Hydrogen sulfide, the next potent preventive and therapeutic agent in aging and age-associated disease

Molecular and Cellular Biology

Volumn 33, Issue 6, 2013, Pages 1104-1113

  Zhang, Yuan ^a   Tang, Zhi Han ^a   Ren, Zhong ^a   Qu, Shun Lin ^a   Liu, Mi Hua ^a   Liu, Lu Shan ^a   Jiang, Zhi Sheng ^a  

^a UNIVERSITY OF SOUTH CHINA   (China)

Author keywords

[No Author keywords available]

Indexed keywords

HOMOCYSTEINE; HYDROGEN SULFIDE; KLOTHO PROTEIN; SIRTUIN 1; SULFORAPHANE;

AGING; ALZHEIMER DISEASE; ANTINEOPLASTIC ACTIVITY; ARTICLE; ATHEROSCLEROSIS; BREAST CANCER; CALORIC RESTRICTION; CANCER INHIBITION; CARDIOVASCULAR DISEASE; CELL VIABILITY; COLON CANCER; DEMENTIA; GLUCOSE METABOLISM; HUMAN; HYPERTENSION; KIDNEY CORTEX; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OXIDATIVE STRESS; PARKINSON DISEASE; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION;

AGE FACTORS; AGING; ANIMALS; CARDIOVASCULAR SYSTEM; HUMANS; HYDROGEN SULFIDE; NERVOUS SYSTEM; OXIDATIVE STRESS; SIGNAL TRANSDUCTION;

EID: 84874687850     PISSN: 02707306     EISSN: 10985549     Source Type: Journal    
DOI: 10.1128/MCB.01215-12     Document Type: Article

References (113)

