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Volumn 7, Issue AUG, 2016, Pages

ICOS co-stimulation: Friend or foe?

Author keywords

Antibody production; Co stimulatory molecules; Parasitic and bacterial infection; T cell activation

Indexed keywords

CD28 ANTIGEN; CHEMOKINE RECEPTOR CXCR5; GAMMA INTERFERON; INDUCIBLE T CELL COSTIMULATOR; INTERLEUKIN 6; PROTEIN BCL 6; PROTEIN KINASE B; TUMOR NECROSIS FACTOR;

EID: 84989291155     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2016.00304     Document Type: Review
Times cited : (217)

References (131)
  • 1
    • 0036484220 scopus 로고    scopus 로고
    • The B7-CD28 superfamily
    • Sharpe AH, Freeman GJ. The B7-CD28 superfamily. Nat Rev Immunol (2002) 2:116-26. doi:10.1038/nri727
    • (2002) Nat Rev Immunol , vol.2 , pp. 116-126
    • Sharpe, A.H.1    Freeman, G.J.2
  • 2
    • 0021175739 scopus 로고
    • A 45-kDa human T-cell membrane glycoprotein functions in the regulation of cell proliferative responses
    • Gmünder H, Lesslauer W. A 45-kDa human T-cell membrane glycoprotein functions in the regulation of cell proliferative responses. Eur J Biochem (1984) 142:153-60. doi:10.1111/j.1432-1033.1984.tb08263.x
    • (1984) Eur J Biochem , vol.142 , pp. 153-160
    • Gmünder, H.1    Lesslauer, W.2
  • 6
    • 84966762527 scopus 로고    scopus 로고
    • Costimulatory and coinhibitory receptor pathways in infectious disease
    • Attanasio J, Wherry EJ. Costimulatory and coinhibitory receptor pathways in infectious disease. Immunity (2016) 44:1052-68. doi:10.1016/j.immuni.2016.04.022
    • (2016) Immunity , vol.44 , pp. 1052-1068
    • Attanasio, J.1    Wherry, E.J.2
  • 7
    • 84966738229 scopus 로고    scopus 로고
    • Coinhibitory pathways in the B7-CD28 ligand-receptor family
    • Schildberg FA, Klein SR, Freeman GJ, Sharpe AH. Coinhibitory pathways in the B7-CD28 ligand-receptor family. Immunity (2016) 44:955-72. doi:10.1016/j.immuni.2016.05.002
    • (2016) Immunity , vol.44 , pp. 955-972
    • Schildberg, F.A.1    Klein, S.R.2    Freeman, G.J.3    Sharpe, A.H.4
  • 9
    • 0033999501 scopus 로고    scopus 로고
    • Molecular cloning and characterization of murine ICOS and identification of B7h as ICOS ligand
    • Mages HW, Hutloff A, Heuck C, Büchner K, Himmelbauer H, Oliveri F, et al. Molecular cloning and characterization of murine ICOS and identification of B7h as ICOS ligand. Eur J Immunol (2000) 30:1040-7. doi:10.1002/(SICI)1521-4141(200004)30:4<1040::AID-IMMU1040>3.0.CO;2-6
    • (2000) Eur J Immunol , vol.30 , pp. 1040-1047
    • Mages, H.W.1    Hutloff, A.2    Heuck, C.3    Büchner, K.4    Himmelbauer, H.5    Oliveri, F.6
  • 10
    • 0142259712 scopus 로고    scopus 로고
    • Unifying concepts in CD28, ICOS and CTLA4 co-receptor signalling
    • Rudd CE, Schneider H. Unifying concepts in CD28, ICOS and CTLA4 co-receptor signalling. Nat Rev Immunol (2003) 3:544-56. doi:10.1038/nri1131
    • (2003) Nat Rev Immunol , vol.3 , pp. 544-556
    • Rudd, C.E.1    Schneider, H.2
  • 11
    • 0034327808 scopus 로고    scopus 로고
    • Mouse inducible costimulatory molecule (ICOS) expression is enhanced by CD28 costimulation and regulates differentiation of CD4+ T cells
    • McAdam AJ, Chang TT, Lumelsky AE, Greenfield EA, Boussiotis VA, Duke-Cohan JS, et al. Mouse inducible costimulatory molecule (ICOS) expression is enhanced by CD28 costimulation and regulates differentiation of CD4+ T cells. J Immunol (2000) 165:5035-40. doi:10.4049/jimmunol.165.9.5035
    • (2000) J Immunol , vol.165 , pp. 5035-5040
    • McAdam, A.J.1    Chang, T.T.2    Lumelsky, A.E.3    Greenfield, E.A.4    Boussiotis, V.A.5    Duke-Cohan, J.S.6
  • 13
    • 14944358732 scopus 로고    scopus 로고
    • A distinct role for ICOS-mediated co-stimulatory signaling in CD4+ and CD8+ T cell subsets
    • Watanabe M, Hara Y, Tanabe K, Toma H, Abe R. A distinct role for ICOS-mediated co-stimulatory signaling in CD4+ and CD8+ T cell subsets. Int Immunol (2005) 17:269-78. doi:10.1093/intimm/dxh206
    • (2005) Int Immunol , vol.17 , pp. 269-278
    • Watanabe, M.1    Hara, Y.2    Tanabe, K.3    Toma, H.4    Abe, R.5
  • 14
    • 0035988233 scopus 로고    scopus 로고
    • A co-stimulatory molecule on activated T cells, H4/ICOS, delivers specific signals in T(h) cells and regulates their responses
    • Arimura Y, Kato H, Dianzani U, Okamoto T, Kamekura S, Buonfiglio D, et al. A co-stimulatory molecule on activated T cells, H4/ICOS, delivers specific signals in T(h) cells and regulates their responses. Int Immunol (2002) 14:555-66. doi:10.1093/intimm/dxf022
    • (2002) Int Immunol , vol.14 , pp. 555-566
    • Arimura, Y.1    Kato, H.2    Dianzani, U.3    Okamoto, T.4    Kamekura, S.5    Buonfiglio, D.6
  • 15
    • 73949090666 scopus 로고    scopus 로고
    • Inducible costimulator promotes helper T-cell differentiation through phosphoinositide 3-kinase
    • Gigoux M, Shang J, Pak Y, Xu M, Choe J, Mak TW, et al. Inducible costimulator promotes helper T-cell differentiation through phosphoinositide 3-kinase. Proc Natl Acad Sci U S A (2009) 106:20371-6. doi:10.1073/pnas.0911573106
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 20371-20376
    • Gigoux, M.1    Shang, J.2    Pak, Y.3    Xu, M.4    Choe, J.5    Mak, T.W.6
  • 16
    • 0034651694 scopus 로고    scopus 로고
    • Cutting edge: identification of GL50, a novel B7-like protein that functionally binds to ICOS receptor
    • Ling V, Wu PW, Finnerty HF, Bean KM, Spaulding V, Fouser LA, et al. Cutting edge: identification of GL50, a novel B7-like protein that functionally binds to ICOS receptor. J Immunol (2000) 164:1653-7. doi:10.4049/jimmunol.164.4.1653
    • (2000) J Immunol , vol.164 , pp. 1653-1657
    • Ling, V.1    Wu, P.W.2    Finnerty, H.F.3    Bean, K.M.4    Spaulding, V.5    Fouser, L.A.6
  • 17
    • 0034193043 scopus 로고    scopus 로고
    • Characterization of human inducible costimulator ligand expression and function
    • Aicher A, Hayden-Ledbetter M, Brady WA, Pezzutto A, Richter G, Magaletti D, et al. Characterization of human inducible costimulator ligand expression and function. J Immunol (2000) 164:4689-96. doi:10.4049/jimmunol.164.9.4689
    • (2000) J Immunol , vol.164 , pp. 4689-4696
    • Aicher, A.1    Hayden-Ledbetter, M.2    Brady, W.A.3    Pezzutto, A.4    Richter, G.5    Magaletti, D.6
  • 18
    • 0027937702 scopus 로고
    • Complementarity determining region 1 (CDR1)-and CDR3-analogous regions in CTLA-4 and CD28 determine the binding to B7-1
    • Peach RJ, Bajorath J, Brady W, Leytze G, Greene J, Naemura J, et al. Complementarity determining region 1 (CDR1)-and CDR3-analogous regions in CTLA-4 and CD28 determine the binding to B7-1. J Exp Med (1994) 180:2049-58. doi:10.1084/jem.180.6.2049
    • (1994) J Exp Med , vol.180 , pp. 2049-2058
    • Peach, R.J.1    Bajorath, J.2    Brady, W.3    Leytze, G.4    Greene, J.5    Naemura, J.6
  • 19
    • 45949106108 scopus 로고    scopus 로고
    • Down-regulation of ICOS ligand by interaction with ICOS functions as a regulatory mechanism for immune responses
    • Watanabe M, Takagi Y, Kotani M, Hara Y, Inamine A, Hayashi K, et al. Down-regulation of ICOS ligand by interaction with ICOS functions as a regulatory mechanism for immune responses. J Immunol (2008) 180:5222-34. doi:10.4049/jimmunol.180.8.5222
    • (2008) J Immunol , vol.180 , pp. 5222-5234
    • Watanabe, M.1    Takagi, Y.2    Kotani, M.3    Hara, Y.4    Inamine, A.5    Hayashi, K.6
  • 20
    • 79961233459 scopus 로고    scopus 로고
    • Noncanonical NF-kappaB regulates inducible costimulator (ICOS) ligand expression and T follicular helper cell development
    • Hu H, Wu X, Jin W, Chang M, Cheng X, Sun S-C. Noncanonical NF-kappaB regulates inducible costimulator (ICOS) ligand expression and T follicular helper cell development. Proc Natl Acad Sci U S A (2011) 108:12827-32. doi:10.1073/pnas.1105774108
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 12827-12832
