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Volumn 21, Issue 3, 2010, Pages 927-938

PD1 negative and PD1 positive CD4+ T regulatory cells in mild cognitive impairment and Alzheimer's disease

Author keywords

Alzheimer's disease; immunology; mild cognitive impairment; PD1; T regulatory cells

Indexed keywords

AMYLOID BETA PROTEIN; PROGRAMMED DEATH 1 RECEPTOR; TRANSCRIPTION FACTOR FOXP3;

EID: 77957283905     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/JAD-2010-091696     Document Type: Article
Times cited : (115)

References (59)
  • 2
    • 0030775197 scopus 로고    scopus 로고
    • Circulating cytokines in Alzheimer's disease
    • DOI 10.1016/S0022-3956(97)00023-X, PII S002239569700023X
    • Singh VK, Guthikonda P (1997) Circulating cytokines in Alzheimer's disease. J Psychiatr Res 31, 657660. (Pubitemid 27522448)
    • (1997) Journal of Psychiatric Research , vol.31 , Issue.6 , pp. 657-660
    • Singh, V.K.1    Guthikonda, P.2
  • 3
    • 0033664955 scopus 로고    scopus 로고
    • Overproduction of IFNgamma andTNF fromnatural killer (NK) cells is associated with abnormal NK reactivity and cognitive derangement in Alzheimer's disease
    • Solerte SB, Cravello L, Ferrari E, Fioravanti M (2000) Overproduction of IFN gamma and TNF fromnatural killer (NK) cells is associated with abnormal NK reactivity and cognitive derangement in Alzheimer's disease. Ann N Y Acad Sci 917, 331340.
    • (2000) Ann N Y Acad Sci , vol.917 , pp. 331-340
    • Solerte, S.B.1    Cravello, L.2    Ferrari, E.3    Fioravanti, M.4
  • 5
    • 0344097504 scopus 로고    scopus 로고
    • Age-related impaired proliferation of peripheral blood mononuclear cells is associated with an increase in both IL-10 and IL-12
    • DOI 10.1016/S0531-5565(98)00064-3, PII S0531556598000643
    • Castle SC, Uyemura K, CrawfordW,WongW, Klaustermeyer WB, Makinodan T (1999) Agerelated impaired proliferation of peripheral blood mononuclear cells is associated with an increase in both IL10 and IL12. Exp Gerontol 34, 243252. (Pubitemid 29153021)
    • (1999) Experimental Gerontology , vol.34 , Issue.2 , pp. 243-252
    • Castleab, S.C.1    Uyemuraabc, K.2    Crawford, W.3    Wongab, W.4    Klaustermeyer, W.B.5    Makinodan, T.6
  • 7
    • 0029053902 scopus 로고
    • T lymphocyte subpopulations and activation markers correlate with severity of Alzheimer's disease
    • Shalit F, Sredni B, Brodie C, Kott E, Huberman M (1995) T lymphocyte subpopulations and activation markers correlate with severity of Alzheimer's disease. Clin Immunol Immunopathol 75, 246250.
    • (1995) Clin Immunol Immunopathol , vol.75 , pp. 246-250
    • Shalit, F.1    Sredni, B.2    Brodie, C.3    Kott, E.4    Huberman, M.5
  • 8
    • 0032964511 scopus 로고    scopus 로고
    • Characterization of cytokine production, screening of lymphocyte subset patterns and in vitro apoptosis in healthy and Alzheimer's Disease (AD) individuals
    • DOI 10.1016/S0165-5728(99)00046-6, PII S0165572899000466
    • Lombardi VR, Garcia M, Rey L, Cacabelos R (1999) Characterization of cytokine production, screening of lymphocyte subset patterns and in vitro apoptosis in healthy and Alzheimer's Disease (AD) individuals. J Neuroimmunol 97, 163171. (Pubitemid 29301426)
    • (1999) Journal of Neuroimmunology , vol.97 , Issue.1-2 , pp. 163-171
    • Lombardi, V.R.M.1    Garcia, M.2    Rey, L.3    Cacabelos, R.4
  • 11
    • 34447629515 scopus 로고    scopus 로고
    • Higher frequency of regulatory T cells in the elderly and increased suppressive activity in neurodegeneration
    • DOI 10.1016/j.jneuroim.2007.05.011, PII S0165572807001749
    • Rosenkranz D,Weyer S, Tolosa E, Gaenslen A, Berg D, Leyhe T, Gasser T, Stoltze L (2007) Higher frequency of regulatory T cells in the elderly and increased suppressive activity in neurodegeneration. J Neuroimmunol 188, 117127. (Pubitemid 47095016)
    • (2007) Journal of Neuroimmunology , vol.188 , Issue.1-2 , pp. 117-127
    • Rosenkranz, D.1    Weyer, S.2    Tolosa, E.3    Gaenslen, A.4    Berg, D.5    Leyhe, T.6    Gasser, T.7    Stoltze, L.8
  • 12
    • 14844345227 scopus 로고    scopus 로고
    • CD4+ Tregs and immune control
    • Fehérvari Z, Sakaguchi S (2004) CD4+ Tregs and immune control. J Clin Invest 114, 12091217.
