메뉴 건너뛰기




Volumn 41, Issue 3, 2016, Pages 211-218

The Warburg Effect: How Does it Benefit Cancer Cells?

Author keywords

ATP synthesis; Chromatin remodeling; Microenvironment acidification; ROS; Warburg Effect

Indexed keywords

ADENOSINE TRIPHOSPHATE; GLUCOSE; LACTATE DEHYDROGENASE; LACTIC ACID; NICOTINAMIDE ADENINE DINUCLEOTIDE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

EID: 84959451365     PISSN: 09680004     EISSN: 13624326     Source Type: Journal    
DOI: 10.1016/j.tibs.2015.12.001     Document Type: Review
Times cited : (3255)

References (62)
  • 1
    • 0001740285 scopus 로고
    • The metabolism of carcinoma cells
    • Warburg O. The metabolism of carcinoma cells. J. Cancer Res. 1925, 9:148-163.
    • (1925) J. Cancer Res. , vol.9 , pp. 148-163
    • Warburg, O.1
  • 2
    • 0000459772 scopus 로고
    • Ueber den stoffwechsel der tumoren
    • Warburg O., et al. Ueber den stoffwechsel der tumoren. Biochem. Zeitschrift 1924, 152:319-344.
    • (1924) Biochem. Zeitschrift , vol.152 , pp. 319-344
    • Warburg, O.1
  • 3
    • 85006768050 scopus 로고
    • The metabolism of tumors in the body
    • Warburg O., et al. The metabolism of tumors in the body. J. Gen. Physiol. 1927, 8:519-530.
    • (1927) J. Gen. Physiol. , vol.8 , pp. 519-530
    • Warburg, O.1
  • 4
    • 0000089325 scopus 로고
    • Observations on the carbohydrate metabolism of tumours
    • Crabtree H.G. Observations on the carbohydrate metabolism of tumours. Biochem. J. 1929, 23:536.
    • (1929) Biochem. J. , vol.23 , pp. 536
    • Crabtree, H.G.1
  • 5
    • 12444279265 scopus 로고
    • On the origin of cancer cells
    • Warburg O. On the origin of cancer cells. Science 1956, 123:309-314.
    • (1956) Science , vol.123 , pp. 309-314
    • Warburg, O.1
  • 6
    • 0015251175 scopus 로고
    • Bioenergetics and the problem of tumor growth: an understanding of the mechanism of the generation and control of biological energy may shed light on the problem of tumor growth
    • Racker E. Bioenergetics and the problem of tumor growth: an understanding of the mechanism of the generation and control of biological energy may shed light on the problem of tumor growth. Am. Sci. 1972, 60:56-63.
    • (1972) Am. Sci. , vol.60 , pp. 56-63
    • Racker, E.1
  • 7
    • 0021949960 scopus 로고
    • Stimulation of glycolysis and amino acid uptake in NRK-49F cells by transforming growth factor beta and epidermal growth factor
    • Boerner P., et al. Stimulation of glycolysis and amino acid uptake in NRK-49F cells by transforming growth factor beta and epidermal growth factor. Proc. Natl. Acad. Sci. U.S.A. 1985, 82:1350-1353.
    • (1985) Proc. Natl. Acad. Sci. U.S.A. , vol.82 , pp. 1350-1353
    • Boerner, P.1
  • 8
    • 0023158728 scopus 로고
    • Elevated levels of glucose transport and transporter messenger RNA are induced by ras or src oncogenes
    • Flier J.S., et al. Elevated levels of glucose transport and transporter messenger RNA are induced by ras or src oncogenes. Science 1987, 235:1492-1495.
    • (1987) Science , vol.235 , pp. 1492-1495
    • Flier, J.S.1
  • 9
    • 0023132221 scopus 로고
    • Transformation of rat fibroblasts by FSV rapidly increases glucose transporter gene transcription
    • Birnbaum M.J., et al. Transformation of rat fibroblasts by FSV rapidly increases glucose transporter gene transcription. Science 1987, 235:1495-1498.