1. Harman D. 1956. Aging: a theory based on free radical and radiation chemistry. J. Gerontol. 11:298-300. Harman D.
2. Fusco D, Colloca G, Lo Monaco MR, Cesari M. 2007. Effects of antioxidant supplementation on the aging process. Clin. Interv. Aging 2:377-387.
3. Chen YH, Yao WZ, Geng B, Ding YL, Lu M, Zhao MW, Tang CS. 2005. Endogenous hydrogen sulfide in patients with COPD. Chest 128: 3205-3211.
4. Perna AF, Lanza D, Sepe I, Raiola I, Capasso R, De Santo NG, Ingrosso D. 2011. Hydrogen sulfide, a toxic gas with cardiovascular properties in uremia: how harmful is it? Blood Purif. 31:102-106.
5. Wang R. 2002. Two's company, three's a crowd: can H2S be the third endogenous gaseous transmitter? FASEB J. 16:1792-1798.
6. Abe K, Kimura H. 1996. The possible role of hydrogen sulfide as an endogenous neuromodulator. J. Neurosci. 16:1066-1071.
7. Hosoki R, Matsuki N, Kimura H. 1997. The possible role of hydrogen sulfide as an endogenous smooth muscle relaxant in synergy with nitric oxide. Biochem. Biophys. Res. Commun. 237:527-531.
8. Diwakar L, Ravindranath V. 2007. Inhibition of cystathionine-gammalyase leads to loss of glutathione and aggravation of mitochondrial dysfunction mediated by excitatory amino acid in the CNS. Neurochem. Int. 50:418-426.
9. Enokido Y, Suzuki E, Iwasawa K, Namekata K, Okazawa H, Kimura H. 2005. Cystathionine beta-synthase, a key enzyme for homocysteine metabolism, is preferentially expressed in the radial glia/astrocyte lineage of developing mouse CNS. FASEB J. 19:1854-1856.
10. Ichinohe A, Kanaumi T, Takashima S, Enokido Y, Nagai Y, Kimura H. 2005. Cystathionine beta-synthase is enriched in the brains of Down's patients. Biochem. Biophys. Res. Commun. 338:1547-1550.
11. Kaneko Y, Kimura Y, Kimura H, Niki I. 2006. L-Cysteine inhibits insulin release from the pancreatic beta-cell: possible involvement of metabolic production of hydrogen sulfide, a novel gasotransmitter. Diabetes 55:1391-1397.
12. Patel P, Vatish M, Heptinstall J, Wang R, Carson RJ. 2009. The endogenous production of hydrogen sulphide in intrauterine tissues. Reprod. Biol. Endocrinol. 7:10. doi:10.1186/1477-7827-7-10.
13. Vitvitsky V, Thomas M, Ghorpade A, Gendelman HE, Banerjee R. 2006. A functional transsulfuration pathway in the brain links to glutathione homeostasis. J. Biol. Chem. 281:35785-35793.
14. Kimura H. 2000. Hydrogen sulfide induces cyclic AMP and modulates the NMDA receptor. Biochem. Biophys. Res. Commun. 267:129-133.
15. Robert K, Vialard F, Thiery E, Toyama K, Sinet PM, Janel N, London J. 2003. Expression of the cystathionine beta synthase (CBS) gene during mouse development and immunolocalization in adult brain. J. Histochem. Cytochem. 51:363-371.
16. Geng B, Yang J, Qi Y, Zhao J, Pang Y, Du J, Tang C. 2004. H2S generated by heart in rat and its effects on cardiac function. Biochem. Biophys. Res. Commun. 313:362-368.
17. Zhao W, Zhang J, Lu Y, Wang R. 2001. The vasorelaxant effect of H(2)S as a novel endogenous gaseous K(ATP) channel opener. EMBO J. 20: 6008-6016.
18. Shibuya N, Mikami Y, Kimura Y, Nagahara N, Kimura H. 2009. Vascular endothelium expresses 3-mercaptopyruvate sulfurtransferase and produces hydrogen sulfide. J. Biochem. 146:623-626.
19. Mustafa AK, Sikka G, Gazi SK, Steppan J, Jung SM, Bhunia AK, Barodka VM, Gazi FK, Barrow RK, Wang R, Amzel LM, Berkowitz DE, Snyder SH. 2011. Hydrogen sulfide as endothelium-derived hyperpolarizing factor sulfhydrates potassium channels. Circ. Res. 109:1259-1268.
20. Yang G, Wu L, Jiang B, Yang W, Qi J, Cao K, Meng Q, Mustafa AK, Mu W, Zhang S, Snyder SH, Wang R. 2008. H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase. Science 322:587-590.
