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Volumn 29, Issue 5, 2017, Pages 821-831

Neuroinflammation, immune system and Alzheimer disease: searching for the missing link

Author keywords

Alzheimer disease; Blood brain barrier; Derived microglia microvesicles; Inflammasome; Neuroinflammation; Signalosome

Indexed keywords

ESTROGEN; INFLAMMASOME; PROTEIN; SIGNALOSOME; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG; AMYLOID BETA PROTEIN;

EID: 84990937734     PISSN: 15940667     EISSN: 17208319     Source Type: Journal    
DOI: 10.1007/s40520-016-0637-z     Document Type: Review
Times cited : (70)

References (81)
  • 2
    • 34548538990 scopus 로고    scopus 로고
    • Prevention of Alzheimer’s disease and dementia. Major findings from the Kungsholmen Project
    • 1:CAS:528:DC%2BD2sXhtVCgsrzJ, PID: 17588621
    • Fratiglioni L, Winblad B, von Strauss E (2007) Prevention of Alzheimer’s disease and dementia. Major findings from the Kungsholmen Project. Physiol Behav 92:98–104
    • (2007) Physiol Behav , vol.92 , pp. 98-104
    • Fratiglioni, L.1    Winblad, B.2    von Strauss, E.3
  • 4
    • 0026447529 scopus 로고
    • Complement activation by beta-amyloid in Alzheimer disease
    • 1:CAS:528:DyaK3sXitVektg%3D%3D, PID: 1438191
    • Rogers J, Cooper NR, Webster S et al (1992) Complement activation by beta-amyloid in Alzheimer disease. Proc Natl Acad Sci USA 89:10016–10020
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 10016-10020
    • Rogers, J.1    Cooper, N.R.2    Webster, S.3
  • 5
    • 84885456046 scopus 로고    scopus 로고
    • The amyloid cascade-inflammatory hypothesis of Alzheimer disease: implications for therapy
    • 1:CAS:528:DC%2BC3sXhsVyltb3K, PID: 24052108
    • McGeer PL, McGeer EG (2013) The amyloid cascade-inflammatory hypothesis of Alzheimer disease: implications for therapy. Acta Neuropathol 126:479–497
    • (2013) Acta Neuropathol , vol.126 , pp. 479-497
    • McGeer, P.L.1    McGeer, E.G.2
  • 6
    • 33847613885 scopus 로고    scopus 로고
    • Inflammatory processes in Alzheimer’s disease
    • 1:CAS:528:DC%2BD2sXislejtLo%3D, PID: 17222916
    • Heneka MT, O’banion MK (2007) Inflammatory processes in Alzheimer’s disease. J Neuroimmunol 184:69–91
    • (2007) J Neuroimmunol , vol.184 , pp. 69-91
    • Heneka, M.T.1    O’banion, M.K.2
  • 7
    • 79952610280 scopus 로고    scopus 로고
    • Age-related alterations in the dynamic behavior of microglia
    • 1:CAS:528:DC%2BC3MXksFOrurg%3D, PID: 21108733
    • Damani MR, Zhao L, Fontainhas AM et al (2011) Age-related alterations in the dynamic behavior of microglia. Aging Cell 10:263–276
    • (2011) Aging Cell , vol.10 , pp. 263-276
    • Damani, M.R.1    Zhao, L.2    Fontainhas, A.M.3
  • 8
    • 33846980461 scopus 로고    scopus 로고
    • Microglia derived from aging mice exhibit altered inflammatory profile
    • 17203473
    • Sierra A, Gottfried-Blackmore AC, Mc Ewen BS et al (2007) Microglia derived from aging mice exhibit altered inflammatory profile. Glia 55:412–424
    • (2007) Glia , vol.55 , pp. 412-424
    • Sierra, A.1    Gottfried-Blackmore, A.C.2    Mc Ewen, B.S.3
  • 9
    • 84881251933 scopus 로고    scopus 로고
    • Microglia during development and aging
    • 1:CAS:528:DC%2BC3sXnvVGqtrg%3D, PID: 23644076
    • Harry GJ (2013) Microglia during development and aging. Pharmacol Ther 139:313–326
    • (2013) Pharmacol Ther , vol.139 , pp. 313-326
    • Harry, G.J.1
  • 10
    • 34147219139 scopus 로고    scopus 로고
    • Simultaneous age-related depolarization of mitochondrial membrane potential and increased mitochondrial reactive oxygen species production correlate with age-related glutamate excitotoxicity in rat hippocampal neurons
    • 1:CAS:528:DC%2BD2sXks1Ohtrw%3D, PID: 17335078
    • Parihar MS, Brewer GJ (2007) Simultaneous age-related depolarization of mitochondrial membrane potential and increased mitochondrial reactive oxygen species production correlate with age-related glutamate excitotoxicity in rat hippocampal neurons. J Neurosci Res 85:1018–1032
    • (2007) J Neurosci Res , vol.85 , pp. 1018-1032
    • Parihar, M.S.1    Brewer, G.J.2
  • 11
    • 84875940314 scopus 로고    scopus 로고
    • Factors regulating microglia activation
    • 1:CAS:528:DC%2BC3sXhtlOhtLvJ, PID: 23630462
    • Kierdorf K, Prinz M (2013) Factors regulating microglia activation. Front Cell Neurosci 7:44