    • Hu, H.1    Wu, X.2    Jin, W.3    Chang, M.4    Cheng, X.5    Sun, S.-C.6
  • 21
    • 0033212778 scopus 로고    scopus 로고
    • B7h, a novel costimulatory homolog of B7.1 and B7.2, is induced by TNFalpha
    • Swallow MM, Wallin JJ, Sha WC. B7h, a novel costimulatory homolog of B7.1 and B7.2, is induced by TNFalpha. Immunity (1999) 11:423-32. doi:10.1016/S1074-7613(00)80117-X
    • (1999) Immunity , vol.11 , pp. 423-432
    • Swallow, M.M.1    Wallin, J.J.2    Sha, W.C.3
  • 22
    • 0033809736 scopus 로고    scopus 로고
    • Characterization of a new human B7-related protein: B7RP-1 is the ligand to the co-stimulatory protein ICOS
    • Yoshinaga SK, Zhang M, Pistillo J, Horan T, Khare SD, Miner K, et al. Characterization of a new human B7-related protein: B7RP-1 is the ligand to the co-stimulatory protein ICOS. Int Immunol (2000) 12:1439-47. doi:10.1093/intimm/12.10.1439
    • (2000) Int Immunol , vol.12 , pp. 1439-1447
    • Yoshinaga, S.K.1    Zhang, M.2    Pistillo, J.3    Horan, T.4    Khare, S.D.5    Miner, K.6
  • 23
    • 0037197828 scopus 로고    scopus 로고
    • ICOS-ligand, expressed on human endothelial cells, costimulates Th1 and Th2 cytokine secretion by memory CD4+ T cells
    • Khayyamian S, Hutloff A, Büchner K, Gräfe M, Henn V, Kroczek RA, et al. ICOS-ligand, expressed on human endothelial cells, costimulates Th1 and Th2 cytokine secretion by memory CD4+ T cells. Proc Natl Acad Sci U S A (2002) 99:6198-203. doi:10.1073/pnas.092576699
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 6198-6203
    • Khayyamian, S.1    Hutloff, A.2    Büchner, K.3    Gräfe, M.4    Henn, V.5    Kroczek, R.A.6
  • 24
    • 33645909564 scopus 로고    scopus 로고
    • The ICOS-ligand B7-H2, expressed on human type II alveolar epithelial cells, plays a role in the pulmonary host defense system
    • Qian X, Agematsu K, Freeman GJ, Tagawa Y-I, Sugane K, Hayashi T. The ICOS-ligand B7-H2, expressed on human type II alveolar epithelial cells, plays a role in the pulmonary host defense system. Eur J Immunol (2006) 36:906-18. doi:10.1002/eji.200535253
    • (2006) Eur J Immunol , vol.36 , pp. 906-918
    • Qian, X.1    Agematsu, K.2    Freeman, G.J.3    Tagawa, Y.-I.4    Sugane, K.5    Hayashi, T.6
  • 25
    • 0037015055 scopus 로고    scopus 로고
    • Modulation of TCR-induced transcriptional profiles by ligation of CD28, ICOS, and CTLA-4 receptors
    • Riley JL, Mao M, Kobayashi S, Biery M, Burchard J, Cavet G, et al. Modulation of TCR-induced transcriptional profiles by ligation of CD28, ICOS, and CTLA-4 receptors. Proc Natl Acad Sci U S A (2002) 99:11790-5. doi:10.1073/pnas.162359999
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 11790-11795
    • Riley, J.L.1    Mao, M.2    Kobayashi, S.3    Biery, M.4    Burchard, J.5    Cavet, G.6
  • 26
    • 0033696961 scopus 로고    scopus 로고
    • The CD28-related molecule ICOS is required for effective T cell-dependent immune responses
    • Coyle AJ, Lehar S, Lloyd C, Tian J, Delaney T, Manning S, et al. The CD28-related molecule ICOS is required for effective T cell-dependent immune responses. Immunity (2000) 13:95-105. doi:10.1016/S1074-7613(00)00011-X
    • (2000) Immunity , vol.13 , pp. 95-105
    • Coyle, A.J.1    Lehar, S.2    Lloyd, C.3    Tian, J.4    Delaney, T.5    Manning, S.6
  • 27
    • 49649098826 scopus 로고    scopus 로고
    • ICOS ligation recruits the p50alpha PI3K regulatory subunit to the immunological synapse
    • Fos C, Salles A, Lang V, Carrette F, Audebert S, Pastor S, et al. ICOS ligation recruits the p50alpha PI3K regulatory subunit to the immunological synapse. J Immunol (2008) 181:1969-77. doi:10.4049/jimmunol.181.3.1969
    • (2008) J Immunol , vol.181 , pp. 1969-1977
    • Fos, C.1    Salles, A.2    Lang, V.3    Carrette, F.4    Audebert, S.5    Pastor, S.6
  • 28
    • 84868528894 scopus 로고    scopus 로고
    • The PI3K/AKT/mTOR pathway as a therapeutic target in endometrial cancer
    • Slomovitz BM, Coleman RL. The PI3K/AKT/mTOR pathway as a therapeutic target in endometrial cancer. Clin Cancer Res (2012) 18:5856-64. doi:10.1158/1078-0432.CCR-12-0662
    • (2012) Clin Cancer Res , vol.18 , pp. 5856-5864
    • Slomovitz, B.M.1    Coleman, R.L.2
  • 29
    • 84920956940 scopus 로고    scopus 로고
    • A p85a-osteopontin axis couples the receptor ICOS to sustained Bcl-6 expression by follicular helper and regulatory T cells
    • Leavenworth JW, Verbinnen B, Yin J, Huang H, Cantor H. A p85a-osteopontin axis couples the receptor ICOS to sustained Bcl-6 expression by follicular helper and regulatory T cells. Nat Immunol (2015) 16:96-106. doi:10.1038/ni.3050
    • (2015) Nat Immunol , vol.16 , pp. 96-106
    • Leavenworth, J.W.1    Verbinnen, B.2    Yin, J.3    Huang, H.4    Cantor, H.5
  • 30
    • 0038545370 scopus 로고    scopus 로고
    • CD28 and inducible costimulatory protein Src homology 2 binding domains show distinct regulation of phosphatidylinositol 3-kinase, Bcl-xL, and IL-2 expression in primary human CD4 T lymphocytes
    • Parry RV, Rumbley CA, Vandenberghe LH, June CH, Riley JL. CD28 and inducible costimulatory protein Src homology 2 binding domains show distinct regulation of phosphatidylinositol 3-kinase, Bcl-xL, and IL-2 expression in primary human CD4 T lymphocytes. J Immunol (2003) 171:166-74. doi:10.4049/jimmunol.171.1.166
    • (2003) J Immunol , vol.171 , pp. 166-174
    • Parry, R.V.1    Rumbley, C.A.2    Vandenberghe, L.H.3    June, C.H.4    Riley, J.L.5
  • 31
    • 0037455064 scopus 로고    scopus 로고
    • A single amino acid alteration in cytoplasmic domain determines IL-2 promoter activation by ligation of CD28 but not inducible costimulator (ICOS)
    • Harada Y, Ohgai D, Watanabe R, Okano K, Koiwai O, Tanabe K, et al. A single amino acid alteration in cytoplasmic domain determines IL-2 promoter activation by ligation of CD28 but not inducible costimulator (ICOS). J Exp Med (2003) 197:257-62. doi:10.1084/jem.20021305
    • (2003) J Exp Med , vol.197 , pp. 257-262
    • Harada, Y.1    Ohgai, D.2    Watanabe, R.3    Okano, K.4    Koiwai, O.5    Tanabe, K.6
  • 32
    • 0035830778 scopus 로고    scopus 로고
    • Five isoforms of the phosphatidylinositol 3-kinase regulatory subunit exhibit different associations with receptor tyrosine kinases and their tyrosine phosphorylations
    • Inukai K, Funaki M, Anai M, Ogihara T, Katagiri H, Fukushima Y, et al. Five isoforms of the phosphatidylinositol 3-kinase regulatory subunit exhibit different associations with receptor tyrosine kinases and their tyrosine phosphorylations. FEBS Lett (2001) 490:32-8. doi:10.1016/S0014-5793(01)02132-9
    • (2001) FEBS Lett , vol.490 , pp. 32-38
    • Inukai, K.1    Funaki, M.2    Anai, M.3    Ogihara, T.4    Katagiri, H.5    Fukushima, Y.6
  • 33
    • 84879659016 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase-independent signaling pathways contribute to ICOS-mediated T cell costimulation in acute graft-versus-host disease in mice
    • Li J, Heinrichs J, Leconte J, Haarberg K, Semple K, Liu C, et al. Phosphatidylinositol 3-kinase-independent signaling pathways contribute to ICOS-mediated T cell costimulation in acute graft-versus-host disease in mice. J Immunol (2013) 191:200-7. doi:10.4049/jimmunol.1203485
    • (2013) J Immunol , vol.191 , pp. 200-207
    • Li, J.1    Heinrichs, J.2    Leconte, J.3    Haarberg, K.4    Semple, K.5    Liu, C.6
  • 34
    • 77958134778 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase activity in T cells regulates the magnitude of the germinal center reaction
    • Rolf J, Bell SE, Kovesdi D, Janas ML, Soond DR, Webb LMC, et al. Phosphoinositide 3-kinase activity in T cells regulates the magnitude of the germinal center reaction. J Immunol (2010) 185:4042-52. doi:10.4049/jimmunol.1001730
    • (2010) J Immunol , vol.185 , pp. 4042-4052
    • Rolf, J.1    Bell, S.E.2    Kovesdi, D.3    Janas, M.L.4    Soond, D.R.5    Webb, L.M.C.6
  • 35
    • 84965000305 scopus 로고    scopus 로고