21. Liu C, Gu X, Zhu YZ. 2010. Synthesis and biological evaluation of novel leonurine-SPRC conjugate as cardioprotective agents. Bioorg. Med. Chem. Lett. 20:6942-6946.
22. Taniguchi S, Kang L, Kimura T, Niki I. 2011. Hydrogen sulphide protects mouse pancreatic beta-cells from cell death induced by oxidative stress, but not by endoplasmic reticulum stress. Br. J. Pharmacol. 162:1171-1178.
23. Zhang H, Zhang A, Guo C, Shi C, Zhang Y, Liu Q, Sparatore A, Wang C. 2011. S-diclofenac protects against doxorubicin-induced cardiomyopathy in mice via ameliorating cardiac gap junction remodeling. PLoS One 6:e26441. doi:10.1371/journal.pone.0026441.
24. Hu LF, Wong PT, Moore PK, Bian JS. 2007. Hydrogen sulfide attenuates lipopolysaccharide-induced inflammation by inhibition of p38 mitogen- activated protein kinase in microglia. J. Neurochem. 100:1121-1128.
25. Jin HF, Liang C, Liang JM, Tang CS, Du JB. 2008. Effects of hydrogen sulfide on vascular inflammation in pulmonary hypertension induced by high pulmonary blood flow: experiment with rats. Zhonghua Yi Xue Za Zhi 88:2235-2239. (In Chinese.)
26. Kim KM, Pae HO, Zhung M, Ha HY, Ha YA, Chai KY, Cheong YK, Kim JM, Chung HT. 2008. Involvement of anti-inflammatory heme oxygenase-1 in the inhibitory effect of curcumin on the expression of pro-inflammatory inducible nitric oxide synthase in RAW264.7 macrophages. Biomed. Pharmacother. 62:630-636.
27. Oh GS, Pae HO, Lee BS, Kim BN, Kim JM, Kim HR, Jeon SB, Jeon WK, Chae HJ, Chung HT. 2006. Hydrogen sulfide inhibits nitric oxide production and nuclear factor-kappaB via heme oxygenase-1 expression in RAW264.7 macrophages stimulated with lipopolysaccharide. Free Radic. Biol. Med. 41:106-119.
28. Pan LL, Liu XH, Gong QH, Wu D, Zhu YZ. 2011. Hydrogen sulfide attenuated tumor necrosis factor-alpha-induced inflammatory signaling and dysfunction in vascular endothelial cells. PLoS One 6:e19766. doi:10 .1371/journal.pone.0019766.
29. Calvert JW, Coetzee WA, Lefer DJ. 2010. Novel insights into hydrogen sulfide-mediated cytoprotection. Antioxid. Redox Signal. 12:1203-1217.
30. Sen N, Paul BD, Gadalla MM, Mustafa AK, Sen T, Xu R, Kim S, Snyder SH. 2012. Hydrogen sulfide-linked sulfhydration of NF-kappaB mediates its antiapoptotic actions. Mol. Cell 45:13-24.
31. Tan G, Pan S, Li J, Dong X, Kang K, Zhao M, Jiang X, Kanwar JR, Qiao H, Jiang H, Sun X. 2011. Hydrogen sulfide attenuates carbon tetrachloride-induced hepatotoxicity, liver cirrhosis and portal hypertension in rats. PLoS One 6:e25943. doi:10.1371/journal.pone.0025943.
32. Wang MJ, Cai WJ, Zhu YC. 2010. Mechanisms of angiogenesis: role of hydrogen sulphide. Clin. Exp. Pharmacol. Physiol. 37:764-771.
33. Cohen HY, Miller C, Bitterman KJ, Wall NR, Hekking B, Kessler B, Howitz KT, Gorospe M, de Cabo R, Sinclair DA. 2004. Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science 305:390-392.
34. Harman D. 1981. The aging process. Proc. Natl. Acad. Sci. U. S. A. 78:7124-7128.
35. Harman D. 1988. Free radicals in aging. Mol. Cell. Biochem. 84:155-161.
36. Benedetti S, Benvenuti F, Nappi G, Fortunati NA, Marino L, Aureli T, De Luca S, Pagliarani S, Canestrari F. 2009. Antioxidative effects of sulfurous mineral water: protection against lipid and protein oxidation. Eur. J. Clin. Nutr. 63:106-112.
37. Fransen M, Nordgren M, Wang B, Apanasets O. 2012. Role of peroxisomes in ROS/RNS-metabolism: implications for human disease. Biochim. Biophys. Acta 1822:1363-1373.