    • (2013) Front Cell Neurosci , vol.7 , pp. 44
    • Kierdorf, K.1    Prinz, M.2
  • 12
    • 79952443654 scopus 로고    scopus 로고
    • Inflammation and gliosis in neurological diseases–clinical implications
    • 1:CAS:528:DC%2BC3MXjtFertb8%3D, PID: 20943275
    • Czlonkowska A, Kurkowska-Jastrzebska I (2011) Inflammation and gliosis in neurological diseases–clinical implications. J Neuroimmunol 231:78–85
    • (2011) J Neuroimmunol , vol.231 , pp. 78-85
    • Czlonkowska, A.1    Kurkowska-Jastrzebska, I.2
  • 13
    • 80051782344 scopus 로고    scopus 로고
    • Cross talk between activation of microglia and astrocytes in pathological conditions in the central nervous system
    • 1:CAS:528:DC%2BC3MXptVaitLo%3D, PID: 21684291
    • Liu W, Tang Y, Feng J (2011) Cross talk between activation of microglia and astrocytes in pathological conditions in the central nervous system. Life Sci 89:141–146
    • (2011) Life Sci , vol.89 , pp. 141-146
    • Liu, W.1    Tang, Y.2    Feng, J.3
  • 14
    • 0028918383 scopus 로고
    • Extracellular neurofibrillary tangles reflect neuronal loss and provide further evidence of extensive protein cross-linking in Alzheimer disease
    • 1:STN:280:DyaK2MzjsFWgtg%3D%3D, PID: 7610759
    • Cras P, Smith MA, Richey PL et al (1995) Extracellular neurofibrillary tangles reflect neuronal loss and provide further evidence of extensive protein cross-linking in Alzheimer disease. Acta Neuropathol 89:291–295
    • (1995) Acta Neuropathol , vol.89 , pp. 291-295
    • Cras, P.1    Smith, M.A.2    Richey, P.L.3
  • 15
    • 0026646605 scopus 로고
    • Isolation and quantification of soluble Alzheimer’s beta-peptide from biological fluids
    • 1:CAS:528:DyaK38XmtFSisrc%3D, PID: 1406936
    • Seubert P, Vigo-Pelfrey C, Esch F et al (1992) Isolation and quantification of soluble Alzheimer’s beta-peptide from biological fluids. Nature 359:325–327
    • (1992) Nature , vol.359 , pp. 325-327
    • Seubert, P.1    Vigo-Pelfrey, C.2    Esch, F.3
  • 16
    • 84861325911 scopus 로고    scopus 로고
    • Alzheimer’s disease, autoimmunity and inflammation. The good, the bad and the ugly
    • 1:CAS:528:DC%2BC3MXhsFGjsbnL, PID: 21996556
    • Sardi F, Fassina L, Venturini L et al (2011) Alzheimer’s disease, autoimmunity and inflammation. The good, the bad and the ugly. Autoimmun Rev 11:149–153
    • (2011) Autoimmun Rev , vol.11 , pp. 149-153
    • Sardi, F.1    Fassina, L.2    Venturini, L.3
  • 17
    • 84964037904 scopus 로고    scopus 로고
    • Microglia in Alzheimer’s disease: the good, the bad and the ugly
    • 1:CAS:528:DC%2BC28Xlt1Khtb8%3D, PID: 26567746
    • Tejera D, Heneka MT (2016) Microglia in Alzheimer’s disease: the good, the bad and the ugly. Curr Alzheimer Res 13:370–380
    • (2016) Curr Alzheimer Res , vol.13 , pp. 370-380
    • Tejera, D.1    Heneka, M.T.2
  • 18
    • 70449529433 scopus 로고    scopus 로고
    • Structure and function of the blood brain barrier
    • 1:CAS:528:DC%2BD1MXhsVGms73P, PID: 19664713
    • Abbott NJ, Patabendige AA, Dolman DE et al (2010) Structure and function of the blood brain barrier. Neurobiol Dis 37:13–25
    • (2010) Neurobiol Dis , vol.37 , pp. 13-25
    • Abbott, N.J.1    Patabendige, A.A.2    Dolman, D.E.3
  • 19
    • 42449110295 scopus 로고    scopus 로고
    • Mechanism of leukocyte migration across the blood–retina-barrier
    • 18305941
    • Crane IJ, Liversidge J (2008) Mechanism of leukocyte migration across the blood–retina-barrier. Semin Immunopathol 30:165–177
    • (2008) Semin Immunopathol , vol.30 , pp. 165-177
    • Crane, I.J.1    Liversidge, J.2
  • 20
    • 84862734721 scopus 로고    scopus 로고
    • T-cell trafficking in the central nervous system
    • 22725964
    • Sallusto F, Impellizieri D, Basso C et al (2012) T-cell trafficking in the central nervous system. Immunol Rev 248:216–227
    • (2012) Immunol Rev , vol.248 , pp. 216-227
    • Sallusto, F.1    Impellizieri, D.2    Basso, C.3
  • 21
    • 80051762728 scopus 로고    scopus 로고
    • Fluids and barriers of the CNS establish immune privilege by confining immune surveillance to a two-walled castle moat surrounding the CNS castle
    • 21349152
    • Engelhardt B, Coisne C (2011) Fluids and barriers of the CNS establish immune privilege by confining immune surveillance to a two-walled castle moat surrounding the CNS castle. Fluids Barriers CNS 8:4