    • (2004) J Clin Invest , vol.114 , pp. 1209-1217
    • Fehérvari, Z.1    Sakaguchi, S.2
  • 13
    • 0033853625 scopus 로고    scopus 로고
    • + T cells as a functionally and phenotypically distinct immunoregulatory T cell subpopulation
    • Kuniyasu Y, Takahashi T, Itoh M, Shimizu J, Toda G, Sakaguchi S (2000) Naturally anergic and suppressive CD25+CD4+ T cells as functionally and phenotypically distinct immunoregulatory T cell subpopulation. Int Immunol 12, 11451155. (Pubitemid 30618021)
    • (2000) International Immunology , vol.12 , Issue.8 , pp. 1145-1155
    • Kuniyasu, Y.1    Takahashi, T.2    Itoh, M.3    Shimizu, J.4    Toda, G.5    Sakaguchi, S.6
  • 14
    • 2442484053 scopus 로고    scopus 로고
    • + regulatory T cells for immunologic self-tolerance and negative control of immune responses
    • DOI 10.1146/annurev.immunol.21.120601.141122
    • Sakaguchi S (2004) Naturally arising CD4+ regulatory t cells for immunologic selftolerance and negative control of immune responses. Ann Rev Immunol 22, 531562. (Pubitemid 38680433)
    • (2004) Annual Review of Immunology , vol.22 , pp. 531-562
    • Sakaguchi, S.1
  • 15
    • 0346888498 scopus 로고    scopus 로고
    • + T Cells
    • DOI 10.1016/S0065-2776(03)81008-8
    • Hori S, Takahashi T, Sakaguchi S (2003) Control of autoimmunity by naturally arising regulatory CD4+ T cells. Adv Immunol 81, 331371. (Pubitemid 38009046)
    • (2003) Advances in Immunology , vol.81 , pp. 331-371
    • Hori, S.1    Takahashi, T.2    Sakaguchi, S.3
  • 16
    • 0242403301 scopus 로고    scopus 로고
    • Quantification of regulatory T cells in patients with systemic lupus erythematosus
    • DOI 10.1016/S0896-8411(03)00121-5
    • Crispin JC, Martínez A, AlcocerVarela J (2003) Quantification of regulatory T cells in patients with systemic lupus erythematosus. J Autoimmun 21, 273276. (Pubitemid 37410115)
    • (2003) Journal of Autoimmunity , vol.21 , Issue.3 , pp. 273-276
    • Crispin, J.C.1    Martinez, A.2    Alcocer-Varela, J.3
  • 19
    • 0037385330 scopus 로고    scopus 로고
    • Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
    • Fontenot JD, Gavin MA, Rudensky AY (2003) Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol 4, 330336.
    • (2003) Nat Immunol , vol.4 , pp. 330-336
    • Fontenot, J.D.1    Gavin, M.A.2    Rudensky, A.Y.3
  • 24
    • 33746336533 scopus 로고    scopus 로고
    • [CTLA4] in regulatory T cell biology
    • [CTLA4] in regulatory Tcell biology. Immunol Rev 212, 131148.
