Preproinsulin I and II mRNAs and insulin electron microscopic immunoreaction are present within the rat fetal nervous system

Brain Research

Volumn 736, Issue 1-2, 1996, Pages 16-27

  Schechter, Ruben ^a,b   Beju, Delia ^a   Gaffney, Tim ^a   Schaefer, Fred ^c   Whetsell, Lynne ^c  

^a UNIVERSITY OF OKLAHOMA   (United States)

^b Saint Francis Hospital Tulsa   (United States)

^c HA Chapman Institute of Medical Genetics   (United States)

Author keywords

brain; dorsal root ganglia; electron microscopy; in solution hybridization; insulin; mRNA; polymerase chain reaction; spinal cord

Indexed keywords

INSULIN; MESSENGER RNA; PROINSULIN;

ANIMAL TISSUE; ARTICLE; BRAIN DEVELOPMENT; CONTROLLED STUDY; ELECTRON MICROSCOPY; FETUS; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RAT; SPINAL CORD; SPINAL GANGLION;

EID: 0030583645     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-8993(96)00664-6     Document Type: Article

References (27)

1. [1] Baskin, D.G., Woods, S.C., West, D.B., van Houten, M., Posner, B.I., Dorsa, D.M. and Porter Jr., D., Immunocytochemical detection of insulin in rat hypothalamus and its possible uptake from cerebrospinal fluid, Endocrinology, 113 (1988) 1818-1825.
2. [2] Bernstein, H.-G., Dorn, A., Reiser, M. and Ziegler, M., Cerebral insulin-like immunoreactivity in rats and mice. Drastic decline during postnatal ontogensis, Acta Histochem., 74 (1984) 33-36.
3. [3] Brewer, G., RNase ONE: Advantages for nuclease protection assays, Promega Note, 38 (1992) 1-7.
4. [4] Budd, G.C., Pansky, B. and Glatzer, L., Preproinsulin MRNA in the rat eye, Invest. Ophthalmol. Vis. Sci., 34 (1993) 463-469.
5. [5] Deltour, L., Leduque, P., Blume, N., Madsen, O., Dubois, P., Jami, L. and Bucchini, D., Differential expression of the two nonallelic proinsulin genes in the developing mouse embryo, Proc. Natl. Acad. Sci. USA, 90 (1993) 527-531.
6. [6] Devaskar, S.U., Giddings, S.J., Rajakumar, P.A., Carnaghi, L.R., Menon, R.K. and Zahm, D.S., Insulin gene expression and insulin synthesis in mammalian neuronal cells, J. Biol. Chem., 269 (1994) 8445-8454.
7. [7] Devaskar, S.U., Singh, B.S., Carnaghi, L.R., Rajakumar, P.A. and Giddings, S.J., Insulin II gene expression in rat central nervous system, Regul. Peptides, 48 (1993) 55-63.
8. [8] Goldstein, B.J. and Dudley, A.L., The rat insulin receptor: Primary structure and conservation of tissue-specific alternative messenger RNA splicing, Mol. Endocrinol., 4 (1989) 235-244.
9. [9] Gorczyca, M., Augart, C. and Budnik, V., Insulin-like receptor and insulin-like peptide are localized at neuromuscular junctions in Drosophila, J. Neurosci., 13 (1993) 3692-3704.
10. [10] Havrankova, J., Schmechel, D., Roth, J. and Brownstein, M.J., Identification of insulin in rat brain, Proc. Natl. Acad. Sci. USA, 75 (1978) 5737-5741.
11. [11] Lomedico, P., Rosenthal, N., Efstratiadis, A., Gilber, W., Kolodner, R. and Tizard, R., The structure and evolution of the two nonallelic rat preproinsulin genes, Cell, 18 (1979) 545-588.
12. [12] Meador III, J., Cannon, B., Cannistrato, V.J. and Kennell, D., Purification and characterization of Escherichia coli RNase I. Comparation with RNase, Eur. J. Biochem., 187 (1990) 549-553.
13. [13] Narita, N., Nishio, H., Kitoh, Y., Ishikawa, Y., Ishikawa, Y., Minami, R., Nakamura, H. and Matsuo, M., Insertion of a 5′-truncated L1 element into the 3′ end of exon 44 of the dystrophin gene resulted in skipping of the exon during splicing in a case of Duchenne muscular dystrophy, J. Clin. Invest., 91 (1993) 1862-1867.
14. [14] Raizada, M.K., Localization of insulin-like immunoreactivity in the neurons from primary cultures of rat brain, Exp. Cell Res., 143 (1983) 351-357.
15. [15] Schechter, R., Holtzclaw, L., Sadiq, F., Kahn, A. and Devaskar, S., Insulin synthesis by isolated rabbit neurons, Endocrinology, 123 (1988) 505-513.
16. [16] Schechter, R., Sadiq, H.F. and Devaskar, S.U., Insulin and insulin mRNA are detected in neuronal cell cultures maintained in an insulin free/serum free medium, J. Histochem. Cytochem., 38 (1990) 829-836.
17. [17] Schechter, R., Whitmire, J., Holtzclaw, L., George, M., Harlow, R. and Devaskar, S.U., Developmental regulation of insulin in the mammalian central nervous system, Brain Res., 582 (1992) 27-37.1
18. [18] Schechter, R., Whitmire, J., Wheet, G.S., Beju, D., Jackson, K.W. and Gavin III, J.R., Immunohistochemical and in situ hybridization study of an insulin-like substance in fetal neuron cell cultures, Brain Res., 636 (1994) 9-27.
19. [19] Shuldiner, A.R., de Pablo, F., Moore, C.A. and Roth, J., Two nonallelic insulin gene in Xenopus Laevis are expressed differentially during neurulation in prepancreatic embryos, Proc. Natl. Acad. Sci. USA, 88 (1991) 7679-7683.
20. [20] Shuldiner, A.R., Tanner, K., Moore, C.A. and Roth, J., RNA template-specific PCR: An improved method that dramatically reduces false positives in RT-PCR, BioTechniques, 11 (1991) 760-763.
21. [21] Srivastava, R.A.K. and Schonfeld, G., Use of riboprobes for northern blotting analysis, BioTechniques, 11 (1991) 584-586.
22. [22] Sundell, C.L. and Singer, R.H., Actin mRNA localized in the absences of protein synthesis, J. Cell Biol., 111 (1990) 2397-2403.
23. [23] Tay, S.S.W. and Wong, W.C., Ultrastructural localization of insulin-like immunoreaction in the rat spinal cord, J. Hirnforsch, 33 (1992) 11-18.
24. [24] Uvnas-Moberg, K., Posloncec, B., Hagerman, M., Castensson, S., Rubio, C. and Uvnas, B., Occurrence of an insulin-like peptide in extracts of peripheral nerves of the cat and in extracts of human vagal nerves, Acta Physiol. Scand., 115 (1982) 471-477.
25. [25] Wallum, B.J., Taborsky, Jr., G.J., Porter, Jr., D., Figlewicz, D.P., Jacobson, L., Beard, J.C., Ward, W.K. and Dorsa, D., Cerobrospinal fluid insulin levels increase during intravenous insulin infusion in man, J. Clin. Endocrinol. Metab., 64 (1987) 190-194.
26. [26] Young, W.S., Periventricular hypothalamic cells in the rat brain contain insulin mRNA, Neuropeptides, 8 (1986) 93-97.
27. [27] Zhang, X.-Y. and Ehrlich, M., Detection and quantitation of low numbers of chromosomes containing bcl-2 oncogene translocations using semi-nested PCR, BioTechniques, 16 (1994) 502-507.