메뉴 건너뛰기




Volumn 2016, Issue , 2016, Pages

Tackling Cancer Stem Cells via Inhibition of EMT Transcription Factors

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BORTEZOMIB; TRANSCRIPTION FACTOR SLUG; TRANSCRIPTION FACTOR SNAIL; TRANSCRIPTION FACTOR TWIST;

EID: 84994438774     PISSN: None     EISSN: 16879678     Source Type: Journal    
DOI: 10.1155/2016/5285892     Document Type: Review
Times cited : (65)

References (123)
  • 1
    • 84901789420 scopus 로고    scopus 로고
    • Epithelial-to-mesenchymal transition and the cancer stem cell phenotype: Insights from cancer biology with therapeutic implications for colorectal cancer
    • V. J. Findlay, C. Wang, D. K. Watson, and E. R. Camp, "Epithelial-to-mesenchymal transition and the cancer stem cell phenotype: insights from cancer biology with therapeutic implications for colorectal cancer," Cancer Gene Therapy, vol. 21, no. 5, pp. 181-187, 2014.
    • (2014) Cancer Gene Therapy , vol.21 , Issue.5 , pp. 181-187
    • Findlay, V.J.1    Wang, C.2    Watson, D.K.3    Camp, E.R.4
  • 3
    • 43049165453 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition generates cells with properties of stemcells
    • S. A. Mani, W. Guo, M.-J. Liao et al., "The epithelial-mesenchymal transition generates cells with properties of stemcells," Cell, vol. 133, no. 4, pp. 704-715, 2008.
    • (2008) Cell , vol.133 , Issue.4 , pp. 704-715
    • Mani, S.A.1    Guo, W.2    Liao, M.-J.3
  • 4
    • 84899726033 scopus 로고    scopus 로고
    • Evaluation of cancer stem cell markers CD133, CD44, CD24: Association with AKT isoforms and radiation resistance in colon cancer cells
    • S. H. Sahlberg, D. Spiegelberg, B. Glimelius, B. Stenerlöw, and M. Nestor, "Evaluation of cancer stem cell markers CD133, CD44, CD24: association with AKT isoforms and radiation resistance in colon cancer cells," PLoS ONE, vol. 9, no. 4, article e94621, 2014.
    • (2014) PLoS ONE , vol.9 , Issue.4
    • Sahlberg, S.H.1    Spiegelberg, D.2    Glimelius, B.3    Stenerlöw, B.4    Nestor, M.5
  • 6
    • 58149340463 scopus 로고    scopus 로고
    • Cancer stem cell analysis and clinical outcome in patients with glioblastoma multiforme
    • R. Pallini, L. Ricci-Vitiani, G. L. Banna et al., "Cancer stem cell analysis and clinical outcome in patients with glioblastoma multiforme," Clinical Cancer Research, vol. 14, no. 24, pp. 8205-8212, 2008.
    • (2008) Clinical Cancer Research , vol.14 , Issue.24 , pp. 8205-8212
    • Pallini, R.1    Ricci-Vitiani, L.2    Banna, G.L.3
  • 7
    • 33847419142 scopus 로고    scopus 로고
    • Molecular definition of breast tumor heterogeneity
    • M. Shipitsin, L. L. Campbell, P. Argani et al., "Molecular definition of breast tumor heterogeneity," Cancer Cell, vol. 11, no. 3, pp. 259-273, 2007.
    • (2007) Cancer Cell , vol.11 , Issue.3 , pp. 259-273
    • Shipitsin, M.1    Campbell, L.L.2    Argani, P.3
  • 9
    • 84945566332 scopus 로고    scopus 로고
    • Cell-of-origin of cancer versus cancer stem cells: Assays and interpretations
    • K. Rycaj and D. G. Tang, "Cell-of-origin of cancer versus cancer stem cells: assays and interpretations," Cancer Research, vol. 75, no. 19, pp. 4003-4011, 2015.
    • (2015) Cancer Research , vol.75 , Issue.19 , pp. 4003-4011
    • Rycaj, K.1    Tang, D.G.2
  • 10
    • 84943143136 scopus 로고    scopus 로고
    • Single-cell analysis reveals a stem-cell program in humanmetastatic breast cancer cells
    • D. A. Lawson, N. R. Bhakta, K. Kessenbrock et al., "Single-cell analysis reveals a stem-cell program in humanmetastatic breast cancer cells," Nature, vol. 526, no. 7571, pp. 131-135, 2015.
    • (2015) Nature , vol.526 , Issue.7571 , pp. 131-135
    • Lawson, D.A.1    Bhakta, N.R.2    Kessenbrock, K.3
  • 11
    • 84896125494 scopus 로고    scopus 로고
    • Evolution of the cancer stem cell model
    • A. Kreso and J. E. Dick, "Evolution of the cancer stem cell model," Cell Stem Cell, vol. 14, no. 3, pp. 275-291, 2014.
    • (2014) Cell Stem Cell , vol.14 , Issue.3 , pp. 275-291
    • Kreso, A.1    Dick, J.E.2
  • 12
    • 83255177150 scopus 로고    scopus 로고
    • Single-cell dissection of transcriptional heterogeneity in human colon tumors
    • P. Dalerba, T. Kalisky, D. Sahoo et al., "Single-cell dissection of transcriptional heterogeneity in human colon tumors," Nature Biotechnology, vol. 29, no. 12, pp. 1120-1127, 2011.
    • (2011) Nature Biotechnology , vol.29 , Issue.12 , pp. 1120-1127
    • Dalerba, P.1    Kalisky, T.2    Sahoo, D.3
  • 13
    • 84868632060 scopus 로고    scopus 로고
    • A PML-PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance
    • K. Ito, A. Carracedo, D. Weiss et al., "A PML-PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance," Nature Medicine, vol. 18, no. 9, pp. 1350-1358, 2012.
    • (2012) Nature Medicine , vol.18 , Issue.9 , pp. 1350-1358
    • Ito, K.1    Carracedo, A.2    Weiss, D.3
  • 14
    • 80053916176 scopus 로고    scopus 로고
    • Metabolic regulation of hematopoietic stemcells in the hypoxic niche
    • T. Suda, K. Takubo, and G. L. Semenza, "Metabolic regulation of hematopoietic stemcells in the hypoxic niche," Cell Stem Cell, vol. 9, no. 4, pp. 298-310, 2011.
    • (2011) Cell Stem Cell , vol.9 , Issue.4 , pp. 298-310
    • Suda, T.1    Takubo, K.2    Semenza, G.L.3
  • 15
    • 62449205665 scopus 로고    scopus 로고
    • Chemoresistant colorectal cancer cells, the cancer stem cell phenotype, and increased sensitivity to insulin-like growth factor-I receptor inhibition
    • N. A. Dallas, L. Xia, F. Fan et al., "Chemoresistant colorectal cancer cells, the cancer stem cell phenotype, and increased sensitivity to insulin-like growth factor-I receptor inhibition," Cancer Research, vol. 69, no. 5, pp. 1951-1957, 2009.
    • (2009) Cancer Research , vol.69 , Issue.5 , pp. 1951-1957
    • Dallas, N.A.1    Xia, L.2    Fan, F.3
  • 16
    • 33846100356 scopus 로고    scopus 로고
    • A human colon cancer cell capable of initiating tumour growth in immunodeficient mice
    • C. A. O'Brien, A. Pollett, S. Gallinger, and J. E. Dick, "A human colon cancer cell capable of initiating tumour growth in immunodeficient mice," Nature, vol. 445, no. 7123, pp. 106-110, 2007.
    • (2007) Nature , vol.445 , Issue.7123 , pp. 106-110
    • O'Brien, C.A.1    Pollett, A.2    Gallinger, S.3    Dick, J.E.4
  • 17
    • 84873084388 scopus 로고    scopus 로고
    • Variable clonal repopulation dynamics influence chemotherapy response in colorectal cancer
    • A. Kreso, C. A. O'Brien, P. Van Galen et al., "Variable clonal repopulation dynamics influence chemotherapy response in colorectal cancer," Science, vol. 339, no. 6119, pp. 543-548, 2013.
    • (2013) Science , vol.339 , Issue.6119 , pp. 543-548
    • Kreso, A.1    O'Brien, C.A.2    Van Galen, P.3
  • 18
    • 69249106131 scopus 로고    scopus 로고
    • Ovarian cancer: Emerging concept on cancer stem cells
    • M. P. Ponnusamy and S. K. Batra, "Ovarian cancer: emerging concept on cancer stem cells," Journal of Ovarian Research, vol. 1, article 4, 2008.
