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Volumn 46, Issue 9, 2015, Pages 1267-1274

Expression of epithelial-mesenchymal transition-related markers in triple-negative breast cancer: ZEB1 as a potential biomarker for poor clinical outcome

Author keywords

CD146; Epithelial mesenchymal transition; Metaplastic carcinoma; Triple negative breast cancer; ZEB1

Indexed keywords

ALDEHYDE DEHYDROGENASE ISOENZYME 1; BIOLOGICAL MARKER; CD146 ANTIGEN; CD24 ANTIGEN; HERMES ANTIGEN; NERVE CELL ADHESION MOLECULE; OSTEONECTIN; SMOOTH MUSCLE ACTIN; TRANSCRIPTION FACTOR ZEB1; UVOMORULIN; VIMENTIN; HOMEODOMAIN PROTEIN; MCAM PROTEIN, HUMAN; TRANSCRIPTION FACTOR; TUMOR MARKER; ZEB1 PROTEIN, HUMAN;

EID: 84940462949     PISSN: 00468177     EISSN: 15328392     Source Type: Journal    
DOI: 10.1016/j.humpath.2015.05.010     Document Type: Article
Times cited : (119)

References (35)
  • 1
    • 34247569300 scopus 로고    scopus 로고
    • Descriptive analysis of estrogen receptor (ER)-negative, progesterone receptor (PR)-negative, and HER2-negative invasive breast cancer, the so-called triple-negative phenotype: A population-based study from the California cancer registry
    • K.R. Bauer, M. Brown, R.D. Cress, C.A. Parise, and V. Caggiano Descriptive analysis of estrogen receptor (ER)-negative, progesterone receptor (PR)-negative, and HER2-negative invasive breast cancer, the so-called triple-negative phenotype: a population-based study from the California cancer registry Cancer 109 2007 1721 1728
    • (2007) Cancer , vol.109 , pp. 1721-1728
    • Bauer, K.R.1    Brown, M.2    Cress, R.D.3    Parise, C.A.4    Caggiano, V.5
  • 2
    • 84863994288 scopus 로고    scopus 로고
    • Dissecting the heterogeneity of triple-negative breast cancer
    • O. Metzger-Filho, A. Tutt, E. de Azambuja, and et al. Dissecting the heterogeneity of triple-negative breast cancer J Clin Oncol 30 2012 1879 1887
    • (2012) J Clin Oncol , vol.30 , pp. 1879-1887
    • Metzger-Filho, O.1    Tutt, A.2    De Azambuja, E.3
  • 3
    • 80054101842 scopus 로고    scopus 로고
    • Molecular heterogeneity of triple-negative breast cancer and its clinical implications
    • S. Irshad, P. Ellis, and A. Tutt Molecular heterogeneity of triple-negative breast cancer and its clinical implications Curr Opin Oncol 23 2011 566 577
    • (2011) Curr Opin Oncol , vol.23 , pp. 566-577
    • Irshad, S.1    Ellis, P.2    Tutt, A.3
  • 4
    • 70349664011 scopus 로고    scopus 로고
    • Clinicopathological characteristics of triple-negative breast cancers
    • Y. Sasaki, and H. Tsuda Clinicopathological characteristics of triple-negative breast cancers Breast Cancer 16 2009 254 259
    • (2009) Breast Cancer , vol.16 , pp. 254-259
    • Sasaki, Y.1    Tsuda, H.2
  • 5
    • 33847063053 scopus 로고    scopus 로고
    • The triple negative paradox: Primary tumor chemosensitivity of breast cancer subtypes
    • L.A. Carey, E.C. Dees, L. Sawyer, and et al. The triple negative paradox: primary tumor chemosensitivity of breast cancer subtypes Clin Cancer Res 13 2007 2329 2334
    • (2007) Clin Cancer Res , vol.13 , pp. 2329-2334
    • Carey, L.A.1    Dees, E.C.2    Sawyer, L.3
  • 6
    • 79960015997 scopus 로고    scopus 로고
    • Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies
    • B.D. Lehmann, J.A. Bauer, X. Chen, and et al. Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies J Clin Invest 121 2011 2750 2767
    • (2011) J Clin Invest , vol.121 , pp. 2750-2767
    • Lehmann, B.D.1    Bauer, J.A.2    Chen, X.3
  • 7
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • J.P. Thiery, H. Acloque, R.Y. Huang, and M.A. Nieto Epithelial-mesenchymal transitions in development and disease Cell 139 2009 871 890
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 8
    • 67650999875 scopus 로고    scopus 로고
    • The basics of epithelial-mesenchymal transition
    • R. Kalluri, and R.A. Weinberg The basics of epithelial-mesenchymal transition J Clin Invest 119 2009 1420 1428
