-
1
-
-
32144457645
-
Über den Stoffwechsel der Carcinomzelle
-
Warburg, O. Über den Stoffwechsel der Carcinomzelle. Naturwissenschaften 12, 1131-1137 (1924).
-
(1924)
Naturwissenschaften
, vol.12
, pp. 1131-1137
-
-
Warburg, O.1
-
2
-
-
58249119446
-
18F-FDG PET and PET/CT in the evaluation of cancer treatment response
-
Ben-Haim, S. & Ell, P. 18F-FDG PET and PET/CT in the evaluation of cancer treatment response. J. Nucl. Med. 50, 88-99 (2009).
-
(2009)
J. Nucl. Med.
, vol.50
, pp. 88-99
-
-
Ben-Haim, S.1
Ell, P.2
-
3
-
-
77949967131
-
Targeting metabolic transformation for cancer therapy
-
Tennant, D. A., Durán, R. V. & Gottlieb, E. Targeting metabolic transformation for cancer therapy. Nat. Rev. Cancer 10, 267-277 (2010).
-
(2010)
Nat. Rev. Cancer
, vol.10
, pp. 267-277
-
-
Tennant, D.A.1
Durán, R.V.2
Gottlieb, E.3
-
4
-
-
37449024702
-
The biology of cancer: Metabolic reprogramming fuels cell growth and proliferation
-
DeBerardinis, R. J., Lum, J. J., Hatzivassiliou, G. & Thompson, C. B. The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab. 7, 11-20 (2008).
-
(2008)
Cell Metab.
, vol.7
, pp. 11-20
-
-
DeBerardinis, R.J.1
Lum, J.J.2
Hatzivassiliou, G.3
Thompson, C.B.4
-
5
-
-
60849115270
-
IDH1 and IDH2 mutations in gliomas
-
Yan, H. et al. IDH1 and IDH2 mutations in gliomas. N. Engl. J. Med. 360, 765-773 (2009).
-
(2009)
N. Engl. J. Med.
, vol.360
, pp. 765-773
-
-
Yan, H.1
-
6
-
-
84856087055
-
Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis
-
Zhang, W. C. et al. Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis. Cell 148, 259-272 (2012).
-
(2012)
Cell
, vol.148
, pp. 259-272
-
-
Zhang, W.C.1
-
7
-
-
0020955571
-
Biochemical strategy of cancer cells and the design of chemotherapy: G.H.A. Clowes Memorial Lecture
-
Weber, G. Biochemical strategy of cancer cells and the design of chemotherapy: G.H.A. Clowes Memorial Lecture. Cancer Res. 43, 3466-3492 (1983).
-
(1983)
Cancer Res.
, vol.43
, pp. 3466-3492
-
-
Weber, G.1
-
8
-
-
0015409718
-
Glycolysis, respiration, and anomalous gene expression in experimental hepatomas: G.H.A. Clowes Memorial Lecture
-
Weinhouse, S. Glycolysis, respiration, and anomalous gene expression in experimental hepatomas: G.H.A. Clowes Memorial Lecture. Cancer Res. 32, 2007-2016 (1972).
-
(1972)
Cancer Res.
, vol.32
, pp. 2007-2016
-
-
Weinhouse, S.1
-
9
-
-
84880321156
-
Heterogeneity of tumor-induced gene expression changes in the human metabolic network
-
Hu, J. et al. Heterogeneity of tumor-induced gene expression changes in the human metabolic network. Nat. Biotechnol. 31, 522-529 (2013).
-
(2013)
Nat. Biotechnol.
, vol.31
, pp. 522-529
-
-
Hu, J.1
-
10
-
-
79551516930
-
GCOD-genechip oncology database
-
Liu, F., White, J. A., Antonescu, C. & Quackenbush, J. GCOD-genechip oncology database. BMC bioinformatics 12, 46 (2011).
-
(2011)
BMC Bioinformatics
, vol.12
, pp. 46
-
-
Liu, F.1
White, J.A.2
Antonescu, C.3
Quackenbush, J.4
-
11
-
-
3042694117
-
Large-scale meta-analysis of cancer microarray data identifies common transcriptional profiles of neoplastic transformation and progression
-
Rhodes, D. R. et al. Large-scale meta-analysis of cancer microarray data identifies common transcriptional profiles of neoplastic transformation and progression. Proc. Natl Acad. Sci. USA 101, 9309-9314 (2004).
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 9309-9314
-
-
Rhodes, D.R.1
-
12
-
-
0035985177
-
Identification of genes periodically expressed in the human cell cycle and their expression in tumors
-
Whitfield, M. L. et al. Identification of genes periodically expressed in the human cell cycle and their expression in tumors. Mol. Biol. Cell 13, 1977-2000 (2002).
