-
1
-
-
80051762728
-
Fluids and barriers of the CNS establish immune privilege by confining immune surveillance to a two-walled castle moat surrounding the CNS castle
-
Engelhardt B, Coisne C. Fluids and barriers of the CNS establish immune privilege by confining immune surveillance to a two-walled castle moat surrounding the CNS castle. Fluids Barriers CNS 2011;8:4.
-
(2011)
Fluids Barriers CNS
, vol.8
, pp. 4
-
-
Engelhardt, B.1
Coisne, C.2
-
2
-
-
70249100293
-
Heterogeneity of CD4+ memory T cells: functional modules for tailored immunity
-
Sallusto F, Lanzavecchia A. Heterogeneity of CD4+ memory T cells: functional modules for tailored immunity. Eur J Immunol 2009;39:2076-2082.
-
(2009)
Eur J Immunol
, vol.39
, pp. 2076-2082
-
-
Sallusto, F.1
Lanzavecchia, A.2
-
3
-
-
80053640690
-
Helper T-cell differentiation and plasticity: insights from epigenetics
-
Hirahara K, et al. Helper T-cell differentiation and plasticity: insights from epigenetics. Immunology 2011;134:235-245.
-
(2011)
Immunology
, vol.134
, pp. 235-245
-
-
Hirahara, K.1
-
4
-
-
0034677646
-
A novel transcription factor, T-bet, directs Th1 lineage commitment
-
Szabo SJ, Kim ST, Costa GL, Zhang X, Fathman CG, Glimcher LH. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 2000;100:655-669.
-
(2000)
Cell
, vol.100
, pp. 655-669
-
-
Szabo, S.J.1
Kim, S.T.2
Costa, G.L.3
Zhang, X.4
Fathman, C.G.5
Glimcher, L.H.6
-
5
-
-
0030810155
-
The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells
-
Zheng W, Flavell RA. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell 1997;89:587-596.
-
(1997)
Cell
, vol.89
, pp. 587-596
-
-
Zheng, W.1
Flavell, R.A.2
-
6
-
-
0032536869
-
Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes
-
Sallusto F, Lenig D, Mackay CR, Lanzavecchia A. Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes. J Exp Med 1998;187:875-883.
-
(1998)
J Exp Med
, vol.187
, pp. 875-883
-
-
Sallusto, F.1
Lenig, D.2
Mackay, C.R.3
Lanzavecchia, A.4
-
7
-
-
0030769920
-
Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells
-
Sallusto F, Mackay CR, Lanzavecchia A. Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells. Science 1997;277:2005-2007.
-
(1997)
Science
, vol.277
, pp. 2005-2007
-
-
Sallusto, F.1
Mackay, C.R.2
Lanzavecchia, A.3
-
8
-
-
0031963014
-
Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s
-
Bonecchi R, et al. Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s. J Exp Med 1998;187:129-134.
-
(1998)
J Exp Med
, vol.187
, pp. 129-134
-
-
Bonecchi, R.1
-
9
-
-
0033784440
-
CRTH2 is the most reliable marker for the detection of circulating human type 2 Th and type 2 T cytotoxic cells in health and disease
-
Cosmi L, Annunziato F, Galli MIG, Maggi RME, Nagata K, Romagnani S. CRTH2 is the most reliable marker for the detection of circulating human type 2 Th and type 2 T cytotoxic cells in health and disease. Eur J Immunol 2000;30:2972-2979.
-
(2000)
Eur J Immunol
, vol.30
, pp. 2972-2979
-
-
Cosmi, L.1
Annunziato, F.2
Galli, M.I.G.3
Maggi, R.M.E.4
Nagata, K.5
Romagnani, S.6
-
10
-
-
27544465354
-
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
-
Park H, et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol 2005;6:1133-1141.
-
(2005)
Nat Immunol
, vol.6
, pp. 1133-1141
-
-
Park, H.1
-
11
-
-
27544490377
-
Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
-
Harrington LE, et al. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 2005;6:1123-1132.
-
(2005)
Nat Immunol
, vol.6
, pp. 1123-1132
-
-
Harrington, L.E.1
-
12
-
-
13244283212
-
IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
-
Langrish CL, et al. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J Exp Med 2005;201:233-240.
-
(2005)
J Exp Med
, vol.201
, pp. 233-240
-
-
Langrish, C.L.1
-
13
-
-
33748588423
-
The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells
-
Ivanov II, et al. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 2006;126:1121-1133.
-
(2006)
Cell
, vol.126
, pp. 1121-1133
-
-
Ivanov, I.I.1
-
14
-
-
41449110468
-
Impaired T(H)17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome
-
Milner JD, et al. Impaired T(H)17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome. Nature 2006;452:773-776.
-
(2006)
Nature
, vol.452
, pp. 773-776
-
-
Milner, J.D.1
-
15
-
-
46949089128
-
Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3
-
Ma CS, et al. Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3. J Exp Med 2008;205:1551-1557.
-
(2008)
J Exp Med
, vol.205
, pp. 1551-1557
-
-
Ma, C.S.1
-
16
-
-
34249079176
-
Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells
-
Acosta-Rodriguez EV, et al. Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells. Nat Immunol 2007;8:639-646.
-
(2007)
Nat Immunol
, vol.8
, pp. 639-646
-
-
Acosta-Rodriguez, E.V.1
-
17
-
-
67651154105
-
Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells
-
Duhen T, Geiger R, Jarrossay D, Lanzavecchia A, Sallusto F. Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells. Nat Immunol 2009;10:857-863.