38. Tyagi N, Moshal KS, Sen U, Vacek TP, Kumar M, Hughes WM, Jr, Kundu S, Tyagi SC. 2009. H2S protects against methionine-induced oxidative stress in brain endothelial cells. Antioxid. Redox Signal. 11:25-33.
39. van der Vliet A, Eiserich JP, O'Neill CA, Halliwell B, Cross CE. 1995. Tyrosine modification by reactive nitrogen species: a closer look. Arch. Biochem. Biophys. 319:341-349.
40. Whiteman M, Armstrong JS, Chu SH, Jia-Ling S, Wong BS, Cheung NS, Halliwell B, Moore PK. 2004. The novel neuromodulator hydrogen sulfide: an endogenous peroxynitrite 'scavenger'? J. Neurochem. 90:765-768.
41. Whiteman M, Li L, Kostetski I, Chu SH, Siau JL, Bhatia M, Moore PK. 2006. Evidence for the formation of a novel nitrosothiol from the gaseous mediators nitric oxide and hydrogen sulphide. Biochem. Biophys. Res. Commun. 343:303-310.
42. Kimura Y, Goto Y, Kimura H. 2010. Hydrogen sulfide increases glutathione production and suppresses oxidative stress in mitochondria. Antioxid. Redox Signal. 12:1-13.
43. Weindruch R. 1996. The retardation of aging by caloric restriction: studies in rodents and primates. Toxicol. Pathol. 24:742-745. 44. Harman D. 1972. The biologic clock: the mitochondria? J. Am. Geriatr. Soc. 20:145-147.
44. Harman D. 1972. The biologic clock: the mitochondria? J. Am. Geriatr. Soc. 20:145-147.
45. Liu Y, Kalogeris T, Wang M, Zuidema MY, Wang Q, Dai H, Davis MJ, Hill MA, Korthuis RJ. 2012. Hydrogen sulfide preconditioning or neutrophil depletion attenuates ischemia-reperfusion-induced mitochondrial dysfunction in rat small intestine. Am. J. Physiol. Gastrointest. Liver Physiol. 302:G44-G54.
46. Sun WH, Liu F, Chen Y, Zhu YC. 2012. Hydrogen sulfide decreases the levels of ROS by inhibiting mitochondrial complex IV and increasing SOD activities in cardiomyocytes under ischemia/reperfusion. Biochem. Biophys. Res. Commun. 421:164-169.
47. Brachmann CB, Sherman JM, Devine SE, Cameron EE, Pillus L, Boeke JD. 1995. The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability. Genes Dev. 9:2888-2902.
48. Kaeberlein M, McVey M, Guarente L. 1999. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev. 13:2570-2580.
49. Lee SS, Kennedy S, Tolonen AC, Ruvkun G. 2003. DAF-16 target genes that control C. elegans life-span and metabolism. Science 300:644-647.
50. Tissenbaum HA, Guarente L. 2001. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 410:227-230.
51. Frye RA. 2000. Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. Biochem. Biophys. Res. Commun. 273:793-798.
52. Shang Z, Lu C, Chen S, Hua L, Qian R. 2012. Effect of H2S on the circadian rhythm of mouse hepatocytes. Lipids Health Dis. 11:23.
53. Miller DL, Roth MB. 2007. Hydrogen sulfide increases thermotolerance and lifespan in Caenorhabditis elegans. Proc. Natl. Acad. Sci. U. S. A. 104:20618-20622.
54. Predmore BL, Alendy MJ, Ahmed KI, Leeuwenburgh C, Julian D. 2010. The hydrogen sulfide signaling system: changes during aging and the benefits of caloric restriction. Age (Dordr) 32:467-481.
55. Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, Lin Y, Tran H, Ross SE, Mostoslavsky R, Cohen HY, Hu LS, Cheng HL, Jedrychowski MP, Gygi SP, Sinclair DA, Alt FW, Greenberg ME. 2004. Stressdependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 303:2011-2015.
56. Park SJ, Ahmad F, Philp A, Baar K, Williams T, Luo H, Ke H, Rehmann H, Taussig R, Brown AL, Kim MK, Beaven MA, Burgin AB, Manganiello V, Chung JH. 2012. Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesteras es. Cell 148: 421-433.
57. Bucci M, Papapetropoulos A, Vellecco V, Zhou Z, Pyriochou A, Roussos C, Roviezzo F, Brancaleone V, Cirino G. 2010. Hydrogen sulfide is an endogenous inhibitor of phosphodiesterase activity. Arterioscler. Thromb. Vasc. Biol. 30:1998-2004.
