MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells

Science

Volumn 351, Issue 6278, 2016, Pages 1214-1218

  Kryukov, Gregory V ^a,b   Wilson, Frederick H ^a,b   Ruth, Jason R ^a,b   Paulk, Joshiawa ^a,b   Tsherniak, Aviad ^b   Marlow, Sara E ^a,b   Vazquez, Francisca ^a,b   Weir, Barbara A ^a,b   Fitzgerald, Mark E ^b   Tanaka, Minoru ^a,b   Bielski, Craig M ^a,b   Scott, Justin M ^b   Dennis, Courtney ^b   Cowley, Glenn S ^b   Boehm, Jesse S ^b   Root, David E ^b   Golub, Todd R ^b   Clish, Clary B ^b   Bradner, James E ^a,b   Hahn, William C ^a,b   Garraway, Levi A ^a,b   more..

^a HARVARD MEDICAL SCHOOL   (United States)

^b BROAD INSTITUTE OF MIT AND HARVARD   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5' METHYLTHIOADENOSINE PHOSPHORYLASE; PROTEIN ARGININE METHYLTRANSFERASE; PROTEIN ARGININE METHYLTRANSFERASE 5; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG; 5'-METHYLTHIOADENOSINE; 5'-METHYLTHIOADENOSINE PHOSPHORYLASE; DEOXYADENOSINE DERIVATIVE; ENZYME INHIBITOR; GSK3235025; ISOQUINOLINE DERIVATIVE; NUCLEOSIDE; P44 PROTEIN, HUMAN; PRMT5 PROTEIN, HUMAN; PURINE NUCLEOSIDE PHOSPHORYLASE; PYRIMIDINE DERIVATIVE; TRANSCRIPTION FACTOR;

CANCER; CELLS AND CELL COMPONENTS; CONCENTRATION (COMPOSITION); DRUG; ENZYME ACTIVITY; GENE EXPRESSION; GENETIC ANALYSIS; GENOMICS; METABOLITE; PROTEIN; TUMOR; VULNERABILITY;

ARTICLE; CANCER CELL; CANCER CELL LINE; CELL VIABILITY; ENZYME ACTIVITY; GENE DELETION; MULTIPLE CANCER; PRIORITY JOURNAL; ANTAGONISTS AND INHIBITORS; ENZYMOLOGY; GENETICS; HUMAN; METABOLISM; NEOPLASMS; TUMOR CELL LINE;

CELL LINE, TUMOR; DEOXYADENOSINES; ENZYME INHIBITORS; GENE DELETION; HUMANS; ISOQUINOLINES; NEOPLASMS; PROTEIN-ARGININE N-METHYLTRANSFERASES; PURINE-NUCLEOSIDE PHOSPHORYLASE; PYRIMIDINES; THIONUCLEOSIDES; TRANSCRIPTION FACTORS;

EID: 84960916279     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aad5214     Document Type: Article

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