    • (1987) Science , vol.235 , pp. 1495-1498
    • Birnbaum, M.J.1
  • 10
    • 0023682108 scopus 로고
    • Growth factors rapidly induce expression of the glucose transporter gene
    • Hiraki Y., et al. Growth factors rapidly induce expression of the glucose transporter gene. J. Biol. Chem. 1988, 263:13655-13662.
    • (1988) J. Biol. Chem. , vol.263 , pp. 13655-13662
    • Hiraki, Y.1
  • 11
    • 33744783432 scopus 로고    scopus 로고
    • Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance
    • Fantin V.R., et al. Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance. Cancer Cell 2006, 9:425-434.
    • (2006) Cancer Cell , vol.9 , pp. 425-434
    • Fantin, V.R.1
  • 12
    • 0032539534 scopus 로고    scopus 로고
    • A unique glucose-dependent apoptotic pathway induced by c-Myc
    • Shim H., et al. A unique glucose-dependent apoptotic pathway induced by c-Myc. Proc. Natl. Acad. Sci. U.S.A. 1998, 95:1511-1516.
    • (1998) Proc. Natl. Acad. Sci. U.S.A. , vol.95 , pp. 1511-1516
    • Shim, H.1
  • 13
    • 84938232611 scopus 로고    scopus 로고
    • An essential role of the mitochondrial electron transport chain in cell proliferation is to enable aspartate synthesis
    • Birsoy K., et al. An essential role of the mitochondrial electron transport chain in cell proliferation is to enable aspartate synthesis. Cell 2015, 162:540-551.
    • (2015) Cell , vol.162 , pp. 540-551
    • Birsoy, K.1
  • 14
    • 84937475615 scopus 로고    scopus 로고
    • Broad anti-tumor activity of a small molecule that selectively targets the Warburg Effect and lipogenesis
    • Flaveny C.A., et al. Broad anti-tumor activity of a small molecule that selectively targets the Warburg Effect and lipogenesis. Cancer Cell 2015, 28:42-56.
    • (2015) Cancer Cell , vol.28 , pp. 42-56
    • Flaveny, C.A.1
  • 15
    • 84938234308 scopus 로고    scopus 로고
    • Supporting aspartate biosynthesis is an essential function of respiration in proliferating cells
    • Sullivan L.B., et al. Supporting aspartate biosynthesis is an essential function of respiration in proliferating cells. Cell 2015, 162:552-563.
    • (2015) Cell , vol.162 , pp. 552-563
    • Sullivan, L.B.1
  • 16
    • 84911861458 scopus 로고    scopus 로고
    • Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function
    • Viale A., et al. Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function. Nature 2014, 514:628-632.
    • (2014) Nature , vol.514 , pp. 628-632
    • Viale, A.1
  • 17
    • 66249108601 scopus 로고    scopus 로고
    • Understanding the Warburg effect: the metabolic requirements of cell proliferation
    • Vander Heiden M.G., et al. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 2009, 324:1029-1033.
    • (2009) Science , vol.324 , pp. 1029-1033
    • Vander Heiden, M.G.1
  • 18
    • 80053922625 scopus 로고    scopus 로고
    • Metabolic flux and the regulation of mammalian cell growth
    • Locasale J.W., Cantley L.C. Metabolic flux and the regulation of mammalian cell growth. Cell Metab. 2011, 14:443-451.
    • (2011) Cell Metab. , vol.14 , pp. 443-451
    • Locasale, J.W.1    Cantley, L.C.2
  • 19
    • 84919412891 scopus 로고    scopus 로고
    • Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step
    • Shestov A.A., et al. Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step. Elife 2014, 3:e03342.
    • (2014) Elife , vol.3 , pp. e03342
    • Shestov, A.A.1
  • 20
    • 0035917865 scopus 로고    scopus 로고
    • Cooperation and competition in the evolution of ATP-producing pathways
    • Pfeiffer T., et al. Cooperation and competition in the evolution of ATP-producing pathways. Science 2001, 292:504-507.
