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Volumn 226, Issue 1-2, 2010, Pages 181-184

Aging sensitizes rapidly isolated hippocampal microglia to LPS ex vivo

Author keywords

Aging; Microglia; Neuroinflammation; Priming; Pro inflammatory cytokines; Sensitization

Indexed keywords

CD11B ANTIGEN; CELL MARKER; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PROTEIN IBA 1; UNCLASSIFIED DRUG; ACTIN BINDING PROTEIN; AIF1 PROTEIN, RAT; CALCIUM BINDING PROTEIN; CYTOKINE; HLA ANTIGEN CLASS 2;

EID: 77956338790     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2010.05.022     Document Type: Article
Times cited : (88)

References (17)
  • 2
    • 61649120189 scopus 로고    scopus 로고
    • Central inhibition of interleukin-1beta ameliorates sickness behavior in aged mice
    • Abraham J., Johnson R.W. Central inhibition of interleukin-1beta ameliorates sickness behavior in aged mice. Brain Behav. Immun. 2009, 23:396-401.
    • (2009) Brain Behav. Immun. , vol.23 , pp. 396-401
    • Abraham, J.1    Johnson, R.W.2
  • 4
    • 56949099327 scopus 로고    scopus 로고
    • Time course of hippocampal IL-1 beta and memory consolidation impairments in aging rats following peripheral infection
    • Barrientos R.M., Frank M.G., Hein A.M., Higgins E.A., Watkins L.R., Rudy J.W., Maier S.F. Time course of hippocampal IL-1 beta and memory consolidation impairments in aging rats following peripheral infection. Brain Behav. Immun. 2009, 23:46-54.
    • (2009) Brain Behav. Immun. , vol.23 , pp. 46-54
    • Barrientos, R.M.1    Frank, M.G.2    Hein, A.M.3    Higgins, E.A.4    Watkins, L.R.5    Rudy, J.W.6    Maier, S.F.7
  • 6
    • 38649119160 scopus 로고    scopus 로고
    • Neuroinflammation and disruption in working memory in aged mice after acute stimulation of the peripheral innate immune system
    • Chen J., Buchanan J.B., Sparkman N.L., Godbout J.P., Freund G.G., Johnson R.W. Neuroinflammation and disruption in working memory in aged mice after acute stimulation of the peripheral innate immune system. Brain Behav. Immun. 2008, 22:301-311.
    • (2008) Brain Behav. Immun. , vol.22 , pp. 301-311
    • Chen, J.1    Buchanan, J.B.2    Sparkman, N.L.3    Godbout, J.P.4    Freund, G.G.5    Johnson, R.W.6
  • 7
    • 54249124166 scopus 로고    scopus 로고
    • Aging, microglial cell priming, and the discordant central inflammatory response to signals from the peripheral immune system
    • Dilger R.N., Johnson R.W. Aging, microglial cell priming, and the discordant central inflammatory response to signals from the peripheral immune system. J. Leukoc. Biol. 2008, 84:932-939.
    • (2008) J. Leukoc. Biol. , vol.84 , pp. 932-939
    • Dilger, R.N.1    Johnson, R.W.2
  • 9
    • 33644511746 scopus 로고    scopus 로고
    • Rapid isolation of highly enriched and quiescent microglia from adult rat hippocampus: immunophenotypic and functional characteristics
    • Frank M.G., Wieseler-Frank J.L., Watkins L.R., Maier S.F. Rapid isolation of highly enriched and quiescent microglia from adult rat hippocampus: immunophenotypic and functional characteristics. J. Neurosci. Meth. 2006, 151:121-130.
    • (2006) J. Neurosci. Meth. , vol.151 , pp. 121-130
    • Frank, M.G.1    Wieseler-Frank, J.L.2    Watkins, L.R.3    Maier, S.F.4
  • 10
    • 23444443814 scopus 로고    scopus 로고
    • Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system
    • Godbout J.P., Chen J., Abraham J., Richwine A.F., Berg B.M., Kelley K.W., Johnson R.W. Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system. FASEB J. 2005, 19:1329-1331.
    • (2005) FASEB J. , vol.19 , pp. 1329-1331
    • Godbout, J.P.1    Chen, J.2    Abraham, J.3    Richwine, A.F.4    Berg, B.M.5    Kelley, K.W.6    Johnson, R.W.7
  • 12
    • 61349193143 scopus 로고    scopus 로고
    • Peripheral lipopolysaccharide (LPS) challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both pro-inflammatory IL-1beta and anti-inflammatory IL-10 cytokines
    • Henry C.J., Huang Y., Wynne A.M., Godbout J.P. Peripheral lipopolysaccharide (LPS) challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both pro-inflammatory IL-1beta and anti-inflammatory IL-10 cytokines. Brain Behav. Immun. 2009, 23:309-317.
    • (2009) Brain Behav. Immun. , vol.23 , pp. 309-317
    • Henry, C.J.1    Huang, Y.2    Wynne, A.M.3    Godbout, J.P.4
  • 13
    • 51449117700 scopus 로고    scopus 로고
    • Exaggerated sickness behavior and brain proinflammatory cytokine expression in aged mice in response to intracerebroventricular lipopolysaccharide
    • Huang Y., Henry C.J., Dantzer R., Johnson R.W., Godbout J.P. Exaggerated sickness behavior and brain proinflammatory cytokine expression in aged mice in response to intracerebroventricular lipopolysaccharide. Neurobiol. Aging 2008, 29:1744-1753.
    • (2008) Neurobiol. Aging , vol.29 , pp. 1744-1753
    • Huang, Y.1    Henry, C.J.2    Dantzer, R.3    Johnson, R.W.4    Godbout, J.P.5
  • 14
    • 0030222037 scopus 로고    scopus 로고
    • Microglia: a sensor for pathological events in the CNS
    • Kreutzberg G.W. Microglia: a sensor for pathological events in the CNS. Trends Neurosci. 1996, 19:312-318.
    • (1996) Trends Neurosci. , vol.19 , pp. 312-318
    • Kreutzberg, G.W.1
  • 15
    • 56749174940 scopus 로고    scopus 로고
    • Exploring the full spectrum of macrophage activation
    • Mosser D.M., Edwards J.P. Exploring the full spectrum of macrophage activation. Nat. Rev. Immunol. 2008, 8:958-969.
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 958-969
    • Mosser, D.M.1    Edwards, J.P.2
  • 16
    • 33846980461 scopus 로고    scopus 로고
    • Microglia derived from aging mice exhibit an altered inflammatory profile
    • Sierra A., Gottfried-Blackmore A.C., McEwen B.S., Bulloch K. Microglia derived from aging mice exhibit an altered inflammatory profile. Glia 2007, 55:412-424.
    • (2007) Glia , vol.55 , pp. 412-424
    • Sierra, A.1    Gottfried-Blackmore, A.C.2    McEwen, B.S.3    Bulloch, K.4
  • 17
    • 0038434118 scopus 로고    scopus 로고
    • Aging and glial responses to lipopolysaccharide in vitro: greater induction of IL-1 and IL-6, but smaller induction of neurotoxicity
    • Xie Z., Morgan T.E., Rozovsky I., Finch C.E. Aging and glial responses to lipopolysaccharide in vitro: greater induction of IL-1 and IL-6, but smaller induction of neurotoxicity. Exp. Neurol. 2003, 182:135-141.
    • (2003) Exp. Neurol. , vol.182 , pp. 135-141
    • Xie, Z.1    Morgan, T.E.2    Rozovsky, I.3    Finch, C.E.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.