    • (2008) Journal of Ovarian Research , vol.1
    • Ponnusamy, M.P.1    Batra, S.K.2
  • 20
    • 1542283717 scopus 로고    scopus 로고
    • Characterization of clonogenic multiple myeloma cells
    • W. Matsui, C. A. Huff, Q. Wang et al., "Characterization of clonogenic multiple myeloma cells," Blood, vol. 103, no. 6, pp. 2332-2336, 2004.
    • (2004) Blood , vol.103 , Issue.6 , pp. 2332-2336
    • Matsui, W.1    Huff, C.A.2    Wang, Q.3
  • 21
    • 0028091194 scopus 로고
    • A cell initiating human acute myeloid leukaemia after transplantation into SCID mice
    • T. Lapidot, C. Sirard, J. Vormoor et al., "A cell initiating human acute myeloid leukaemia after transplantation into SCID mice," Nature, vol. 367, no. 6464, pp. 645-648, 1994.
    • (1994) Nature , vol.367 , Issue.6464 , pp. 645-648
    • Lapidot, T.1    Sirard, C.2    Vormoor, J.3
  • 22
    • 0030789242 scopus 로고    scopus 로고
    • Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
    • D. Bonnet and J. E. Dick, "Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell," Nature Medicine, vol. 3, no. 7, pp. 730-737, 1997.
    • (1997) Nature Medicine , vol.3 , Issue.7 , pp. 730-737
    • Bonnet, D.1    Dick, J.E.2
  • 23
    • 84924249260 scopus 로고    scopus 로고
    • Thecancer stem cell niche: How essential is the niche in regulating stemness of tumor cells?
    • V. Plaks, N. Kong, and Z. Werb, "Thecancer stem cell niche: how essential is the niche in regulating stemness of tumor cells?" Cell Stem Cell, vol. 16, no. 3, pp. 225-238, 2015.
    • (2015) Cell Stem Cell , vol.16 , Issue.3 , pp. 225-238
    • Plaks, V.1    Kong, N.2    Werb, Z.3
  • 24
    • 0022891340 scopus 로고
    • Tumors: Wounds that do not heal: Similarities between tumor stroma generation and wound healing
    • H. F. Dvorak, "Tumors: wounds that do not heal: similarities between tumor stroma generation and wound healing," New England Journal of Medicine, vol. 315, no. 26, pp. 1650-1659, 1986.
    • (1986) New England Journal of Medicine , vol.315 , Issue.26 , pp. 1650-1659
    • Dvorak, H.F.1
  • 25
    • 0020456385 scopus 로고
    • How does the extracellular matrix direct gene expression?
    • M. J. Bissell, H. G. Hall, and G. Parry, "How does the extracellular matrix direct gene expression?" Journal of Theoretical Biology, vol. 99, no. 1, pp. 31-68, 1982.
    • (1982) Journal of Theoretical Biology , vol.99 , Issue.1 , pp. 31-68
    • Bissell, M.J.1    Hall, H.G.2    Parry, G.3
  • 26
    • 84948407218 scopus 로고    scopus 로고
    • Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer
    • X. Zheng, J. L. Carstens, J. Kim et al., "Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer," Nature, vol. 527, no. 7579, pp. 525-530, 2015.
    • (2015) Nature , vol.527 , Issue.7579 , pp. 525-530
    • Zheng, X.1    Carstens, J.L.2    Kim, J.3
  • 27
    • 67650999875 scopus 로고    scopus 로고
    • The basics of epithelial-mesenchymal transition
    • R. Kalluri and R. A. Weinberg, "The basics of epithelial-mesenchymal transition," Journal of Clinical Investigation, vol. 119, no. 6, pp. 1420-1428, 2009.
    • (2009) Journal of Clinical Investigation , vol.119 , Issue.6 , pp. 1420-1428
    • Kalluri, R.1    Weinberg, R.A.2
  • 28
    • 33244463813 scopus 로고    scopus 로고
    • Complex networks orchestrate epithelial-mesenchymal transitions
    • J. P. Thiery and J. P. Sleeman, "Complex networks orchestrate epithelial-mesenchymal transitions," Nature Reviews Molecular Cell Biology, vol. 7, no. 2, pp. 131-142, 2006.
    • (2006) Nature Reviews Molecular Cell Biology , vol.7 , Issue.2 , pp. 131-142
    • Thiery, J.P.1    Sleeman, J.P.2
  • 29
    • 80053336355 scopus 로고    scopus 로고
    • Mesenchymal transition and dissemination of cancer cells is driven by myeloid-derived suppressor cells infiltrating the primary tumor
    • B. Toh, X. Wang, J. Keeble et al., "Mesenchymal transition and dissemination of cancer cells is driven by myeloid-derived suppressor cells infiltrating the primary tumor," PLoS Biology, vol. 9, no. 9, Article ID e1001162, 2011.
    • (2011) PLoS Biology , vol.9 , Issue.9
    • Toh, B.1    Wang, X.2    Keeble, J.3
  • 30
    • 0033784843 scopus 로고    scopus 로고
    • The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression
    • A. Cano, M. A. Pérez-Moreno, I. Rodrigo et al., "The transcription factor Snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression," Nature Cell Biology, vol. 2, no. 2, pp. 76-83, 2000.
    • (2000) Nature Cell Biology , vol.2 , Issue.2 , pp. 76-83
    • Cano, A.1    Pérez-Moreno, M.A.2    Rodrigo, I.3
  • 31
    • 13044251809 scopus 로고    scopus 로고
    • Mutated epithelial cadherin is associated with increased tumorigenicity and loss of adhesion and of responsiveness to the motogenic trefoil factor 2 in colon carcinoma cells
    • J. A. Efstathiou, D. Liu, J. M. D. Wheeler et al., "Mutated epithelial cadherin is associated with increased tumorigenicity and loss of adhesion and of responsiveness to the motogenic trefoil factor 2 in colon carcinoma cells," Proceedings of the National Academy of Sciences of the United States of America, vol. 96, no. 5, pp. 2316-2321, 1999.
    • (1999) Proceedings of the National Academy of Sciences of the United States of America , vol.96 , Issue.5 , pp. 2316-2321
    • Efstathiou, J.A.1    Liu, D.2    Wheeler, J.M.D.3
  • 32
    • 84971578290 scopus 로고    scopus 로고
    • CYB5R1 links epithelial-mesenchymal transition and poor prognosis in colorectal cancer
    • C. Woischke, C. Blaj, E. M. Schmidt et al., "CYB5R1 links epithelial-mesenchymal transition and poor prognosis in colorectal cancer," Oncotarget, vol. 7, no. 21, pp. 31350-31360, 2016.
    • (2016) Oncotarget , vol.7 , Issue.21 , pp. 31350-31360
    • Woischke, C.1    Blaj, C.2    Schmidt, E.M.3
  • 33
    • 84940462949 scopus 로고    scopus 로고
    • Expression of epithelial-mesenchymal transition-related markers in triple-negative breast cancer: ZEB1 as a potential biomarker for poor clinical outcome
    • M. H. Jang, H. J. Kim, E. J. Kim, Y. R. Chung, and S. Y. Park, "Expression of epithelial-mesenchymal transition-related markers in triple-negative breast cancer: ZEB1 as a potential biomarker for poor clinical outcome," Human Pathology, vol. 46, no. 9, pp. 1267-1274, 2015.
    • (2015) Human Pathology , vol.46 , Issue.9 , pp. 1267-1274
    • Jang, M.H.1    Kim, H.J.2    Kim, E.J.3    Chung, Y.R.4    Park, S.Y.5
  • 34
    • 36349033966 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition (EMT) and activated extracellular signal-regulated kinase (p-erk) in surgically resectedpancreatic cancer
    • M. M. Javle, J. F. Gibbs, K. K. Iwata et al., "Epithelial-Mesenchymal Transition (EMT) and activated extracellular signal-regulated kinase (p-Erk) in surgically resectedpancreatic cancer," Annals of Surgical Oncology, vol. 14, no. 12, pp. 3527-3533, 2007.