    • (2011) Fluids Barriers CNS , vol.8 , pp. 4
    • Engelhardt, B.1    Coisne, C.2
  • 22
    • 84865600703 scopus 로고    scopus 로고
    • Going against the tide—how encephalitogenic T cells breach the blood brain barrier
    • 22948545
    • Lyck R, Engelhardt B (2012) Going against the tide—how encephalitogenic T cells breach the blood brain barrier. J Vasc Res 49:497–509
    • (2012) J Vasc Res , vol.49 , pp. 497-509
    • Lyck, R.1    Engelhardt, B.2
  • 23
    • 0034609968 scopus 로고    scopus 로고
    • T-cell function and migration. Two sides of the same coin
    • Von Andrian UH, Mackay CR (2000) T-cell function and migration. Two sides of the same coin. N Engl J Med 343:1020–1034
    • (2000) N Engl J Med , vol.343 , pp. 1020-1034
    • Von Andrian, U.H.1    Mackay, C.R.2
  • 24
    • 0025981021 scopus 로고
    • T lymphocyte entry into the central nervous system
    • 1:STN:280:DyaK3M3jslOnug%3D%3D, PID: 2033653
    • Hickey WF, Hsu BL, Kimura H (1991) T lymphocyte entry into the central nervous system. J Neurosci Res 28:254–260
    • (1991) J Neurosci Res , vol.28 , pp. 254-260
    • Hickey, W.F.1    Hsu, B.L.2    Kimura, H.3
  • 25
    • 58149402415 scopus 로고    scopus 로고
    • Perivascular spaces and the two steps to neuroinflammation
    • 19018243
    • Owens T, Bechmann I, Engelhardt B (2008) Perivascular spaces and the two steps to neuroinflammation. J Neuropathol Exp Neurol 67:1113–1121
    • (2008) J Neuropathol Exp Neurol , vol.67 , pp. 1113-1121
    • Owens, T.1    Bechmann, I.2    Engelhardt, B.3
  • 26
    • 78049504134 scopus 로고    scopus 로고
    • Differential roles for endothelial ICAM-1, ICAM-2 and VCAM-1 in shear resistant T cell arrest, polarization, and directed crawling on BBB endothelium
    • 1:CAS:528:DC%2BC3cXht1Ggu7bF, PID: 20861356
    • Steiner O (2010) Differential roles for endothelial ICAM-1, ICAM-2 and VCAM-1 in shear resistant T cell arrest, polarization, and directed crawling on BBB endothelium. J Immunol 185:4846–4855
    • (2010) J Immunol , vol.185 , pp. 4846-4855
    • Steiner, O.1
  • 27
    • 60549086393 scopus 로고    scopus 로고
    • Beta 1 integrins differentially control extravasation of inflammatory cell subsets into the CNS during autoimmunity
    • 1:CAS:528:DC%2BD1MXitVGmsrw%3D, PID: 19179279
    • Bauer M, Brakebusch C, Coisne C et al (2009) Beta 1 integrins differentially control extravasation of inflammatory cell subsets into the CNS during autoimmunity. Proc Natl Acad Sci USA 106:1920–1925
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 1920-1925
    • Bauer, M.1    Brakebusch, C.2    Coisne, C.3
  • 28
    • 77949862490 scopus 로고    scopus 로고
    • The final steps of integrin activation: the end game
    • 1:CAS:528:DC%2BC3cXjs1Kju7g%3D, PID: 20308986
    • Shattil SJ, Kim C, Ginsberg MH (2010) The final steps of integrin activation: the end game. Nat Rev Mol Cell Biol 11:288–300
    • (2010) Nat Rev Mol Cell Biol , vol.11 , pp. 288-300
    • Shattil, S.J.1    Kim, C.2    Ginsberg, M.H.3
  • 29
    • 33846253253 scopus 로고    scopus 로고
    • Intercellular adhesion molecule-1 expression is required on multiple cell types for development of experimental autoimmune encephalomyelitis
    • 1:CAS:528:DC%2BD2sXhvVajtQ%3D%3D, PID: 17202346
    • Bullard DC, Hu X, Schoeb TR et al (2007) Intercellular adhesion molecule-1 expression is required on multiple cell types for development of experimental autoimmune encephalomyelitis. J Immunol 178:851–857
    • (2007) J Immunol , vol.178 , pp. 851-857
    • Bullard, D.C.1    Hu, X.2    Schoeb, T.R.3
  • 30
    • 57449111231 scopus 로고    scopus 로고
    • Immune defects in Alzheimer’s disease: new medications development
    • 19090986
    • Cashman JR, Ghirmai S, Abel KJ et al (2008) Immune defects in Alzheimer’s disease: new medications development. BMC Neurosci 9(Suppl 2):S13
    • (2008) BMC Neurosci , vol.9 , pp. S13
    • Cashman, J.R.1    Ghirmai, S.2    Abel, K.J.3
  • 31
    • 77957283905 scopus 로고    scopus 로고
    • PD1 negative and PD1 positive CD4+ T regulatory cells in mild cognitive impairment and Alzheimer’s disease
    • 1:CAS:528:DC%2BC3cXhtFKmurjM
    • Saresella M, Calabrese E, Marventano I et al (2010) PD1 negative and PD1 positive CD4+ T regulatory cells in mild cognitive impairment and Alzheimer’s disease. J Alzheimer Dis 21:927–938