-
(2009)
Nat Immunol
, vol.10
, pp. 857-863
-
-
Duhen, T.1
Geiger, R.2
Jarrossay, D.3
Lanzavecchia, A.4
Sallusto, F.5
-
18
-
-
67651171182
-
Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from T(H)-17, T(H)1 and T(H)2 cells
-
Trifari S, Kaplan CD, Tran EH, Crellin NK, Spits H. Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from T(H)-17, T(H)1 and T(H)2 cells. Nat Immunol 2009;10:864-871.
-
(2009)
Nat Immunol
, vol.10
, pp. 864-871
-
-
Trifari, S.1
Kaplan, C.D.2
Tran, E.H.3
Crellin, N.K.4
Spits, H.5
-
19
-
-
72849131815
-
Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling
-
Eyerich S, et al. Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling. J Clin Invest 2009;119:3573-3585.
-
(2009)
J Clin Invest
, vol.119
, pp. 3573-3585
-
-
Eyerich, S.1
-
20
-
-
33846906224
-
Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
-
Zheng Y, et al. Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis. Nature 2007;445:648-651.
-
(2007)
Nature
, vol.445
, pp. 648-651
-
-
Zheng, Y.1
-
21
-
-
0036604122
-
Cutting edge: immune cells as sources and targets of the IL-10 family members?
-
Wolk K, Kunz S, Asadullah K, Sabat R. Cutting edge: immune cells as sources and targets of the IL-10 family members? J Immunol 2002;168:5397-5402.
-
(2002)
J Immunol
, vol.168
, pp. 5397-5402
-
-
Wolk, K.1
Kunz, S.2
Asadullah, K.3
Sabat, R.4
-
22
-
-
56349154943
-
Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset
-
Veldhoen M, et al. Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset. Nat Immunol 2008;9:1341-1346.
-
(2008)
Nat Immunol
, vol.9
, pp. 1341-1346
-
-
Veldhoen, M.1
-
23
-
-
0037236203
-
Memory and flexibility of cytokine gene expression as separable properties of human T(H)1 and T(H)2 lymphocytes
-
Messi M, Giacchetto I, Nagata K, Lanzavecchia A, Natoli G, Sallusto F. Memory and flexibility of cytokine gene expression as separable properties of human T(H)1 and T(H)2 lymphocytes. Nat Immunol 2003;4:78-86.
-
(2003)
Nat Immunol
, vol.4
, pp. 78-86
-
-
Messi, M.1
Giacchetto, I.2
Nagata, K.3
Lanzavecchia, A.4
Natoli, G.5
Sallusto, F.6
-
24
-
-
77649220954
-
Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cells
-
O'Shea JJ, Paul WE. Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cells. Science 2010;327:1098-1102.
-
(2010)
Science
, vol.327
, pp. 1098-1102
-
-
O'Shea, J.J.1
Paul, W.E.2
-
25
-
-
79961117793
-
Evidence of the transient nature of the Th17 phenotype of CD4+CD161+ T cells in the synovial fluid of patients with juvenile idiopathic arthritis
-
Cosmi L, et al. Evidence of the transient nature of the Th17 phenotype of CD4+CD161+ T cells in the synovial fluid of patients with juvenile idiopathic arthritis. Arthritis Rheum 2011;63:2504-2515.
-
(2011)
Arthritis Rheum
, vol.63
, pp. 2504-2515
-
-
Cosmi, L.1
-
26
-
-
34547734621
-
Phenotypic and functional features of human Th17 cells
-
Annunziato F, et al. Phenotypic and functional features of human Th17 cells. J Exp Med 2007;204:1849-1861.
-
(2007)
J Exp Med
, vol.204
, pp. 1849-1861
-
-
Annunziato, F.1
-
27
-
-
70350052626
-
Preferential recruitment of interferon-gamma-expressing TH17 cells in multiple sclerosis
-
Kebir H, et al. Preferential recruitment of interferon-gamma-expressing TH17 cells in multiple sclerosis. Ann Neurol 2009;66:390-402.
-
(2009)
Ann Neurol
, vol.66
, pp. 390-402
-
-
Kebir, H.1
-
28
-
-
49249135394
-
Human interleukin 17-producing cells originate from a CD161+CD4+ T cell precursor
-
Cosmi L, et al. Human interleukin 17-producing cells originate from a CD161+CD4+ T cell precursor. J Exp Med 2008;205:1903-1916.
-
(2008)
J Exp Med
, vol.205
, pp. 1903-1916
-
-
Cosmi, L.1
-
29
-
-
72549107316
-
Differential regulation of interleukin 17 and interferon gamma production in inflammatory bowel disease
-
Rovedatti L, et al. Differential regulation of interleukin 17 and interferon gamma production in inflammatory bowel disease. Gut 2009;58:1629-1636.
-
(2009)
Gut
, vol.58
, pp. 1629-1636
-
-
Rovedatti, L.1
-
30
-
-
3142724732
-
Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis
-
Bettelli E, Sullivan B, Szabo SJ, Sobel RA, Glimcher LH, Kuchroo VK. Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis. J Exp Med 2004;200:79-87.