    • (2007) Annals of Surgical Oncology , vol.14 , Issue.12 , pp. 3527-3533
    • Javle, M.M.1    Gibbs, J.F.2    Iwata, K.K.3
  • 35
    • 84941662549 scopus 로고    scopus 로고
    • Molecular profiles of cancer stem-like cell populations in aggressive thyroid cancers
    • M. Dima, V. Pecce, M. Biffoni et al., "Molecular profiles of cancer stem-like cell populations in aggressive thyroid cancers," Endocrine, vol. 53, no. 1, pp. 145-156, 2016.
    • (2016) Endocrine , vol.53 , Issue.1 , pp. 145-156
    • Dima, M.1    Pecce, V.2    Biffoni, M.3
  • 36
    • 84934942475 scopus 로고    scopus 로고
    • Molecular profiling of circulating tumor cells links plasticity to the metastatic process in endometrial cancer
    • L. Alonso-Alconada, L. Muinelo-Romay, K. Madissoo et al., "Molecular profiling of circulating tumor cells links plasticity to the metastatic process in endometrial cancer," Molecular Cancer, vol. 13, no. 1, article 223, 2014.
    • (2014) Molecular Cancer , vol.13 , Issue.1
    • Alonso-Alconada, L.1    Muinelo-Romay, L.2    Madissoo, K.3
  • 37
    • 84896912505 scopus 로고    scopus 로고
    • Investigating molecular profiles of ovarian cancer: An update on cancer stem cells
    • F. Tomao, A. Papa, S. Martina et al., "Investigating molecular profiles of ovarian cancer: an update on cancer stem cells," Journal of Cancer, vol. 5, no. 5, pp. 301-310, 2014.
    • (2014) Journal of Cancer , vol.5 , Issue.5 , pp. 301-310
    • Tomao, F.1    Papa, A.2    Martina, S.3
  • 38
    • 67650496215 scopus 로고    scopus 로고
    • Anovel lungmetastasis signature links wnt signaling with cancer cell self-renewal and epithelial-mesenchymal transition in basal-like breast cancer
    • T.A. DiMeo, K. Anderson, P. Phadke et al., "Anovel lungmetastasis signature links Wnt signaling with cancer cell self-renewal and epithelial-mesenchymal transition in basal-like breast cancer," Cancer Research, vol. 69, no. 13, pp. 5364-5373, 2009.
    • (2009) Cancer Research , vol.69 , Issue.13 , pp. 5364-5373
    • DiMeo, T.A.1    Anderson, K.2    Phadke, P.3
  • 39
    • 42049116522 scopus 로고    scopus 로고
    • Epithelial-tomesenchymal transition and integrin-linked kinase mediate sensitivity to epidermal growth factor receptor inhibition in human hepatoma cells
    • B. C. Fuchs, T. Fujii, J. D. Dorfman et al., "Epithelial-tomesenchymal transition and integrin-linked kinase mediate sensitivity to epidermal growth factor receptor inhibition in human hepatoma cells," Cancer Research, vol. 68, no. 7, pp. 2391-2399, 2008.
    • (2008) Cancer Research , vol.68 , Issue.7 , pp. 2391-2399
    • Fuchs, B.C.1    Fujii, T.2    Dorfman, J.D.3
  • 40
    • 63049123066 scopus 로고    scopus 로고
    • Transitions between epithelial and mesenchymal states: Acquisition of malignant and stem cell traits
    • K. Polyak and R. A. Weinberg, "Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits," Nature Reviews Cancer, vol. 9, no. 4, pp. 265-273, 2009.
    • (2009) Nature Reviews Cancer , vol.9 , Issue.4 , pp. 265-273
    • Polyak, K.1    Weinberg, R.A.2
  • 41
    • 84973456757 scopus 로고    scopus 로고
    • New insights into the crossroads between EMT and stemness in the context of cancer
    • I. Fabregat, A. Malfettone, and J. Soukupova, "New insights into the crossroads between EMT and stemness in the context of cancer," Journal of Clinical Medicine, vol. 5, no. 3, article 37, 2016.
    • (2016) Journal of Clinical Medicine , vol.5 , Issue.3
    • Fabregat, I.1    Malfettone, A.2    Soukupova, J.3
  • 42
    • 84884926755 scopus 로고    scopus 로고
    • Regulation of epithelial to mesenchymal transition by bone morphogenetic proteins
    • N. McCormack and S. O'Dea, "Regulation of epithelial to mesenchymal transition by bone morphogenetic proteins," Cellular Signalling, vol. 25, no. 12, pp. 2856-2862, 2013.
    • (2013) Cellular Signalling , vol.25 , Issue.12 , pp. 2856-2862
    • McCormack, N.1    O'Dea, S.2
  • 43
    • 33749188859 scopus 로고    scopus 로고
    • MDM2 promotes cell motility and invasiveness by regulating E-cadherin degradation
    • J.-Y. Yang, C. S. Zong, W. Xia et al., "MDM2 promotes cell motility and invasiveness by regulating E-cadherin degradation," Molecular and Cellular Biology, vol. 26, no. 19, pp. 7269-7282, 2006.
    • (2006) Molecular and Cellular Biology , vol.26 , Issue.19 , pp. 7269-7282
    • Yang, J.-Y.1    Zong, C.S.2    Xia, W.3
  • 44
    • 84901787644 scopus 로고    scopus 로고
    • Oncogenic roles of EMT-inducing transcription factors
    • A. Puisieux, T. Brabletz, and J. Caramel, "Oncogenic roles of EMT-inducing transcription factors," Nature Cell Biology, vol. 16, no. 6, pp. 488-494, 2014.
    • (2014) Nature Cell Biology , vol.16 , Issue.6 , pp. 488-494
    • Puisieux, A.1    Brabletz, T.2    Caramel, J.3
  • 45
    • 84897977206 scopus 로고    scopus 로고
    • Multilayer control of the EMT master regulators
    • H. Zheng and Y. Kang, "Multilayer control of the EMT master regulators," Oncogene, vol. 33, no. 14, pp. 1755-1763, 2014.
    • (2014) Oncogene , vol.33 , Issue.14 , pp. 1755-1763
    • Zheng, H.1    Kang, Y.2
  • 46
    • 84900449511 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition-activating transcription factors-multifunctional regulators in cancer
    • M. Garg, "Epithelial-mesenchymal transition-activating transcription factors-multifunctional regulators in cancer," World Journal of Stem Cells, vol. 5, no. 4, pp. 188-195, 2013.
    • (2013) World Journal of Stem Cells , vol.5 , Issue.4 , pp. 188-195
    • Garg, M.1
  • 47
    • 34547141894 scopus 로고    scopus 로고
    • Mesenchyme forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers
    • S. A. Mani, J. Yang, M. Brooks et al., "Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers," Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 24, pp. 10069-10074, 2007.
    • (2007) Proceedings of the National Academy of Sciences of the United States of America , vol.104 , Issue.24 , pp. 10069-10074
    • Mani, S.A.1    Yang, J.2    Brooks, M.3
  • 48
    • 33947192053 scopus 로고    scopus 로고
    • Twist transcriptionally up-regulates AKT2 in breast cancer cells leading to increased migration, invasion, and resistance to paclitaxel
    • G. Z. Cheng, J. Chan, Q. Wang, W. Zhang, C. D. Sun, and L.-H. Wang, "Twist transcriptionally up-regulates AKT2 in breast cancer cells leading to increased migration, invasion, and resistance to paclitaxel," Cancer Research, vol. 67, no. 5, pp. 1979-1987, 2007.
    • (2007) Cancer Research , vol.67 , Issue.5 , pp. 1979-1987
    • Cheng, G.Z.1    Chan, J.2    Wang, Q.3    Zhang, W.4    Sun, C.D.5    Wang, L.-H.6
  • 50
    • 84894593599 scopus 로고    scopus 로고
    • Molecular mechanisms of epithelial-mesenchymal transition
    • S. Lamouille, J. Xu, and R. Derynck, "Molecular mechanisms of epithelial-mesenchymal transition," Nature Reviews Molecular Cell Biology, vol. 15, no. 3, pp. 178-196, 2014.
    • (2014) Nature Reviews Molecular Cell Biology , vol.15 , Issue.3 , pp. 178-196
    • Lamouille, S.1    Xu, J.2    Derynck, R.3
  • 51
    • 84857817163 scopus 로고    scopus 로고
    • Slug and sox9 cooperatively determine the mammary stemcell state
    • W. Guo, Z. Keckesova, J. L. Donaher et al., "Slug and Sox9 cooperatively determine the mammary stemcell state," Cell, vol. 148, no. 5, pp. 1015-1028, 2012.