58. Yamamoto M, Clark JD, Pastor JV, Gurnani P, Nandi A, Kurosu H, Miyoshi M, Ogawa Y, Castrillon DH, Rosenblatt KP, Kuro-o M. 2005. Regulation of oxidative stress by the anti-aging hormone klotho. J. Biol. Chem. 280:38029-38034.
59. Château MT, Araiz C, Descamps S, Galas S. 2010. Klotho interferes with a novel FGF-signalling pathway and insulin/Igf-like signalling to improve longevity and stress resistance in Caenorhabditis elegans. Aging (Albany NY) 2:567-581.
60. Mitani H, Ishizaka N, Aizawa T, Ohno M, Usui S, Suzuki T, Amaki T, Mori I, Nakamura Y, Sato M, Nangaku M, Hirata Y, Nagai R. 2002. In vivo klotho gene transfer ameliorates angiotensin II-induced renal damage. Hypertension 39:838-843.
61. Yoon HE, Ghee JY, Piao S, Song JH, Han DH, Kim S, Ohashi N, Kobori H, Kuro-o M, Yang CW. 2011. Angiotensin II blockade upregulates the expression of Klotho, the anti-ageing gene, in an experimental model of chronic cyclosporine nephropathy. Nephrol. Dial. Transplant. 26:800-813.
62. Laggner H, Hermann M, Esterbauer H, Muellner MK, Exner M, Gmeiner BM, Kapiotis S. 2007. The novel gaseous vasorelaxant hydrogen sulfide inhibits angiotensin-converting enzyme activity of endothelial cells. J. Hypertens. 25:2100-2104.
63. Zhao X, Zhang LK, Zhang CY, Zeng XJ, Yan H, Jin HF, Tang CS, Du JB. 2008. Regulatory effect of hydrogen sulfide on vascular collagen content in spontaneously hypertensive rats. Hypertens. Res. 31:1619-1630.
64. Lu M, Liu YH, Goh HS, Wang JJ, Yong QC, Wang R, Bian JS. 2010. Hydrogen sulfide inhibits plasma renin activity. J. Am. Soc. Nephrol. 21:993-1002.
65. Du J, Yan H, Tang C. 2003. Endogenous H2S is involved in the development of spontaneous hypertension. Beijing Da Xue Xue Bao 35:102. (In Chinese.)
66. Laggner H, Muellner MK, Schreier S, Sturm B, Hermann M, Exner M, Gmeiner BM, Kapiotis S. 2007. Hydrogen sulphide: a novel physiological inhibitor of LDL atherogenic modification by HOCl. Free Radic. Res. 41:741-747.
67. Zhao ZZ, Wang Z, Li GH, Wang R, Tan JM, Cao X, Suo R, Jiang ZS. 2011. Hydrogen sulfide inhibits macrophage-derived foam cell formation. Exp. Biol. Med. (Maywood) 236:169-176.
68. Hu LF, Lu M, Tiong CX, Dawe GS, Hu G, Bian JS. 2010. Neuroprotective effects of hydrogen sulfide on Parkinson's disease rat models. Aging Cell 9:135-146.
69. Zhang LM, Jiang CX, Liu DW. 2009. Hydrogen sulfide attenuates neuronal injury induced by vascular dementia via inhibiting apoptosis in rats. Neurochem. Res. 34:1984-1992.
70. Liu YY, Bian JS. 2010. Hydrogen sulfide protects amyloid-beta induced cell toxicity in microglia. J. Alzheimers Dis. 22:1189-1200.
71. Seshadri S, Beiser A, Selhub J, Jacques PF, Rosenberg IH, D'Agostino RB, Wilson PW, Wolf PA. 2002. Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N. Engl. J. Med. 346:476-483.
72. Tang XQ, Shen XT, Huang YE, Ren YK, Chen RQ, Hu B, He JQ, Yin WL, Xu JH, Jiang ZS. 2010. Hydrogen sulfide antagonizes homocysteine- induced neurotoxicity in PC12 cells. Neurosci. Res. 68:241-249.
73. Yang G, Tang G, Zhang L, Wu L, Wang R. 2011. The pathogenic role of cystathionine gamma-lyase/hydrogen sulfide in streptozotocininduced diabetes in mice. Am. J. Pathol. 179:869-879.
74. Yang G, Yang W, Wu L, Wang R. 2007. H2S, endoplasmic reticulum stress, and apoptosis of insulin-secreting beta cells. J. Biol. Chem. 282: 16567-16576.
75. Yang W, Yang G, Jia X, Wu L, Wang R. 2005. Activation of KATP channels by H2S in rat insulin-secreting cells and the underlying mechanisms. J. Physiol. 569:519-531.