-
(2004)
J Exp Med
, vol.200
, pp. 79-87
-
-
Bettelli, E.1
Sullivan, B.2
Szabo, S.J.3
Sobel, R.A.4
Glimcher, L.H.5
Kuchroo, V.K.6
-
31
-
-
33646433989
-
Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis
-
Chen Y, et al. Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis. J Clin Invest 2006;116:1317-1326.
-
(2006)
J Clin Invest
, vol.116
, pp. 1317-1326
-
-
Chen, Y.1
-
32
-
-
36248965294
-
TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology
-
McGeachy MJ, et al. TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology. Nat Immunol 2007;8:1390-1397.
-
(2007)
Nat Immunol
, vol.8
, pp. 1390-1397
-
-
McGeachy, M.J.1
-
33
-
-
77958584113
-
Generation of pathogenic T(H)17 cells in the absence of TGF-beta signalling
-
Ghoreschi K, et al. Generation of pathogenic T(H)17 cells in the absence of TGF-beta signalling. Nature 2010;467:967-971.
-
(2010)
Nature
, vol.467
, pp. 967-971
-
-
Ghoreschi, K.1
-
34
-
-
79951677394
-
Fate mapping of IL-17-producing T cells in inflammatory responses
-
Hirota K, et al. Fate mapping of IL-17-producing T cells in inflammatory responses. Nat Immunol 2011;12:255-263.
-
(2011)
Nat Immunol
, vol.12
, pp. 255-263
-
-
Hirota, K.1
-
35
-
-
79956116032
-
RORgammat drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation
-
Codarri L, et al. RORgammat drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation. Nat Immunol 2011;12:560-567.
-
(2011)
Nat Immunol
, vol.12
, pp. 560-567
-
-
Codarri, L.1
-
36
-
-
79956152607
-
The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF
-
El-Behi M, et al. The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF. Nat Immunol 2011;12:568-575.
-
(2011)
Nat Immunol
, vol.12
, pp. 568-575
-
-
El-Behi, M.1
-
37
-
-
65749103365
-
The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation
-
Koch MA, Tucker-Heard G, Perdue NR, Killebrew JR, Urdahl KB, Campbell DJ. The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation. Nat Immunol 2009;10:595-602.
-
(2009)
Nat Immunol
, vol.10
, pp. 595-602
-
-
Koch, M.A.1
Tucker-Heard, G.2
Perdue, N.R.3
Killebrew, J.R.4
Urdahl, K.B.5
Campbell, D.J.6
-
38
-
-
62649165369
-
Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses
-
Zheng Y, et al. Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses. Nature 2009;458:351-356.
-
(2009)
Nature
, vol.458
, pp. 351-356
-
-
Zheng, Y.1
-
39
-
-
70049113279
-
CD4+ regulatory T cells control TH17 responses in a Stat3-dependent manner
-
Chaudhry A, et al. CD4+ regulatory T cells control TH17 responses in a Stat3-dependent manner. Science 2009;326:986-991.
-
(2009)
Science
, vol.326
, pp. 986-991
-
-
Chaudhry, A.1
-
40
-
-
84861039642
-
Functionally distinct subsets of human FOXP3+ Treg cells that phenotypically mirror effector TH cells
-
Duhen T, Duhen R, Lanzavecchia A, Sallusto F, Campbell DJ. Functionally distinct subsets of human FOXP3+ Treg cells that phenotypically mirror effector TH cells. Blood 2012;119:4430-4440.
-
(2012)
Blood
, vol.119
, pp. 4430-4440
-
-
Duhen, T.1
Duhen, R.2
Lanzavecchia, A.3
Sallusto, F.4
Campbell, D.J.5
-
41
-
-
0034609968
-
T-cell function and migration. Two sides of the same coin
-
von Andrian UH, Mackay CR. T-cell function and migration. Two sides of the same coin. N Engl J Med 2000;343:1020-1034.
-
(2000)
N Engl J Med
, vol.343
, pp. 1020-1034
-
-
von Andrian, U.H.1
Mackay, C.R.2
-
42
-
-
0030781393
-
Multistep navigation and the combinatorial control of leukocyte chemotaxis
-
Foxman EF, Campbell JJ, Butcher EC. Multistep navigation and the combinatorial control of leukocyte chemotaxis. J Cell Biol 1997;139:1349-1360.
-
(1997)
J Cell Biol
, vol.139
, pp. 1349-1360
-
-
Foxman, E.F.1
Campbell, J.J.2
Butcher, E.C.3
-
43
-
-
50049106591
-
Environmental cues, dendritic cells and the programming of tissue-selective lymphocyte trafficking
-
Sigmundsdottir H, Butcher EC. Environmental cues, dendritic cells and the programming of tissue-selective lymphocyte trafficking. Nat Immunol 2008;9:981-987.
-
(2008)
Nat Immunol
, vol.9
, pp. 981-987
-
-
Sigmundsdottir, H.1
Butcher, E.C.2
-
44
-
-
7044233625
-
Chemoattractants and their receptors in homeostasis and inflammation
-
Sallusto F, Mackay CR. Chemoattractants and their receptors in homeostasis and inflammation. Curr Opin Immunol 2004;16:724-731.
-
(2004)
Curr Opin Immunol
, vol.16
, pp. 724-731
-
-
Sallusto, F.1
Mackay, C.R.2
-
45
-
-
0025717402
-
Migration of hematogenous cells through the blood-brain barrier and the initiation of CNS inflammation
-
Hickey WF. Migration of hematogenous cells through the blood-brain barrier and the initiation of CNS inflammation. Brain Pathol 1991;1:97-105.