    • (2009) J Clin Invest , vol.119 , pp. 1420-1428
    • Kalluri, R.1    Weinberg, R.A.2
  • 9
    • 84860389952 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition and cancer stem cells: A dangerously dynamic duo in breast cancer progression
    • C.D. May, N. Sphyris, K.W. Evans, S.J. Werden, W. Guo, and S.A. Mani Epithelial-mesenchymal transition and cancer stem cells: a dangerously dynamic duo in breast cancer progression Breast Cancer Res 13 2011 202
    • (2011) Breast Cancer Res , vol.13 , pp. 202
    • May, C.D.1    Sphyris, N.2    Evans, K.W.3    Werden, S.J.4    Guo, W.5    Mani, S.A.6
  • 10
    • 77954860302 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition traits in human breast cancer cell lines parallel the CD44(hi/)CD24 (lo/-) stem cell phenotype in human breast cancer
    • T. Blick, H. Hugo, E. Widodo, and et al. Epithelial-mesenchymal transition traits in human breast cancer cell lines parallel the CD44(hi/)CD24 (lo/-) stem cell phenotype in human breast cancer J Mammary Gland Biol Neoplasia 15 2010 235 252
    • (2010) J Mammary Gland Biol Neoplasia , vol.15 , pp. 235-252
    • Blick, T.1    Hugo, H.2    Widodo, E.3
  • 11
    • 43049165453 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition generates cells with properties of stem cells
    • S.A. Mani, W. Guo, M.J. Liao, and et al. The epithelial-mesenchymal transition generates cells with properties of stem cells Cell 133 2008 704 715
    • (2008) Cell , vol.133 , pp. 704-715
    • Mani, S.A.1    Guo, W.2    Liao, M.J.3
  • 12
    • 84880326175 scopus 로고    scopus 로고
    • Tissue-based identification of stem cells and epithelial-to-mesenchymal transition in breast cancer
    • T.E. Anwar, and C.G. Kleer Tissue-based identification of stem cells and epithelial-to-mesenchymal transition in breast cancer Hum Pathol 44 2013 1457 1464
    • (2013) Hum Pathol , vol.44 , pp. 1457-1464
    • Anwar, T.E.1    Kleer, C.G.2
  • 14
    • 84862820130 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition in breast cancer correlates with high histological grade and triple-negative phenotype
    • H. Jeong, Y.J. Ryu, J. An, Y. Lee, and A. Kim Epithelial-mesenchymal transition in breast cancer correlates with high histological grade and triple-negative phenotype Histopathology 60 2012 E87 E95
    • (2012) Histopathology , vol.60 , pp. E87-E95
    • Jeong, H.1    Ryu, Y.J.2    An, J.3    Lee, Y.4    Kim, A.5
  • 15
    • 84885632147 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition increases during the progression of in situ to invasive basal-like breast cancer
    • Y. Choi, H.J. Lee, M.H. Jang, and et al. Epithelial-mesenchymal transition increases during the progression of in situ to invasive basal-like breast cancer Hum Pathol 44 2013 2581 2589
    • (2013) Hum Pathol , vol.44 , pp. 2581-2589
    • Choi, Y.1    Lee, H.J.2    Jang, M.H.3
  • 16
    • 77954526150 scopus 로고    scopus 로고
    • American Society of Clinical Oncology/College of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer
    • M.E. Hammond, D.F. Hayes, M. Dowsett, and et al. American Society of Clinical Oncology/College of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer J Clin Oncol 28 2010 2784 2795
    • (2010) J Clin Oncol , vol.28 , pp. 2784-2795
    • Hammond, M.E.1    Hayes, D.F.2    Dowsett, M.3
  • 17
    • 33847147313 scopus 로고    scopus 로고
    • American Society of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer
    • A.C. Wolff, M.E. Hammond, J.N. Schwartz, and et al. American Society of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer J Clin Oncol 25 2007 118 145
    • (2007) J Clin Oncol , vol.25 , pp. 118-145
    • Wolff, A.C.1    Hammond, M.E.2    Schwartz, J.N.3
  • 18
    • 84925229539 scopus 로고    scopus 로고
    • High EGFR gene copy number predicts poor outcome in triple-negative breast cancer