    • (2012) Cell , vol.148 , Issue.5 , pp. 1015-1028
    • Guo, W.1    Keckesova, Z.2    Donaher, J.L.3
  • 52
    • 79651474948 scopus 로고    scopus 로고
    • The TWIST/Mi2/NuRD protein complex and its essential role in cancer metastasis
    • J. Fu, L. Qin, T. He et al., "The TWIST/Mi2/NuRD protein complex and its essential role in cancer metastasis," Cell Research, vol. 21, no. 2, pp. 275-289, 2011.
    • (2011) Cell Research , vol.21 , Issue.2 , pp. 275-289
    • Fu, J.1    Qin, L.2    He, T.3
  • 53
    • 0033789680 scopus 로고    scopus 로고
    • The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells
    • E. Batlle, E. Sancho, C. Franci et al., "The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells," Nature Cell Biology, vol. 2, no. 2, pp. 84-89, 2000.
    • (2000) Nature Cell Biology , vol.2 , Issue.2 , pp. 84-89
    • Batlle, E.1    Sancho, E.2    Franci, C.3
  • 54
    • 0346363757 scopus 로고    scopus 로고
    • Snail mediates E-cadherin repression by the recruitment of the sin3a/histone deacetylase 1 (HDAC1)/HDAC2 complex
    • H. Peinado, E. Ballestar, M. Esteller, and A. Cano, "Snail mediates E-cadherin repression by the recruitment of the Sin3A/histone deacetylase 1 (HDAC1)/HDAC2 complex," Molecular and Cellular Biology, vol. 24, no. 1, pp. 306-319, 2004.
    • (2004) Molecular and Cellular Biology , vol.24 , Issue.1 , pp. 306-319
    • Peinado, H.1    Ballestar, E.2    Esteller, M.3    Cano, A.4
  • 55
    • 0037326569 scopus 로고    scopus 로고
    • The transcription factor slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: A comparison with snail and E47 repressors
    • V. Bolós, H. Peinado, M. A. Pérez-Moreno, M. F. Fraga, M. Esteller, and A. Cano, "The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors," Journal of Cell Science, vol. 116, no. 3, pp. 499-511, 2003.
    • (2003) Journal of Cell Science , vol.116 , Issue.3 , pp. 499-511
    • Bolós, V.1    Peinado, H.2    Pérez-Moreno, M.A.3    Fraga, M.F.4    Esteller, M.5    Cano, A.6
  • 56
    • 84900456721 scopus 로고    scopus 로고
    • Snail contributes to the maintenance of stem cell-like phenotype cells in human pancreatic cancer
    • W. Zhou, R. Lv, W. Qi et al., "Snail contributes to the maintenance of stem cell-like phenotype cells in human pancreatic cancer," PLoS ONE, vol. 9, no. 1, article e87409, 2014.
    • (2014) PLoS ONE , vol.9 , Issue.1
    • Zhou, W.1    Lv, R.2    Qi, W.3
  • 57
    • 84872608167 scopus 로고    scopus 로고
    • MiR-1 and miR-200 inhibit EMT via slug-dependent and tumorigenesis via slugindependent mechanisms
    • Y.-N. Liu, J. J. Yin, W. Abou-Kheir et al., "MiR-1 and miR-200 inhibit EMT via Slug-dependent and tumorigenesis via Slugindependent mechanisms," Oncogene, vol. 32, no. 3, pp. 296-306, 2013.
    • (2013) Oncogene , vol.32 , Issue.3 , pp. 296-306
    • Liu, Y.-N.1    Yin, J.J.2    Abou-Kheir, W.3
  • 58
    • 79551614327 scopus 로고    scopus 로고
    • Genetic predisposition directs breast cancer phenotype by dictating progenitor cell fate
    • T. A. Proia, P. J. Keller, P. B. Gupta et al., "Genetic predisposition directs breast cancer phenotype by dictating progenitor cell fate," Cell Stem Cell, vol. 8, no. 2, pp. 149-163, 2011.
    • (2011) Cell Stem Cell , vol.8 , Issue.2 , pp. 149-163
    • Proia, T.A.1    Keller, P.J.2    Gupta, P.B.3
  • 59
    • 70349859809 scopus 로고    scopus 로고
    • Snail and slug mediate radioresistance and chemoresistance by antagonizing p53-mediated apoptosis and acquiring a stem-like phenotype in ovarian cancer cells
    • N.K. Kurrey, S. P. Jalgaonkar, A.V. Joglekar et al., "Snail and slug mediate radioresistance and chemoresistance by antagonizing p53-mediated apoptosis and acquiring a stem-like phenotype in ovarian cancer cells," Stem Cells, vol. 27, no. 9, pp. 2059-2068, 2009.
    • (2009) Stem Cells , vol.27 , Issue.9 , pp. 2059-2068
    • Kurrey, N.K.1    Jalgaonkar, S.P.2    Joglekar, A.V.3
  • 60
    • 2942707848 scopus 로고    scopus 로고
    • Twist, amaster regulator of morphogenesis, plays an essential role in tumor metastasis
    • J. Yang, S. A. Mani, J.L. Donaher et al., "Twist, amaster regulator of morphogenesis, plays an essential role in tumor metastasis," Cell, vol. 117, no. 7, pp. 927-939, 2004.
    • (2004) Cell , vol.117 , Issue.7 , pp. 927-939
    • Yang, J.1    Mani, S.A.2    Donaher, J.L.3
  • 61
    • 78651401992 scopus 로고    scopus 로고
    • Snail2 is an essential mediator of twist1-induced epithelial mesenchymal transition and metastasis
    • E. Casas, J. Kim, A. Bendesky, L. Ohno-Machado, C. J. Wolfe, and J. Yang, "Snail2 is an essential mediator of twist1-induced epithelial mesenchymal transition and metastasis," Cancer Research, vol. 71, no. 1, pp. 245-254, 2011.
    • (2011) Cancer Research , vol.71 , Issue.1 , pp. 245-254
    • Casas, E.1    Kim, J.2    Bendesky, A.3    Ohno-Machado, L.4    Wolfe, C.J.5    Yang, J.6
  • 62
    • 84855340668 scopus 로고    scopus 로고
    • SET8 promotes epithelial-mesenchymal transition and confers TWIST dual transcriptional activities
    • F. Yang, L. Sun, Q. Li et al., "SET8 promotes epithelial-mesenchymal transition and confers TWIST dual transcriptional activities," EMBO Journal, vol. 31, no. 1, pp. 110-123, 2012.
    • (2012) EMBO Journal , vol.31 , Issue.1 , pp. 110-123
    • Yang, F.1    Sun, L.2    Li, Q.3
  • 63
    • 77957583439 scopus 로고    scopus 로고
    • Bmi1 is essential in twist1-induced epithelial-mesenchymal transition
    • M.-H. Yang, D. S.-S. Hsu, H.-W. Wang et al., "Bmi1 is essential in Twist1-induced epithelial-mesenchymal transition," Nature Cell Biology, vol. 12, no. 10, pp. 982-992, 2010.
    • (2010) Nature Cell Biology , vol.12 , Issue.10 , pp. 982-992
    • Yang, M.-H.1    Hsu, D.S.-S.2    Wang, H.-W.3
  • 64
    • 79953325707 scopus 로고    scopus 로고
    • Functional cooperation between snail1 and twist in the regulation of ZEB1 expression during epithelial to mesenchymal transition
    • N. Dave, S. Guaita-Esteruelas, S. Gutarra et al., "Functional cooperation between snail1 and twist in the regulation of ZEB1 expression during epithelial to mesenchymal transition," Journal of Biological Chemistry, vol. 286, no. 14, pp. 12024-12032, 2011.
    • (2011) Journal of Biological Chemistry , vol.286 , Issue.14 , pp. 12024-12032
    • Dave, N.1    Guaita-Esteruelas, S.2    Gutarra, S.3
  • 65
    • 73049110243 scopus 로고    scopus 로고
    • The EMT-activator ZEB1 promotes tumorigenicity by repressing stemnessinhibiting microRNAs
    • U. Wellner, J. Schubert, U. C. Burk et al., "The EMT-activator ZEB1 promotes tumorigenicity by repressing stemnessinhibiting microRNAs," Nature Cell Biology, vol. 11, no. 12, pp. 1487-1495, 2009.