-
(1991)
Brain Pathol
, vol.1
, pp. 97-105
-
-
Hickey, W.F.1
-
47
-
-
85047682713
-
Alpha4-integrin-VCAM-1 binding mediates G protein-independent capture of encephalitogenic T cell blasts to CNS white matter microvessels
-
Vajkoczy P, Laschinger M, Engelhardt B. Alpha4-integrin-VCAM-1 binding mediates G protein-independent capture of encephalitogenic T cell blasts to CNS white matter microvessels. J Clin Invest 2001;108:557-565.
-
(2001)
J Clin Invest
, vol.108
, pp. 557-565
-
-
Vajkoczy, P.1
Laschinger, M.2
Engelhardt, B.3
-
48
-
-
0142259710
-
Three or more routes for leukocyte migration into the central nervous system
-
Ransohoff RM, Kivisakk P, Kidd G. Three or more routes for leukocyte migration into the central nervous system. Nat Rev Immunol 2003;3:569-581.
-
(2003)
Nat Rev Immunol
, vol.3
, pp. 569-581
-
-
Ransohoff, R.M.1
Kivisakk, P.2
Kidd, G.3
-
49
-
-
77649192491
-
Choroid plexus: biology and pathology
-
Wolburg H, Paulus W. Choroid plexus: biology and pathology. Acta Neuropathol 2010;119:75-88.
-
(2010)
Acta Neuropathol
, vol.119
, pp. 75-88
-
-
Wolburg, H.1
Paulus, W.2
-
50
-
-
0029952623
-
ICAM-1, VCAM-1, and MAdCAM-1 are expressed on choroid plexus epithelium but not endothelium and mediate binding of lymphocytes in vitro
-
Steffen BJ, Breier G, Butcher EC, Schulz M, Engelhardt B. ICAM-1, VCAM-1, and MAdCAM-1 are expressed on choroid plexus epithelium but not endothelium and mediate binding of lymphocytes in vitro. Am J Pathol 1996;148:1819-1838.
-
(1996)
Am J Pathol
, vol.148
, pp. 1819-1838
-
-
Steffen, B.J.1
Breier, G.2
Butcher, E.C.3
Schulz, M.4
Engelhardt, B.5
-
51
-
-
0037816192
-
Human cerebrospinal fluid central memory CD4+ T cells: evidence for trafficking through choroid plexus and meninges via P-selectin
-
Kivisakk P, et al. Human cerebrospinal fluid central memory CD4+ T cells: evidence for trafficking through choroid plexus and meninges via P-selectin. Proc Natl Acad Sci U S A 2005;100:8389-8394.
-
(2005)
Proc Natl Acad Sci U S A
, vol.100
, pp. 8389-8394
-
-
Kivisakk, P.1
-
52
-
-
65249175159
-
C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE
-
Reboldi A, et al. C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE. Nat Immunol 2009;10:514-523.
-
(2009)
Nat Immunol
, vol.10
, pp. 514-523
-
-
Reboldi, A.1
-
53
-
-
33646468932
-
Reevaluation of P-selectin and alpha 4 integrin as targets for the treatment of experimental autoimmune encephalomyelitis
-
Kerfoot SM, Norman MU, Lapointe BM, Bonder CS, Zbytnuik L, Kubes P. Reevaluation of P-selectin and alpha 4 integrin as targets for the treatment of experimental autoimmune encephalomyelitis. J Immunol 2006;176:6225-6234.
-
(2006)
J Immunol
, vol.176
, pp. 6225-6234
-
-
Kerfoot, S.M.1
Norman, M.U.2
Lapointe, B.M.3
Bonder, C.S.4
Zbytnuik, L.5
Kubes, P.6
-
54
-
-
79951801328
-
TET inducible expression of the alpha4beta7-integrin ligand MAdCAM-1 on the blood-brain barrier does not influence the immunopathogenesis of experimental autoimmune encephalomyelitis
-
Doring A, et al. TET inducible expression of the alpha4beta7-integrin ligand MAdCAM-1 on the blood-brain barrier does not influence the immunopathogenesis of experimental autoimmune encephalomyelitis. Eur J Immunol 2011;41:813-821.
-
(2011)
Eur J Immunol
, vol.41
, pp. 813-821
-
-
Doring, A.1
-
55
-
-
84855475637
-
Th17 lymphocytes traffic to the central nervous system independently of alpha4 integrin expression during EAE
-
Rothhammer V, et al. Th17 lymphocytes traffic to the central nervous system independently of alpha4 integrin expression during EAE. J Exp Med 2011;208:2465-2476.
-
(2011)
J Exp Med
, vol.208
, pp. 2465-2476
-
-
Rothhammer, V.1
-
56
-
-
83755184226
-
Cutting edge: loss of alpha4 integrin expression differentially affects the homing of Th1 and Th17 cells
-
Glatigny S, Duhen R, Oukka M, Bettelli E. Cutting edge: loss of alpha4 integrin expression differentially affects the homing of Th1 and Th17 cells. J Immunol 2011;187:6176-6179.
-
(2011)
J Immunol
, vol.187
, pp. 6176-6179
-
-
Glatigny, S.1
Duhen, R.2
Oukka, M.3
Bettelli, E.4
-
57
-
-
68049115475
-
Mice deficient for CCR6 fail to control chronic experimental autoimmune encephalomyelitis
-
Elhofy A, Depaolo RW, Lira SA, Lukacs NW, Karpus WJ. Mice deficient for CCR6 fail to control chronic experimental autoimmune encephalomyelitis. J Neuroimmunol 2009;213:91-99.