    • Immunol Rev , vol.212 , pp. 131-148
  • 26
    • 33644548654 scopus 로고    scopus 로고
    • + resting regulatory T cells from activated T cells
    • Raimondi G, Shufesky WJ, Tokita D, Morelli AE, Thomson AW (2006) Regulated compartmentalization of programmed cell death1 discriminates CD4+CD25+ resting regulatory T cells from activated T cells. J Immunol 176, 28082816. (Pubitemid 43306940)
    • (2006) Journal of Immunology , vol.176 , Issue.5 , pp. 2808-2816
    • Raimondi, G.1    Shufesky, W.J.2    Tokita, D.3    Morelli, A.E.4    Thomson, A.W.5
  • 27
    • 0021271971 scopus 로고
    • Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA work group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease
    • McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM(1984) Clinical diagnosis of Alzheimer's disease: Report of the NINCDS ADRDA Work Group under the auspices ofDepartment ofHealth andHuman Services Task Force on Alzheimer's Disease. Neurology 34, 939-944. (Pubitemid 14076461)
    • (1984) Neurology , vol.34 , Issue.7 , pp. 939-944
    • McKhann, G.1    Drachman, D.2    Folstein, M.3
  • 29
    • 0016823810 scopus 로고
    • Minimental state" A practical method for grading the cognitive state of patients for the clinicians
    • Folstein MF, Folstein SE, McHugh PR (1975) "Minimental state" A practical method for grading the cognitive state of patients for the clinicians. J Psychiat Res 12, 189198.
    • (1975) J Psychiat Res , vol.12 , pp. 189-198
    • Folstein, M.F.1    Folstein, S.E.2    McHugh, P.R.3
  • 30
    • 0020040238 scopus 로고
    • A new clinical scale for the staging of dementia
    • Hughes CP, Berg L, Danziger WL, Coben LA, Martin RL (1982) A new clinical scale for staging of dementia. Br J Psychiatry 140, 566572. (Pubitemid 12124384)
    • (1982) British Journal of Psychiatry , vol.140 , Issue.6 , pp. 566-572
    • Hughes, C.P.1    Berg, L.2    Danziger, W.L.3
  • 31
    • 4544335597 scopus 로고    scopus 로고
    • Mild cognitive impairment as a diagnostic entity
    • DOI 10.1111/j.1365-2796.2004.01388.x
    • Petersen RC (2004)Mild cognitive impairment as a diagnostic entity. J Intern Med 256, 183-194. (Pubitemid 39222988)
    • (2004) Journal of Internal Medicine , vol.256 , Issue.3 , pp. 183-194
    • Petersen, R.C.1
  • 33
    • 0021739814 scopus 로고
    • Admission criteria for immunogerontological studies in man: The SENIEUR protocol
    • DOI 10.1016/0047-6374(84)90152-0
    • Ligthart GJ, Corberand JX, Fournier C, Galanaud P, Hijmans W, Kennes B, MüllerHermelink HK, Steinmann GG (1984) Admission criteria for immunogerontological studies in man: The SENIEUR protocol. Mech Ageing Dev 28, 4755. (Pubitemid 15222465)
    • (1984) Mechanisms of Ageing and Development , vol.28 , Issue.1 , pp. 47-55
    • Ligthart, G.J.1    Corberand, J.X.2    Fournier, C.3
  • 34
    • 0034699367 scopus 로고    scopus 로고
    • Analysing cell division in vivo and in vitro using flow cytometric measurement of CFSE dye dilution
    • Lyons AB (2000) Analysing cell division in vivo and in vitro using flow cytometric measurement of CFSE dye dilution. J Immunol Methods 243, 147154.
    • (2000) J Immunol Methods , vol.243 , pp. 147-154
    • Lyons, A.B.1
  • 36
    • 0028832354 scopus 로고
    • Amyloid peptide potentiate cytokine secretion by interleukin 1 activated human astrocytoma cell
    • Gitter BD, Cox LM, Rydel LE, May PC (1995) Amyloid peptide potentiate cytokine secretion by interleukin 1 activated human astrocytoma cell. Proc Natl Acad Sci U S A 92, 1073810741.