    • (2009) Nature Cell Biology , vol.11 , Issue.12 , pp. 1487-1495
    • Wellner, U.1    Schubert, J.2    Burk, U.C.3
  • 66
    • 84941737633 scopus 로고    scopus 로고
    • A self-enforcing CD44s/ZEB1 feedback loop maintains EMT and stemness properties in cancer cells
    • B.-T. Preca, K. Bajdak, K. Mock et al., "A self-enforcing CD44s/ZEB1 feedback loop maintains EMT and stemness properties in cancer cells," International Journal of Cancer, vol. 137, no. 11, pp. 2566-2577, 2015.
    • (2015) International Journal of Cancer , vol.137 , Issue.11 , pp. 2566-2577
    • Preca, B.-T.1    Bajdak, K.2    Mock, K.3
  • 67
    • 84923332481 scopus 로고    scopus 로고
    • ZEB1: At the crossroads of epithelial-mesenchymal transition, metastasis and therapy resistance
    • P. Zhang, Y. Sun, and L. Ma, "ZEB1: at the crossroads of epithelial-mesenchymal transition, metastasis and therapy resistance," Cell Cycle, vol. 14, no. 4, pp. 481-487, 2015.
    • (2015) Cell Cycle , vol.14 , Issue.4 , pp. 481-487
    • Zhang, P.1    Sun, Y.2    Ma, L.3
  • 68
    • 0141760411 scopus 로고    scopus 로고
    • Hypoxia attenuates the expression of E-cadherin via up-regulation of SNAIL in ovarian carcinoma cells
    • T. Imai, A. Horiuchi, C. Wang et al., "Hypoxia attenuates the expression of E-cadherin via up-regulation of SNAIL in ovarian carcinoma cells," American Journal of Pathology, vol. 163, no. 4, pp. 1437-1447, 2003.
    • (2003) American Journal of Pathology , vol.163 , Issue.4 , pp. 1437-1447
    • Imai, T.1    Horiuchi, A.2    Wang, C.3
  • 70
    • 73349108404 scopus 로고    scopus 로고
    • Wt1 is required for cardiovascular progenitor cell formation through transcriptional control of snail and E-cadherin
    • O. M. Martínez-Estrada, L. A. Lettice, A. Essafi et al., "Wt1 is required for cardiovascular progenitor cell formation through transcriptional control of Snail and E-cadherin," Nature Genetics, vol. 42, no. 1, pp. 89-93, 2010.
    • (2010) Nature Genetics , vol.42 , Issue.1 , pp. 89-93
    • Martínez-Estrada, O.M.1    Lettice, L.A.2    Essafi, A.3
  • 71
    • 84904257935 scopus 로고    scopus 로고
    • Wilms' tumor protein induces an epithelial-mesenchymal hybrid differentiation state in clear cell renal cell carcinoma
    • V. B. Sampson, J. M. David, I. Puig et al., "Wilms' tumor protein induces an epithelial-mesenchymal hybrid differentiation state in clear cell renal cell carcinoma," PLoS ONE, vol. 9, no. 7, article e102041, 2014.
    • (2014) PLoS ONE , vol.9 , Issue.7
    • Sampson, V.B.1    David, J.M.2    Puig, I.3
  • 72
    • 84866874659 scopus 로고    scopus 로고
    • MiR-145 regulates epithelial to mesenchymal transition of breast cancer cells by targeting oct4
    • J. Hu, H. Guo, H. Li et al., "MiR-145 regulates epithelial to mesenchymal transition of breast cancer cells by targeting Oct4," PLoS ONE, vol. 7, no. 9, Article ID e45965, 2012.
    • (2012) PLoS ONE , vol.7 , Issue.9
    • Hu, J.1    Guo, H.2    Li, H.3
  • 73
    • 77957551870 scopus 로고    scopus 로고
    • Amesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts
    • R. Li, J. Liang, S. Ni et al., "Amesenchymal-to-Epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts," Cell Stem Cell, vol. 7, no. 1, pp. 51-63, 2010.
    • (2010) Cell Stem Cell , vol.7 , Issue.1 , pp. 51-63
    • Li, R.1    Liang, J.2    Ni, S.3
  • 74
    • 0038713805 scopus 로고    scopus 로고
    • The radioresistance biological function of the SCF/kit signaling pathway is mediated by the zinc-finger transcription factor slug
    • J. Pérez-Losada, M. Sánchez-Martín, M. Pérez-Caro, P. A. Pérez-Mancera, and I. Sánchez-García, "The radioresistance biological function of the SCF/kit signaling pathway is mediated by the zinc-finger transcription factor Slug," Oncogene, vol. 22, no. 27, pp. 4205-4211, 2003.
    • (2003) Oncogene , vol.22 , Issue.27 , pp. 4205-4211
    • Pérez-Losada, J.1    Sánchez-Martín, M.2    Pérez-Caro, M.3    Pérez-Mancera, P.A.4    Sánchez-García, I.5
  • 75
    • 77956534980 scopus 로고    scopus 로고
    • Expression of slug is regulated by c-myb and is required for invasion and bone marrow homing of cancer cells of different origin
    • B. Tanno, F. Sesti, V. Cesi et al., "Expression of slug is regulated by c-Myb and is required for invasion and bone marrow homing of cancer cells of different origin," Journal of Biological Chemistry, vol. 285, no. 38, pp. 29434-29445, 2010.
    • (2010) Journal of Biological Chemistry , vol.285 , Issue.38 , pp. 29434-29445
    • Tanno, B.1    Sesti, F.2    Cesi, V.3
  • 76
    • 84863160718 scopus 로고    scopus 로고
    • Critical and reciprocal regulation of KLF4 and SLUG in transforming growth factor β-initiated prostate cancer epithelial-mesenchymal transition
    • Y.-N. Liu, W. Abou-Kheir, J. J. Yin et al., "Critical and reciprocal regulation of KLF4 and SLUG in transforming growth factor β-initiated prostate cancer epithelial-mesenchymal transition," Molecular and Cellular Biology, vol. 32, no. 5, pp. 941-953, 2012.
    • (2012) Molecular and Cellular Biology , vol.32 , Issue.5 , pp. 941-953
    • Liu, Y.-N.1    Abou-Kheir, W.2    Yin, J.J.3
  • 77
    • 84863280130 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition induced by TNF-α requires NF-κB-mediated transcriptional upregulation of twist1
    • C.-W. Li, W. Xia, L. Huo et al., "Epithelial-mesenchymal transition induced by TNF-α requires NF-κB-mediated transcriptional upregulation of Twist1," Cancer Research, vol. 72, no. 5, pp. 1290-1300, 2012.
    • (2012) Cancer Research , vol.72 , Issue.5 , pp. 1290-1300
    • Li, C.-W.1    Xia, W.2    Huo, L.3
  • 78
    • 84865339352 scopus 로고    scopus 로고
    • Activation of the Notch1/STAT3/Twist signaling axis promotes gastric cancer progression
    • K.-W. Hsu, R.-H. Hsieh, K.-H. Huang et al., "Activation of the Notch1/STAT3/Twist signaling axis promotes gastric cancer progression," Carcinogenesis, vol. 33, no. 8, pp. 1459-1467, 2012.
    • (2012) Carcinogenesis , vol.33 , Issue.8 , pp. 1459-1467
    • Hsu, K.-W.1    Hsieh, R.-H.2    Huang, K.-H.3
  • 79
    • 0028933142 scopus 로고
    • Twist is required in head mesenchyme for cranial neural tubemorphogenesis
    • Z.-F. Chen and R. R. Behringer, "Twist is required in head mesenchyme for cranial neural tubemorphogenesis," Genes and Development, vol. 9, no. 6, pp. 686-699, 1995.
    • (1995) Genes and Development , vol.9 , Issue.6 , pp. 686-699
    • Chen, Z.-F.1    Behringer, R.R.2
  • 80
    • 40249113328 scopus 로고    scopus 로고
    • Direct regulation of TWIST by HIF-1α promotes metastasis
    • M.-H. Yang, M.-Z. Wu, S.-H. Chiou et al., "Direct regulation of TWIST by HIF-1α promotes metastasis," Nature Cell Biology, vol. 10, no. 3, pp. 295-305, 2008.