76. Yusuf M, Kwong Huat BT, Hsu A, Whiteman M, Bhatia M, Moore PK. 2005. Streptozotocin-induced diabetes in the rat is associated with enhanced tissue hydrogen sulfide biosynthesis. Biochem. Biophys. Res. Commun. 333:1146-1152.
77. Jain SK, Bull R, Rains JL, Bass PF, Levine SN, Reddy S, McVie R, Bocchini JA. 2010. Low levels of hydrogen sulfide in the blood of diabetes patients and streptozotocin-treated rats causes vascular inflammation? Antioxid. Redox Signal. 12:1333-1337.
78. Pei Y, Wu B, Cao Q, Wu L, Yang G. 2011. Hydrogen sulfide mediates the anti-survival effect of sulforaphane on human prostate cancer cells. Toxicol. Appl. Pharmacol. 257:420-428.
79. Chattopadhyay M, Kodela R, Nath N, Barsegian A, Boring D, Kashfi K. 2012. Hydrogen sulfide-releasing aspirin suppresses NF-kappaB signaling in estrogen receptor negative breast cancer cells in vitro and in vivo. Biochem. Pharmacol. 83:723-732.
80. Chattopadhyay M, Kodela R, Olson KR, Kashfi K. 2012. NOSH-aspirin (NBS-1120), a novel nitric oxide- and hydrogen sulfide-releasing hybrid is a potent inhibitor of colon cancer cell growth in vitro and in a xenograft mouse model. Biochem. Biophys. Res. Commun. 419:523-528.
81. Fukutomi M, Kario K. 2010. Aging and hypertension. Expert Rev. Cardiovasc. Ther. 8:1531-1539.
82. Zhong G, Chen F, Cheng Y, Tang C, Du J. 2003. The role of hydrogen sulfide generation in the pathogenesis of hypertension in rats induced by inhibition of nitric oxide synthase. J. Hypertens. 21:1879-1885.
83. Touyz RM. 2000. Molecular and cellular mechanisms regulating vascular function and structure-implications in the pathogenesis of hypertension. Can. J. Cardiol. 16:1137-1146.
84. Cheng Y, Ndisang JF, Tang G, Cao K, Wang R. 2004. Hydrogen sulfide-induced relaxation of resistance mesenteric artery beds of rats. Am. J. Physiol. Heart Circ. Physiol. 287:H2316-H2323.
85. Baukrowitz T, Schulte U, Oliver D, Herlitze S, Krauter T, Tucker SJ, Ruppersberg JP, Fakler B. 1998. PIP2 and PIP as determinants for ATP inhibition of KATP channels. Science 282:1141-1144.
86. Nishimura T, Vaszar LT, Faul JL, Zhao G, Berry GJ, Shi L, Qiu D, Benson G, Pearl RG, Kao PN. 2003. Simvastatin rescues rats from fatal pulmonary hypertension by inducing apoptosis of neointimal smooth muscle cells. Circulation 108:1640-1645.
87. Du J, Hui Y, Cheung Y, Bin G, Jiang H, Chen X, Tang C. 2004. The possible role of hydrogen sulfide as a smooth muscle cell proliferation inhibitor in rat cultured cells. Heart Vessels 19:75-80.
88. Lusis AJ. 2000. Atherosclerosis. Nature 407:233-241.
89. Lynn EG, Austin RC. 2011. Hydrogen sulfide in the pathogenesis of atherosclerosis and its therapeutic potential. Expert Rev. Clin. Pharmacol. 4:97-108.
90. Jiang HL, Wu HC, Li ZL, Geng B, Tang CS. 2005. Changes of the new gaseous transmitter H2S in patients with coronary heart disease. Di Yi Jun Yi Da Xue Xue Bao 25:951-954. (In Chinese.)
91. Zunnunov ZR. 2004. Efficacy and safety of hydrogen sulfide balneotherapy in ischemic heart disease the arid zone. Ter. Arkh. 76:15-18. (In Russian.)
92. Xie X, Sun A, Zhu W, Huang Z, Hu X, Jia J, Zou Y, Ge J. 2012. Transplantation of mesenchymal stem cells preconditioned with hydrogen sulfide enhances repair of myocardial infarction in rats. Tohoku J. Exp. Med. 226:29-36.
93. Korczyn AD. 2010. Vascular contribution to dementia in Parkinson's disease. Neurodegener. Dis. 7:127-130.
94. Kidd PM. 2008. Alzheimer's disease, amnestic mild cognitive impairment, and age-associated memory impairment: current understanding and progress toward integrative prevention. Altern. Med. Rev. 13:85-115.