    • (2010) J Alzheimer Dis , vol.21 , pp. 927-938
    • Saresella, M.1    Calabrese, E.2    Marventano, I.3
  • 32
    • 77957744665 scopus 로고    scopus 로고
    • An Association between immunosenescence and CD4+ CD25+ regulatory T Cells: a systematic review
    • 1:CAS:528:DC%2BC3cXhsVSqu7vP, PID: 20934123
    • Wang L, Xie Y, Zhu LJ et al (2010) An Association between immunosenescence and CD4+ CD25+ regulatory T Cells: a systematic review. Biomed Environ Sci 23:327–332
    • (2010) Biomed Environ Sci , vol.23 , pp. 327-332
    • Wang, L.1    Xie, Y.2    Zhu, L.J.3
  • 33
    • 67650921447 scopus 로고    scopus 로고
    • Dramatic shifts in circulating CD4 but not CD8 T cell subsets in mild Alzheimer’s disease
    • Larbia A, Paweleca G, Witkowskib JM et al (2009) Dramatic shifts in circulating CD4 but not CD8 T cell subsets in mild Alzheimer’s disease. J Alzheimer Dis 17:91–103
    • (2009) J Alzheimer Dis , vol.17 , pp. 91-103
    • Larbia, A.1    Paweleca, G.2    Witkowskib, J.M.3
  • 34
    • 80052315340 scopus 로고    scopus 로고
    • Toll-like receptors in health and disease in the brain: mechanisms and therapeutic potential
    • 1:CAS:528:DC%2BC3MXoslClt7k%3D, PID: 21745188
    • Hanke ML, Kielian T (2011) Toll-like receptors in health and disease in the brain: mechanisms and therapeutic potential. Clin Sci 121:367–387
    • (2011) Clin Sci , vol.121 , pp. 367-387
    • Hanke, M.L.1    Kielian, T.2
  • 36
    • 77950516194 scopus 로고    scopus 로고
    • Contributions of peripheral inflammation to seizure susceptibility: cytokines and brain excitability
    • 1:CAS:528:DC%2BC3cXjvFynu7w%3D, PID: 19804959
    • Riazi K, Galic MA, Pittman QJ (2010) Contributions of peripheral inflammation to seizure susceptibility: cytokines and brain excitability. Epilepsy Res 89:34–42
    • (2010) Epilepsy Res , vol.89 , pp. 34-42
    • Riazi, K.1    Galic, M.A.2    Pittman, Q.J.3
  • 37
    • 0030101648 scopus 로고    scopus 로고
    • Release site of TNF alpha after intravenous and intraperitoneal injection of LPS from Escherichia coli in rats
    • 1:STN:280:DyaK283nt1OgsA%3D%3D, PID: 8696985
    • Asari Y, Majima M, Sugimoto K et al (1996) Release site of TNF alpha after intravenous and intraperitoneal injection of LPS from Escherichia coli in rats. Shock 5:208–212
    • (1996) Shock , vol.5 , pp. 208-212
    • Asari, Y.1    Majima, M.2    Sugimoto, K.3
  • 38
    • 84935010590 scopus 로고    scopus 로고
    • Peripheral inflammation increases seizure susceptibility via the induction of neuroinflammation and oxidative stress in the hippocampus
    • 26100815
    • Ho Y, Lin Y, Wu C et al (2015) Peripheral inflammation increases seizure susceptibility via the induction of neuroinflammation and oxidative stress in the hippocampus. J Biomed Sci 22:46
    • (2015) J Biomed Sci , vol.22 , pp. 46
    • Ho, Y.1    Lin, Y.2    Wu, C.3
  • 39
    • 0033106495 scopus 로고    scopus 로고
    • Interleukin-1beta in immune cells of the abdominal vagus nerve: A link between the immune and nervous systems?
    • 1:CAS:528:DyaK1MXitFShtbo%3D, PID: 10087091
    • Goehler LE, Gaykema RP, Nguyen KT et al (1999) Interleukin-1beta in immune cells of the abdominal vagus nerve: A link between the immune and nervous systems? J Neurosci 19:2799–2806
    • (1999) J Neurosci , vol.19 , pp. 2799-2806
    • Goehler, L.E.1    Gaykema, R.P.2    Nguyen, K.T.3
  • 40
    • 84920886169 scopus 로고    scopus 로고
    • Astrocytic TLR4 expression and LPS-induced nuclear translocation of STAT3 in the sensory circumventricular organs of adult mouse brain
    • 1:CAS:528:DC%2BC2MXkslWmuw%3D%3D, PID: 25595264
    • Nakano Y, Furube E, Morita S et al (2015) Astrocytic TLR4 expression and LPS-induced nuclear translocation of STAT3 in the sensory circumventricular organs of adult mouse brain. J Neuroimmunol 278:144–158
    • (2015) J Neuroimmunol , vol.278 , pp. 144-158
    • Nakano, Y.1    Furube, E.2    Morita, S.3
  • 41
    • 33845768784 scopus 로고    scopus 로고
    • Microglia-mediated neurotoxicity: uncovering the molecular mechanisms
    • 1:CAS:528:DC%2BD28XhtlemtL7M, PID: 17180163
    • Block ML, Zecca L, Hong JS (2007) Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat Rev Neurosci 8:57–69
    • (2007) Nat Rev Neurosci , vol.8 , pp. 57-69
    • Block, M.L.1    Zecca, L.2    Hong, J.S.3
  • 42