    • (2008) Nature Cell Biology , vol.10 , Issue.3 , pp. 295-305
    • Yang, M.-H.1    Wu, M.-Z.2    Chiou, S.-H.3
  • 81
    • 84883470829 scopus 로고    scopus 로고
    • Mesenchymal CD44 expression contributes to the acquisition of an activated fibroblast phenotype via TWIST activation in the tumor microenvironment
    • E. L. Spaeth, A. M. Labaff, B. P. Toole, A. Klopp, M. Andreeff, and F. C. Marini, "Mesenchymal CD44 expression contributes to the acquisition of an activated fibroblast phenotype via TWIST activation in the tumor microenvironment," Cancer Research, vol. 73, no. 17, pp. 5347-5359, 2013.
    • (2013) Cancer Research , vol.73 , Issue.17 , pp. 5347-5359
    • Spaeth, E.L.1    Labaff, A.M.2    Toole, B.P.3    Klopp, A.4    Andreeff, M.5    Marini, F.C.6
  • 82
    • 0035803583 scopus 로고    scopus 로고
    • Functional anatomy of siRNAs for mediating efficient RNAi in drosophila melanogaster embryo lysate
    • S. M. Elbashir, J. Martinez, A. Patkaniowska, W. Lendeckel, and T. Tuschl, "Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate," EMBO Journal, vol. 20, no. 23, pp. 6877-6888, 2001.
    • (2001) EMBO Journal , vol.20 , Issue.23 , pp. 6877-6888
    • Elbashir, S.M.1    Martinez, J.2    Patkaniowska, A.3    Lendeckel, W.4    Tuschl, T.5
  • 83
    • 0035863097 scopus 로고    scopus 로고
    • RNA interference is mediated by 21- and 22-nucleotide RNAs
    • S.M. Elbashir, W. Lendeckel, and T. Tuschl, "RNA interference is mediated by 21- and 22-nucleotide RNAs," Genes and Development, vol. 15, no. 2, pp. 188-200, 2001.
    • (2001) Genes and Development , vol.15 , Issue.2 , pp. 188-200
    • Elbashir, S.M.1    Lendeckel, W.2    Tuschl, T.3
  • 84
    • 68749117685 scopus 로고    scopus 로고
    • Prognostic value of dicer expression in human breast cancers and association with the mesenchymal phenotype
    • G. Grelier, N. Voirin, A.-S. Ay et al., "Prognostic value of Dicer expression in human breast cancers and association with the mesenchymal phenotype," British Journal of Cancer, vol. 101, no. 4, pp. 673-683, 2009.
    • (2009) British Journal of Cancer , vol.101 , Issue.4 , pp. 673-683
    • Grelier, G.1    Voirin, N.2    Ay, A.-S.3
  • 85
    • 84855729906 scopus 로고    scopus 로고
    • A p53/miRNA-34 axis regulates snail1-dependent cancer cell epithelial-mesenchymal transition
    • N. H. Kim, H. S. Kim, X.-Y. Li et al., "A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial-mesenchymal transition," Journal of Cell Biology, vol. 195, no. 3, pp. 417-433, 2011.
    • (2011) Journal of Cell Biology , vol.195 , Issue.3 , pp. 417-433
    • Kim, N.H.1    Kim, H.S.2    Li, X.-Y.3
  • 86
    • 84055184850 scopus 로고    scopus 로고
    • MiR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions
    • H. Siemens, R. Jackstadt, S. Hünten et al., "miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions," Cell Cycle, vol. 10, no. 24, pp. 4256-4271, 2011.
    • (2011) Cell Cycle , vol.10 , Issue.24 , pp. 4256-4271
    • Siemens, H.1    Jackstadt, R.2    Hünten, S.3
  • 87
    • 84877263242 scopus 로고    scopus 로고
    • A microRNA miR-34aregulated bimodal switch targets notch in colon cancer stem cells
    • P. Bu, K.-Y. Chen, J. H. Chen et al., "A microRNA miR-34aregulated bimodal switch targets notch in colon cancer stem cells," Cell Stem Cell, vol. 12, no. 5, pp. 602-615, 2013.
    • (2013) Cell Stem Cell , vol.12 , Issue.5 , pp. 602-615
    • Bu, P.1    Chen, K.-Y.2    Chen, J.H.3
  • 88
    • 84920783923 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition transcription factors and miRNAs: 'Plastic surgeons' of breast cancer
    • C. Moyret-Lalle, E. Ruiz, and A. Puisieux, "Epithelial-mesenchymal transition transcription factors and miRNAs: 'Plastic surgeons' of breast cancer," World Journal of Clinical Oncology, vol. 5, no. 3, pp. 311-322, 2014.
    • (2014) World Journal of Clinical Oncology , vol.5 , Issue.3 , pp. 311-322
    • Moyret-Lalle, C.1    Ruiz, E.2    Puisieux, A.3
  • 89
    • 84857507248 scopus 로고    scopus 로고
    • MicroRNA-30a inhibits epithelial-to-mesenchymal transition by targeting snai1 and is downregulated in non-small cell lung cancer
    • R. Kumarswamy, G. Mudduluru, P. Ceppi et al., "MicroRNA-30a inhibits epithelial-to-mesenchymal transition by targeting Snai1 and is downregulated in non-small cell lung cancer," International Journal of Cancer, vol. 130, no. 9, pp. 2044-2053, 2012.
    • (2012) International Journal of Cancer , vol.130 , Issue.9 , pp. 2044-2053
    • Kumarswamy, R.1    Mudduluru, G.2    Ceppi, P.3
  • 90
    • 82755182755 scopus 로고    scopus 로고
    • MicroRNA-9 up-regulates E-cadherin through inhibition of NF-κB1-snail1 pathway in melanoma
    • S. Liu, S. M. Kumar, H. Lu et al., "MicroRNA-9 up-regulates E-cadherin through inhibition of NF-κB1-Snail1 pathway in melanoma," Journal of Pathology, vol. 226, no. 1, pp. 61-72, 2012.
    • (2012) Journal of Pathology , vol.226 , Issue.1 , pp. 61-72
    • Liu, S.1    Kumar, S.M.2    Lu, H.3
  • 91
    • 84944930262 scopus 로고    scopus 로고
    • The role of MALAT1/miR-1/slug axis on radioresistance in nasopharyngeal carcinoma
    • C. Jin, B. Yan, Q. Lu, Y. Lin, and L. Ma, "The role of MALAT1/miR-1/slug axis on radioresistance in nasopharyngeal carcinoma," Tumor Biology, vol. 37, no. 3, pp. 4025-4033, 2016.
    • (2016) Tumor Biology , vol.37 , Issue.3 , pp. 4025-4033
    • Jin, C.1    Yan, B.2    Lu, Q.3    Lin, Y.4    Ma, L.5
  • 92
    • 84858992906 scopus 로고    scopus 로고
    • Loss of brain-enriched miR-124 microRNA enhances stem-like traits and invasiveness of glioma cells
    • H. Xia, W. K. C. Cheung, S. S. Ng et al., "Loss of brain-enriched miR-124 microRNA enhances stem-like traits and invasiveness of glioma cells," Journal of Biological Chemistry, vol. 287, no. 13, pp. 9962-9971, 2012.
    • (2012) Journal of Biological Chemistry , vol.287 , Issue.13 , pp. 9962-9971
    • Xia, H.1    Cheung, W.K.C.2    Ng, S.S.3
  • 93
    • 84859121913 scopus 로고    scopus 로고
    • Epigenetic silencing of miR-203 upregulates SNAI2 and contributes to the invasiveness of malignant breast cancer cells
    • Z. Zhang, B. Zhang, W. Li et al., "Epigenetic silencing of miR-203 upregulates SNAI2 and Contributes to the invasiveness of malignant breast cancer cells," Genes and Cancer, vol. 2, no. 8, pp. 782-791, 2011.
    • (2011) Genes and Cancer , vol.2 , Issue.8 , pp. 782-791
    • Zhang, Z.1    Zhang, B.2    Li, W.3
  • 94
    • 77952307133 scopus 로고    scopus 로고
    • MicroRNA-204/211 alters epithelial physiology
    • F. E. Wang, C. Zhang, A. Maminishkis et al., "MicroRNA-204/211 alters epithelial physiology," FASEB Journal, vol. 24, no. 5, pp. 1552-1571, 2010.
    • (2010) FASEB Journal , vol.24 , Issue.5 , pp. 1552-1571
    • Wang, F.E.1    Zhang, C.2    Maminishkis, A.3
  • 95
    • 77958117982 scopus 로고    scopus 로고
    • MiR-124a is important for migratory cell fate transition during gastrulation of human embryonic stem cells
    • M. R. Lee, J. S. Kim, and K.-S. Kim, "MiR-124a is important for migratory cell fate transition during gastrulation of human embryonic stem cells," Stem Cells, vol. 28, no. 9, pp. 1550-1559, 2010.