-
(2009)
J Neuroimmunol
, vol.213
, pp. 91-99
-
-
Elhofy, A.1
Depaolo, R.W.2
Lira, S.A.3
Lukacs, N.W.4
Karpus, W.J.5
-
59
-
-
33645869560
-
Dystroglycan is selectively cleaved at the parenchymal basement membrane at sites of leukocyte extravasation in experimental autoimmune encephalomyelitis
-
Agrawal S, et al. Dystroglycan is selectively cleaved at the parenchymal basement membrane at sites of leukocyte extravasation in experimental autoimmune encephalomyelitis. J Exp Med 2006;203:1007-1019.
-
(2006)
J Exp Med
, vol.203
, pp. 1007-1019
-
-
Agrawal, S.1
-
60
-
-
33750837704
-
Metalloproteinases control brain inflammation induced by pertussis toxin in mice overexpressing the chemokine CCL2 in the central nervous system
-
Toft-Hansen H, Buist R, Sun XJ, Schellenberg A, Peeling J, Owens T. Metalloproteinases control brain inflammation induced by pertussis toxin in mice overexpressing the chemokine CCL2 in the central nervous system. J Immunol 2006;177:7242-7249.
-
(2006)
J Immunol
, vol.177
, pp. 7242-7249
-
-
Toft-Hansen, H.1
Buist, R.2
Sun, X.J.3
Schellenberg, A.4
Peeling, J.5
Owens, T.6
-
61
-
-
0026506799
-
Prevention of experimental autoimmune encephalomyelitis by antibodies against alpha 4 beta 1 integrin
-
Yednock TA, Cannon C, Fritz LC, Sanchez-Madrid F, Steinman L, Karin N. Prevention of experimental autoimmune encephalomyelitis by antibodies against alpha 4 beta 1 integrin. Nature 1992;356:63-66.
-
(1992)
Nature
, vol.356
, pp. 63-66
-
-
Yednock, T.A.1
Cannon, C.2
Fritz, L.C.3
Sanchez-Madrid, F.4
Steinman, L.5
Karin, N.6
-
62
-
-
78751706537
-
T cell migration into the central nervous system during health and disease: different molecular keys allow access to different central nervous system compartments
-
Engelhardt B. T cell migration into the central nervous system during health and disease: different molecular keys allow access to different central nervous system compartments. Clin Exp Neuroimmunol 2010;1:1-15.
-
(2010)
Clin Exp Neuroimmunol
, vol.1
, pp. 1-15
-
-
Engelhardt, B.1
-
63
-
-
0032535368
-
The development of experimental autoimmune encephalomyelitis in the mouse requires alpha4-integrin but not alpha4beta7-integrin
-
Engelhardt B, Laschinger M, Schulz M, Samulowitz U, Vestweber D, Hoch G. The development of experimental autoimmune encephalomyelitis in the mouse requires alpha4-integrin but not alpha4beta7-integrin. J Clin Invest 1998;102:2096-2105.
-
(1998)
J Clin Invest
, vol.102
, pp. 2096-2105
-
-
Engelhardt, B.1
Laschinger, M.2
Schulz, M.3
Samulowitz, U.4
Vestweber, D.5
Hoch, G.6
-
64
-
-
60549086393
-
β1 integrins differentially control extravasation of inflammatory cell subsets into the CNS during autoimmunity
-
Bauer M, et al. β1 integrins differentially control extravasation of inflammatory cell subsets into the CNS during autoimmunity. Proc Natl Acad Sci U S A 2009;106:1920-1925.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 1920-1925
-
-
Bauer, M.1
-
65
-
-
78049504134
-
Differential roles for endothelial ICAM-1, ICAM-2, and VCAM-1 in shear-resistant T cell arrest, polarization, and directed crawling on blood-brain barrier endothelium
-
Steiner O, et al. Differential roles for endothelial ICAM-1, ICAM-2, and VCAM-1 in shear-resistant T cell arrest, polarization, and directed crawling on blood-brain barrier endothelium. J Immunol 2010;185:4846-4855.
-
(2010)
J Immunol
, vol.185
, pp. 4846-4855
-
-
Steiner, O.1
-
66
-
-
70449106029
-
Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions
-
Bartholomaus I, et al. Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions. Nature 2009;462:94-98.
-
(2009)
Nature
, vol.462
, pp. 94-98
-
-
Bartholomaus, I.1
-
67
-
-
33846253253
-
Intercellular adhesion molecule-1 expression is required on multiple cell types for the development of experimental autoimmune encephalomyelitis
-
Bullard DC, Hu X, Schoeb TR, Collins RG, Beaudet AL, Barnum SR. Intercellular adhesion molecule-1 expression is required on multiple cell types for the development of experimental autoimmune encephalomyelitis. J Immunol 2007;178:851-857.
-
(2007)
J Immunol
, vol.178
, pp. 851-857
-
-
Bullard, D.C.1
Hu, X.2
Schoeb, T.R.3
Collins, R.G.4
Beaudet, A.L.5
Barnum, S.R.6
-
68
-
-
0037100456
-
Overlapping roles of P-selectin and alpha 4 integrin to recruit leukocytes to the central nervous system in experimental autoimmune encephalomyelitis
-
Kerfoot S, Kubes P. Overlapping roles of P-selectin and alpha 4 integrin to recruit leukocytes to the central nervous system in experimental autoimmune encephalomyelitis. J Immunol 2002;169:1000-1006.
