Signalosomes in the brain: Relevance in the development of certain neuropathologies such as Alzheimer's disease

Frontiers in Physiology

Volumn JUN, Issue , 2011, Pages

  Marin, Raquel ^a,b  

^a UNIVERSIDAD DE LA LAGUNA   (Spain)

^b Canarian Institute of Cancer Research   (Spain)

Author keywords

Alzheimer's disease; Membrane estrogen receptor; Neuroprotection; Signaling platforms in neurons; Voltage dependent anion channel

Indexed keywords

EID: 84857060684     PISSN: None     EISSN: 1664042X     Source Type: Journal    
DOI: 10.3389/fphys.2011.00023     Document Type: Short Survey

References (41)

1. Aksenov, M. Y., Aksenova, M. V., Butterfield, D. A., Geddes, J. W., and Markesbery, W. R. (2001). Protein oxidation in the brain in Alzheimer's disease. Neuroscience 103, 373-383.
2. Arcaro, A., Aubert, M., Espinosa del Hierro, M. E., Khanzada, U. K., Angelidou, S., Tetely, T. D., Bittermann, A. G., Frame, M. C., and Seckl, M. J. (2007). Critical role for lipid raft-associated Src kinases in activation of PI3K-Akt signaling. Cell. Signal. 19, 1081-1092.
3. Boulware, M. I., Kordasiewicz J., and Mermelstein, P. G. (2007). Caveolin proteins are essential for distinct effects of membrane estrogen receptors in neurons. J. Neurosci. 27, 9941-9950.
4. Diaz, M., Bahamonde, M. I., Lock, H., Muñoz, F. J., Hardy, S. P., Posas, F., and Valverde, M. A. (2001). Okadaic acid-sensitive activation of Maxi Cl(-) channels by triphenylethylene antioestrogens in C1300 mouse neuroblastoma cells. J. Physiol. 536, 79-88.
5. Ehehalt, R., Keller, P., Haass, C., Thiele, C., and Simons, K. (2003). Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts. J. Cell Biol. 160, 113-123.
6. Ferrer, I. (2009). Altered mitochondria, energy metabolism, voltage-dependent anion channel, and lipid rafts converge to exhaust neurons in Alzheimer's disease. J. Bioenerg. Biomembr. 41, 425-431.
7. Fortin, D. L., Troyer, M. D., Nakamura, K., Kubo, S., Anthony, M. D., and Edwards, R. H. (2004). Lipid rafts mediate the synaptic localization of α-synuclein. Neurobiol. Dis. 24, 6715-6723.
8. Garcia-Segura, L. M., Diz-Chaves, Y., Perez-Martin, M., and Darnaudery, M. (2007). Estradiol, insulin-like growth factor-1 and brain aging. Psychoneuroendocrinology 32, 557-561.
9. Guerra, B., Diaz, M., Alonso, R., and Marin, R. (2004). Plasma membrane oestrogen receptor mediates neuroprotection against β-amyloid toxicity through activation of Raf1/MEK/ERK cascade in septal-derived cholinergic SN56 cells. J. Neurochem. 91, 99-109.
10. Hashimoto, M., Hossain, S., Shimada, T., Sugioka, K., Yamasaki, H., Fujii, Y., Ishibashi, Y., Oka, J. I., and Shido, O. (2002). Docosahexaenoic acid provides protection from impairment of learning ability in Alzheimer's disease model rats. J. Neurochem. 81, 1084-1091.
11. Herrera, J. L., Díaz, M., Hernández-Fernaud, J. R., Salido, E., Alonso, R., Fernández, C., Morales, A., and Marin, R. (2011a). Voltage-dependent anion channel as a resident protein of lipid rafts: pots-transductional regulation by estrogens and involvement in neuronal preservation against Alzheimer's disease. J. Neurochem. 116, 820-827.
12. Herrera, J. L., Fernandez, C. E., Diaz, M., Cury, D., and Marin, R. (2011b). Estradiol and tamoxifen differentially regulate a voltage-dependent anion channel involved in amyloid-beta induced neurotoxicity. Steroids. doi: 10.1016/j.steroids.2011.02.014
13. Lajoie P., Goetz, J. G., Dennis, J. W., and Nabi, I. R. (2009). Lattices, rafts, and scaffolds: domain regulation of receptor signaling at the plasma membrane. J. Cell Biol. 185, 381-385.
14. Lu, Y.-P., Zeng, M., Hu, X.-Y., Xu, H., Swaab, D. F., Ravid, R., and Zhou, J.-N. (2003). Estrogen receptor α-immunoreactive astrocytes are increased in the hippocampus in Alzheimer's disease. Exp. Neurol. 183, 482-488.
15. Marin, R., Diaz, M., Alonso, R., Sanz, A., Arevalo, M. A., and Garcia-Segura, L. M. (2009). Role of estrogen receptor alpha in membrane-initiated signaling in neural cells: interaction with IGF-1 receptor. J. Steroid Biochem. Mol. Biol. 114, 2-7.
16. Marin, R., Guerra, B., Alonso, R., Ramírez, C. M., and Díaz M. (2005). Estrogen activates classical and alternative mechanisms to orchestrate neuroprotection. Curr. Neurovasc. Res. 2, 287-301.
17. Marin, R., Guerra, B., Morales, A., Diaz, M., and Alonso, R. (2003). An oestrogen membrane receptor participates in estradiol actions for the prevention of amyloid-β peptide 1-40-induced toxicity in septal-derived cholinergic SN56 cells. J. Neurochem. 85,1180-1189.