    • 1242336763 scopus 로고    scopus 로고
    • Exacerbation of motor neuron disease by chronic stimulation of innate immunity in a mouse model of amyotrophic lateral sclerosis
    • 1:CAS:528:DC%2BD2cXhs1Sqtro%3D, PID: 14960605
    • Nguyen MD, D’Aigle T, Gowing G et al (2004) Exacerbation of motor neuron disease by chronic stimulation of innate immunity in a mouse model of amyotrophic lateral sclerosis. J Neurosci 24:1340–1349
    • (2004) J Neurosci , vol.24 , pp. 1340-1349
    • Nguyen, M.D.1    D’Aigle, T.2    Gowing, G.3
  • 43
    • 84865238053 scopus 로고    scopus 로고
    • Lipopolysaccharide-induced microglial activation and neuroprotection against experimental brain injury is independent of hematogenous TLR4
    • 1:CAS:528:DC%2BC38Xht1Ortr%2FN, PID: 22915113
    • Chen Z, Jalabi W, Shpargel KB et al (2012) Lipopolysaccharide-induced microglial activation and neuroprotection against experimental brain injury is independent of hematogenous TLR4. J Neurosci 32:11706–11715
    • (2012) J Neurosci , vol.32 , pp. 11706-11715
    • Chen, Z.1    Jalabi, W.2    Shpargel, K.B.3
  • 44
    • 61349193143 scopus 로고    scopus 로고
    • Peripheral lipopolysaccharide challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both pro-inflammatory IL-1beta and anti-inflammatory IL-10 cytokines
    • 1:CAS:528:DC%2BD1MXisFSquro%3D, PID: 18814846
    • Henry CJ, Huang Y, Wynne AM et al (2009) Peripheral lipopolysaccharide challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both pro-inflammatory IL-1beta and anti-inflammatory IL-10 cytokines. Brain Behav Immun 23:309–317
    • (2009) Brain Behav Immun , vol.23 , pp. 309-317
    • Henry, C.J.1    Huang, Y.2    Wynne, A.M.3
  • 45
    • 84862027973 scopus 로고    scopus 로고
    • Age-dependent neuroinflammatory responses and deficits in long-term potentiation in the hippocampus during systemic inflammation
    • 1:CAS:528:DC%2BC38Xot1yksrw%3D, PID: 22554776
    • Liu X, Wu Z, Hayashi Y et al (2012) Age-dependent neuroinflammatory responses and deficits in long-term potentiation in the hippocampus during systemic inflammation. Neuroscience 216:133–142
    • (2012) Neuroscience , vol.216 , pp. 133-142
    • Liu, X.1    Wu, Z.2    Hayashi, Y.3
  • 46
    • 84866425004 scopus 로고    scopus 로고
    • Microglial Microvesicle Secretion and Intercellular Signaling
    • 1:CAS:528:DC%2BC38XptV2itro%3D, PID: 22661954
    • Turola E, Furlan R, Bianco F et al (2012) Microglial Microvesicle Secretion and Intercellular Signaling. Front Physiol 3:149
    • (2012) Front Physiol , vol.3 , pp. 149
    • Turola, E.1    Furlan, R.2    Bianco, F.3
  • 48
    • 18944380607 scopus 로고    scopus 로고
    • Astrocyte-derived ATP induces vesicle shedding and IL-1 beta release from microglia
    • 1:CAS:528:DC%2BD2MXkt1Olsr8%3D, PID: 15905573
    • Bianco F, Pravettoni E, Colombo A et al (2005) Astrocyte-derived ATP induces vesicle shedding and IL-1 beta release from microglia. J Immunol 174:7268–7277
    • (2005) J Immunol , vol.174 , pp. 7268-7277
    • Bianco, F.1    Pravettoni, E.2    Colombo, A.3
  • 49
    • 61449242774 scopus 로고    scopus 로고
    • 7 receptor, an ATP-gated channel, controls its expression and association with lipid rafts
    • 1:CAS:528:DC%2BD1MXislaltb8%3D, PID: 18971257
    • 7 receptor, an ATP-gated channel, controls its expression and association with lipid rafts. FASEB J 23:795–805
    • (2009) FASEB J , vol.23 , pp. 795-805
    • Gonnord, P.1    Delarasse, C.2    Auger, R.3
  • 50
    • 84857998516 scopus 로고    scopus 로고
    • Microvesicles released from microglia stimulate synaptic activity via enhanced sphingolipid metabolism
    • Antonucci F, Turola E, Riganti L et al (2012) Microvesicles released from microglia stimulate synaptic activity via enhanced sphingolipid metabolism. EMBO J 31:1240
    • (2012) EMBO J , vol.31 , pp. 1240
    • Antonucci, F.1    Turola, E.2    Riganti, L.3
  • 51
    • 84866343704 scopus 로고    scopus 로고
    • Myeloid microvesicles are a marker and a therapeutic target for neuroinflammation
    • 1:CAS:528:DC%2BC38Xhs1ShsbrI, PID: 23109155
    • Verderio C, Muzio L, Turola E et al (2012) Myeloid microvesicles are a marker and a therapeutic target for neuroinflammation. Ann Neurol 72:610–624
    • (2012) Ann Neurol , vol.72 , pp. 610-624
    • Verderio, C.1    Muzio, L.2    Turola, E.3
  • 52
