy L, Shavandi N, Sanavi S. Effects of aerobic exercise and resistance training on lipid profiles and inflammation status in patients on maintainance hemodialysis. Indian J Nephrol 2010; 20: 185-9.
119. Anand S, Chertow GM, Johansen KL, et al. Association of self-reported physical activity with laboratory markers of nutrition and inflammation: the comprehensive dialysis study. J Ren Nutr 2011; Epub ahead of print.
120. Adamopoulos S, Parissis J, Kroupis C, et al. Physical training reduces peripheral markers of inflammation in patients with chronic heart failure. Eur Heart J 2001; 22: 791-7.
121. Tsarouhas K, Karatzaferi C, Tsitsimpikou C, et al. Effects of walking in heart rate recovery, endothelium modulators and quality of life in patients with heart failure. Eur J Cardiovasc Prev Rehab 2011; Epub ahead of print.
122. Tisi PV, Hulse M, Chulakadabba A, Gosling P, Shearman CP. Exercise training for intermittent claudication: does it adversely affect biochemical markers of the exercise-induced inflammatory response? Eur J Vasc Endovasc Surg 1997; 14: 344-50.
123. Smith JK, Dykes R, Douglas JE, Krishnaswamy G, Berk S. Long-term exercise and atherogenic activity of blood mononuclear cells in persons at risk of developing ischemic heart disease. JAMA 1999; 281: 1722-7.
124. Mattusch F, Dufaux B, Heine O, Mertens I, Rost R. Reduction of the plasma concentration of C-reactive protein following nine months of endurance training. Int J Sports Med 2000; 21: 21-4.
125. Lindström J, Louheranta A, Mannelin M, et al.; The Finnish Diabetes Prevention Study (DPS). Lifestyle intervention and 3-year results on diet and physical activity. Diab Care 2003; 26: 3230-6.
126. Balen S, Vukelić-Damijani N, Persić V, et al. Anti-inflammatory effects of exercise training in the early period after myocardial infarction. Coll Antropol 2008; 32: 285-91.
127. Gray SR, Baker G, Wright A, et al. The effect of a 12 week walking intervention on markers of insulin resistance and systemic inflammation. Prev Med 2009; 48: 39-44.
128. Balducci S, Zanuso S, Nicolucci A, et al. Effect of an intensive exercise intervention strategy on modifiable cardiovascular risk factors in subjects with type 2 diabetes mellitus: a randomized, controlled trial: the Italian Diabetes and Exercise Study (IDES). Arch Intern Med 2010; 170: 1794-803.
129. Astengo M, Dahl A, Karlsson T, Mattsson- Hulten L, Wiklund O, Wennerblom B. Physical training after percutaneous coronary intervention in patients with stable angina: effects on working capacity, metabolism and markers of inflammation. Eur J Cardiovasc Prev Rehabil 2010; 17: 349-54.
130. Beavers KM, Hsu FC, Isom S, et al. Longterm physical activity and inflammatory biomarkers in older adults. Med Sci Sports Exerc 2010; 42: 2189-96.