    • (2001) Science , vol.292 , pp. 504-507
    • Pfeiffer, T.1
  • 21
    • 84899925866 scopus 로고    scopus 로고
    • Constant growth rate can be supported by decreasing energy flux and increasing aerobic glycolysis
    • Slavov N., et al. Constant growth rate can be supported by decreasing energy flux and increasing aerobic glycolysis. Cell Rep. 2014, 7:705-714.
    • (2014) Cell Rep. , vol.7 , pp. 705-714
    • Slavov, N.1
  • 22
    • 84941344937 scopus 로고    scopus 로고
    • Metabolic competition in the tumor microenvironment is a driver of cancer progression
    • Chang C-H., et al. Metabolic competition in the tumor microenvironment is a driver of cancer progression. Cell 2015, 162:1229-1241.
    • (2015) Cell , vol.162 , pp. 1229-1241
    • Chang, C.-H.1
  • 23
    • 84941366350 scopus 로고    scopus 로고
    • Phosphoenolpyruvate is a metabolic checkpoint of anti-tumor T cell responses
    • Ho P-C., et al. Phosphoenolpyruvate is a metabolic checkpoint of anti-tumor T cell responses. Cell 2015, 162:1217-1228.
    • (2015) Cell , vol.162 , pp. 1217-1228
    • Ho, P.-C.1
  • 24
    • 85069238534 scopus 로고    scopus 로고
    • Separation of metabolic supply and demand: aerobic glycolysis as a normal physiological response to fluctuating energetic demands in the membrane
    • Epstein T., et al. Separation of metabolic supply and demand: aerobic glycolysis as a normal physiological response to fluctuating energetic demands in the membrane. Cancer Metab. 2014, 2:7.
    • (2014) Cancer Metab. , vol.2 , pp. 7
    • Epstein, T.1
  • 25
    • 80054046029 scopus 로고    scopus 로고
    • Aerobic glycolysis: meeting the metabolic requirements of cell proliferation
    • Lunt S.Y., Vander Heiden M.G. Aerobic glycolysis: meeting the metabolic requirements of cell proliferation. Annu. Rev. Cell Dev. Biol. 2011, 27:441-464.
    • (2011) Annu. Rev. Cell Dev. Biol. , vol.27 , pp. 441-464
    • Lunt, S.Y.1    Vander Heiden, M.G.2
  • 26
    • 78649711427 scopus 로고    scopus 로고
    • The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes
    • Levine A.J., Puzio-Kuter A.M. The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes. Science 2010, 330:1340-1344.
    • (2010) Science , vol.330 , pp. 1340-1344
    • Levine, A.J.1    Puzio-Kuter, A.M.2
  • 27
    • 37449024702 scopus 로고    scopus 로고
    • The biology of cancer: metabolic reprogramming fuels cell growth and proliferation
    • DeBerardinis R.J., et al. The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab. 2008, 7:11-20.
    • (2008) Cell Metab. , vol.7 , pp. 11-20
    • DeBerardinis, R.J.1
  • 28
    • 84860512005 scopus 로고    scopus 로고
    • Links between metabolism and cancer
    • Dang C.V. Links between metabolism and cancer. Genes Dev. 2012, 26:877-890.
    • (2012) Genes Dev. , vol.26 , pp. 877-890
    • Dang, C.V.1
  • 29
    • 79955398591 scopus 로고    scopus 로고
    • Otto Warburg's contributions to current concepts of cancer metabolism
    • Koppenol W.H., et al. Otto Warburg's contributions to current concepts of cancer metabolism. Nat. Rev. Cancer 2011, 11:325-337.
    • (2011) Nat. Rev. Cancer , vol.11 , pp. 325-337
    • Koppenol, W.H.1
  • 30
    • 79251517382 scopus 로고    scopus 로고
    • Regulation of cancer cell metabolism
    • Cairns R.A., et al. Regulation of cancer cell metabolism. Nat. Rev. Cancer 2011, 11:85-95.
    • (2011) Nat. Rev. Cancer , vol.11 , pp. 85-95
    • Cairns, R.A.1
  • 31
    • 84881557242 scopus 로고    scopus 로고
    • Hexokinase 2 is required for tumor initiation and maintenance and its systemic deletion is therapeutic in mouse models of cancer
    • Patra K.C., et al. Hexokinase 2 is required for tumor initiation and maintenance and its systemic deletion is therapeutic in mouse models of cancer. Cancer Cell 2013, 24:213-228.