    • 84903362492 scopus 로고    scopus 로고
    • Microglia convert aggregated amyloid-β into neurotoxic forms through the shedding of microvesicles
    • 1:CAS:528:DC%2BC3sXhvFCqsr%2FP, PID: 24336048
    • Joshi P, Turola E, Ruiz A et al (2014) Microglia convert aggregated amyloid-β into neurotoxic forms through the shedding of microvesicles. Cell Death Differ 21:582–593
    • (2014) Cell Death Differ , vol.21 , pp. 582-593
    • Joshi, P.1    Turola, E.2    Ruiz, A.3
  • 53
    • 84869504451 scopus 로고    scopus 로고
    • Inflammasomes and their roles in health and disease
    • 1:CAS:528:DC%2BC38Xhslagtb3J, PID: 22974247
    • Lamkanfi M, Dixit VM (2012) Inflammasomes and their roles in health and disease. Annu Rev Cell Dev Biol 28:137–161
    • (2012) Annu Rev Cell Dev Biol , vol.28 , pp. 137-161
    • Lamkanfi, M.1    Dixit, V.M.2
  • 54
    • 80455176839 scopus 로고    scopus 로고
    • Non-canonical inflammasome activation targets caspase-11
    • 1:CAS:528:DC%2BC3MXhtlWksr7E, PID: 22002608
    • Kayagaki N, Warming S, Lamkanfi M et al (2011) Non-canonical inflammasome activation targets caspase-11. Nature 479:117–121
    • (2011) Nature , vol.479 , pp. 117-121
    • Kayagaki, N.1    Warming, S.2    Lamkanfi, M.3
  • 55
    • 0036671894 scopus 로고    scopus 로고
    • The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta
    • Martinon F, Burns K, Tschopp J (2002) The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell 2:417–426
    • (2002) Mol Cell , vol.2 , pp. 417-426
    • Martinon, F.1    Burns, K.2    Tschopp, J.3
  • 56
    • 66749174867 scopus 로고    scopus 로고
    • The inflammasomes: guardians of the body
    • 1:CAS:528:DC%2BD1MXlsFSlsbc%3D, PID: 19302040
    • Martinon F, Mayor A, Tschopp J (2009) The inflammasomes: guardians of the body. Annu Rev Immunol 27:229–265
    • (2009) Annu Rev Immunol , vol.27 , pp. 229-265
    • Martinon, F.1    Mayor, A.2    Tschopp, J.3
  • 57
    • 34548027736 scopus 로고    scopus 로고
    • Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration
    • 1:CAS:528:DC%2BD2sXptFymurg%3D, PID: 17599094
    • Petrilli V, Papin S, Dostert C et al (2007) Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration. Cell Death Differ 14:1583–1589
    • (2007) Cell Death Differ , vol.14 , pp. 1583-1589
    • Petrilli, V.1    Papin, S.2    Dostert, C.3
  • 58
    • 64049096334 scopus 로고    scopus 로고
    • NLRP3 (NALP3/CIAS1/Cryopyrin) mediates key innate and healing responses to influenza A virus via the regulation of caspase-1
    • 1:CAS:528:DC%2BD1MXls1Sqsrw%3D, PID: 19362023
    • Thomas PG, Dash P, Aldridge JR et al (2009) NLRP3 (NALP3/CIAS1/Cryopyrin) mediates key innate and healing responses to influenza A virus via the regulation of caspase-1. Immunity 30:566–575
    • (2009) Immunity , vol.30 , pp. 566-575
    • Thomas, P.G.1    Dash, P.2    Aldridge, J.R.3
  • 59
    • 47849085872 scopus 로고    scopus 로고
    • The NALP3 inflammasome is involved in the innate immune response to amyloid-β
    • 1:CAS:528:DC%2BD1cXoslCmu74%3D, PID: 18604209
    • Halle A, Hornung V, Petzold GC et al (2008) The NALP3 inflammasome is involved in the innate immune response to amyloid-β. Nat Immunol 9:857–865
    • (2008) Nat Immunol , vol.9 , pp. 857-865
    • Halle, A.1    Hornung, V.2    Petzold, G.C.3
  • 60
    • 84882285470 scopus 로고    scopus 로고
    • Specific inflammasomes in complex diseases
    • 23294928
    • Masters SL (2012) Specific inflammasomes in complex diseases. Clin Immunol 147:223–228
    • (2012) Clin Immunol , vol.147 , pp. 223-228
    • Masters, S.L.1
  • 61
    • 84873087532 scopus 로고    scopus 로고
    • NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice
    • 1:CAS:528:DC%2BC38XhvV2ntLfM, PID: 23254930
    • Heneka MT, Kummer MP, Stutz A et al (2013) NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice. Nature 493:674–678
    • (2013) Nature , vol.493 , pp. 674-678
    • Heneka, M.T.1    Kummer, M.P.2    Stutz, A.3
  • 62
    • 84857060684 scopus 로고    scopus 로고
    • Signalosomes in the brain: relevance in the development of certain neuropathologies such as Alzheimer’s disease
    • 1:CAS:528:DC%2BC3MXovVyhtbc%3D, PID: 21852974
    • Marin R (2011) Signalosomes in the brain: relevance in the development of certain neuropathologies such as Alzheimer’s disease. Front Physiol 2:23
    • (2011) Front Physiol , vol.2 , pp. 23