-
(2002)
Mol. Biol. Cell
, vol.13
, pp. 1977-2000
-
-
Whitfield, M.L.1
-
13
-
-
0035163845
-
Transcriptional regulation and function during the human cell cycle
-
Cho, R. J. et al. Transcriptional regulation and function during the human cell cycle. Nat. Genet. 27, 48-54 (2001).
-
(2001)
Nat. Genet.
, vol.27
, pp. 48-54
-
-
Cho, R.J.1
-
14
-
-
33846910173
-
Global reconstruction of the human metabolic network based on genomic and bibliomic data
-
Duarte, N. C. et al. Global reconstruction of the human metabolic network based on genomic and bibliomic data. Proc. Natl Acad. Sci. USA 104, 1777-1782 (2007).
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 1777-1782
-
-
Duarte, N.C.1
-
15
-
-
7944226627
-
Genes of glycolysis are ubiquitously overexpressed in 24 cancer classes
-
Altenberg, B. & Greulich, K. O. Genes of glycolysis are ubiquitously overexpressed in 24 cancer classes. Genomics 84, 1014-1020 (2004).
-
(2004)
Genomics
, vol.84
, pp. 1014-1020
-
-
Altenberg, B.1
Greulich, K.O.2
-
16
-
-
0344442890
-
Oxygen tension regulates the expression of a group of procollagen hydroxylases
-
Hofbauer, K.-H. et al. Oxygen tension regulates the expression of a group of procollagen hydroxylases. Eur. J. Biochem. 270, 4515-4522 (2003).
-
(2003)
Eur. J. Biochem.
, vol.270
, pp. 4515-4522
-
-
Hofbauer, K.-H.1
-
17
-
-
0032714567
-
Glycoprotein glycosylation and cancer progression
-
Dennis, J. W., Granovsky, M. & Warren, C. E. Glycoprotein glycosylation and cancer progression. Biochim. Biophys. Acta. 1473, 21-34 (1999).
-
(1999)
Biochim. Biophys. Acta
, vol.1473
, pp. 21-34
-
-
Dennis, J.W.1
Granovsky, M.2
Warren, C.E.3
-
18
-
-
42649112047
-
An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors
-
Ben-Porath, I. et al. An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat. Genet. 40, 499-507 (2008).
-
(2008)
Nat. Genet.
, vol.40
, pp. 499-507
-
-
Ben-Porath, I.1
-
19
-
-
80051923932
-
Functional genomics reveal that the serine synthesis pathway is essential in breast cancer
-
Possemato, R. et al. Functional genomics reveal that the serine synthesis pathway is essential in breast cancer. Nature 476, 346-350 (2011).
-
(2011)
Nature
, vol.476
, pp. 346-350
-
-
Possemato, R.1
-
20
-
-
0141919565
-
Elevated FX expression and increased production of GDP-L-fucose, a common donor substrate for fucosylation in human hepatocellular carcinoma and hepatoma cell lines
-
Noda, K. et al. Elevated FX expression and increased production of GDP-L-fucose, a common donor substrate for fucosylation in human hepatocellular carcinoma and hepatoma cell lines. Cancer Res. 63, 6282-6289 (2003).
-
(2003)
Cancer Res.
, vol.63
, pp. 6282-6289
-
-
Noda, K.1
-
21
-
-
84861891911
-
Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC
-
Liu, W. et al. Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC. Proc. Natl Acad. Sci. USA 109, 8983-8988 (2012).
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
, pp. 8983-8988
-
-
Liu, W.1
-
22
-
-
84866423983
-
Functional specialization in proline biosynthesis of melanoma
-
De Ingeniis, J. et al. Functional specialization in proline biosynthesis of melanoma. PLoS One 7, e45190 (2012).
-
(2012)
PLoS One
, vol.7
-
-
De Ingeniis, J.1
-
23
-
-
0020806677
-
Transfer of reducing equivalents into mitochondria by the interconversions of proline and delta1-pyrroline-5-carboxylate
-
Hagedorn, C. H. & Phang, J. M. Transfer of reducing equivalents into mitochondria by the interconversions of proline and delta1-pyrroline-5-carboxylate. Arch. Biochem. Biophys. 225, 95-101 (1983).
-
(1983)
Arch. Biochem. Biophys.