    • (2013) Cancer Cell , vol.24 , pp. 213-228
    • Patra, K.C.1
  • 32
    • 84925969707 scopus 로고    scopus 로고
    • Metabolic pathways promoting cancer cell survival and growth
    • Boroughs L.K., DeBerardinis R.J. Metabolic pathways promoting cancer cell survival and growth. Nat. Cell Biol. 2015, 17:351-359.
    • (2015) Nat. Cell Biol. , vol.17 , pp. 351-359
    • Boroughs, L.K.1    DeBerardinis, R.J.2
  • 33
    • 84858604270 scopus 로고    scopus 로고
    • Metabolic reprogramming: a cancer hallmark even warburg did not anticipate
    • Ward P.S., Thompson C.B. Metabolic reprogramming: a cancer hallmark even warburg did not anticipate. Cancer Cell 2012, 21:297-308.
    • (2012) Cancer Cell , vol.21 , pp. 297-308
    • Ward, P.S.1    Thompson, C.B.2
  • 34
    • 84928795829 scopus 로고    scopus 로고
    • A growth-rate composition formula for the growth of E. coli on co-utilized carbon substrates
    • Hermsen R., et al. A growth-rate composition formula for the growth of E. coli on co-utilized carbon substrates. Mol. Syst. Biol. 2015, 11:801.
    • (2015) Mol. Syst. Biol. , vol.11 , pp. 801
    • Hermsen, R.1
  • 35
    • 84923658662 scopus 로고    scopus 로고
    • Quantitative proteomic analysis reveals a simple strategy of global resource allocation in bacteria
    • Hui S., et al. Quantitative proteomic analysis reveals a simple strategy of global resource allocation in bacteria. Mol. Syst. Biol. 2015, 11:784.
    • (2015) Mol. Syst. Biol. , vol.11 , pp. 784
    • Hui, S.1
  • 36
    • 79953661070 scopus 로고    scopus 로고
    • Genome-scale metabolic modeling elucidates the role of proliferative adaptation in causing the Warburg effect
    • Shlomi T., et al. Genome-scale metabolic modeling elucidates the role of proliferative adaptation in causing the Warburg effect. PLoS Comput. Biol. 2011, 7:e1002018.
    • (2011) PLoS Comput. Biol. , vol.7 , pp. e1002018
    • Shlomi, T.1
  • 37
    • 77951803596 scopus 로고    scopus 로고
    • Catabolic efficiency of aerobic glycolysis: the Warburg effect revisited
    • Vazquez A., et al. Catabolic efficiency of aerobic glycolysis: the Warburg effect revisited. BMC Syst. Biol. 2010, 4:58.
    • (2010) BMC Syst. Biol. , vol.4 , pp. 58
    • Vazquez, A.1
  • 38
    • 73149109962 scopus 로고    scopus 로고
    • Shifts in growth strategies reflect tradeoffs in cellular economics
    • Molenaar D., et al. Shifts in growth strategies reflect tradeoffs in cellular economics. Mol. Syst. Biol. 2009, 5:323.
    • (2009) Mol. Syst. Biol. , vol.5 , pp. 323
    • Molenaar, D.1
  • 39
    • 84858796367 scopus 로고    scopus 로고
    • A two-way street: reciprocal regulation of metabolism and signalling
    • Wellen K.E., Thompson C.B. A two-way street: reciprocal regulation of metabolism and signalling. Nat. Rev. Mol. Cell Biol. 2012, 13:270-276.
    • (2012) Nat. Rev. Mol. Cell Biol. , vol.13 , pp. 270-276
    • Wellen, K.E.1    Thompson, C.B.2
  • 40
    • 84875465199 scopus 로고    scopus 로고
    • Cancer metabolism: fatty acid oxidation in the limelight
    • Carracedo A., et al. Cancer metabolism: fatty acid oxidation in the limelight. Nat. Rev. Cancer 2013, 13:227-232.