    • H.S. Park, M.H. Jang, E.J. Kim, and et al. High EGFR gene copy number predicts poor outcome in triple-negative breast cancer Mod Pathol 27 2014 1212 1222
    • (2014) Mod Pathol , vol.27 , pp. 1212-1222
    • Park, H.S.1    Jang, M.H.2    Kim, E.J.3
  • 19
    • 84886412350 scopus 로고    scopus 로고
    • Differential response to neoadjuvant chemotherapy among 7 triple-negative breast cancer molecular subtypes
    • H. Masuda, K.A. Baggerly, Y. Wang, and et al. Differential response to neoadjuvant chemotherapy among 7 triple-negative breast cancer molecular subtypes Clin Cancer Res 19 2013 5533 5540
    • (2013) Clin Cancer Res , vol.19 , pp. 5533-5540
    • Masuda, H.1    Baggerly, K.A.2    Wang, Y.3
  • 20
    • 37149040456 scopus 로고    scopus 로고
    • Molecular signatures of metaplastic carcinoma of the breast by large-scale transcriptional profiling: Identification of genes potentially related to epithelial-mesenchymal transition
    • H.C. Lien, Y.H. Hsiao, Y.S. Lin, and et al. Molecular signatures of metaplastic carcinoma of the breast by large-scale transcriptional profiling: identification of genes potentially related to epithelial-mesenchymal transition Oncogene 26 2007 7859 7871
    • (2007) Oncogene , vol.26 , pp. 7859-7871
    • Lien, H.C.1    Hsiao, Y.H.2    Lin, Y.S.3
  • 21
    • 68949136025 scopus 로고    scopus 로고
    • Metaplastic breast carcinomas are basal-like breast cancers: A genomic profiling analysis
    • B. Weigelt, B. Kreike, and J.S. Reis-Filho Metaplastic breast carcinomas are basal-like breast cancers: a genomic profiling analysis Breast Cancer Res Treat 117 2009 273 280
    • (2009) Breast Cancer Res Treat , vol.117 , pp. 273-280
    • Weigelt, B.1    Kreike, B.2    Reis-Filho, J.S.3
  • 22
    • 84876295683 scopus 로고    scopus 로고
    • Vimentin as a poor prognostic factor for triple-negative breast cancer
    • N. Yamashita, E. Tokunaga, H. Kitao, and et al. Vimentin as a poor prognostic factor for triple-negative breast cancer J Cancer Res Clin Oncol 139 2013 739 746
    • (2013) J Cancer Res Clin Oncol , vol.139 , pp. 739-746
    • Yamashita, N.1    Tokunaga, E.2    Kitao, H.3
  • 23
    • 77954656936 scopus 로고    scopus 로고
    • Significance of E-cadherin expression in triple-negative breast cancer
    • S. Kashiwagi, M. Yashiro, T. Takashima, and et al. Significance of E-cadherin expression in triple-negative breast cancer Br J Cancer 103 2010 249 255
    • (2010) Br J Cancer , vol.103 , pp. 249-255
    • Kashiwagi, S.1    Yashiro, M.2    Takashima, T.3
  • 24
    • 84864472736 scopus 로고    scopus 로고
    • The expression and clinical significance of the androgen receptor and E-cadherin in triple-negative breast cancer
    • D. Tang, S. Xu, Q. Zhang, and W. Zhao The expression and clinical significance of the androgen receptor and E-cadherin in triple-negative breast cancer Med Oncol 29 2012 526 533
    • (2012) Med Oncol , vol.29 , pp. 526-533
    • Tang, D.1    Xu, S.2    Zhang, Q.3    Zhao, W.4
  • 25
    • 67549149803 scopus 로고    scopus 로고
    • CD146 expression is associated with a poor prognosis in human breast tumors and with enhanced motility in breast cancer cell lines
    • G. Zabouo, A.M. Imbert, J. Jacquemier, and et al. CD146 expression is associated with a poor prognosis in human breast tumors and with enhanced motility in breast cancer cell lines Breast Cancer Res 11 2009 R1
    • (2009) Breast Cancer Res , vol.11 , pp. R1
    • Zabouo, G.1    Imbert, A.M.2    Jacquemier, J.3
  • 26
    • 79954610473 scopus 로고    scopus 로고
    • Up-regulation of METCAM/MUC18 promotes motility, invasion, and tumorigenesis of human breast cancer cells
    • G.F. Zeng, S.X. Cai, and G.J. Wu Up-regulation of METCAM/MUC18 promotes motility, invasion, and tumorigenesis of human breast cancer cells BMC Cancer 11 2011 113
    • (2011) BMC Cancer , vol.11 , pp. 113
    • Zeng, G.F.1    Cai, S.X.2    Wu, G.J.3
  • 27
    • 34248191183 scopus 로고    scopus 로고