    • A TRAF-like motif of the inducible costimulator ICOS controls development of germinal center TFH cells via the kinase TBK1
    • Pedros C, Zhang Y, Hu JK, Choi YS, Canonigo-Balancio AJ, Yates JR, et al. A TRAF-like motif of the inducible costimulator ICOS controls development of germinal center TFH cells via the kinase TBK1. Nat Immunol (2016) 17:825-33. doi:10.1038/ni.3463
    • (2016) Nat Immunol , vol.17 , pp. 825-833
    • Pedros, C.1    Zhang, Y.2    Hu, J.K.3    Choi, Y.S.4    Canonigo-Balancio, A.J.5    Yates, J.R.6
  • 36
    • 0033595893 scopus 로고    scopus 로고
    • How NF-kappaB is activated: the role of the IkappaB kinase (IKK) complex
    • Karin M. How NF-kappaB is activated: the role of the IkappaB kinase (IKK) complex. Oncogene (1999) 18:6867-74. doi:10.1038/sj.onc.1203219
    • (1999) Oncogene , vol.18 , pp. 6867-6874
    • Karin, M.1
  • 37
    • 0035804254 scopus 로고    scopus 로고
    • ICOS co-stimulatory receptor is essential for T-cell activation and function
    • Dong C, Juedes AE, Temann UA, Shresta S, Allison JP, Ruddle NH, et al. ICOS co-stimulatory receptor is essential for T-cell activation and function. Nature (2001) 409:97-101. doi:10.1038/35051100
    • (2001) Nature , vol.409 , pp. 97-101
    • Dong, C.1    Juedes, A.E.2    Temann, U.A.3    Shresta, S.4    Allison, J.P.5    Ruddle, N.H.6
  • 39
    • 33746891247 scopus 로고    scopus 로고
    • B7RP-1-ICOS interactions are required for optimal infection-induced expansion of CD4+ Th1 and Th2 responses
    • Wilson EH, Zaph C, Mohrs M, Welcher A, Siu J, Artis D, et al. B7RP-1-ICOS interactions are required for optimal infection-induced expansion of CD4+ Th1 and Th2 responses. J Immunol (2006) 177:2365-72. doi:10.4049/jimmunol.177.4.2365
    • (2006) J Immunol , vol.177 , pp. 2365-2372
    • Wilson, E.H.1    Zaph, C.2    Mohrs, M.3    Welcher, A.4    Siu, J.5    Artis, D.6
  • 40
    • 0037371432 scopus 로고    scopus 로고
    • Inducible costimulatory molecule-B7-related protein 1 interactions are important for the clonal expansion and B cell helper functions of naive, Th1, and Th2 T cells
    • Smith KM, Brewer JM, Webb P, Coyle AJ, Gutierrez-Ramos C, Garside P. Inducible costimulatory molecule-B7-related protein 1 interactions are important for the clonal expansion and B cell helper functions of naive, Th1, and Th2 T cells. J Immunol (2003) 170:2310-5. doi:10.4049/jimmunol.170.5.2310
    • (2003) J Immunol , vol.170 , pp. 2310-2315
    • Smith, K.M.1    Brewer, J.M.2    Webb, P.3    Coyle, A.J.4    Gutierrez-Ramos, C.5    Garside, P.6
  • 41
    • 0017199306 scopus 로고
    • Selective in vitro growth of T lymphocytes from normal human bone marrows
    • Morgan DA, Ruscetti FW, Gallo R. Selective in vitro growth of T lymphocytes from normal human bone marrows. Science (1976) 193:1007-8. doi:10.1126/science.181845
    • (1976) Science , vol.193 , pp. 1007-1008
    • Morgan, D.A.1    Ruscetti, F.W.2    Gallo, R.3
  • 42
    • 0036740602 scopus 로고    scopus 로고
    • ICOS and CD28 reversely regulate IL-10 on re-activation of human effector T cells with mature dendritic cells
    • Witsch EJ, Peiser M, Hutloff A, Büchner K, Dorner BG, Jonuleit H, et al. ICOS and CD28 reversely regulate IL-10 on re-activation of human effector T cells with mature dendritic cells. Eur J Immunol (2002) 32:2680-6. doi:10.1002/1521-4141(200209)32:9<2680::AID-IMMU2680>3.0.CO;2-6
    • (2002) Eur J Immunol , vol.32 , pp. 2680-2686
    • Witsch, E.J.1    Peiser, M.2    Hutloff, A.3    Büchner, K.4    Dorner, B.G.5    Jonuleit, H.6
  • 43
    • 79953037866 scopus 로고    scopus 로고
    • Impact of inducible co-stimulatory molecule (ICOS) on T-cell responses and protection against Mycobacterium tuberculosis infection
    • Nouailles G, Day TA, Kuhlmann S, Loewe D, Dorhoi A, Gamradt P, et al. Impact of inducible co-stimulatory molecule (ICOS) on T-cell responses and protection against Mycobacterium tuberculosis infection. Eur J Immunol (2011) 41:981-91. doi:10.1002/eji.201040608
    • (2011) Eur J Immunol , vol.41 , pp. 981-991
    • Nouailles, G.1    Day, T.A.2    Kuhlmann, S.3    Loewe, D.4    Dorhoi, A.5    Gamradt, P.6
  • 44
    • 77951628752 scopus 로고    scopus 로고
    • Th1 cytokine responses fail to effectively control Chlamydia lung infection in ICOS ligand knockout mice
    • Kadkhoda K, Wang S, Joyee AG, Fan Y, Yang J, Yang X. Th1 cytokine responses fail to effectively control Chlamydia lung infection in ICOS ligand knockout mice. J Immunol (2010) 184:3780-8. doi:10.4049/jimmunol.0901384
    • (2010) J Immunol , vol.184 , pp. 3780-3788
    • Kadkhoda, K.1    Wang, S.2    Joyee, A.G.3    Fan, Y.4    Yang, J.5    Yang, X.6
  • 45
    • 84871507876 scopus 로고    scopus 로고
    • Anti-chlamydial Th17 responses are controlled by the inducible costimulator partially through phosphoinositide 3-kinase signaling
    • Gao X, Gigoux M, Yang J, Leconte J, Yang X, Suh W-K. Anti-chlamydial Th17 responses are controlled by the inducible costimulator partially through phosphoinositide 3-kinase signaling. PLoS One (2012) 7:e52657. doi:10.1371/journal.pone.0052657
    • (2012) PLoS One , vol.7
    • Gao, X.1    Gigoux, M.2    Yang, J.3    Leconte, J.4    Yang, X.5    Suh, W.-K.6
  • 46
    • 34548480512 scopus 로고    scopus 로고
    • Differential CD28 and inducible costimulatory molecule signaling requirements for protective CD4+ T-cell-mediated immunity against genital tract Chlamydia trachomatis infection
    • Marks E, Verolin M, Stensson A, Lycke N. Differential CD28 and inducible costimulatory molecule signaling requirements for protective CD4+ T-cell-mediated immunity against genital tract Chlamydia trachomatis infection. Infect Immun (2007) 75:4638-47. doi:10.1128/IAI.00465-07
    • (2007) Infect Immun , vol.75 , pp. 4638-4647
    • Marks, E.1    Verolin, M.2    Stensson, A.3    Lycke, N.4
  • 47
    • 0037972475 scopus 로고    scopus 로고
    • Disruption of the ICOS-B7RP-1 costimulatory pathway leads to enhanced hepatic immunopathology and increased gamma interferon production by CD4 T cells in murine schistosomiasis
    • Rutitzky LI, Ozkaynak E, Rottman JB, Stadecker MJ. Disruption of the ICOS-B7RP-1 costimulatory pathway leads to enhanced hepatic immunopathology and increased gamma interferon production by CD4 T cells in murine schistosomiasis. Infect Immun (2003) 71:4040-4. doi:10.1128/IAI.71.7.4040-4044.2003
    • (2003) Infect Immun , vol.71 , pp. 4040-4044
    • Rutitzky, L.I.1    Ozkaynak, E.2    Rottman, J.B.3    Stadecker, M.J.4
  • 48
    • 84954091632 scopus 로고    scopus 로고
    • The costimulatory molecule ICOS regulates host Th1 and follicular Th cell differentiation in response to Plasmodium chabaudi chabaudi AS Infection
    • Wikenheiser DJ, Ghosh D, Kennedy B, Stumhofer JS. The costimulatory molecule ICOS regulates host Th1 and follicular Th cell differentiation in response to Plasmodium chabaudi chabaudi AS Infection. J Immunol (2016) 196:778-91. doi:10.4049/jimmunol.1403206
    • (2016) J Immunol , vol.196 , pp. 778-791
    • Wikenheiser, D.J.1    Ghosh, D.2    Kennedy, B.3    Stumhofer, J.S.4
  • 49
    • 31844435407 scopus 로고    scopus 로고
    • Role for inducible costimulator in control of Salmonella enterica serovar Typhimurium infection in mice
    • Vidric M, Bladt AT, Dianzani U, Watts TH. Role for inducible costimulator in control of Salmonella enterica serovar Typhimurium infection in mice. Infect Immun (2006) 74:1050-61. doi:10.1128/IAI.74.2.1050-1061.2006
    • (2006) Infect Immun , vol.74 , pp. 1050-1061
    • Vidric, M.1    Bladt, A.T.2    Dianzani, U.3    Watts, T.H.4
  • 50
    • 0037111417 scopus 로고    scopus 로고
    • Inducible costimulator protein controls the protective T cell response against Listeria monocytogenes
    • Mittrücker H-W, Kursar M, Köhler A, Yanagihara D, Yoshinaga SK, Kaufmann SHE. Inducible costimulator protein controls the protective T cell response against Listeria monocytogenes. J Immunol (2002) 169:5813-7. doi:10.4049/jimmunol.169.10.5813