95. Hampel H. 2013. Amyloid-beta and cognition in aging and Alzheimer's disease: molecular and neurophysiological mechanisms. J. Alzheimers Dis. 33:S79-S86.
96. Moore PK, Bhatia M, Moochhala S. 2003. Hydrogen sulfide: from the smell of the past to the mediator of the future? Trends Pharmacol. Sci. 24:609-611.
97. Tang XQ, Shen XT, Huang YE, Chen RQ, Ren YK, Fang HR, Zhuang YY, Wang CY. 2011. Inhibition of endogenous hydrogen sulfide generation is associated with homocysteine-induced neurotoxicity: role of ERK1/2 activation. J. Mol. Neurosci. 45:60-67.
98. Kimura Y, Kimura H. 2004. Hydrogen sulfide protects neurons from oxidative stress. FASEB J. 18:1165-1167.
99. Koster JC, Permutt MA, Nichols CG. 2005. Diabetes and insulin secre-tion: the ATP-sensitive K channel (K ATP) connection. Diabetes 54: 3065-3072.
100. Mathis D, Vence L, Benoist C. 2001. beta-cell death during progression to diabetes. Nature 414:792-798.
101. Wu L, Yang W, Jia X, Yang G, Duridanova D, Cao K, Wang R. 2009. Pancreatic islet overproduction of H2S and suppressed insulin release in Zucker diabetic rats. Lab. Invest. 89:59-67.
102. Martin BC, Warram JH, Krolewski AS, Bergman RN, Soeldner JS, Kahn CR. 1992. Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study. Lancet 340:925-929.
103. Weyer C, Tataranni PA, Bogardus C, Pratley RE. 2001. Insulin resistance and insulin secretory dysfunction are independent predictors of worsening of glucose tolerance during each stage of type 2 diabetes development. Diabetes Care 24:89-94.
104. Feller DD, Feist E. 1963. Conversion of methionine and threonine to fatty acids by adipose tissue. Can. J. Biochem. Physiol. 41:269-273.
105. Feng X, Chen Y, Zhao J, Tang C, Jiang Z, Geng B. 2009. Hydrogen sulfide from adipose tissue is a novel insulin resistance regulator. Biochem. Biophys. Res. Commun. 380:153-159.
106. Brancaleone V, Roviezzo F, Vellecco V, De Gruttola L, Bucci M, Cirino G. 2008. Biosynthesis of H2S is impaired in non-obese diabetic (NOD) mice. Br. J. Pharmacol. 155:673-680.
107. Guan Q, Zhang Y, Yu C, Liu Y, Gao L, Zhao J. 2012. Hydrogen sulfide protects against high-glucose-induced apoptosis in endothelial cells. J. Cardiovasc. Pharmacol. 59:188-193.
108. Suzuki K, Olah G, Modis K, Coletta C, Kulp G, Gero D, Szoleczky P, Chang T, Zhou Z, Wu L, Wang R, Papapetropoulos A, Szabo C. 2011. Hydrogen sulfide replacement therapy protects the vascular endothelium in hyperglycemia by preserving mitochondrial function. Proc. Natl. Acad. Sci. U. S. A. 108:13829-13834.
109. Solski LV, Longyhore DS. 2008. Prevention of type 2 diabetes mellitus with angiotensin-converting-enzyme inhibitors. Am. J. Health Syst. Pharm. 65:935-940.
110. Yuan P, Xue H, Zhou L, Qu L, Li C, Wang Z, Ni J, Yu C, Yao T, Huang Y, Wang R, Lu L. 2011. Rescue of mesangial cells from high glucoseinduced over-proliferation and extracellular matrix secretion by hydrogen sulfide. Nephrol. Dial. Transplant. 26:2119-2126.
111. Szabo C. 2012. Roles of hydrogen sulfide in the pathogenesis of diabetes mellitus and its complications. Antioxid. Redox Signal. 17:68-80.
112. Lee ZW, Zhou J, Chen CS, Zhao Y, Tan CH, Li L, Moore PK, Deng LW. 2011. The slow-releasing hydrogen sulfide donor, GYY4137, exhibits novel anti-cancer effects in vitro and in vivo. PLoS One 6:e21077. doi:10.1371/journal.pone.0021077.
113. Chattopadhyay M, Kodela R, Nath N, Dastagirzada YM, Velazquez- Martinez CA, Boring D, Kashfi K. 2012. Hydrogen sulfide-releasing NSAIDs inhibit the growth of human cancer cells: a general property and evidence of a tissue type-independent effect. Biochem. Pharmacol. 83: 715-722.