    • (2013) Nat. Rev. Cancer , vol.13 , pp. 227-232
    • Carracedo, A.1
  • 41
    • 84922022722 scopus 로고    scopus 로고
    • Organization of enzyme concentration across the metabolic network in cancer cells
    • Madhukar N.S., et al. Organization of enzyme concentration across the metabolic network in cancer cells. PLoS ONE 2015, 10:e0117131.
    • (2015) PLoS ONE , vol.10 , pp. e0117131
    • Madhukar, N.S.1
  • 42
    • 84874886049 scopus 로고    scopus 로고
    • Acidity generated by the tumor microenvironment drives local invasion
    • Estrella V., et al. Acidity generated by the tumor microenvironment drives local invasion. Cancer Res. 2013, 73:1524-1535.
    • (2013) Cancer Res. , vol.73 , pp. 1524-1535
    • Estrella, V.1
  • 43
    • 0029751950 scopus 로고    scopus 로고
    • A reaction-diffusion model of cancer invasion
    • Gatenby R.A., Gawlinski E.T. A reaction-diffusion model of cancer invasion. Cancer Res. 1996, 56:5745-5753.
    • (1996) Cancer Res. , vol.56 , pp. 5745-5753
    • Gatenby, R.A.1    Gawlinski, E.T.2
  • 44
    • 84907223092 scopus 로고    scopus 로고
    • Functional polarization of tumour-associated macrophages by tumour-derived lactic acid
    • Colegio O.R., et al. Functional polarization of tumour-associated macrophages by tumour-derived lactic acid. Nature 2014, 513:559-563.
    • (2014) Nature , vol.513 , pp. 559-563
    • Colegio, O.R.1
  • 45
    • 84860321700 scopus 로고    scopus 로고
    • Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism
    • Ying H., et al. Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism. Cell 2012, 149:656-670.
    • (2012) Cell , vol.149 , pp. 656-670
    • Ying, H.1
  • 46
    • 84946887722 scopus 로고    scopus 로고
    • The genetic evolution of melanoma from precursor lesions
    • Shain A.H., et al. The genetic evolution of melanoma from precursor lesions. N. Engl. J. Med 2015, 373:1926-1936.
    • (2015) N. Engl. J. Med , vol.373 , pp. 1926-1936
    • Shain, A.H.1
  • 47
    • 66249105703 scopus 로고    scopus 로고
    • ATP-citrate lyase links cellular metabolism to histone acetylation
    • Wellen K.E., et al. ATP-citrate lyase links cellular metabolism to histone acetylation. Science 2009, 324:1076-1080.
    • (2009) Science , vol.324 , pp. 1076-1080
    • Wellen, K.E.1
  • 48
    • 78649391422 scopus 로고    scopus 로고
    • Cellular metabolic stress: considering how cells respond to nutrient excess
    • Wellen K.E., Thompson C.B. Cellular metabolic stress: considering how cells respond to nutrient excess. Mol. Cell 2010, 40:323-332.
    • (2010) Mol. Cell , vol.40 , pp. 323-332
    • Wellen, K.E.1    Thompson, C.B.2
  • 49
    • 82755165163 scopus 로고    scopus 로고
    • Warburg effect and redox balance
    • Hamanaka R.B., Chandel N.S. Warburg effect and redox balance. Science 2011, 334:1219-1220.
    • (2011) Science , vol.334 , pp. 1219-1220
    • Hamanaka, R.B.1    Chandel, N.S.2
  • 50
    • 84878831880 scopus 로고    scopus 로고
    • Posttranscriptional control of T cell effector function by aerobic glycolysis
    • Chang C-H., et al. Posttranscriptional control of T cell effector function by aerobic glycolysis. Cell 2013, 153:1239-1251.
    • (2013) Cell , vol.153 , pp. 1239-1251
    • Chang, C.-H.1
  • 51
    • 84868007565 scopus 로고    scopus 로고
    • Physiological roles of mitochondrial reactive oxygen species
    • Sena L.A., Chandel N.S. Physiological roles of mitochondrial reactive oxygen species. Mol. Cell 2012, 48:158-167.