    • (2002) J Immunol , vol.169 , pp. 5813-5817
    • Mittrücker, H.-W.1    Kursar, M.2    Köhler, A.3    Yanagihara, D.4    Yoshinaga, S.K.5    Kaufmann, S.H.E.6
  • 51
    • 0037100389 scopus 로고    scopus 로고
    • A role for inducible costimulator protein in the CD28-independent mechanism of resistance to Toxoplasma gondii
    • Villegas EN, Lieberman LA, Mason N, Blass SL, Zediak VP, Peach R, et al. A role for inducible costimulator protein in the CD28-independent mechanism of resistance to Toxoplasma gondii. J Immunol (2002) 169:937-43. doi:10.4049/jimmunol.169.2.937
    • (2002) J Immunol , vol.169 , pp. 937-943
    • Villegas, E.N.1    Lieberman, L.A.2    Mason, N.3    Blass, S.L.4    Zediak, V.P.5    Peach, R.6
  • 52
    • 0034600567 scopus 로고    scopus 로고
    • Inducible costimulator protein (ICOS) controls T helper cell subset polarization after virus and parasite infection
    • Kopf M, Coyle AJ, Schmitz N, Barner M, Oxenius A, Gallimore A, et al. Inducible costimulator protein (ICOS) controls T helper cell subset polarization after virus and parasite infection. J Exp Med (2000) 192:53-61. doi:10.1084/jem.192.1.53
    • (2000) J Exp Med , vol.192 , pp. 53-61
    • Kopf, M.1    Coyle, A.J.2    Schmitz, N.3    Barner, M.4    Oxenius, A.5    Gallimore, A.6
  • 53
    • 0036467340 scopus 로고    scopus 로고
    • Cutting edge: inducible costimulator protein regulates both Th1 and Th2 responses to cutaneous leishmaniasis
    • Greenwald RJ, McAdam AJ, Van der Woude D, Satoskar AR, Sharpe AH. Cutting edge: inducible costimulator protein regulates both Th1 and Th2 responses to cutaneous leishmaniasis. J Immunol (2002) 168:991-5. doi:10.4049/jimmunol.168.3.991
    • (2002) J Immunol , vol.168 , pp. 991-995
    • Greenwald, R.J.1    McAdam, A.J.2    Van der Woude, D.3    Satoskar, A.R.4    Sharpe, A.H.5
  • 54
    • 2142825777 scopus 로고    scopus 로고
    • Human T cell activation by costimulatory signal-deficient allogeneic cells induces inducible costimulator-expressing anergic T cells with regulatory cell activity
    • Vermeiren J, Ceuppens JL, Van Ghelue M, Witters P, Bullens D, Mages HW, et al. Human T cell activation by costimulatory signal-deficient allogeneic cells induces inducible costimulator-expressing anergic T cells with regulatory cell activity. J Immunol (2004) 172:5371-8. doi:10.4049/jimmunol.172.9.5371
    • (2004) J Immunol , vol.172 , pp. 5371-5378
    • Vermeiren, J.1    Ceuppens, J.L.2    Van Ghelue, M.3    Witters, P.4    Bullens, D.5    Mages, H.W.6
  • 55
    • 0036732461 scopus 로고    scopus 로고
    • Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity
    • Akbari O, Freeman GJ, Meyer EH, Greenfield EA, Chang TT, Sharpe AH, et al. Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity. Nat Med (2002) 8:1024-32. doi:10.1038/nm745
    • (2002) Nat Med , vol.8 , pp. 1024-1032
    • Akbari, O.1    Freeman, G.J.2    Meyer, E.H.3    Greenfield, E.A.4    Chang, T.T.5    Sharpe, A.H.6
  • 56
    • 0037455003 scopus 로고    scopus 로고
    • Expression of ICOS in vivo defines CD4+ effector T cells with high inflammatory potential and a strong bias for secretion of interleukin 10
    • Löhning M, Hutloff A, Kallinich T, Mages HW, Bonhagen K, Radbruch A, et al. Expression of ICOS in vivo defines CD4+ effector T cells with high inflammatory potential and a strong bias for secretion of interleukin 10. J Exp Med (2003) 197:181-93. doi:10.1084/jem.20020632
    • (2003) J Exp Med , vol.197 , pp. 181-193
    • Löhning, M.1    Hutloff, A.2    Kallinich, T.3    Mages, H.W.4    Bonhagen, K.5    Radbruch, A.6
  • 57
    • 84866170168 scopus 로고    scopus 로고
    • ICOS-expressing CD4 T cells induced via TLR4 in the nasal mucosa are capable of inhibiting experimental allergic asthma
    • Shalaby KH, Jo T, Nakada E, Allard-Coutu A, Tsuchiya K, Hirota N, et al. ICOS-expressing CD4 T cells induced via TLR4 in the nasal mucosa are capable of inhibiting experimental allergic asthma. J Immunol (2012) 189:2793-804. doi:10.4049/jimmunol.1201194
    • (2012) J Immunol , vol.189 , pp. 2793-2804
    • Shalaby, K.H.1    Jo, T.2    Nakada, E.3    Allard-Coutu, A.4    Tsuchiya, K.5    Hirota, N.6
  • 58
    • 84864823851 scopus 로고    scopus 로고
    • ICOS mediates the generation and function of CD4+CD25+Foxp3+ regulatory T cells conveying respiratory tolerance
    • Busse M, Krech M, Meyer-Bahlburg A, Hennig C, Hansen G. ICOS mediates the generation and function of CD4+CD25+Foxp3+ regulatory T cells conveying respiratory tolerance. J Immunol (2012) 189:1975-82. doi:10.4049/jimmunol.1103581
    • (2012) J Immunol , vol.189 , pp. 1975-1982
    • Busse, M.1    Krech, M.2    Meyer-Bahlburg, A.3    Hennig, C.4    Hansen, G.5
  • 59
    • 84874996294 scopus 로고    scopus 로고
    • ICOS controls Foxp3(+) regulatory T-cell expansion, maintenance and IL-10 production during helminth infection
    • Redpath SA, van der Werf N, Cervera AM, MacDonald AS, Gray D, Maizels RM, et al. ICOS controls Foxp3(+) regulatory T-cell expansion, maintenance and IL-10 production during helminth infection. Eur J Immunol (2013) 43:705-15. doi:10.1002/eji.201242794
    • (2013) Eur J Immunol , vol.43 , pp. 705-715
    • Redpath, S.A.1    van der Werf, N.2    Cervera, A.M.3    MacDonald, A.S.4    Gray, D.5    Maizels, R.M.6
  • 60
    • 0031882588 scopus 로고    scopus 로고
    • Potential role of B7-1 and CD28 molecules in immunosuppression in leprosy
    • Agrewala JN, Kumar B, Vohra H. Potential role of B7-1 and CD28 molecules in immunosuppression in leprosy. Clin Exp Immunol (1998) 111:56-63. doi:10.1046/j.1365-2249.1998.00463.x
    • (1998) Clin Exp Immunol , vol.111 , pp. 56-63
    • Agrewala, J.N.1    Kumar, B.2    Vohra, H.3
  • 61
    • 0035708538 scopus 로고    scopus 로고
    • Downmodulation of CD18 and CD86 on macrophages and VLA-4 on lymphocytes in experimental tuberculosis
    • Bonato VL, Medeiros AI, Lima VM, Dias AR, Faccioliti LH, Silva CL. Downmodulation of CD18 and CD86 on macrophages and VLA-4 on lymphocytes in experimental tuberculosis. Scand J Immunol (2001) 54:564-73. doi:10.1046/j.1365-3083.2001.00996.x
    • (2001) Scand J Immunol , vol.54 , pp. 564-573
    • Bonato, V.L.1    Medeiros, A.I.2    Lima, V.M.3    Dias, A.R.4    Faccioliti, L.H.5    Silva, C.L.6
  • 62
    • 0344562930 scopus 로고    scopus 로고
    • Suppression of T and B lymphocyte activation by a Yersinia pseudotuberculosis virulence factor, yopH
    • Yao T, Mecsas J, Healy JI, Falkow S, Chien Y. Suppression of T and B lymphocyte activation by a Yersinia pseudotuberculosis virulence factor, yopH. J Exp Med (1999) 190:1343-50. doi:10.1084/jem.190.9.1343
    • (1999) J Exp Med , vol.190 , pp. 1343-1350
    • Yao, T.1    Mecsas, J.2    Healy, J.I.3    Falkow, S.4    Chien, Y.5
  • 63
    • 25444510358 scopus 로고    scopus 로고
    • The Nef protein of HIV-1 induces loss of cell surface costimulatory molecules CD80 and CD86 in APCs
    • Chaudhry A, Das SR, Hussain A, Mayor S, George A, Bal V, et al. The Nef protein of HIV-1 induces loss of cell surface costimulatory molecules CD80 and CD86 in APCs. J Immunol (2005) 175:4566-74. doi:10.4049/jimmunol.175.7.4566
    • (2005) J Immunol , vol.175 , pp. 4566-4574
    • Chaudhry, A.1    Das, S.R.2    Hussain, A.3    Mayor, S.4    George, A.5    Bal, V.6
  • 64
    • 20844458651 scopus 로고    scopus 로고
    • Antagonism between MyD88-and TRIF-dependent signals in B7RP-1 up-regulation
    • Zhou Z, Hoebe K, Du X, Jiang Z, Shamel L, Beutler B. Antagonism between MyD88-and TRIF-dependent signals in B7RP-1 up-regulation. Eur J Immunol (2005) 35:1918-27. doi:10.1002/eji.200525971
    • (2005) Eur J Immunol , vol.35 , pp. 1918-1927
    • Zhou, Z.1    Hoebe, K.2    Du, X.3    Jiang, Z.4    Shamel, L.5    Beutler, B.6
  • 65
    • 0042195831 scopus 로고    scopus 로고