-
(2002)
J Immunol
, vol.169
, pp. 1000-1006
-
-
Kerfoot, S.1
Kubes, P.2
-
69
-
-
10744233874
-
CD8+ T cells from patients with acute multiple sclerosis display selective increase of adhesiveness in brain venules: a critical role for P-selectin glycoprotein ligand-1
-
Battistini L, et al. CD8+ T cells from patients with acute multiple sclerosis display selective increase of adhesiveness in brain venules: a critical role for P-selectin glycoprotein ligand-1. Blood 2003;101:4775-4782.
-
(2003)
Blood
, vol.101
, pp. 4775-4782
-
-
Battistini, L.1
-
70
-
-
33644956900
-
IL-12 driven upregulation of P-selectin ligand on myelin-specific T cells is a critical step in an animal model of autoimmune demyelination
-
Deshpande P, King IL, Segal BM. IL-12 driven upregulation of P-selectin ligand on myelin-specific T cells is a critical step in an animal model of autoimmune demyelination. J Neuroimmunol 2006;173:35-44.
-
(2006)
J Neuroimmunol
, vol.173
, pp. 35-44
-
-
Deshpande, P.1
King, I.L.2
Segal, B.M.3
-
71
-
-
0036687120
-
Functional expression of the lymphoid chemokines CCL19 (ELC) and CCL 21 (SLC) at the blood-brain barrier suggests their involvement in G-protein-dependent lymphocyte recruitment into the central nervous system during experimental autoimmune encephalomyelitis
-
Alt C, Laschinger M, Engelhardt B. Functional expression of the lymphoid chemokines CCL19 (ELC) and CCL 21 (SLC) at the blood-brain barrier suggests their involvement in G-protein-dependent lymphocyte recruitment into the central nervous system during experimental autoimmune encephalomyelitis. Eur J Immunol 2002;32:2133-2144.
-
(2002)
Eur J Immunol
, vol.32
, pp. 2133-2144
-
-
Alt, C.1
Laschinger, M.2
Engelhardt, B.3
-
72
-
-
35448986091
-
CCL19 is constitutively expressed in the CNS, up-regulated in neuroinflammation, active and also inactive multiple sclerosis lesions
-
Krumbholz M, et al. CCL19 is constitutively expressed in the CNS, up-regulated in neuroinflammation, active and also inactive multiple sclerosis lesions. J Neuroimmunol 2007;190:72-79.
-
(2007)
J Neuroimmunol
, vol.190
, pp. 72-79
-
-
Krumbholz, M.1
-
73
-
-
0029988267
-
Brain endothelium lack one of two pathways of P-selectin-mediated neutrophil adhesion
-
Barkalow FJ, Goodman MJ, Gerritsen ME, Mayadas TN. Brain endothelium lack one of two pathways of P-selectin-mediated neutrophil adhesion. Blood 1996;88:4585-4593.
-
(1996)
Blood
, vol.88
, pp. 4585-4593
-
-
Barkalow, F.J.1
Goodman, M.J.2
Gerritsen, M.E.3
Mayadas, T.N.4
-
74
-
-
0034123924
-
Differential adhesion molecule requirements for immune surveillance and inflammatory recruiment
-
Carrithers MD, Visintin I, Kang SJ, Janeway CA Jr. Differential adhesion molecule requirements for immune surveillance and inflammatory recruiment. Brain 2000;123:1092-1101.
-
(2000)
Brain
, vol.123
, pp. 1092-1101
-
-
Carrithers, M.D.1
Visintin, I.2
Kang, S.J.3
Janeway Jr., C.A.4
-
75
-
-
33751557620
-
CXCL12 limits inflammation by localizing mononuclear infiltrates to the perivascular space during experimental autoimmune encephalomyelitis
-
McCandless EE, Wang Q, Woerner BM, Harper JM, Klein RS. CXCL12 limits inflammation by localizing mononuclear infiltrates to the perivascular space during experimental autoimmune encephalomyelitis. J Immunol 2006;177:8053-8064.
-
(2006)
J Immunol
, vol.177
, pp. 8053-8064
-
-
McCandless, E.E.1
Wang, Q.2
Woerner, B.M.3
Harper, J.M.4
Klein, R.S.5
-
76
-
-
79951694551
-
CXCR7 influences leukocyte entry into the CNS parenchyma by controlling abluminal CXCL12 abundance during autoimmunity
-
Cruz-Orengo L, et al. CXCR7 influences leukocyte entry into the CNS parenchyma by controlling abluminal CXCL12 abundance during autoimmunity. J Exp Med 2011;208:327-339.
-
(2011)
J Exp Med
, vol.208
, pp. 327-339
-
-
Cruz-Orengo, L.1
-
77
-
-
80052555420
-
Different patterns of peripheral migration by memory CD4+ and CD8+ T cells
-
et a.
-
Gebhardt T, et a. Different patterns of peripheral migration by memory CD4+ and CD8+ T cells. Nature 2011;477:216-219.