    • (2012) Mol. Cell , vol.48 , pp. 158-167
    • Sena, L.A.1    Chandel, N.S.2
  • 52
    • 84867142346 scopus 로고    scopus 로고
    • The consequences of enhanced cell-autonomous glucose metabolism
    • Locasale J.W. The consequences of enhanced cell-autonomous glucose metabolism. Trends Endocrinol. Metab. 2012, 23:545-551.
    • (2012) Trends Endocrinol. Metab. , vol.23 , pp. 545-551
    • Locasale, J.W.1
  • 53
    • 84878679199 scopus 로고    scopus 로고
    • A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence
    • Kaplon J., et al. A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence. Nature 2013, 498:109-112.
    • (2013) Nature , vol.498 , pp. 109-112
    • Kaplon, J.1
  • 54
    • 84912139448 scopus 로고    scopus 로고
    • Characterization of the usage of the serine metabolic network in human cancer
    • Mehrmohamadi M., et al. Characterization of the usage of the serine metabolic network in human cancer. Cell Rep. 2014, 9:1507-1519.
    • (2014) Cell Rep. , vol.9 , pp. 1507-1519
    • Mehrmohamadi, M.1
  • 55
    • 84902332213 scopus 로고    scopus 로고
    • Quantitative flux analysis reveals folate-dependent NADPH production
    • Fan J., et al. Quantitative flux analysis reveals folate-dependent NADPH production. Nature 2014, 510:298-302.
    • (2014) Nature , vol.510 , pp. 298-302
    • Fan, J.1
  • 56
    • 84863534997 scopus 로고    scopus 로고
    • Metabolic regulation of epigenetics
    • Lu C., Thompson C.B. Metabolic regulation of epigenetics. Cell Metab. 2012, 16:9-17.
    • (2012) Cell Metab. , vol.16 , pp. 9-17
    • Lu, C.1    Thompson, C.B.2
  • 57
    • 85013861713 scopus 로고    scopus 로고
    • The rate of glycolysis quantitatively mediates specific histone acetylation sites
    • Cluntun A.A., et al. The rate of glycolysis quantitatively mediates specific histone acetylation sites. Cancer Metab. 2015, 3:1-12.
    • (2015) Cancer Metab. , vol.3 , pp. 1-12
    • Cluntun, A.A.1
  • 58
    • 84924272203 scopus 로고    scopus 로고
    • Glycolytic metabolism influences global chromatin structure
    • Liu X-S., et al. Glycolytic metabolism influences global chromatin structure. Oncotarget 2015, 6:4214.
    • (2015) Oncotarget , vol.6 , pp. 4214
    • Liu, X.-S.1
  • 59
    • 84876898716 scopus 로고    scopus 로고
    • Quantitative dynamics of the link between cellular metabolism and histone acetylation
    • Evertts A.G., et al. Quantitative dynamics of the link between cellular metabolism and histone acetylation. J. Biol. Chem. 2013, 288:12142-12151.
    • (2013) J. Biol. Chem. , vol.288 , pp. 12142-12151
    • Evertts, A.G.1
  • 60
    • 79955960768 scopus 로고    scopus 로고
    • Acetyl-CoA induces cell growth and proliferation by promoting the acetylation of histones at growth genes
    • Cai L., et al. Acetyl-CoA induces cell growth and proliferation by promoting the acetylation of histones at growth genes. Mol. Cell 2011, 42:426-437.
    • (2011) Mol. Cell , vol.42 , pp. 426-437
    • Cai, L.1
  • 61
    • 79960060305 scopus 로고    scopus 로고
    • Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
    • DeNicola G.M., et al. Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis. Nature 2011, 475:106-109.
    • (2011) Nature , vol.475 , pp. 106-109
    • DeNicola, G.M.1
  • 62
    • 84947583295 scopus 로고    scopus 로고
    • Overflow metabolism in Escherichia coli results from efficient proteome allocation
    • Basan M., et al. Overflow metabolism in Escherichia coli results from efficient proteome allocation. Nature 2015, 528:99-104.
    • (2015) Nature , vol.528 , pp. 99-104
    • Basan, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.