    • Costimulation through the inducible costimulator ligand is essential for both T helper and B cell functions in T cell-dependent B cell responses
    • Mak TW, Shahinian A, Yoshinaga SK, Wakeham A, Boucher L-M, Pintilie M, et al. Costimulation through the inducible costimulator ligand is essential for both T helper and B cell functions in T cell-dependent B cell responses. Nat Immunol (2003) 4:765-72. doi:10.1038/ni947
    • (2003) Nat Immunol , vol.4 , pp. 765-772
    • Mak, T.W.1    Shahinian, A.2    Yoshinaga, S.K.3    Wakeham, A.4    Boucher, L.-M.5    Pintilie, M.6
  • 66
    • 0042738928 scopus 로고    scopus 로고
    • Impaired germinal center formation and recall T-cell-dependent immune responses in mice lacking the costimulatory ligand B7-H2
    • Wong S-C, Oh E, Ng C-H, Lam K-P. Impaired germinal center formation and recall T-cell-dependent immune responses in mice lacking the costimulatory ligand B7-H2. Blood (2003) 102:1381-8. doi:10.1182/blood-2002-08-2416
    • (2003) Blood , vol.102 , pp. 1381-1388
    • Wong, S.-C.1    Oh, E.2    Ng, C.-H.3    Lam, K.-P.4
  • 67
    • 7244257496 scopus 로고    scopus 로고
    • Effect of inducible costimulator blockade on the pathological and protective immune responses induced by the gastrointestinal helminth Trichinella spiralis
    • Scales HE, Ierna MX, Gutierrez-Ramos J-C, Coyle AJ, Garside P, Lawrence CE. Effect of inducible costimulator blockade on the pathological and protective immune responses induced by the gastrointestinal helminth Trichinella spiralis. Eur J Immunol (2004) 34:2854-62. doi:10.1002/eji.200324364
    • (2004) Eur J Immunol , vol.34 , pp. 2854-2862
    • Scales, H.E.1    Ierna, M.X.2    Gutierrez-Ramos, J.-C.3    Coyle, A.J.4    Garside, P.5    Lawrence, C.E.6
  • 68
    • 12444300786 scopus 로고    scopus 로고
    • Involvement of ICOS-B7RP-1 costimulatory pathway in the regulation of immune responses to Leishmania major and Nippostrongylus brasiliensis infections
    • Miyahira Y, Akiba H, Ogawa S-H, Ishi T, Watanabe S, Kobayashi S, et al. Involvement of ICOS-B7RP-1 costimulatory pathway in the regulation of immune responses to Leishmania major and Nippostrongylus brasiliensis infections. Immunol Lett (2003) 89:193-9. doi:10.1016/S0165-2478(03)00137-8
    • (2003) Immunol Lett , vol.89 , pp. 193-199
    • Miyahira, Y.1    Akiba, H.2    Ogawa, S.-H.3    Ishi, T.4    Watanabe, S.5    Kobayashi, S.6
  • 69
    • 22244481598 scopus 로고    scopus 로고
    • Inducible costimulator is required for type 2 antibody isotype switching but not T helper cell type 2 responses in chronic nematode infection
    • Loke P, Zang X, Hsuan L, Waitz R, Locksley RM, Allen JE, et al. Inducible costimulator is required for type 2 antibody isotype switching but not T helper cell type 2 responses in chronic nematode infection. Proc Natl Acad Sci U S A (2005) 102:9872-7. doi:10.1073/pnas.0503961102
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 9872-9877
    • Loke, P.1    Zang, X.2    Hsuan, L.3    Waitz, R.4    Locksley, R.M.5    Allen, J.E.6
  • 71
    • 23444434705 scopus 로고    scopus 로고
    • The role of ICOS in the CXCR5+ follicular B helper T cell maintenance in vivo
    • Akiba H, Takeda K, Kojima Y, Usui Y, Harada N, Yamazaki T, et al. The role of ICOS in the CXCR5+ follicular B helper T cell maintenance in vivo. J Immunol (2005) 175:2340-8. doi:10.4049/jimmunol.175.4.2340
    • (2005) J Immunol , vol.175 , pp. 2340-2348
    • Akiba, H.1    Takeda, K.2    Kojima, Y.3    Usui, Y.4    Harada, N.5    Yamazaki, T.6
  • 72
    • 0035869525 scopus 로고    scopus 로고
    • Cutting edge: critical role of inducible costimulator in germinal center reactions
    • Dong C, Temann UA, Flavell RA. Cutting edge: critical role of inducible costimulator in germinal center reactions. J Immunol (2001) 166:3659-62. doi:10.4049/jimmunol.166.6.3659
    • (2001) J Immunol , vol.166 , pp. 3659-3662
    • Dong, C.1    Temann, U.A.2    Flavell, R.A.3
  • 73
    • 58849137120 scopus 로고    scopus 로고
    • A novel ICOS-independent, but CD28-and SAP-dependent, pathway of T cell-dependent, polysaccharide-specific humoral immunity in response to intact Streptococcus pneumoniae versus pneumococcal conjugate vaccine
    • Chen Q, Cannons JL, Paton JC, Akiba H, Schwartzberg PL, Snapper CM. A novel ICOS-independent, but CD28-and SAP-dependent, pathway of T cell-dependent, polysaccharide-specific humoral immunity in response to intact Streptococcus pneumoniae versus pneumococcal conjugate vaccine. J Immunol (2008) 181:8258-66. doi:10.4049/jimmunol.181.12.8258
    • (2008) J Immunol , vol.181 , pp. 8258-8266
    • Chen, Q.1    Cannons, J.L.2    Paton, J.C.3    Akiba, H.4    Schwartzberg, P.L.5    Snapper, C.M.6
  • 74
    • 0037017391 scopus 로고    scopus 로고
    • Low-level hypermutation in T cell-independent germinal centers compared with high mutation rates associated with T cell-dependent germinal centers
    • Toellner K-M, Jenkinson WE, Taylor DR, Khan M, Sze DM-Y, Sansom DM, et al. Low-level hypermutation in T cell-independent germinal centers compared with high mutation rates associated with T cell-dependent germinal centers. J Exp Med (2002) 195:383-9. doi:10.1084/jem.20011112
    • (2002) J Exp Med , vol.195 , pp. 383-389
    • Toellner, K.-M.1    Jenkinson, W.E.2    Taylor, D.R.3    Khan, M.4    Sze, D.M.-Y.5    Sansom, D.M.6
  • 77
    • 77958487137 scopus 로고    scopus 로고
    • Plasticity and heterogeneity in the generation of memory B cells and long-lived plasma cells: the influence of germinal center interactions and dynamics
    • Good-Jacobson KL, Shlomchik MJ. Plasticity and heterogeneity in the generation of memory B cells and long-lived plasma cells: the influence of germinal center interactions and dynamics. J Immunol (2010) 185:3117-25. doi:10.4049/jimmunol.1001155
    • (2010) J Immunol , vol.185 , pp. 3117-3125
    • Good-Jacobson, K.L.1    Shlomchik, M.J.2
  • 78
    • 63149093151 scopus 로고    scopus 로고
    • B7RP-1 blockade ameliorates autoimmunity through regulation of follicular helper T cells
    • Hu Y-L, Metz DP, Chung J, Siu G, Zhang M. B7RP-1 blockade ameliorates autoimmunity through regulation of follicular helper T cells. J Immunol (2009) 182:1421-8. doi:10.4049/jimmunol.182.3.1421
    • (2009) J Immunol , vol.182 , pp. 1421-1428
    • Hu, Y.-L.1    Metz, D.P.2    Chung, J.3    Siu, G.4    Zhang, M.5
  • 79
    • 79959328032 scopus 로고    scopus 로고
    • ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6
    • Choi YS, Kageyama R, Eto D, Escobar TC, Johnston RJ, Monticelli L, et al. ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6. Immunity (2011) 34:932-46. doi:10.1016/j.immuni.2011.03.023
    • (2011) Immunity , vol.34 , pp. 932-946
    • Choi, Y.S.1    Kageyama, R.2    Eto, D.3    Escobar, T.C.4    Johnston, R.J.5    Monticelli, L.6
  • 80
    • 84922695639 scopus 로고    scopus 로고
    • ICOS maintains the T follicular helper cell phenotype by down-regulating Krüppel-like factor 2
    • Weber JP, Fuhrmann F, Feist RK, Lahmann A, Al Baz MS, Gentz L-J, et al. ICOS maintains the T follicular helper cell phenotype by down-regulating Krüppel-like factor 2. J Exp Med (2015) 212:217-33. doi:10.1084/jem.20141432
    • (2015) J Exp Med , vol.212 , pp. 217-233
    • Weber, J.P.1    Fuhrmann, F.2    Feist, R.K.3    Lahmann, A.4    Al Baz, M.S.5    Gentz, L.-J.6
  • 81
    • 84923044855 scopus 로고    scopus 로고
    • ICOS coreceptor signaling inactivates the transcription factor FOXO1 to promote Tfh cell differentiation
    • Stone EL, Pepper M, Katayama CD, Kerdiles YM, Lai C-Y, Emslie E, et al. ICOS coreceptor signaling inactivates the transcription factor FOXO1 to promote Tfh cell differentiation. Immunity (2015) 42:239-51. doi:10.1016/j.immuni.2015.01.017
    • (2015) Immunity , vol.42 , pp. 239-251
    • Stone, E.L.1    Pepper, M.2    Katayama, C.D.3    Kerdiles, Y.M.4    Lai, C.-Y.5    Emslie, E.6
  • 82
    • 69249109601 scopus 로고    scopus 로고
    • Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation
    • Johnston RJ, Poholek AC, DiToro D, Yusuf I, Eto D, Barnett B, et al. Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation. Science (2009) 325:1006-10. doi:10.1126/science.1175870
    • (2009) Science , vol.325 , pp. 1006-1010
    • Johnston, R.J.1    Poholek, A.C.2    DiToro, D.3    Yusuf, I.4    Eto, D.5    Barnett, B.6
  • 84
    • 84908148200 scopus 로고    scopus 로고
    • T Follicular helper cell differentiation, function, and roles in disease
    • Crotty S. T Follicular helper cell differentiation, function, and roles in disease. Immunity (2014) 41:529-42. doi:10.1016/j.immuni.2014.10.004
    • (2014) Immunity , vol.41 , pp. 529-542
    • Crotty, S.1
  • 85
    • 84933678575 scopus 로고    scopus 로고
    • CD8a(-) dendritic cells induce antigen-specific T follicular helper cells generating efficient humoral immune responses
    • Shin C, Han J-A, Koh H, Choi B, Cho Y, Jeong H, et al. CD8a(-) dendritic cells induce antigen-specific T follicular helper cells generating efficient humoral immune responses. Cell Rep (2015) 11:1929-40. doi:10.1016/j.celrep.2015.05.042
    • (2015) Cell Rep , vol.11 , pp. 1929-1940
    • Shin, C.1    Han, J.-A.2    Koh, H.3    Choi, B.4    Cho, Y.5    Jeong, H.6
  • 86
    • 84923778281 scopus 로고    scopus 로고
    • T-B-cell entanglement and ICOSL-driven feed-forward regulation of germinal centre reaction
    • Liu D, Xu H, Shih C, Wan Z, Ma X, Ma W, et al. T-B-cell entanglement and ICOSL-driven feed-forward regulation of germinal centre reaction. Nature (2015) 517:214-8. doi:10.1038/nature13803
    • (2015) Nature , vol.517 , pp. 214-218
    • Liu, D.1    Xu, H.2    Shih, C.3    Wan, Z.4    Ma, X.5    Ma, W.6
  • 87
    • 80051618656 scopus 로고    scopus 로고
    • Cutting edge: dendritic cell-restricted antigen presentation initiates the follicular helper T cell program but cannot complete ultimate effector differentiation
    • Goenka R, Barnett LG, Silver JS, O'Neill PJ, Hunter CA, Cancro MP, et al. Cutting edge: dendritic cell-restricted antigen presentation initiates the follicular helper T cell program but cannot complete ultimate effector differentiation. J Immunol (2011) 187:1091-5. doi:10.4049/jimmunol.1100853
    • (2011) J Immunol , vol.187 , pp. 1091-1095
    • Goenka, R.1    Barnett, L.G.2    Silver, J.S.3    O'Neill, P.J.4    Hunter, C.A.5    Cancro, M.P.6
  • 88
    • 46749115446 scopus 로고    scopus 로고
    • A fundamental role for interleukin-21 in the generation of T follicular helper cells
    • Vogelzang A, McGuire HM, Yu D, Sprent J, Mackay CR, King C. A fundamental role for interleukin-21 in the generation of T follicular helper cells. Immunity (2008) 29:127-37. doi:10.1016/j.immuni.2008.06.001
    • (2008) Immunity , vol.29 , pp. 127-137
    • Vogelzang, A.1    McGuire, H.M.2    Yu, D.3    Sprent, J.4    Mackay, C.R.5    King, C.6
  • 89
    • 84875414166 scopus 로고    scopus 로고
    • Young lives lost as B cells falter: what we are learning about antibody responses in malaria
    • Portugal S, Pierce SK, Crompton PD. Young lives lost as B cells falter: what we are learning about antibody responses in malaria. J Immunol (2013) 190:3039-46. doi:10.4049/jimmunol.1203067
    • (2013) J Immunol , vol.190 , pp. 3039-3046
    • Portugal, S.1    Pierce, S.K.2    Crompton, P.D.3
  • 90
    • 84897501021 scopus 로고    scopus 로고
    • B cells in T follicular helper cell development and function: separable roles in delivery of ICOS ligand and antigen
    • Weinstein JS, Bertino SA, Hernandez SG, Poholek AC, Teplitzky TB, Nowyhed HN, et al. B cells in T follicular helper cell development and function: separable roles in delivery of ICOS ligand and antigen. J Immunol (2014) 192:3166-79. doi:10.4049/jimmunol.1302617
    • (2014) J Immunol , vol.192 , pp. 3166-3179
    • Weinstein, J.S.1    Bertino, S.A.2    Hernandez, S.G.3    Poholek, A.C.4    Teplitzky, T.B.5    Nowyhed, H.N.6
  • 91
    • 77955924180 scopus 로고    scopus 로고
    • Follicular helper T cell differentiation requires continuous antigen presentation that is independent of unique B cell signaling
    • Deenick EK, Chan A, Ma CS, Gatto D, Schwartzberg PL, Brink R, et al. Follicular helper T cell differentiation requires continuous antigen presentation that is independent of unique B cell signaling. Immunity (2010) 33:241-53. doi:10.1016/j.immuni.2010.07.015
    • (2010) Immunity , vol.33 , pp. 241-253
    • Deenick, E.K.1    Chan, A.2    Ma, C.S.3    Gatto, D.4    Schwartzberg, P.L.5    Brink, R.6
  • 92
    • 84876793426 scopus 로고    scopus 로고
    • Follicular T-helper cell recruitment governed by bystander B cells and ICOS-driven motility
    • Xu H, Li X, Liu D, Li J, Zhang X, Chen X, et al. Follicular T-helper cell recruitment governed by bystander B cells and ICOS-driven motility. Nature (2013) 496:523-7. doi:10.1038/nature12058
    • (2013) Nature , vol.496 , pp. 523-527
    • Xu, H.1    Li, X.2    Liu, D.3    Li, J.4    Zhang, X.5    Chen, X.6
  • 93
    • 84948441210 scopus 로고    scopus 로고
    • Osteopontin in immune-mediated diseases
    • Rittling SR, Singh R. Osteopontin in immune-mediated diseases. J Dent Res (2015) 94:1638-45. doi:10.1177/0022034515605270
    • (2015) J Dent Res , vol.94 , pp. 1638-1645
    • Rittling, S.R.1    Singh, R.2
  • 95
    • 0038363463 scopus 로고    scopus 로고
    • Triggering the interferon antiviral response through an IKK-related pathway
    • Sharma S, Tenoever BR, Grandvaux N, Zhou G-P, Lin R, Hiscott J. Triggering the interferon antiviral response through an IKK-related pathway. Science (2003) 300:1148-51. doi:10.1126/science.1081315
    • (2003) Science , vol.300 , pp. 1148-1151
    • Sharma, S.1    Tenoever, B.R.2    Grandvaux, N.3    Zhou, G.-P.4    Lin, R.5    Hiscott, J.6
  • 97
    • 84860363209 scopus 로고    scopus 로고
    • A germinal center-independent pathway generates unswitched memory B cells early in the primary response
    • Taylor JJ, Pape KA, Jenkins MK. A germinal center-independent pathway generates unswitched memory B cells early in the primary response. J Exp Med (2012) 209:597-606. doi:10.1084/jem.20111696
    • (2012) J Exp Med , vol.209 , pp. 597-606
    • Taylor, J.J.1    Pape, K.A.2    Jenkins, M.K.3
  • 98
    • 23844445862 scopus 로고    scopus 로고
    • Two waves of memory B-cell generation in the primary immune response
    • Inamine A, Takahashi Y, Baba N, Miyake K, Tokuhisa T, Takemori T, et al. Two waves of memory B-cell generation in the primary immune response. Int Immunol (2005) 17:581-9. doi:10.1093/intimm/dxh241
    • (2005) Int Immunol , vol.17 , pp. 581-589
    • Inamine, A.1    Takahashi, Y.2    Baba, N.3    Miyake, K.4    Tokuhisa, T.5    Takemori, T.6
  • 99
    • 84958831765 scopus 로고    scopus 로고
    • A temporal switch in the germinal center determines differential output of memory B and plasma cells
    • Weisel FJ, Zuccarino-Catania GV, Chikina M, Shlomchik MJ. A temporal switch in the germinal center determines differential output of memory B and plasma cells. Immunity (2016) 44:116-30. doi:10.1016/j.immuni.2015.12.004
    • (2016) Immunity , vol.44 , pp. 116-130
    • Weisel, F.J.1    Zuccarino-Catania, G.V.2    Chikina, M.3    Shlomchik, M.J.4
  • 100
    • 5644273872 scopus 로고    scopus 로고
    • Involvement of inducible costimulator in the exaggerated memory B cell and plasma cell generation in systemic lupus erythematosus
    • Hutloff A, Büchner K, Reiter K, Baelde HJ, Odendahl M, Jacobi A, et al. Involvement of inducible costimulator in the exaggerated memory B cell and plasma cell generation in systemic lupus erythematosus. Arthritis Rheum (2004) 50:3211-20. doi:10.1002/art.20519
    • (2004) Arthritis Rheum , vol.50 , pp. 3211-3220
    • Hutloff, A.1    Büchner, K.2    Reiter, K.3    Baelde, H.J.4    Odendahl, M.5    Jacobi, A.6
  • 101
    • 34250883267 scopus 로고    scopus 로고
    • Human IgM+CD27+ B cells: memory B cells or "memory" B cells?
