A gnotobiotic mouse model demonstrates that dietary fiber protects against colorectal tumorigenesis in a microbiota- and butyrate-dependent manner

Cancer Discovery

Volumn 4, Issue 12, 2014, Pages 1387-1397

  Donohoe, Dallas R ^a   Holley, Darcy ^a   Collins, Leonard B ^b   Montgomery, Stephanie A ^c   Whitmore, Alan C ^a,d   Hillhouse, Andrew ^e   Curry, Kaitlin P ^a   Renner, Sarah W ^a   Greenwalt, Alicia ^a   Ryan, Elizabeth P ^f   Godfrey, Virginia ^a   Heise, Mark T ^a,d   Threadgill, Deborah S ^g   Han, Anna ^h   Swenberg, James A ^b   Threadgill, David W ^e,g   Bultman, Scott J ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b University of North Carolina at Chapel Hill   (United States)

^c NORTH CAROLINA STATE UNIVERSITY   (United States)

^d UNIVERSITY OF NORTH CAROLINA   (United States)

^e TEXAS A AND M UNIVERSITY   (United States)

^f Department of Environmental and Radiological Health Sciences   (United States)

^g TEXAS A AND M UNIVERSITY   (United States)

^h UNIVERSITY OF TENNESSEE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BUTYRIC ACID; KI 67 ANTIGEN; MESSENGER RNA; BUTYRIC ACID DERIVATIVE; CARCINOGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BACTERIAL COLONIZATION; CANCER INHIBITION; CARCINOGENESIS; CELL PROLIFERATION; CHROMATIN IMMUNOPRECIPITATION; COLORECTAL CANCER; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIETARY FIBER; FATTY ACID METABOLISM; FLOW CYTOMETRY; GNOTOBIOTICS; HISTONE ACETYLATION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MICROFLORA; MOUSE; NONHUMAN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; WNT SIGNALING PATHWAY; ANIMAL; CANCER GRADING; CELL TRANSFORMATION; COLORECTAL NEOPLASMS; DISEASE MODEL; GERMFREE ANIMAL; INTESTINE MUCOSA; METABOLISM; PATHOLOGY;

ANIMALS; BUTYRATES; CARCINOGENS; CELL TRANSFORMATION, NEOPLASTIC; COLORECTAL NEOPLASMS; DIETARY FIBER; DISEASE MODELS, ANIMAL; GERM-FREE LIFE; HUMANS; INTESTINAL MUCOSA; MICE; MICROBIOTA; NEOPLASM GRADING;

EID: 84911993839     PISSN: 21598274     EISSN: 21598290     Source Type: Journal    
DOI: 10.1158/2159-8290.CD-14-0501     Document Type: Article

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