    • Marin, R.1
  • 63
    • 24744449748 scopus 로고    scopus 로고
    • Estrogen activates classical and alternative mechanisms to orchestrate neuroprotection
    • 1:CAS:528:DC%2BD2MXhtVyktL3I, PID: 16181121
    • Marin R, Guerra B, Alonso R et al (2005) Estrogen activates classical and alternative mechanisms to orchestrate neuroprotection. Curr Neurovasc Res 2:287–301
    • (2005) Curr Neurovasc Res , vol.2 , pp. 287-301
    • Marin, R.1    Guerra, B.2    Alonso, R.3
  • 64
    • 4744343726 scopus 로고    scopus 로고
    • Plasma membrane estrogen receptor mediates neuroprotection against β-amyloid toxicity through activation of Raf1/MEK/ERK cascade in septal-derived cholinergic SN56 cells
    • 1:CAS:528:DC%2BD2cXosVKqurs%3D, PID: 15379891
    • Guerra B, Diaz M, Alonso R et al (2004) Plasma membrane estrogen receptor mediates neuroprotection against β-amyloid toxicity through activation of Raf1/MEK/ERK cascade in septal-derived cholinergic SN56 cells. J Neurochem 91:99–1099
    • (2004) J Neurochem , vol.91 , pp. 99-1099
    • Guerra, B.1    Diaz, M.2    Alonso, R.3
  • 65
    • 69349092641 scopus 로고    scopus 로고
    • VDAC and ERα interaction in caveolae from human cortex is altered in Alzheimer’s disease
    • 1:CAS:528:DC%2BD1MXhtVKkt7nM, PID: 19595769
    • Ramirez CM, Gonzalez M, Diaz M et al (2009) VDAC and ERα interaction in caveolae from human cortex is altered in Alzheimer’s disease. Mol Cell Neurosci 42:172–183
    • (2009) Mol Cell Neurosci , vol.42 , pp. 172-183
    • Ramirez, C.M.1    Gonzalez, M.2    Diaz, M.3
  • 66
    • 77954623481 scopus 로고    scopus 로고
    • Neuroprotective mechanism conferred by 17beta-estradiol on the biochemical basis of Alzheimer’s disease
    • 1:CAS:528:DC%2BC3cXos1ymtLk%3D, PID: 20493928
    • Amtul Z, Wang L, Westaway D et al (2010) Neuroprotective mechanism conferred by 17beta-estradiol on the biochemical basis of Alzheimer’s disease. Neuroscience 169:781–786
    • (2010) Neuroscience , vol.169 , pp. 781-786
    • Amtul, Z.1    Wang, L.2    Westaway, D.3
  • 67
    • 30044438885 scopus 로고    scopus 로고
    • Brain estrogen deficiency accelerates A(beta) plaque formation in an Alzheimer’s disease animal model
    • 1:CAS:528:DC%2BD28XivV2ntQ%3D%3D, PID: 16365303
    • Yue X, Lu M, Lancaster T et al (2005) Brain estrogen deficiency accelerates A(beta) plaque formation in an Alzheimer’s disease animal model. Proc Natl Acad Sci USA 102:19198–19203
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 19198-19203
    • Yue, X.1    Lu, M.2    Lancaster, T.3
  • 68
    • 25144456905 scopus 로고    scopus 로고
    • Estradiol prevents neural tau hyperphosphorylation characteristic of Alzheimer’s disease
    • 1:CAS:528:DC%2BD2MXhtFaktbrJ, PID: 16024764
    • Alvarez-De-La-Rosa M, Silva I, Nilsen J et al (2005) Estradiol prevents neural tau hyperphosphorylation characteristic of Alzheimer’s disease. Ann NY Acad Sci 1052:210–224
    • (2005) Ann NY Acad Sci , vol.1052 , pp. 210-224
    • Alvarez-De-La-Rosa, M.1    Silva, I.2    Nilsen, J.3
  • 69
    • 67449141652 scopus 로고    scopus 로고
    • Protective actions of sex steroid hormones in Alzheimer’s disease
    • 1:CAS:528:DC%2BD1MXnsV2rsbw%3D, PID: 19427328
    • Pike CJ, Carroll JC, Rosario ER et al (2009) Protective actions of sex steroid hormones in Alzheimer’s disease. Front Neuroendocrinol 30:239–258
    • (2009) Front Neuroendocrinol , vol.30 , pp. 239-258
    • Pike, C.J.1    Carroll, J.C.2    Rosario, E.R.3
  • 70
    • 77956176352 scopus 로고    scopus 로고
    • Mitochondrial mechanisms of estrogen neuroprotection
    • 1:CAS:528:DC%2BC3cXhtV2isbfN, PID: 19931595
    • Simpkins JW, Yi KD, Yang SH et al (2010) Mitochondrial mechanisms of estrogen neuroprotection. Biochim Biophys Acta 1800:1113–1120
    • (2010) Biochim Biophys Acta , vol.1800 , pp. 1113-1120
    • Simpkins, J.W.1    Yi, K.D.2    Yang, S.H.3
  • 71
    • 0032997908 scopus 로고    scopus 로고
    • Estrogen modulates neuronal Bcl-xL expression and β-amyloid-induced apoptosis: relevance to Alzheimer’s disease
    • 1:CAS:528:DyaK1MXitFCksLY%3D, PID: 10098861
    • Pike CJ (1999) Estrogen modulates neuronal Bcl-xL expression and β-amyloid-induced apoptosis: relevance to Alzheimer’s disease. J Neurochem 72:1552–1563
    • (1999) J Neurochem , vol.72 , pp. 1552-1563
    • Pike, C.J.1
  • 72
    • 51649127553 scopus 로고    scopus 로고