    • Tangye SG, Good KL. Human IgM+CD27+ B cells: memory B cells or "memory" B cells? J Immunol (2007) 179:13-9. doi:10.4049/jimmunol.179.1.13
    • (2007) J Immunol , vol.179 , pp. 13-19
    • Tangye, S.G.1    Good, K.L.2
  • 102
    • 34447570588 scopus 로고    scopus 로고
    • The role of ICOS in the development of CD4 T cell help and the reactivation of memory T cells
    • Mahajan S, Cervera A, MacLeod M, Fillatreau S, Perona-Wright G, Meek S, et al. The role of ICOS in the development of CD4 T cell help and the reactivation of memory T cells. Eur J Immunol (2007) 37:1796-808. doi:10.1002/eji.200636661
    • (2007) Eur J Immunol , vol.37 , pp. 1796-1808
    • Mahajan, S.1    Cervera, A.2    MacLeod, M.3    Fillatreau, S.4    Perona-Wright, G.5    Meek, S.6
  • 104
    • 42149168527 scopus 로고    scopus 로고
    • ICOS, CD40, and lymphotoxin beta receptors signal sequentially and interdependently to initiate a germinal center reaction
    • Vu F, Dianzani U, Ware CF, Mak T, Gommerman JL. ICOS, CD40, and lymphotoxin beta receptors signal sequentially and interdependently to initiate a germinal center reaction. J Immunol (2008) 180:2284-93. doi:10.4049/jimmunol.180.4.2284
    • (2008) J Immunol , vol.180 , pp. 2284-2293
    • Vu, F.1    Dianzani, U.2    Ware, C.F.3    Mak, T.4    Gommerman, J.L.5
  • 105
    • 84873748148 scopus 로고    scopus 로고
    • Lymphotoxin α1β2 expression on B cells is required for follicular dendritic cell activation during the germinal center response
    • Myers RC, King RG, Carter RH, Justement LB. Lymphotoxin α1β2 expression on B cells is required for follicular dendritic cell activation during the germinal center response. Eur J Immunol (2013) 43:348-59. doi:10.1002/eji.201242471
    • (2013) Eur J Immunol , vol.43 , pp. 348-359
    • Myers, R.C.1    King, R.G.2    Carter, R.H.3    Justement, L.B.4
  • 106
    • 84930417028 scopus 로고    scopus 로고
    • ICOS is required for the generation of both central and effector CD4(+) memory T-cell populations following acute bacterial infection
    • Marriott CL, Carlesso G, Herbst R, Withers DR. ICOS is required for the generation of both central and effector CD4(+) memory T-cell populations following acute bacterial infection. Eur J Immunol (2015) 45:1706-15. doi:10.1002/eji.201445421
    • (2015) Eur J Immunol , vol.45 , pp. 1706-1715
    • Marriott, C.L.1    Carlesso, G.2    Herbst, R.3    Withers, D.R.4
  • 107
    • 74049131014 scopus 로고    scopus 로고
    • Different routes of bacterial infection induce long-lived TH1 memory cells and short-lived TH17 cells
    • Pepper M, Linehan JL, Pagán AJ, Zell T, Dileepan T, Cleary PP, et al. Different routes of bacterial infection induce long-lived TH1 memory cells and short-lived TH17 cells. Nat Immunol (2010) 11:83-9. doi:10.1038/ni.1826
    • (2010) Nat Immunol , vol.11 , pp. 83-89
    • Pepper, M.1    Linehan, J.L.2    Pagán, A.J.3    Zell, T.4    Dileepan, T.5    Cleary, P.P.6
  • 108
    • 84934889059 scopus 로고    scopus 로고
    • ICOS and Bcl6-dependent pathways maintain a CD4 T cell population with memory-like properties during tuberculosis
    • Moguche AO, Shafiani S, Clemons C, Larson RP, Dinh C, Higdon LE, et al. ICOS and Bcl6-dependent pathways maintain a CD4 T cell population with memory-like properties during tuberculosis. J Exp Med (2015) 212:715-28. doi:10.1084/jem.20141518
    • (2015) J Exp Med , vol.212 , pp. 715-728
    • Moguche, A.O.1    Shafiani, S.2    Clemons, C.3    Larson, R.P.4    Dinh, C.5    Higdon, L.E.6
  • 109
    • 80755172184 scopus 로고    scopus 로고
    • Opposing signals from the Bcl6 transcription factor and the interleukin-2 receptor generate T helper 1 central and effector memory cells
    • Pepper M, Pagán AJ, Igyártó BZ, Taylor JJ, Jenkins MK. Opposing signals from the Bcl6 transcription factor and the interleukin-2 receptor generate T helper 1 central and effector memory cells. Immunity (2011) 35:583-95. doi:10.1016/j.immuni.2011.09.009
    • (2011) Immunity , vol.35 , pp. 583-595
    • Pepper, M.1    Pagán, A.J.2    Igyártó, B.Z.3    Taylor, J.J.4    Jenkins, M.K.5
  • 110
    • 66949171812 scopus 로고    scopus 로고
    • Impaired CD4 and CD8 effector function and decreased memory T cell populations in ICOS-deficient patients
    • Takahashi N, Matsumoto K, Saito H, Nanki T, Miyasaka N, Kobata T, et al. Impaired CD4 and CD8 effector function and decreased memory T cell populations in ICOS-deficient patients. J Immunol (2009) 182:5515-27. doi:10.4049/jimmunol.0803256
    • (2009) J Immunol , vol.182 , pp. 5515-5527
    • Takahashi, N.1    Matsumoto, K.2    Saito, H.3    Nanki, T.4    Miyasaka, N.5    Kobata, T.6
  • 111
    • 0037340349 scopus 로고    scopus 로고
    • Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency
    • Grimbacher B, Hutloff A, Schlesier M, Glocker E, Warnatz K, Dräger R, et al. Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency. Nat Immunol (2003) 4:261-8. doi:10.1038/ni902
    • (2003) Nat Immunol , vol.4 , pp. 261-268
    • Grimbacher, B.1    Hutloff, A.2    Schlesier, M.3    Glocker, E.4    Warnatz, K.5    Dräger, R.6
  • 112
    • 2342467376 scopus 로고    scopus 로고
    • Common variable immunodeficiency: a review
    • Di Renzo M, Pasqui AL, Auteri A. Common variable immunodeficiency: a review. Clin Exp Med (2004) 3:211-7. doi:10.1007/s10238-004-0027-2
    • (2004) Clin Exp Med , vol.3 , pp. 211-217
    • Di Renzo, M.1    Pasqui, A.L.2    Auteri, A.3
  • 113
    • 33749151018 scopus 로고    scopus 로고
    • ICOS deficiency is associated with a severe reduction of CXCR5+CD4 germinal center Th cells
    • Bossaller L, Burger J, Draeger R, Grimbacher B, Knoth R, Plebani A, et al. ICOS deficiency is associated with a severe reduction of CXCR5+CD4 germinal center Th cells. J Immunol (2006) 177:4927-32. doi:10.4049/jimmunol.177.7.4927
    • (2006) J Immunol , vol.177 , pp. 4927-4932
    • Bossaller, L.1    Burger, J.2    Draeger, R.3    Grimbacher, B.4    Knoth, R.5    Plebani, A.6
  • 114
    • 84885741984 scopus 로고    scopus 로고
    • Circulating precursor CCR7(lo)PD-1(hi) CXCR5+ CD4+ T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposure
    • He J, Tsai LM, Leong YA, Hu X, Ma CS, Chevalier N, et al. Circulating precursor CCR7(lo)PD-1(hi) CXCR5+ CD4+ T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposure. Immunity (2013) 39:770-81. doi:10.1016/j.immuni.2013.09.007
    • (2013) Immunity , vol.39 , pp. 770-781
    • He, J.1    Tsai, L.M.2    Leong, Y.A.3    Hu, X.4    Ma, C.S.5    Chevalier, N.6
  • 115
    • 84885743368 scopus 로고    scopus 로고
    • Human circulating PD-1(+)CXCR3(-)CXCR5(+) memory Tfh Cells are highly functional and correlate with broadly neutralizing HIV antibody responses
    • Locci M, Havenar-Daughton C, Landais E, Wu J, Kroenke MA, Arlehamn CL, et al. Human circulating PD-1(+)CXCR3(-)CXCR5(+) memory Tfh Cells are highly functional and correlate with broadly neutralizing HIV antibody responses. Immunity (2013) 39:758-69. doi:10.1016/j.immuni.2013.08.031
    • (2013) Immunity , vol.39 , pp. 758-769
    • Locci, M.1    Havenar-Daughton, C.2    Landais, E.3    Wu, J.4    Kroenke, M.A.5    Arlehamn, C.L.6
  • 116
    • 74849138095 scopus 로고    scopus 로고
    • Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus
    • Simpson N, Gatenby PA, Wilson A, Malik S, Fulcher DA, Tangye SG, et al. Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus. Arthritis Rheum (2010) 62:234-44. doi:10.1002/art.25032
    • (2010) Arthritis Rheum , vol.62 , pp. 234-244
    • Simpson, N.1    Gatenby, P.A.2    Wilson, A.3    Malik, S.4    Fulcher, D.A.5    Tangye, S.G.6
  • 117
    • 84930040863 scopus 로고    scopus 로고
    • Genetics and pathogenesis of systemic lupus erythematosus and lupus nephritis