-
(2011)
Nature
, vol.477
, pp. 216-219
-
-
Gebhardt, T.1
-
78
-
-
84862777442
-
Skin infection generates non-migratory memory CD8+ T(RM) cells providing global skin immunity
-
Jiang X, Clark RA, Liu L, Wagers AJ, Fuhlbrigge RC, Kupper TS. Skin infection generates non-migratory memory CD8+ T(RM) cells providing global skin immunity. Nature 2012;483:227-231.
-
(2012)
Nature
, vol.483
, pp. 227-231
-
-
Jiang, X.1
Clark, R.A.2
Liu, L.3
Wagers, A.J.4
Fuhlbrigge, R.C.5
Kupper, T.S.6
-
79
-
-
0025370870
-
T-cell recognition of an immunodominant myelin basic protein epitope in multiple sclerosis
-
Ota K, Matsui M, Milford EL, Mackin GA, Weiner HL, Hafler DA. T-cell recognition of an immunodominant myelin basic protein epitope in multiple sclerosis. Nature 1990;346:183-187.
-
(1990)
Nature
, vol.346
, pp. 183-187
-
-
Ota, K.1
Matsui, M.2
Milford, E.L.3
Mackin, G.A.4
Weiner, H.L.5
Hafler, D.A.6
-
80
-
-
0027170328
-
Skewed T-cell receptor repertoire in genetically identical twins correlates with multiple sclerosis
-
Utz U, Biddison WE, McFarland HF, McFarlin DE, Flerlage M, Martin R. Skewed T-cell receptor repertoire in genetically identical twins correlates with multiple sclerosis. Nature 1993;364:243-247.
-
(1993)
Nature
, vol.364
, pp. 243-247
-
-
Utz, U.1
Biddison, W.E.2
McFarland, H.F.3
McFarlin, D.E.4
Flerlage, M.5
Martin, R.6
-
81
-
-
0030749517
-
Immunodominance of a low-affinity major histocompatibility complex-binding myelin basic protein epitope (residues 111-129) in HLA-DR4 (B1*0401) subjects is associated with a restricted T cell receptor repertoire
-
Muraro PA, et al. Immunodominance of a low-affinity major histocompatibility complex-binding myelin basic protein epitope (residues 111-129) in HLA-DR4 (B1*0401) subjects is associated with a restricted T cell receptor repertoire. J Clin Invest 1997;100:339-349.
-
(1997)
J Clin Invest
, vol.100
, pp. 339-349
-
-
Muraro, P.A.1
-
83
-
-
78049247168
-
How thymic antigen presenting cells sample the body's self-antigens
-
Derbinski J, Kyewski B. How thymic antigen presenting cells sample the body's self-antigens. Curr Opin Immunol 2010;22:592-600.
-
(2010)
Curr Opin Immunol
, vol.22
, pp. 592-600
-
-
Derbinski, J.1
Kyewski, B.2
-
84
-
-
84856874763
-
Self-reactive human CD4 T cell clones form unusual immunological synapses
-
Schubert DA, et al. Self-reactive human CD4 T cell clones form unusual immunological synapses. J Exp Med 2012;209:335-352.
-
(2012)
J Exp Med
, vol.209
, pp. 335-352
-
-
Schubert, D.A.1
-
85
-
-
36549034729
-
Dysregulated Epstein-Barr virus infection in the multiple sclerosis brain
-
Serafini B, et al. Dysregulated Epstein-Barr virus infection in the multiple sclerosis brain. J Exp Med 2007;204:2899-2912.
-
(2007)
J Exp Med
, vol.204
, pp. 2899-2912
-
-
Serafini, B.1
-
86
-
-
81855167104
-
Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination
-
Berer K, et al. Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination. Nature 2011;479:538-541.
-
(2011)
Nature
, vol.479
, pp. 538-541
-
-
Berer, K.1
-
87
-
-
0033865109
-
Driver clones and determinant spreading
-
Sercarz EE. Driver clones and determinant spreading. J Autoimmun 2000;14:275-277.
-
(2000)
J Autoimmun
, vol.14
, pp. 275-277
-
-
Sercarz, E.E.1
-
88
-
-
67650469829
-
Human naive and memory CD4+ T cell repertoires specific for naturally processed antigens analyzed using libraries of amplified T cells
-
Geiger R, Duhen T, Lanzavecchia A, Sallusto F. Human naive and memory CD4+ T cell repertoires specific for naturally processed antigens analyzed using libraries of amplified T cells. J Exp Med 2009;206:1525-1534.
-
(2009)
J Exp Med
, vol.206
, pp. 1525-1534
-
-
Geiger, R.1
Duhen, T.2
Lanzavecchia, A.3
Sallusto, F.4
-
89
-
-
79951859220
-
Dissecting the human immunologic memory for pathogens
-
Zielinski CE, Corti D, Mele F, Pinto D, Lanzavecchia A, Sallusto F. Dissecting the human immunologic memory for pathogens. Immunol Rev 2011;240:40-51.
-
(2011)
Immunol Rev
, vol.240
, pp. 40-51
-
-
Zielinski, C.E.1
Corti, D.2
Mele, F.3
Pinto, D.4
Lanzavecchia, A.5
Sallusto, F.6
-
90
-
-
84860241847
-
Pathogen-induced human T(H)17 cells produce IFN-gamma or IL-10 and are regulated by IL-1beta
-
Zielinski CE, et al. Pathogen-induced human T(H)17 cells produce IFN-gamma or IL-10 and are regulated by IL-1beta. Nature 2012;484:514-518.