18. Marin, R., Ramírez, C. M., González, M., González-Muñoz, E., Zorzano, A., Camps, M., Alonso R., and Díaz M. (2007). Voltage-dependent anion channel (VDAC) participates in amyloid beta-induced toxicity and interacts with plasma membrane estrogen receptor α in septal and hippocampal neurons. Mol. Membr. Biol. 24, 148-160.
19. Marin, R., Ramirez, C. M., Morales, A., Gonzalez, M., Alonso, R., and Diaz, M. (2008). Modulation of Aβ-induced neurotoxicity by estrogen receptor alpha and other associated proteins in lipid rafts. Steroids 73, 992-996.
20. Martens, J. R., Navarro-Polanco, R., Coppock, E. A., Nishiyama, A., Parshley, L., Grobaski, T. D., and Tamkun, M. M. (2000). Differential targeting of shakerlike potassium channels to lipid rafts. J. Biol. Chem. 275, 7443-7446.
21. Martin, V., Fabelo, N., Santpere, G., Puig, B., Marin, R., Ferrer, I., and Diaz, M. (2010). Lipid alterations in lipid rafts from Alzheimer's disease human brain cortex. J. Alzheimers Dis. 19, 489-502.
22. Morris, R. J., Parkyn, C. J., and Jen, A. (2006). Traffic of prion protein between different compartments on the neuronal surface, and the propagation of prion disease. FEBS Lett. 580, 5565-5571.
23. Pani, A., Mandas, A., and Dessì, S. (2010). Cholesterol, Alzheimer's disease, prion disorders: a ménage à trois? Curr. Drug Targets 11, 1018-1031.
24. Park, J. Y., Kim, K. S., Lee, S. B., Ryu, J. S., Chung, K. C., Choo, Y. K., Jou, I., Kim, J., and Park, S. M. (2009). On the mechanism of internalization of alpha-synuclein into microglia: roles of ganglioside GM1 and lipid raft. J. Neurochem. 110, 400-411.
25. Parton, R. G. (2003). Caveolae-form ultrastructure to molecular mechanisms. Nat. Rev. Mol. Cell Biol. 4, 162-167.
26. Paulick, M. G., and Bertozzi, C. R. (2008). The glycosylphosmarkers phatidylinositol anchor: a comp l ex membrane-anchoring structure for proteins. Biochemistry 47, 6991-7000.
27. Pedram, A., Razandi, M., Sainson, R. C., Kim, J. K., Hughes, C. C., and Levin, E. R. (2007). A conserved mechanism for steroid receptor translocation to the plasma membrane. J. Biol. Chem. 282, 22278-22288.
28. Pike, C. J., Carroll, J. C., Rosario, E. R., and Barron, A. M. (2009). Protective actions of sex steroid hormones in Alzheimer's disease. Front. Neuroendocrinol. 3, 239-258.
29. Ramirez, C. M., Gonzalez, M., Diaz, M., Alonso, R., Ferrer, I., Santpere, G., Puig, B., Meyer G., and Marin, R. (2009). VDAC and ERα interaction in caveolae from human cortex is altered in Alzheimer's disease. Mol. Cell. Neurosci. 42, 172-183.
30. Raz, L., Khan, M. M., Mahesh, V. B., Vadlamudi, R. K., and Brann, D. W. (2008). Rapid estrogen signalling in the brain. Neurosignals 16, 140-153
31. Rushworth, J. V., and Hooper, N. M. (2011). Lipid rafts: linking Alzheimer's amyloid-β production, aggregation, and toxicity at neuronal membranes. Int. J. Alzheimers Dis. doi: 10.4061/2011/603052
32. Russelakis-Caneiro, M., Hetz, C., Maundrell, K., and Soto C. (2004). Prion replication alters the distribution of synaptophysin and caveolin 1 in neuronal lipid rafts. Am. J. Pathol. 165, 1839-1848.
33. Sato I., Obata Y., Kasahara K., Nakayama, Y., Fukumoto, Y., Yamasaki, T., Yokohama, K. K., Saito, T., and Yamaguchi, N. (2009). Differential trafficking of Src, Lyn, Yes and Fyn is specified by the state of palmitoylation in the SH4 domain. J. Cell Sci. 122, 965-975.
34. Schengrund, C. L. (2010). Lipid rafts: keys to neurodegeneration. Brain Res. Bull. 82, 7-17.
35. Simons, K., and Gerl, M. J. (2010). Revitalizing membrane rafts: new tools and insights. Nat. Rev. 11, 688-699.
36. Suzuki, S., Brown, C. M., and Wise, P. M. (2006). Mechanisms of neuroprotection by estrogen. Endocrine 29, 209-215.
37. Taylor, D. R., and Hooper, N. M. (2007). Role of lipid rafts in the processing of the pathogenic prion and Alzheimer's amyloid-beta proteins. Semin. Cell Dev. Biol. 18, 638-648.
38. Thinnes, F. P. (2010). Aβ, cut from APP by β-secretase BACE1 and γ-secretase, induces apoptosis via opening type-1 porin/VDAC in cell membranes of hypometabolic cells - a basic model for the induction of apoptosis? Mol. Genet. Metab. 101, 301-303.
39. Tsui-Pierchala, B., Encinas, M., Milbrandt, J., and Jonson, E. M. (2002). Lipid rafts in neuronal signaling and function. Trends Neurosci. 25, 412-417.
40. Vardy, E. R. L. C., Catto, A. J., and Hooper, N. M. (2005). Proteolytic mechanisms in amyloid-β metabolism: therapeutic implications for Alzheimer's disease. Trends Mol. Med. 11, 464-472.
41. Vasudeban, N., and Pfaff, D. W. (2008). Non-genomic actions of estrogens and their interaction with genomic actions in the brain. Front. Neuroendocrinol. 29, 238-257.