    • Poor prognosis in breast carcinomas correlates with increased expression of targetable CD146 and c-Met and with proteomic basal-like phenotype
    • S. Garcia, J.P. Dales, E. Charafe-Jauffret, and et al. Poor prognosis in breast carcinomas correlates with increased expression of targetable CD146 and c-Met and with proteomic basal-like phenotype Hum Pathol 38 2007 830 841
    • (2007) Hum Pathol , vol.38 , pp. 830-841
    • Garcia, S.1    Dales, J.P.2    Charafe-Jauffret, E.3
  • 28
    • 84863012785 scopus 로고    scopus 로고
    • CD146, an epithelial-mesenchymal transition inducer, is associated with triple-negative breast cancer
    • Q. Zeng, W. Li, D. Lu, and et al. CD146, an epithelial-mesenchymal transition inducer, is associated with triple-negative breast cancer Proc Natl Acad Sci U S A 109 2012 1127 1132
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 1127-1132
    • Zeng, Q.1    Li, W.2    Lu, D.3
  • 29
    • 39049160267 scopus 로고    scopus 로고
    • The transcriptional repressor ZEB1 promotes metastasis and loss of cell polarity in cancer
    • S. Spaderna, O. Schmalhofer, M. Wahlbuhl, and et al. The transcriptional repressor ZEB1 promotes metastasis and loss of cell polarity in cancer Cancer Res 68 2008 537 544
    • (2008) Cancer Res , vol.68 , pp. 537-544
    • Spaderna, S.1    Schmalhofer, O.2    Wahlbuhl, M.3
  • 30
    • 0034964418 scopus 로고    scopus 로고
    • The two-handed e box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion
    • J. Comijn, G. Berx, P. Vermassen, and et al. The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion Mol Cell 7 2001 1267 1278
    • (2001) Mol Cell , vol.7 , pp. 1267-1278
    • Comijn, J.1    Berx, G.2    Vermassen, P.3
  • 31
    • 20144388095 scopus 로고    scopus 로고
    • DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells
    • A. Eger, K. Aigner, S. Sonderegger, and et al. DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells Oncogene 24 2005 2375 2385
    • (2005) Oncogene , vol.24 , pp. 2375-2385
    • Eger, A.1    Aigner, K.2    Sonderegger, S.3
  • 32
    • 79951555293 scopus 로고    scopus 로고
    • Transcription factors zeb1, twist and snai1 in breast carcinoma
    • Y. Soini, H. Tuhkanen, R. Sironen, and et al. Transcription factors zeb1, twist and snai1 in breast carcinoma BMC Cancer 11 2011 73
    • (2011) BMC Cancer , vol.11 , pp. 73
    • Soini, Y.1    Tuhkanen, H.2    Sironen, R.3
  • 33
    • 84874668049 scopus 로고    scopus 로고
    • Vimentin, zeb1 and sip1 are up-regulated in triple-negative and basal-like breast cancers: Association with an aggressive tumour phenotype
    • P. Karihtala, P. Auvinen, S. Kauppila, K.M. Haapasaari, A. Jukkola-Vuorinen, and Y. Soini Vimentin, zeb1 and sip1 are up-regulated in triple-negative and basal-like breast cancers: association with an aggressive tumour phenotype Breast Cancer Res Treat 138 2013 81 90
    • (2013) Breast Cancer Res Treat , vol.138 , pp. 81-90
    • Karihtala, P.1    Auvinen, P.2    Kauppila, S.3    Haapasaari, K.M.4    Jukkola-Vuorinen, A.5    Soini, Y.6
  • 34
    • 46049120814 scopus 로고    scopus 로고
    • ZEB1 expression in type i vs type II endometrial cancers: A marker of aggressive disease
    • M. Singh, N.S. Spoelstra, A. Jean, and et al. ZEB1 expression in type I vs type II endometrial cancers: a marker of aggressive disease Mod Pathol 21 2008 912 923
    • (2008) Mod Pathol , vol.21 , pp. 912-923
    • Singh, M.1    Spoelstra, N.S.2    Jean, A.3
  • 35
    • 33645732687 scopus 로고    scopus 로고
    • The transcription factor ZEB1 is aberrantly expressed in aggressive uterine cancers
    • N.S. Spoelstra, N.G. Manning, Y. Higashi, and et al. The transcription factor ZEB1 is aberrantly expressed in aggressive uterine cancers Cancer Res 66 2006 3893 3902
    • (2006) Cancer Res , vol.66 , pp. 3893-3902
    • Spoelstra, N.S.1    Manning, N.G.2    Higashi, Y.3


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