An association between immunosenescence and CD4+CD25+ regulatory T cells: A systematic review

Biomedical and Environmental Sciences

Volumn 23, Issue 4, 2010, Pages 327-332

  Wang, Ling ^a   Xie, Yan ^a   Zhu, Li Jing ^a   Chang, Ting Ting ^a   Ing Mao, Yan Q ^a   Li, Jie ^a  

^a SOOCHOW UNIVERSITY   (China)

Author keywords

Aging; Case control studies; CD4+CD25+ T cell; Cohort studies; Cross sectional studies; Immunosenescence; Treg

Indexed keywords

CD4 ANTIGEN; INTERLEUKIN 2 RECEPTOR ALPHA;

AGING; ANIMAL; ARTICLE; HUMAN; IMMUNOLOGY; REGULATORY T LYMPHOCYTE;

AGING; ANIMALS; ANTIGENS, CD4; HUMANS; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; T-LYMPHOCYTES, REGULATORY;

ANIMALIA;

EID: 77957744665     PISSN: 08953988     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0895-3988(10)60072-4     Document Type: Article

References (25)

1. G Pawelec Immunosenescence: impact in the young as well as the old ? Mech Ageing Dev 108 1 1999 1 7
2. G Pawelec, S Koch, C Franceschi Human immunosenescence: does it have an infectious component? Ann NY Acad Sci 1067 2006 56 65
3. FT Hakim, FA Flomerfelt, M Boyiadzis Aging, immunity and cancer Curr Opin Immunol 16 2 2004 151 156
4. D Aw, AB Silva, DB Palmer Immunosenescence: emerging challenges for an ageing population Immunology 120 4 2007 435 446
5. RD Kovaiou, B Grubeck-Loebenstein Age-associated changes within CD4-T cells Immunol Lett 107 1 2006 8 14
6. C Baecher-Allan, JA Brown, GJ Freeman CD4+CD25 high regulatory cells in human peripheral blood J Immunol 167 3 2001 1245 1253
7. L Tsaknaridis, L Spencer, N Culbertson Functional assay for human CD4+CD25+ Treg cells reveals an age-dependent loss of suppressive activity J Neurosci Res 74 2 2003 296 308
8. + cells of elderly people is associated with faster loss of activation-related antigens and accumulation of regulatory T cells Experimental Gerontology 39 4 2004 587 595
9. high regulatory T cells increases with age Clinical and Experimental Immunology 140 3 2005 540 546
10. + T regulatory cells inhibit cytotoxic activity of CTL and NK cells in humans-impact of immunosenescence Clinical Immunology 119 3 2006 307 316
11. D Rosenkranz, S Weyer, E Tolosa Higher frequency of regulatory T cells in the elderly and increased suppressive activity in neurodegeneration J Neuroimmunol 188 1 2007 117 127
12. CS Lages, I Suffia, PA Velilla Functional regulatory T cells accumulate in aged hosts and promote chronic infectious disease reactivation J Immunol 181 3 2008 1835 1848
13. + regulatory T cells Mechanisms of Ageing and Development 130 8 2009 509 517
14. + T cells Mechanisms of Ageing and Development 131 2 2010 96 104
15. + Treg is in part responsible for altered cytokine production by cells of aged mice which follows injection with a fetal liver extract Immunology Letters 109 2 2007 101 112
16. +cells in BDC2?5NOD mice Immunology 121 4 2007 565 576
17. + T Cells in aged mice J Immunol 176 11 2006 6586 6593
18. S Sharma, AL Dominguez, J Lustgarten High accumulation of T regulatory cells prevents the activation of immune responses in aged animals J Immunol 177 12 2006 8348 8355
19. + regulatory T cells in aged Balb/c mice J Leukoc Biol 81 6 2007 1386 1394
20. + Treg cell activity reduces dendritic cell co-stimulatory molecule expression in aged mice Mech Ageing Dev 128 11-12 2007 618 627
21. + regulatory T cells in aging of mice Journal of Shandong University 46 10 2008 927 930 (In Chinese).
22. + regulatory T cells by peripheral expansion J Immunol 173 12 2004 7259 7268
23. +-derived T regulatory cell lines express Foxp3 protein and manifest potent suppressor function Blood 105 2 2005 750 758
24. + T cells in thymus, cord and adult blood Immunology 106 2 2002 190 199
25. RA Clark, TS Kupper IL-15 and dermal fibroblasts induce proliferation of natural regulatory T cells isolated from human skin Blood 109 1 2007 194 202