    • Mohan C, Putterman C. Genetics and pathogenesis of systemic lupus erythematosus and lupus nephritis. Nat Rev Nephrol (2015) 11:329-41. doi:10.1038/nrneph.2015.33
    • (2015) Nat Rev Nephrol , vol.11 , pp. 329-341
    • Mohan, C.1    Putterman, C.2
  • 118
    • 34247551065 scopus 로고    scopus 로고
    • Expression and function of inducible co-stimulator in patients with systemic lupus erythematosus: possible involvement in excessive interferon-gamma and anti-double-stranded DNA antibody production
    • Kawamoto M, Harigai M, Hara M, Kawaguchi Y, Tezuka K, Tanaka M, et al. Expression and function of inducible co-stimulator in patients with systemic lupus erythematosus: possible involvement in excessive interferon-gamma and anti-double-stranded DNA antibody production. Arthritis Res Ther (2006) 8:R62. doi:10.1186/ar1928
    • (2006) Arthritis Res Ther , vol.8
    • Kawamoto, M.1    Harigai, M.2    Hara, M.3    Kawaguchi, Y.4    Tezuka, K.5    Tanaka, M.6
  • 119
    • 60849107595 scopus 로고    scopus 로고
    • A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice
    • Bubier JA, Sproule TJ, Foreman O, Spolski R, Shaffer DJ, Morse HC, et al. A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice. Proc Natl Acad Sci U S A (2009) 106:1518-23. doi:10.1073/pnas.0807309106
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 1518-1523
    • Bubier, J.A.1    Sproule, T.J.2    Foreman, O.3    Spolski, R.4    Shaffer, D.J.5    Morse, H.C.6
  • 120
    • 84924993521 scopus 로고    scopus 로고
    • Local triggering of the ICOS coreceptor by CD11c(+) myeloid cells drives organ inflammation in lupus
    • Teichmann LL, Cullen JL, Kashgarian M, Dong C, Craft J, Shlomchik MJ. Local triggering of the ICOS coreceptor by CD11c(+) myeloid cells drives organ inflammation in lupus. Immunity (2015) 42:552-65. doi:10.1016/j.immuni.2015.02.015
    • (2015) Immunity , vol.42 , pp. 552-565
    • Teichmann, L.L.1    Cullen, J.L.2    Kashgarian, M.3    Dong, C.4    Craft, J.5    Shlomchik, M.J.6
  • 121
    • 21144438325 scopus 로고    scopus 로고
    • A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity
    • Vinuesa CG, Cook MC, Angelucci C, Athanasopoulos V, Rui L, Hill KM, et al. A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity. Nature (2005) 435:452-8. doi:10.1038/nature03555
    • (2005) Nature , vol.435 , pp. 452-458
    • Vinuesa, C.G.1    Cook, M.C.2    Angelucci, C.3    Athanasopoulos, V.4    Rui, L.5    Hill, K.M.6
  • 122
    • 36048946330 scopus 로고    scopus 로고
    • Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA
    • Yu D, Tan AH-M, Hu X, Athanasopoulos V, Simpson N, Silva DG, et al. Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA. Nature (2007) 450:299-303. doi:10.1038/nature06253
    • (2007) Nature , vol.450 , pp. 299-303
    • Yu, D.1    Tan, A.H.-M.2    Hu, X.3    Athanasopoulos, V.4    Simpson, N.5    Silva, D.G.6
  • 123
    • 77954959530 scopus 로고    scopus 로고
    • Roquin binds inducible costimulator mRNA and effectors of mRNA decay to induce microRNA-independent post-transcriptional repression
    • Glasmacher E, Hoefig KP, Vogel KU, Rath N, Du L, Wolf C, et al. Roquin binds inducible costimulator mRNA and effectors of mRNA decay to induce microRNA-independent post-transcriptional repression. Nat Immunol (2010) 11:725-33. doi:10.1038/ni.1902
    • (2010) Nat Immunol , vol.11 , pp. 725-733
    • Glasmacher, E.1    Hoefig, K.P.2    Vogel, K.U.3    Rath, N.4    Du, L.5    Wolf, C.6
  • 124
    • 85027542056 scopus 로고    scopus 로고
    • Administration of AMG 557, a human Anti-B7RP-1 (ICOSL) antibody, leads to the selective inhibition of Anti-KLH IgG responses in subjects with SLE: results of a phase 1 randomized, double-blind, placebo-controlled, sequential, rising, multiple-dose study [abstract]
    • Sullivan B, Tsuji WH, Chindalore VL, Geppert TD, Rudinskaya A, Pardo P, et al. Administration of AMG 557, a human Anti-B7RP-1 (ICOSL) antibody, leads to the selective inhibition of Anti-KLH IgG responses in subjects with SLE: results of a phase 1 randomized, double-blind, placebo-controlled, sequential, rising, multiple-dose study [abstract]. Arthritis Rheum (2013) 65:1743
    • (2013) Arthritis Rheum , vol.65 , pp. 1743
    • Sullivan, B.1    Tsuji, W.H.2    Chindalore, V.L.3    Geppert, T.D.4    Rudinskaya, A.5    Pardo, P.6
  • 125
    • 84989302826 scopus 로고    scopus 로고
    • Inducible T-cell co-stimulator ligand (ICOSL) blockade leads to selective inhibition of anti-KLH IgG responses in subjects with systemic lupus erythematosus
    • Sullivan BA, Tsuji W, Kivitz A, Peng J, Arnold GE, Boedigheimer MJ, et al. Inducible T-cell co-stimulator ligand (ICOSL) blockade leads to selective inhibition of anti-KLH IgG responses in subjects with systemic lupus erythematosus. Lupus Sci Med (2016) 3:e000146. doi:10.1136/lupus-2016-000146
    • (2016) Lupus Sci Med , vol.3
    • Sullivan, B.A.1    Tsuji, W.2    Kivitz, A.3    Peng, J.4    Arnold, G.E.5    Boedigheimer, M.J.6
  • 126
  • 127
    • 84925121085 scopus 로고    scopus 로고
    • ICOS:ICOS-ligand interaction is required for type 2 innate lymphoid cell function, homeostasis, and induction of airway hyperreactivity
    • Maazi H, Patel N, Sankaranarayanan I, Suzuki Y, Rigas D, Soroosh P, et al. ICOS:ICOS-ligand interaction is required for type 2 innate lymphoid cell function, homeostasis, and induction of airway hyperreactivity. Immunity (2015) 42:538-51. doi:10.1016/j.immuni.2015.02.007
    • (2015) Immunity , vol.42 , pp. 538-551
    • Maazi, H.1    Patel, N.2    Sankaranarayanan, I.3    Suzuki, Y.4    Rigas, D.5    Soroosh, P.6
  • 128
    • 23044471742 scopus 로고    scopus 로고
    • Inhibition of chronic rejection and development of tolerogenic T cells after ICOS-ICOSL and CD40-CD40L co-stimulation blockade
    • Guillonneau C, Aubry V, Renaudin K, Séveno C, Usal C, Tezuka K, et al. Inhibition of chronic rejection and development of tolerogenic T cells after ICOS-ICOSL and CD40-CD40L co-stimulation blockade. Transplantation (2005) 80:546-54. doi:10.1097/01.TP.0000165429.57421.D6
    • (2005) Transplantation , vol.80 , pp. 546-554
    • Guillonneau, C.1    Aubry, V.2    Renaudin, K.3    Séveno, C.4    Usal, C.5    Tezuka, K.6
  • 129
    • 50649125413 scopus 로고    scopus 로고
    • Further study of anti-ICOS immunotherapy for rat cardiac allograft rejection
    • Pan X-C, Guo L, Deng Y-B, Naruse K, Kimura H, Sugawara Y, et al. Further study of anti-ICOS immunotherapy for rat cardiac allograft rejection. Surg Today (2008) 38:815-25. doi:10.1007/s00595-007-3734-y
    • (2008) Surg Today , vol.38 , pp. 815-825
    • Pan, X.-C.1    Guo, L.2    Deng, Y.-B.3    Naruse, K.4    Kimura, H.5    Sugawara, Y.6
  • 130
    • 10744223143 scopus 로고    scopus 로고
    • Simultaneous blockade of co-stimulatory signals, CD28 and ICOS, induced a stable tolerance in rat heart transplantation
    • Guo L, Fujino M, Kimura H, Funeshima N, Kitazawa Y, Harihara Y, et al. Simultaneous blockade of co-stimulatory signals, CD28 and ICOS, induced a stable tolerance in rat heart transplantation. Transpl Immunol (2003) 12:41-8. doi:10.1016/S0966-3274(03)00016-9
    • (2003) Transpl Immunol , vol.12 , pp. 41-48
    • Guo, L.1    Fujino, M.2    Kimura, H.3    Funeshima, N.4    Kitazawa, Y.5    Harihara, Y.6
  • 131
    • 84925296544 scopus 로고    scopus 로고
    • A pilot trial targeting the ICOS-ICOS-L pathway in nonhuman primate kidney transplantation
    • Lo DJ, Anderson DJ, Song M, Leopardi F, Farris AB, Strobert E, et al. A pilot trial targeting the ICOS-ICOS-L pathway in nonhuman primate kidney transplantation. Am J Transplant (2015) 15:984-92. doi:10.1111/ajt.13100
    • (2015) Am J Transplant , vol.15 , pp. 984-992
    • Lo, D.J.1    Anderson, D.J.2    Song, M.3    Leopardi, F.4    Farris, A.B.5    Strobert, E.6


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