A single amino acid alteration in cytoplasmic domain determines IL-2 promoter activation by ligation of CD28 but not inducible costimulator (ICOS)

Journal of Experimental Medicine

Volumn 197, Issue 2, 2003, Pages 257-262

  Harada, Yohsuke ^a   Ohgai, Daisuke ^a   Watanabe, Ryosuke ^a   Okano, Kazuhiro ^a   Koiwai, Osamu ^a   Tanabe, Kazunari ^b   Toma, Hiroshi ^b   Altman, Amnon ^c   Abe, Ryo ^a  

^a TOKYO UNIVERSITY OF SCIENCE   (Japan)

^b TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^c LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

Author keywords

AP 1; Grb2; NF b; NFAT; Phosphatidylinositol 3 kinase

Indexed keywords

AMINO ACID; CD28 ANTIGEN; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; ICOS ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 2; PHOSPHATIDYLINOSITOL 3 KINASE; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR NFAT; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CROSS LINKING; CYTOKINE RELEASE; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN MOTIF;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID MOTIFS; AMINO ACID SUBSTITUTION; ANIMALS; ANTIGENS, CD28; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; BINDING SITES; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; GRB2 ADAPTOR PROTEIN; HUMANS; INTERLEUKIN-2; JURKAT CELLS; MICE; MUTAGENESIS, SITE-DIRECTED; NF-KAPPA B; NFATC TRANSCRIPTION FACTORS; NUCLEAR PROTEINS; PROMOTER REGIONS (GENETICS); PROTEIN STRUCTURE, TERTIARY; PROTEINS; RECOMBINANT FUSION PROTEINS; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION FACTORS; TRANSFECTION;

EID: 0037455064     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20021305     Document Type: Article

References (30)