, vol.225
, pp. 95-101
-
-
Hagedorn, C.H.1
Phang, J.M.2
-
24
-
-
38649109148
-
Proline modulates the intracellular redox environment and protects mammalian cells against oxidative stress
-
Krishnan, N., Dickman, M. B. & Becker, D. F. Proline modulates the intracellular redox environment and protects mammalian cells against oxidative stress. Free Radic. Biol. Med. 44, 671-681 (2008).
-
(2008)
Free Radic. Biol. Med.
, vol.44
, pp. 671-681
-
-
Krishnan, N.1
Dickman, M.B.2
Becker, D.F.3
-
25
-
-
69349089323
-
Mutations in PYCR1 cause cutis laxa with progeroid features
-
Reversade, B. et al. Mutations in PYCR1 cause cutis laxa with progeroid features. Nat. Genet. 41, 1016-1021 (2009).
-
(2009)
Nat. Genet.
, vol.41
, pp. 1016-1021
-
-
Reversade, B.1
-
26
-
-
84861420588
-
Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation
-
Jain, M. et al. Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation. Science 336, 1040-1044 (2012).
-
(2012)
Science
, vol.336
, pp. 1040-1044
-
-
Jain, M.1
-
27
-
-
77955616558
-
Compartmentalization of mammalian folate-mediated one-carbon metabolism
-
Tibbetts, A. S. & Appling, D. R. Compartmentalization of mammalian folate-mediated one-carbon metabolism. Annu. Rev. Nutr. 30, 57-81 (2010).
-
(2010)
Annu. Rev. Nutr.
, vol.30
, pp. 57-81
-
-
Tibbetts, A.S.1
Appling, D.R.2
-
28
-
-
0022378021
-
NAD-dependent methylenetetrahydrofolate dehydrogenase is expressed by immortal cells
-
Mejia, N. R. & MacKenzie, R. E. NAD-dependent methylenetetrahydrofolate dehydrogenase is expressed by immortal cells. J. Biol. Chem. 260, 14616-14620 (1985).
-
(1985)
J. Biol. Chem.
, vol.260
, pp. 14616-14620
-
-
Mejia, N.R.1
MacKenzie, R.E.2
-
29
-
-
0036261663
-
Mitochondrial NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase is essential for embryonic development
-
Di Pietro, E., Sirois, J., Tremblay, M. & MacKenzie, R. Mitochondrial NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase is essential for embryonic development. Mol. Cell Biol. 22, 4158 (2002).
-
(2002)
Mol. Cell Biol.
, vol.22
, pp. 4158
-
-
Di Pietro, E.1
Sirois, J.2
Tremblay, M.3
MacKenzie, R.4
-
30
-
-
0025676019
-
Activity of an NAD-dependent 5,10-methylenetetrahydrofolate dehydrogenase in normal tissue, neoplastic cells, and oncogene-transformed cells
-
Smith, G. K. et al. Activity of an NAD-dependent 5,10-methylenetetrahydrofolate dehydrogenase in normal tissue, neoplastic cells, and oncogene-transformed cells. Arch. Biochem. Biophys. 283, 367-371 (1990).
-
(1990)
Arch. Biochem. Biophys.
, vol.283
, pp. 367-371
-
-
Smith, G.K.1
-
31
-
-
0038819954
-
Mammalian fibroblasts lacking mitochondrial NAD+-dependent methylenetetrahydrofolate dehydrogenase-cyclohydrolase are glycine auxotrophs
-
Patel, H., Pietro, E. D. & MacKenzie, R. E. Mammalian fibroblasts lacking mitochondrial NAD+-dependent methylenetetrahydrofolate dehydrogenase-cyclohydrolase are glycine auxotrophs. J. Biol. Chem. 278, 19436-19441 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 19436-19441
-
-
Patel, H.1
Pietro, E.D.2
MacKenzie, R.E.3
-
32
-
-
84875782309
-
High-throughput RNAi screening for novel modulators of vimentin expression identifies MTHFD2 as a regulator of breast cancer cell migration and invasion
-
Lehtinen, L., Ketola, K., Mäkelä, R. & Mpindi, J. High-throughput RNAi screening for novel modulators of vimentin expression identifies MTHFD2 as a regulator of breast cancer cell migration and invasion. Oncotarget 4, 48-63 (2013).
-
(2013)
Oncotarget
, vol.4
, pp. 48-63
-
-
Lehtinen, L.1
Ketola, K.2
Mäkelä, R.3
Mpindi, J.4
-
33
-
-
0019417331
-
The methyl folate trap
-
Weir, D. G. & Scott, J. M. The methyl folate trap. Lancet 318, 337-340 (1981).