    • (1995) Proc Natl Acad Sci U S B. , vol.92 , pp. 10738-10741
    • Gitter, B.D.1    Cox, L.M.2    Rydel, L.E.3    May, P.C.4
  • 38
    • 0034968481 scopus 로고    scopus 로고
    • Cerebrospinal fluid Aβ40 and Aβ42: Natural course and clinical usefulness
    • Shoji M, Kanai M (2001) Cerebrospinal fluid Abeta40 and Abeta42: Natural course and clinical usefulness. J Alzheimers Dis 3, 313321. (Pubitemid 32577635)
    • (2001) Journal of Alzheimer's Disease , vol.3 , Issue.3 , pp. 313-321
    • Shoji, M.1    Kanai, M.2
  • 41
    • 34147092225 scopus 로고    scopus 로고
    • + regulatory T cell mediated suppression of auto-antigen specific and polyclonal T cell responses
    • DOI 10.1016/j.jim.2007.01.025, PII S0022175907000518
    • Venken K, Thewissen M, Hellings N, Somers V, Hensen K, Rummens JL, Stinissen P (2007) A CFSE based assay for measuring CD4+CD25+ regulatory T cell mediated suppression of autoantigen specific and polyclonal T cell responses. J Immunol Meth 322, 111. (Pubitemid 46560587)
    • (2007) Journal of Immunological Methods , vol.322 , Issue.1-2 , pp. 1-11
    • Venken, K.1    Thewissen, M.2    Hellings, N.3    Somers, V.4    Hensen, K.5    Rummens, J.-L.6    Stinissen, P.7
  • 42
    • 36549083642 scopus 로고    scopus 로고
    • Neuroinflammation: Implications for the pathogenesis and molecular diagnosis of Alzheimer's disease
    • Rojo LE, Fernández JA,Maccioni AA, Jimenez JM,Maccioni RB (2008) Neuroinflammation: Implications for the pathogenesis and molecular diagnosis of Alzheimer's disease. Arch Med Res 39, 116.
    • (2008) Arch Med Res , vol.39 , pp. 116
    • Rojo, L.E.1    Fernández, J.A.2    Maccioni, A.A.3    Jimenez, J.M.4    Maccioni, R.B.5
  • 43
    • 58149216847 scopus 로고    scopus 로고
    • Nonviral DNA vaccination augments microglial phagocytosis of betaamyloid deposits as a major clearance pathway in an Alzheimer disease mouse model
    • Marins Okura Y, Kohyama K, Park IK, Matsumoto Y (2008) Nonviral DNA vaccination augments microglial phagocytosis of betaamyloid deposits as a major clearance pathway in an Alzheimer disease mouse model. J Neuropathol Exp Neurol 67, 1063-1071.
    • (2008) J Neuropathol Exp Neurol , vol.67 , pp. 1063-1071
    • Marins Okura, Y.1    Kohyama, K.2    Park, I.K.3    Matsumoto, Y.4
  • 45
    • 73049110767 scopus 로고    scopus 로고
    • The multifaceted profile of activated microglia
    • Lynch MA (2009) The multifaceted profile of activated microglia. Mol Neurobiol 40, 13956.
    • (2009) Mol Neurobiol , vol.40 , pp. 139-156
    • Lynch, M.B.1
  • 46
    • 58149181978 scopus 로고    scopus 로고
    • Fibrillar amyloidbeta peptides activate microglia via TLR2: Implications for Alzheimer's disease
    • Jana M, Palencia CA, Pahan K (2008) Fibrillar amyloidbeta peptides activate microglia via TLR2: Implications for Alzheimer's disease. J Immunol 181, 72547262.
    • (2008) J Immunol , vol.181 , pp. 7254-7262
    • Jana, M.1    Palencia, C.A.2    Pahan, K.3
  • 47
    • 34548434392 scopus 로고    scopus 로고
    • Chronic interleukin-1β expression in mouse brain leads to leukocyte infiltration and neutrophil-independent blood-brain barrier permeability without overt neurodegeneration
    • DOI 10.1523/JNEUROSCI.1418-07.2007
    • Shaftel SS, Carlson TJ, Olschowka JA, Kyrkanides S, Matousek SB, O'Banion MK (2007) Chronic interleukin1beta expression in mouse brain leads to leukocyte infiltration and neutrophilindependent blood brain barrier permeability without overt neurodegeneration. J Neurosci 27, 9301-9309. (Pubitemid 47358197)
    • (2007) Journal of Neuroscience , vol.27 , Issue.35 , pp. 9301-9309
    • Shaftel, S.S.1    Carlson, T.J.2    Olschowka, J.A.3    Kyrkanides, S.4    Matousek, S.B.5    O'Banion, M.K.6
  • 48
    • 70449534695 scopus 로고    scopus 로고
    • CNS infiltration of peripheral immune cells: DDay for neurodegenerative disease?
    • RezaiZadeh K, Gate D, Town T (2009) CNS infiltration of peripheral immune cells: DDay for neurodegenerative disease? J Neuroimmune Pharmacol 4, 462475.