1. June, C.H., J.A. Bluestone, L.M. Nadler, and C.B. Thompson. 1994. The B7 and CD28 receptor families. Immunol. Today. 15:321-331.
2. Tamatani, T., K. Tezuka, and N. Hanzawa-Higuchi. 2000. AILIM/ICOS: a novel lymphocyte adhesion molecule. Int. Immunol. 12:51-55.
3. Hutloff, A., A.M. Dittrich, K.C. Beier, B. Eljaschewitsch, R. Kraft, I. Anagnostopoulos, and R.A. Kroczek. 1999. ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28. Nature. 397:263-266.
4. Yoshinaga, S.K., J.S. Whoriskey, S.D. Khare, U. Sarmiento, J. Guo, T. Horan, G. Shih, M. Zhang, M.A. Coccia, T. Kohno, et al. 1999. T-cell co-stimulation through B7RP-1 and ICOS. Nature. 402:827-832.
5. McAdam, A.J., T.T. Chang, A.E. Lumelsky, E.A. Greenfield, V.A. Boussiotis, J.S. Duke-Cohan, T. Chernova, N. Malenkovich, C. Jabs, V.K. Kuchroo, et al. 2000. Mouse inducible costimulatory molecule (ICOS) expression is enhanced by CD28 costimulation and regulates differentiation of CD4+ T cells. J. Immunol. 165:5035-5040.
6. Sharpe, A.H., and G.J. Freeman. 2002. The B7-CD28 superfamily. Nature Ref. Immunol. 2:116-126.
7. Ogawa, S., G. Nagamatsu, M. Watanabe, S. Watanabe, T. Hayashi, S. Horita, K. Nitta, H. Nihei, K. Tezuka, and R. Abe. 2001. Opposing effects of anti-activation-inducible lymphocyte-immunomodulatory molecule/inducible costimulator antibody on the development of acute versus chronic graft-versus-host disease. J. Immunol. 167:5741-5748.
8. Coyle, A.J., S. Lehar, C. Lloyd, J. Tian, T. Delaney, S. Manning, T. Nguyen, T. Burwell, H. Schneider, J.A. Gonzalo, et al. 2000. The CD28-related molecule ICOS is required for effective T cell-dependent immune responses. Immunity. 13:95-105.
9. Dong, C., A.E. Juedes, U.A. Temann, S. Shresta, J.P. Allison, N.H. Ruddle, and R.A. Flavell. 2001. ICOS co-stimulatory receptor is essential for T-cell activation and function. Nature. 409:97-101.
10. McAdam, A.J., R.J. Greenwald, M.A. Levin, T. Chernova, N. Malenkovich, V. Ling, G.J. Freeman, and A.H. Sharpe. 2001. ICOS is critical for CD40-mediated antibody class switching. Nature. 409:102-105.
11. Tafuri, A., A. Shahinian, F. Bladt, S.K. Yoshinaga, M. Jordana, A. Wakeham, L.M. Boucher, D. Bouchard, V.S. Chan, G. Duncan, et al. 2001. ICOS is essential for effective T-helper-cell responses. Nature. 409:105-109.
12. Harada, Y., E. Tanabe, R. Watanabe, B.D. Weiss, A. Matsumoto, H. Ariga, O. Koiwai, Y. Fukui, M. Kubo, C.H. June, and R. Abe. 2001. Novel role of PI3-K in CD28-mediated costimulation. J. Biol. Chem. 276:9003-9008.
13. Abe, R., P. Vandenberghe, N. Craighead, D.S. Smoot, K.P. Lee, and C.H. June. 1995. Distinct signal transduction in mouse CD4+ and CD8+ splenic T cells after CD28 receptor ligation. J. Immunol. 154:985-997.
14. Sakamoto, S., K. Tezuka, T. Tsuji, N. Hori, and T. Tamatani. 2001. AILIM/ICOS: its expression and functional analysis with monoclonal antibodies. Hybrid Hybridomics. 20:293-303.
15. Harada, Y., M. Tokushima, Y. Matsumoto, S. Ogawa, M. Otsuka, K. Hayashi, B.D. Weiss, C.H. June, and R. Abe. 2001. Critical requirement for the membrane-proximal cytosolic tyrosine residue for CD28-mediated costimulation in vivo. J. Immunol. 166:3797-3803.
16. Jain, J., C. Loh, and A. Rao. 1995. Transcriptional regulation of the IL-2 gene. Curr. Opin. Immunol. 7:333-342.
17. Shapiro, V.S., K.E. Truitt, J.B. Imboden, and A. Weiss. 1997. CD28 mediates transcriptional upregulation of the interleukin-2 (IL-2) promoter through a composite element containing the CD28RE and NF-IL-2B AP-1 sites. Mol. Cell. Biol. 17:4051-4058.
18. Ghosh, P., T.H. Tan, N.R. Rice, A. Sica, and H.A. Young. 1993. The interleukin 2 CD28-responsive complex contains at least three members of the NF kappa B family: c-Rel, p50, and p65. Proc. Natl. Acad. Sci. USA. 90:1696-1700.
19. Lai, J.H., G. Horvath, J. Subleski, J. Bruder, P. Ghosh, and T.H. Tan. 1995. RelA is a potent transcriptional activator of the CD28 response element within the interleukin 2 promoter. Mol. Cell. Biol. 15:4260-4271.
20. Ghosh, P., A. Sica, M. Cippitelli, J. Subleski, R. Lahesmaa, H.A. Young, and N.R. Rice. 1996. Activation of nuclear factor of activated T cells in a cyclosporin A-resistant pathway. J. Biol. Chem. 271:7700-7704.
21. Su, B., E. Jacinto, M. Hibi, T. Kallunki, M. Karin, and Y. Ben-Neriah. 1994. JNK is involved in signal integration during costimulation of T lymphocytes. Cell. 77:727-736.
22. Bryan, R.G., Y. Li, J.H. Lai, M. Van, N.R. Rice, R.R. Rich, and T.H. Tan. 1994. Effect of CD28 signal transduction on c-Rel in human peripheral blood T cells. Mol. Cell. Biol. 14:7933-7942.
23. Truitt, K.E., T. Nagel, L.F. Suen, and J.B Imboden. 1996. Structural requirements for CD28-mediated costimulation of IL-2 production in Jurkat T cells. J. Immunol. 156:4539-4541.
24. Holdorf, A.D., J.M. Green, S.D. Levin, M.F. Denny, D.B. Straus, V. Link, P.S. Changelian, P.M. Allen, and A.S. Shaw. 1999. Proline residues in CD28 and the Src homology (SH)3 domain of Lck are required for T cell costimulation. J. Exp. Med. 190:375-384.
25. Burr, J.S., N.D. Savage, G.E. Messah, S.L. Kimzey, A.S. Shaw, R.H. Arch, and J.M. Green. 2001. Cutting edge: distinct motifs within CD28 regulate T cell proliferation and induction of Bcl-X(L). J. Immunol. 166:5331-5335.
26. Datta, S.R., A. Brunet, and M.E. Greenberg. 1999. Cellular survival: a play in three Akts. Genes Dev. 13:2905-2927.
27. Brennan, P., J.W. Babbage, B.M. Burgering, B. Groner, K. Reif, and D.A. Cantrell. 1997. Phosphatidylinositol 3-kinase couples the interleukin-2 receptor to the cell cycle regulator E2F. Immunity. 7:679-689.
28. Arimura, Y., H. Kato, U. Dianzani, T. Okamoto, S. Kamekura, D. Buonfiglio, T. Miyoshi-Akiyama, T. Uchiyama, and J. Yagi. 2002. A co-stimulatory molecule on activated T cells, H4/ICOS, delivers specific signals in T(h) cells and regulates their responses. Int. Immunol. 14:555-566.
29. Su, B., E. Jacinto, M. Hibi, T. Kallunki, M. Karin, and Y. Ben-Neriah. 1994. JNK is involved in signal integration during costimulation of T lymphocytes. Cell. 77:727-736.
30. Schafer, P.H., S.A. Wadsworth, L. Wang, and J.J. Siekierka. 1999. p38 α mitogen-activated protein kinase is activated by CD28-mediated signaling and is required for IL-4 production by human CD4+CD45RO+ T cells and Th2 effector cells. J. Immunol. 162:7110-7119.