    • Estradiol and neurodegenerative oxidative stress
    • 1:CAS:528:DC%2BD1cXhtFCktLzK, PID: 18275991
    • Nilsen J (2008) Estradiol and neurodegenerative oxidative stress. Front Neuroendocrinol 29:463–475
    • (2008) Front Neuroendocrinol , vol.29 , pp. 463-475
    • Nilsen, J.1
  • 73
    • 0037373449 scopus 로고    scopus 로고
    • Mitochondria from females exhibit higher antioxidant gene expression and lower oxidative damage than males
    • 1:CAS:528:DC%2BD3sXhsVant7c%3D, PID: 12614843
    • Borras C, Sastre J, Garcia-Sala D et al (2003) Mitochondria from females exhibit higher antioxidant gene expression and lower oxidative damage than males. Free Radic Biol Med 34:546–552
    • (2003) Free Radic Biol Med , vol.34 , pp. 546-552
    • Borras, C.1    Sastre, J.2    Garcia-Sala, D.3
  • 74
    • 77956173214 scopus 로고    scopus 로고
    • Influence of different estrogens on neuroplasticity and cognition in the hippocampus
    • 1:CAS:528:DC%2BC3cXhtV2isbnL, PID: 20100545
    • Barha CK, Galea LA (2010) Influence of different estrogens on neuroplasticity and cognition in the hippocampus. Biochim Biophys Acta 1800:1056–1067
    • (2010) Biochim Biophys Acta , vol.1800 , pp. 1056-1067
    • Barha, C.K.1    Galea, L.A.2
  • 75
    • 58149400495 scopus 로고    scopus 로고
    • Estrogen and hippocampal plasticity in rodent models
    • 1:CAS:528:DC%2BD1cXhsFSmt7jM, PID: 19096158
    • Foy MR, Baudry M, Diaz Brinton R et al (2008) Estrogen and hippocampal plasticity in rodent models. J Alzheimers Dis 15:589–603
    • (2008) J Alzheimers Dis , vol.15 , pp. 589-603
    • Foy, M.R.1    Baudry, M.2    Diaz Brinton, R.3
  • 76
    • 0029924284 scopus 로고    scopus 로고
    • Estrogens attenuate and corticosterone exacerbates excitotoxicity, oxidative injury, and amyloid β-peptide toxicity in hippocampal neurons
    • 1:CAS:528:DyaK28XisVSkurs%3D, PID: 8780008
    • Goodman Y, Bruce AJ, Cheng B et al (1996) Estrogens attenuate and corticosterone exacerbates excitotoxicity, oxidative injury, and amyloid β-peptide toxicity in hippocampal neurons. J Neurochem 66:1836–1844
    • (1996) J Neurochem , vol.66 , pp. 1836-1844
    • Goodman, Y.1    Bruce, A.J.2    Cheng, B.3
  • 77
    • 84858702953 scopus 로고    scopus 로고
    • The ageing cortical synapse: hallmarks and implications for cognitive decline
    • 1:CAS:528:DC%2BC38XjtlOnsrk%3D, PID: 22395804
    • Morrison JH, Baxter MG (2012) The ageing cortical synapse: hallmarks and implications for cognitive decline. Nat Rev Neurosci 13:240–250
    • (2012) Nat Rev Neurosci , vol.13 , pp. 240-250
    • Morrison, J.H.1    Baxter, M.G.2
  • 78
    • 38449089795 scopus 로고    scopus 로고
    • Estradiol in vivo regulation of brain mitochondrial proteome
    • 1:CAS:528:DC%2BD1cXisVGgsA%3D%3D, PID: 18094246
    • Nilsen J, Irwin RW, Gallaher TK et al (2007) Estradiol in vivo regulation of brain mitochondrial proteome. J Neurosci 27:14069–14077
    • (2007) J Neurosci , vol.27 , pp. 14069-14077
    • Nilsen, J.1    Irwin, R.W.2    Gallaher, T.K.3
  • 79
    • 0035964288 scopus 로고    scopus 로고
    • High-dose estradiol improves cognition for women with AD: results of a randomized study
    • 1:CAS:528:DC%2BD3MXmslymtrs%3D, PID: 11524467
    • Asthana S, Baker LD, Craft S et al (2001) High-dose estradiol improves cognition for women with AD: results of a randomized study. Neurology 57:605–612
    • (2001) Neurology , vol.57 , pp. 605-612
    • Asthana, S.1    Baker, L.D.2    Craft, S.3
  • 80
    • 0029886801 scopus 로고    scopus 로고
    • Effects of estrogen replacement therapy on response to tacrine in patients with Alzheimer’s disease
    • 1:STN:280:DyaK283kvV2ksw%3D%3D, PID: 8649552
    • Schneider LS, Farlow MR, Henderson VW et al (1996) Effects of estrogen replacement therapy on response to tacrine in patients with Alzheimer’s disease. Neurology 46:1580–1584
    • (1996) Neurology , vol.46 , pp. 1580-1584
    • Schneider, L.S.1    Farlow, M.R.2    Henderson, V.W.3
  • 81
    • 11144275942 scopus 로고    scopus 로고
    • Add Alzheimer’s disease to the list of autoimmune diseases
    • 15617848
    • D’Andrea MR (2005) Add Alzheimer’s disease to the list of autoimmune diseases. Med Hypotheses 64:458–463
    • (2005) Med Hypotheses , vol.64 , pp. 458-463
    • D’Andrea, M.R.1


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