    • (2009) J Neuroimmune Pharmacol , vol.4 , pp. 462-475
    • RezaiZadeh, K.1    Gate, D.2    Town, T.3
  • 50
    • 59049104731 scopus 로고    scopus 로고
    • Selective targeting of perivascular macrophages for clearance of betaamyloid in cerebral amyloid angiopathy
    • Hawkes CA,McLaurin J (2009) Selective targeting of perivascular macrophages for clearance of betaamyloid in cerebral amyloid angiopathy. ProcNatlAcad SciUS A 106, 12611266.
    • (2009) ProcNatlAcad SciUS B. , vol.106 , pp. 1261-1266
    • Hawkes, C.A.1    McLaurin, J.2
  • 52
    • 0036667394 scopus 로고    scopus 로고
    • CD40CD40L interaction in Alzheimer's disease
    • Tan J, Town T, Mullan M (2002) CD40CD40L interaction in Alzheimer's disease. Curr Opin Pharmacol 2, 445451.
    • (2002) Curr Opin Pharmacol , vol.2 , pp. 445-451
    • Tan, J.1    Town, T.2    Mullan, M.3
  • 53
    • 27744464859 scopus 로고    scopus 로고
    • The microglial "activation" continuum: From innate to adaptive responses
    • DOI 10.1186/1742-2094-2-24
    • Town T, Nikolic V, Tan J (2005) The microglial activation continuum: from innate to adaptive responses. J Neuroinflammation 2, 24. (Pubitemid 41631819)
    • (2005) Journal of Neuroinflammation , vol.2 , pp. 24
    • Town, T.1    Nikolic, V.2    Tan, J.3
  • 55
    • 1642421839 scopus 로고    scopus 로고
    • + cells of elderly people is associated with faster loss of activation-related antigens and accumulation of regulatory T cells
    • DOI 10.1016/j.exger.2003.10.029, PII S0531556504000312
    • Bryl E,Witkowski JM(2004) Decreased proliferative capability of CD4(+) cells of elderly people isassociated with faster loss of activationrelated antigens and accumulation of regulatory T cells. Exp Gerontol 39, 587595. (Pubitemid 38402085)
    • (2004) Experimental Gerontology , vol.39 , Issue.4 , pp. 587-595
    • Bryl, E.1    Witkowski, J.M.2
  • 56
    • 33646397029 scopus 로고    scopus 로고
    • CD4+CD25+ T regulatory cells inhibit cytotoxic activity of CTL and NK cells in humansimpact of immunosenescence
    • Trzonkowski P, Szmit E, Myśliwska J, Myśliwski A (2006) CD4+CD25+ T regulatory cells inhibit cytotoxic activity of CTL and NK cells in humansimpact of immunosenescence. Clin Immunol 119, 307316.
    • (2006) Clin Immunol , vol.119 , pp. 307-316
    • Trzonkowski, P.1    Szmit, E.2    Myśliwska, J.3    Myśliwski, B.4
  • 57
    • 0034747056 scopus 로고    scopus 로고
    • - T suppressor cells and the induction of antigen-specific, antigen-presenting cell-mediated suppression of Th reactivity
    • DOI 10.1034/j.1600-065X.2001.1820116.x
    • Cortesini R, LeMaoult J, Ciubotariu R, SuciuFoca N (2001) CD8+CD28-T suppressor cells and the induction of antigenspecific, antigenpresenting cellmediated suppression of Th reactivity. Immunol Rev 182, 201206. (Pubitemid 33070219)
    • (2001) Immunological Reviews , vol.182 , pp. 201-206
    • Cortesini, R.1    LeMaoult, J.2    Ciubotariu, R.3    Cortesini, N.S.F.4
  • 59
    • 14644414819 scopus 로고    scopus 로고
    • The association between promoter polymorphism of the interleukin-10 gene and Alzheimer's disease
    • DOI 10.1016/j.neurobiolaging.2004.08.010
    • Ma SL, Tang NL, Lam LC, Chiu HF (2005) The association between promoter polymorphism of the interleukin10 gene and Alzheimer's disease. Neurobiol Aging 7, 10051010. (Pubitemid 40312663)
    • (2005) Neurobiology of Aging , vol.26 , Issue.7 , pp. 1005-1010
    • Ma, S.L.1    Tang, N.L.S.2    Lam, L.C.W.3    Chiu, H.F.K.4


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