-
(2012)
Nature
, vol.484
, pp. 514-518
-
-
Zielinski, C.E.1
-
91
-
-
70149111495
-
Progressive multifocal leukoencephalopathy after natalizumab monotherapy
-
Linda H, et al. Progressive multifocal leukoencephalopathy after natalizumab monotherapy. N Engl J Med 2009;361:1081-1087.
-
(2009)
N Engl J Med
, vol.361
, pp. 1081-1087
-
-
Linda, H.1
-
92
-
-
84856724312
-
Risk stratification for progressive multifocal leukoencephalopathy in patients treated with natalizumab
-
Sorenson PS, et al. Risk stratification for progressive multifocal leukoencephalopathy in patients treated with natalizumab. Mult Scler 2012;18:143-152.
-
(2012)
Mult Scler
, vol.18
, pp. 143-152
-
-
Sorenson, P.S.1
-
93
-
-
82455201061
-
Central nervous system recruitment of effector memory CD8+ T lymphocytes during neuroinflammation is dependent on alpha4 integrin
-
Ifergan I, et al. Central nervous system recruitment of effector memory CD8+ T lymphocytes during neuroinflammation is dependent on alpha4 integrin. Brain 2011;134:3560-3577.
-
(2011)
Brain
, vol.134
, pp. 3560-3577
-
-
Ifergan, I.1
-
94
-
-
80051603391
-
CD8+ T cells primed in the periphery provide time-bound immune-surveillance to the central nervous system
-
Young KG, Maclean S, Dudani R, Krishnan L, Sad S. CD8+ T cells primed in the periphery provide time-bound immune-surveillance to the central nervous system. J Immunol 2011;187:1192-1200.
-
(2011)
J Immunol
, vol.187
, pp. 1192-1200
-
-
Young, K.G.1
Maclean, S.2
Dudani, R.3
Krishnan, L.4
Sad, S.5
-
95
-
-
79961160742
-
Flt3L controls the development of radiosensitive dendritic cells in the meninges and choroid plexus of the steady-state mouse brain
-
Anandasabapathy N, et al. Flt3L controls the development of radiosensitive dendritic cells in the meninges and choroid plexus of the steady-state mouse brain. J Exp Med 2011;208:1695-1705.
-
(2011)
J Exp Med
, vol.208
, pp. 1695-1705
-
-
Anandasabapathy, N.1
-
96
-
-
61449227381
-
Decrease in the numbers of dendritic cells and CD4+ T cells in cerebral perivascular spaces due to natalizumab
-
del Pilar Martin M, et al. Decrease in the numbers of dendritic cells and CD4+ T cells in cerebral perivascular spaces due to natalizumab. Arch Neurol 2008;65:1596-1603.
-
(2008)
Arch Neurol
, vol.65
, pp. 1596-1603
-
-
del Pilar Martin, M.1
-
97
-
-
77953642555
-
Alpha4beta1 integrin mediates the recruitment of immature dendritic cells across the blood-brain barrier during experimental autoimmune encephalomyelitis
-
Jain P, Coisne C, Enzmann G, Rottapel R, Engelhardt B. Alpha4beta1 integrin mediates the recruitment of immature dendritic cells across the blood-brain barrier during experimental autoimmune encephalomyelitis. J Immunol 2010;184:7196-7206.
-
(2010)
J Immunol
, vol.184
, pp. 7196-7206
-
-
Jain, P.1
Coisne, C.2
Enzmann, G.3
Rottapel, R.4
Engelhardt, B.5
-
98
-
-
70350721913
-
Peripheral blood CD4+ T lymphocytes from multiple sclerosis patients are characterized by higher PSGL-1 expression and transmigration capacity across a human blood-brain barrier-derived endothelial cell line
-
Bahbouhi B, et al. Peripheral blood CD4+ T lymphocytes from multiple sclerosis patients are characterized by higher PSGL-1 expression and transmigration capacity across a human blood-brain barrier-derived endothelial cell line. J Leukoc Biol 2009;86:1049-1063.
-
(2009)
J Leukoc Biol
, vol.86
, pp. 1049-1063
-
-
Bahbouhi, B.1
-
99
-
-
70350741505
-
PSGL-1-the hidden player in T cell trafficking into the brain in multiple sclerosis?
-
Engelhardt B. PSGL-1-the hidden player in T cell trafficking into the brain in multiple sclerosis? J Leukoc Biol 2009;86:1023-1025.
-
(2009)
J Leukoc Biol
, vol.86
, pp. 1023-1025
-
-
Engelhardt, B.1
-
100
-
-
10744221289
-
Developmental stage, phenotype, and migration distinguish naive- and effector/memory-like CD4+ regulatory T cells
-
Huehn J, et al. Developmental stage, phenotype, and migration distinguish naive- and effector/memory-like CD4+ regulatory T cells. J Exp Med 2004;199:303-313.
-
(2004)
J Exp Med
, vol.199
, pp. 303-313
-
-
Huehn, J.1
-
101
-
-
67649525179
-
CCR6 regulates EAE pathogenesis by controlling regulatory CD4+ T-cell recruitment to target tissues
-
Villares R, et al. CCR6 regulates EAE pathogenesis by controlling regulatory CD4+ T-cell recruitment to target tissues. Eur J Immunol 2009;39:1671-1681.
-
(2009)
Eur J Immunol
, vol.39
, pp. 1671-1681
-
-
Villares, R.1
|