    • (2010) Stem Cells , vol.28 , Issue.9 , pp. 1550-1559
    • Lee, M.R.1    Kim, J.S.2    Kim, K.-S.3
  • 96
    • 84862513160 scopus 로고    scopus 로고
    • Downregulation of miR-214 contributes to intrahepatic cholangiocarcinoma metastasis by targeting twist
    • B. Li, Q. Han, Y. Zhu, Y. Yu, J. Wang, and X. Jiang, "Downregulation of miR-214 contributes to intrahepatic cholangiocarcinoma metastasis by targeting Twist," FEBS Journal, vol. 279, no. 13, pp. 2393-2398, 2012.
    • (2012) FEBS Journal , vol.279 , Issue.13 , pp. 2393-2398
    • Li, B.1    Han, Q.2    Zhu, Y.3    Yu, Y.4    Wang, J.5    Jiang, X.6
  • 97
    • 84870065750 scopus 로고    scopus 로고
    • Translational control of TWIST1 expression in MCF-10A cell lines recapitulating breast cancer progression
    • M.-L. Nairismägi, A. Vislovukh, Q. Meng et al., "Translational control of TWIST1 expression in MCF-10A cell lines recapitulating breast cancer progression," Oncogene, vol. 31, no. 47, pp. 4960-4966, 2012.
    • (2012) Oncogene , vol.31 , Issue.47 , pp. 4960-4966
    • Nairismägi, M.-L.1    Vislovukh, A.2    Meng, Q.3
  • 98
    • 79960799901 scopus 로고    scopus 로고
    • Let-7d functions as novel regulator of epithelial-mesenchymal transition and chemoresistant property in oral cancer
    • C.-J. Chang, C.-C. Hsu, C.-H. Chang et al., "Let-7d functions as novel regulator of epithelial-mesenchymal transition and chemoresistant property in oral cancer," Oncology Reports, vol. 26, no. 4, pp. 1003-1010, 2011.
    • (2011) Oncology Reports , vol.26 , Issue.4 , pp. 1003-1010
    • Chang, C.-J.1    Hsu, C.-C.2    Chang, C.-H.3
  • 99
    • 84867578091 scopus 로고    scopus 로고
    • EMT-activating transcription factors in cancer: Beyond EMT and tumor invasiveness
    • E. Sánchez-Tilló, Y. Liu, O. De Barrios et al., "EMT-activating transcription factors in cancer: beyond EMT and tumor invasiveness," Cellular and Molecular Life Sciences, vol. 69, no. 20, pp. 3429-3456, 2012.
    • (2012) Cellular and Molecular Life Sciences , vol.69 , Issue.20 , pp. 3429-3456
    • Sánchez-Tilló, E.1    Liu, Y.2    De Barrios, O.3
  • 100
    • 79751473114 scopus 로고    scopus 로고
    • ThemicroRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44
    • C. Liu, K. Kelnar, B. Liu et al., "ThemicroRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44," Nature Medicine, vol. 17, no. 2, pp. 211-216, 2011.
    • (2011) Nature Medicine , vol.17 , Issue.2 , pp. 211-216
    • Liu, C.1    Kelnar, K.2    Liu, B.3
  • 101
    • 79957900919 scopus 로고    scopus 로고
    • Systemic delivery of tumor suppressor microRNA mimics using a neutral lipid emulsion inhibits lung tumors in mice
    • P. Trang, J. F. Wiggins, C. L. Daige et al., "Systemic delivery of tumor suppressor microRNA mimics using a neutral lipid emulsion inhibits lung tumors in mice," Molecular Therapy, vol. 19, no. 6, pp. 1116-1122, 2011.
    • (2011) Molecular Therapy , vol.19 , Issue.6 , pp. 1116-1122
    • Trang, P.1    Wiggins, J.F.2    Daige, C.L.3
  • 102
    • 16844377441 scopus 로고    scopus 로고
    • Pak1 phosphorylation of snail, amaster regulator of epithelial-to-mesenchyme transition, modulates Snail's subcellular localization and functions
    • Z. Yang, S. Rayala, D. Nguyen, R. K. Vadlamudi, S. Chen, and R. Kumar, "Pak1 phosphorylation of Snail, amaster regulator of epithelial-to-mesenchyme transition, modulates Snail's subcellular localization and functions," Cancer Research, vol. 65, no. 8, pp. 3179-3184, 2005.
    • (2005) Cancer Research , vol.65 , Issue.8 , pp. 3179-3184
    • Yang, Z.1    Rayala, S.2    Nguyen, D.3    Vadlamudi, R.K.4    Chen, S.5    Kumar, R.6
  • 103
    • 84855358964 scopus 로고    scopus 로고
    • Lats2 kinase potentiates snail1 activity by promoting nuclear retention upon phosphorylation
    • K. Zhang, E. Rodriguez-Aznar, N. Yabuta et al., "Lats2 kinase potentiates Snail1 activity by promoting nuclear retention upon phosphorylation," EMBO Journal, vol. 31, no. 1, pp. 29-43, 2012.
    • (2012) EMBO Journal , vol.31 , Issue.1 , pp. 29-43
    • Zhang, K.1    Rodriguez-Aznar, E.2    Yabuta, N.3
  • 104
    • 78049284317 scopus 로고    scopus 로고
    • Protein kinase D1 suppresses epithelial-to-mesenchymal transition through phosphorylation of snail
    • C. Du, C. Zhang, S. Hassan, M. H. U. Biswas, and K. C. Balaji, "Protein kinase D1 suppresses epithelial-to-mesenchymal transition through phosphorylation of snail," Cancer Research, vol. 70, no. 20, pp. 7810-7819, 2010.
    • (2010) Cancer Research , vol.70 , Issue.20 , pp. 7810-7819
    • Du, C.1    Zhang, C.2    Hassan, S.3    Biswas, M.H.U.4    Balaji, K.C.5
  • 105
    • 84905993798 scopus 로고    scopus 로고
    • Snail promotes epithelial mesenchymal transition in breast cancer cells in part via activation of nuclear ERK2
    • B. N. Smith, L. J. Burton, V. Henderson et al., "Snail promotes epithelial mesenchymal transition in breast cancer cells in part via activation of nuclear ERK2," PLoS ONE, vol. 9, no. 8, Article ID e104987, 2014.
    • (2014) PLoS ONE , vol.9 , Issue.8
    • Smith, B.N.1    Burton, L.J.2    Henderson, V.3
  • 106
    • 33751514601 scopus 로고    scopus 로고
    • A wnt-axin2-GSK3β cascade regulates snail1 activity in breast cancer cells
    • J. I. Yook, X.-Y. Li, I. Ota et al., "A Wnt-Axin2-GSK3β cascade regulates Snail1 activity in breast cancer cells," Nature Cell Biology, vol. 8, no. 12, pp. 1398-1406, 2006.
    • (2006) Nature Cell Biology , vol.8 , Issue.12 , pp. 1398-1406
    • Yook, J.I.1    Li, X.-Y.2    Ota, I.3
  • 107
    • 84962205007 scopus 로고    scopus 로고
    • AKT1 inhibits epithelial-tomesenchymal transition in breast cancer through phosphorylation-dependent twist1 degradation
    • C. W. Li, W. Xia, S. O. Lim et al., "AKT1 inhibits epithelial-tomesenchymal transition in breast cancer through phosphorylation-dependent twist1 degradation," Cancer Research, vol. 76, no. 6, pp. 1451-1462, 2016.
    • (2016) Cancer Research , vol.76 , Issue.6 , pp. 1451-1462
    • Li, C.W.1    Xia, W.2    Lim, S.O.3
  • 108
    • 84881298549 scopus 로고    scopus 로고
    • Degradation of the transcription factor twist, an oncoprotein that promotes cancer metastasis
    • J. Zhong, K. Ogura, Z. Wang, and H. Inuzuka, "Degradation of the transcription factor twist, an oncoprotein that promotes cancer metastasis," Discovery Medicine, vol. 15, no. 80, pp. 7-15, 2013.
