Peripheral inflammation increases seizure susceptibility via the induction of neuroinflammation and oxidative stress in the hippocampus

Journal of Biomedical Science

Volumn 22, Issue 1, 2015, Pages

  Ho, Ying Hao ^a,b   Lin, Yu Te ^b   Wu, Chih Wei J ^c   Chao, Yung Mei ^c   Chang, Alice Y W ^d   Chan, Julie Y H ^a,c  

^a NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

^b KAOHSIUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^c CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^d NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

Cycloxygenase 2; Hippocampus; Microglia activation; Neuroinflammation; Oxidative stress; Pro inflammatory cytokines; Seizure; Systemic inflammation

Indexed keywords

ESCHERICHIA COLI LIPOPOLYSACCHARIDE; INTERLEUKIN 1BETA; INTERLEUKIN 6; KAINIC ACID; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; TEMPOL; TUMOR NECROSIS FACTOR ALPHA; AMINE OXIDE; IL6 PROTEIN, HUMAN; LIPOPOLYSACCHARIDE; N-(2-CYCLOHEXYLOXY-4-NITROPHENYL)METHANESULFONAMIDE; NITROBENZENE DERIVATIVE; SPIN LABEL; SULFONAMIDE; TNF PROTEIN, HUMAN; TUMOR NECROSIS FACTOR;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE PREDISPOSITION; ENZYME SUBUNIT; HIPPOCAMPUS; INFLAMMATION; MALE; MICROGLIA; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; OXIDATIVE STRESS; PERIPHERAL INFLAMMATION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT; SEIZURE; UPREGULATION; ANIMAL; BLOOD; CHEMICALLY INDUCED; DRUG EFFECTS; EPILEPSY, TEMPORAL LOBE; HUMAN; PATHOLOGY; PATHOPHYSIOLOGY; SEIZURES;

ANIMALIA; ESCHERICHIA COLI; RATTUS;

ANIMALS; CYCLIC N-OXIDES; EPILEPSY, TEMPORAL LOBE; HIPPOCAMPUS; HUMANS; INFLAMMATION; INTERLEUKIN-1BETA; INTERLEUKIN-6; KAINIC ACID; LIPOPOLYSACCHARIDES; MICROGLIA; NITROBENZENES; OXIDATIVE STRESS; RATS; SEIZURES; SPIN LABELS; SULFONAMIDES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84935010590     PISSN: 10217770     EISSN: 14230127     Source Type: Journal    
DOI: 10.1186/s12929-015-0157-8     Document Type: Article

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