-
(1981)
Lancet
, vol.318
, pp. 337-340
-
-
Weir, D.G.1
Scott, J.M.2
-
34
-
-
84872715396
-
Metabolite damage and its repair or pre-emption
-
Linster, C. L., Van Schaftingen, E. & Hanson, A. D. Metabolite damage and its repair or pre-emption. Nat. Chem. Biol. 9, 72-80 (2013).
-
(2013)
Nat. Chem. Biol.
, vol.9
, pp. 72-80
-
-
Linster, C.L.1
Van Schaftingen, E.2
Hanson, A.D.3
-
35
-
-
0001677717
-
Controlling the false discovery rate: A practical and powerful approach to multiple testing
-
Benjamini, Y. & Hochberg, Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J. R. Stat. Soc. Ser. B Stat. Methodol. 57, 289-300 (1995).
-
(1995)
J. R. Stat. Soc. Ser. B Stat. Methodol.
, vol.57
, pp. 289-300
-
-
Benjamini, Y.1
Hochberg, Y.2
-
36
-
-
27344435774
-
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
-
Subramanianan, A. et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl Acad. Sci. USA 102, 15545-15550 (2005).
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 15545-15550
-
-
Subramanianan, A.1
-
37
-
-
11144358198
-
A gene atlas of the mouse and human protein-encoding transcriptomes
-
Su, A. I. et al. A gene atlas of the mouse and human protein-encoding transcriptomes. Proc. Natl Acad. Sci. USA 101, 6062-6067 (2004).
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 6062-6067
-
-
Su, A.I.1
-
38
-
-
84863744150
-
Production of tissue microarrays, immunohistochemistry staining and digitalization within the human protein atlas
-
Kampf, C., Olsson, I., Ryberg, U., Sjöstedt, E. & Pontén, F. Production of tissue microarrays, immunohistochemistry staining and digitalization within the human protein atlas. J. Vis. Exp. 63, e3620 (2012).
-
(2012)
J. Vis. Exp.
, vol.63
-
-
Kampf, C.1
Olsson, I.2
Ryberg, U.3
Sjöstedt, E.4
Pontén, F.5
-
39
-
-
33845191779
-
Genomic and transcriptional aberrations linked to breast cancer pathophysiologies
-
Chin, K. et al. Genomic and transcriptional aberrations linked to breast cancer pathophysiologies. Cancer cell 10, 529-541 (2006).
-
(2006)
Cancer Cell
, vol.10
, pp. 529-541
-
-
Chin, K.1
-
40
-
-
0037137519
-
A gene-expression signature as a predictor of survival in breast cancer
-
Van de Vijver, M. J. et al. A gene-expression signature as a predictor of survival in breast cancer. N. Engl. J. Med. 347, 1999-2009 (2002).
-
(2002)
N. Engl. J. Med.
, vol.347
, pp. 1999-2009
-
-
Van De Vijver, M.J.1
-
41
-
-
34250652449
-
Strong time dependence of the 76-gene prognostic signature for node-negative breast cancer patients in the TRANSBIG multicenter independent validation series
-
Desmedt, C. et al. Strong time dependence of the 76-gene prognostic signature for node-negative breast cancer patients in the TRANSBIG multicenter independent validation series. Clin. Cancer Res. 13, 3207-3214 (2007).
-
(2007)
Clin. Cancer Res.
, vol.13
, pp. 3207-3214
-
-
Desmedt, C.1
-
42
-
-
34447632167
-
Gene expression profiling spares early breast cancer patients from adjuvant therapy: Derived and validated in two population-based cohorts
-
Pawitan, Y. et al. Gene expression profiling spares early breast cancer patients from adjuvant therapy: derived and validated in two population-based cohorts. Breast Cancer Res. 7, R953-R964 (2005).
-
(2005)
Breast Cancer Res.
, vol.7
, pp. R953-R964
-
-
Pawitan, Y.1
-
43
-
-
26444546442
-
An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survival
-
Miller, L. D. et al. An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survival. Proc. Natl Acad. Sci. USA 102, 13550-13555 (2005).
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 13550-13555
-
-
Miller, L.D.1
-
44
-
-
79955121426
-
Correlation of microarray-based breast cancer molecular subtypes and clinical outcomes: Implications for treatment optimization
-
Kao, K.-J., Chang, K.-M., Hsu, H.-C. & Huang, A. T. Correlation of microarray-based breast cancer molecular subtypes and clinical outcomes: implications for treatment optimization. BMC Cancer 11, 143 (2011).
-
(2011)
BMC Cancer
, vol.11
, pp. 143
-
-
Kao, K.-J.1
Chang, K.-M.2
Hsu, H.-C.3
Huang, A.T.4
|