    • (2013) Discovery Medicine , vol.15 , Issue.80 , pp. 7-15
    • Zhong, J.1    Ogura, K.2    Wang, Z.3    Inuzuka, H.4
  • 109
    • 84874586520 scopus 로고    scopus 로고
    • Interactions between twist and other core epithelial-mesenchymal transition factors are controlled by GSK3-mediated phosphorylation
    • R. Lander, T. Nasr, S. D. Ochoa, K. Nordin, M. S. Prasad, and C. Labonne, "Interactions between Twist and other core epithelial-mesenchymal transition factors are controlled by GSK3-mediated phosphorylation," Nature Communications, vol. 4, article 1542, 2013.
    • (2013) Nature Communications , vol.4
    • Lander, R.1    Nasr, T.2    Ochoa, S.D.3    Nordin, K.4    Prasad, M.S.5    Labonne, C.6
  • 110
    • 79957883313 scopus 로고    scopus 로고
    • Phosphorylation of serine 68 of twist1 by MAPKs stabilizes twist1 protein and promotes breast cancer cell invasiveness
    • J. Hong, J. Zhou, J. Fu et al., "Phosphorylation of serine 68 of twist1 by MAPKs stabilizes twist1 protein and promotes breast cancer cell invasiveness," Cancer Research, vol. 71, no. 11, pp. 3980-3990, 2011.
    • (2011) Cancer Research , vol.71 , Issue.11 , pp. 3980-3990
    • Hong, J.1    Zhou, J.2    Fu, J.3
  • 111
    • 79960283982 scopus 로고    scopus 로고
    • The F-box protein ppa is a common regulator of core EMT factors twist, snail, slug, and sip1
    • R. Lander, K. Nordin, and C. LaBonne, "The F-box protein Ppa is a common regulator of core EMT factors Twist, Snail, Slug, and Sip1," Journal of Cell Biology, vol. 194, no. 1, pp. 17-25, 2011.
    • (2011) Journal of Cell Biology , vol.194 , Issue.1 , pp. 17-25
    • Lander, R.1    Nordin, K.2    LaBonne, C.3
  • 112
    • 84893519959 scopus 로고    scopus 로고
    • Disrupting the interaction of BRD4 with diacetylated twist suppresses tumorigenesis in basal-like breast cancer
    • J. Shi, Y. Wang, L. Zeng et al., "Disrupting the interaction of BRD4 with diacetylated twist suppresses tumorigenesis in basal-like breast cancer," Cancer Cell, vol. 25, no. 2, pp. 210-225, 2014.
    • (2014) Cancer Cell , vol.25 , Issue.2 , pp. 210-225
    • Shi, J.1    Wang, Y.2    Zeng, L.3
  • 113
    • 67349166210 scopus 로고    scopus 로고
    • P53 controls cancer cell invasion by inducing the MDM2-mediated degradation of slug
    • S.-P. Wang, W.-L. Wang, Y.-L. Chang et al., "p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug," Nature Cell Biology, vol. 11, no. 6, pp. 694-704, 2009.
    • (2009) Nature Cell Biology , vol.11 , Issue.6 , pp. 694-704
    • Wang, S.-P.1    Wang, W.-L.2    Chang, Y.-L.3
  • 114
    • 84908666051 scopus 로고    scopus 로고
    • PKD1 phosphorylation dependent degradation of SNAIL by SCF-FBXO11 regulates epithelial-mesenchymal transition and metastasis
    • H. Zheng, M. Shen, Y.-L. Zha et al., "PKD1 phosphorylation dependent degradation of SNAIL by SCF-FBXO11 regulates epithelial-mesenchymal transition and metastasis," Cancer Cell, vol. 26, no. 3, pp. 358-373, 2014.
    • (2014) Cancer Cell , vol.26 , Issue.3 , pp. 358-373
    • Zheng, H.1    Shen, M.2    Zha, Y.-L.3
  • 115
    • 84902533403 scopus 로고    scopus 로고
    • MicroRNAs as therapeutic targets in human cancers
    • M. Y. Shah and G. A. Calin, "MicroRNAs as therapeutic targets in human cancers," Wiley Interdisciplinary Reviews: RNA, vol. 5, no. 4, pp. 537-548, 2014.
    • (2014) Wiley Interdisciplinary Reviews: RNA , vol.5 , Issue.4 , pp. 537-548
    • Shah, M.Y.1    Calin, G.A.2
  • 116
    • 67650403364 scopus 로고    scopus 로고
    • Controlled delivery of antisense oligonucleotides: A brief review of current strategies
    • X. Zhao, F. Pan, C.M. Holt, A.L. Lewis, and J. R. Lu, "Controlled delivery of antisense oligonucleotides: a brief review of current strategies," Expert Opinion on Drug Delivery, vol. 6, no. 7, pp. 673-686, 2009.
    • (2009) Expert Opinion on Drug Delivery , vol.6 , Issue.7 , pp. 673-686
    • Zhao, X.1    Pan, F.2    Holt, C.M.3    Lewis, A.L.4    Lu, J.R.5
  • 117
    • 77957361864 scopus 로고    scopus 로고
    • Targeting microRNAs in cancer: Rationale, strategies and challenges
    • R. Garzon, G. Marcucci, and C. M. Croce, "Targeting microRNAs in cancer: rationale, strategies and challenges," Nature Reviews Drug Discovery, vol. 9, no. 10, pp. 775-789, 2010.
    • (2010) Nature Reviews Drug Discovery , vol.9 , Issue.10 , pp. 775-789
    • Garzon, R.1    Marcucci, G.2    Croce, C.M.3
  • 118
    • 84892948811 scopus 로고    scopus 로고
    • Emerging therapies targeting the ubiquitin proteasome systemin cancer
    • N. M. Weathington and R. K. Mallampalli, "Emerging therapies targeting the ubiquitin proteasome systemin cancer," Journal of Clinical Investigation, vol. 124, no. 1, pp. 6-12, 2014.
    • (2014) Journal of Clinical Investigation , vol.124 , Issue.1 , pp. 6-12
    • Weathington, N.M.1    Mallampalli, R.K.2
  • 119
    • 84863338304 scopus 로고    scopus 로고
    • Ubiquitination in signaling to and activation of IKK
    • Z. J. Chen, "Ubiquitination in signaling to and activation of IKK," Immunological Reviews, vol. 246, no. 1, pp. 95-106, 2012.
    • (2012) Immunological Reviews , vol.246 , Issue.1 , pp. 95-106
    • Chen, Z.J.1
  • 120
    • 84908073344 scopus 로고    scopus 로고
    • Posttranslational regulation of akt in human cancer
    • C. H. Chan, U. Jo, A. Kohrman et al., "Posttranslational regulation of Akt in human cancer," Cell & Bioscience, vol. 4, no. 1, article 59, 2014.
    • (2014) Cell & Bioscience , vol.4 , Issue.1
    • Chan, C.H.1    Jo, U.2    Kohrman, A.3
  • 121
    • 84991701993 scopus 로고    scopus 로고
    • The DNA damage transducer RNF8 facilitates cancer chemoresistance and progression through twist activation
    • H. Lee, C. Li, D. Ruan et al., "The DNA damage transducer RNF8 facilitates cancer chemoresistance and progression through twist activation," Molecular Cell, vol. 63, no. 6, pp. 1021-1033, 2016.
    • (2016) Molecular Cell , vol.63 , Issue.6 , pp. 1021-1033
    • Lee, H.1    Li, C.2    Ruan, D.3
  • 122
    • 84920733761 scopus 로고    scopus 로고
    • Different levels of twist1 regulate skin tumor initiation, stemness, and progression
    • B. Beck, G. Lapouge, S. Rorive et al., "Different levels of Twist1 regulate skin tumor initiation, stemness, and progression," Cell Stem Cell, vol. 16, no. 1, pp. 67-79, 2015.
    • (2015) Cell Stem Cell , vol.16 , Issue.1 , pp. 67-79
    • Beck, B.1    Lapouge, G.2    Rorive, S.3
  • 123
    • 84920942890 scopus 로고    scopus 로고
    • Stem-celllike properties and epithelial plasticity arise as stable traits after transient twist1 activation
    • J. M. Schmidt, E. Panzilius, H. S. Bartsch et al., "Stem-celllike properties and epithelial plasticity arise as stable traits after transient twist1 activation," Cell Reports, vol. 10, no. 2, pp. 131-139, 2015.
    • (2015) Cell Reports , vol.10 , Issue.2 , pp. 131-139
    • Schmidt, J.M.1    Panzilius, E.2    Bartsch, H.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.