Antagonism between MyD88- and TRIF-dependent signals in B7RP-1 up-regulation

European Journal of Immunology

Volumn 35, Issue 6, 2005, Pages 1918-1927

  Zhou, Zuping ^a   Hoebe, Kasper ^a   Du, Xin ^a   Jiang, Zhengfan ^a   Shamel, Louis ^a   Beutler, Bruce ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

B cells; B7RP 1; Macrophages; Toll like receptor; Type I IFN

Indexed keywords

ADAPTOR PROTEIN; B7 ANTIGEN; B7 RELATED PROTEIN 1; CD86 ANTIGEN; CELL PROTEIN; INTERFERON; LIPOPOLYSACCHARIDE; MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 4; TRIF PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIGEN EXPRESSION; ANTIGEN PRESENTING CELL; ARTICLE; B LYMPHOCYTE; CELL CULTURE; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; FLOW CYTOMETRY; IN VIVO STUDY; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SPLEEN CELL; STATISTICAL ANALYSIS; UPREGULATION; WILD TYPE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADAPTOR PROTEINS, VESICULAR TRANSPORT; ANIMALS; ANTIGENS, CD80; ANTIGENS, DIFFERENTIATION; GENE EXPRESSION REGULATION; INTERFERON-BETA; LIPOPOLYSACCHARIDES; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MYELOID DIFFERENTIATION FACTOR 88; POLY I-C; RECEPTORS, CELL SURFACE; RECEPTORS, IMMUNOLOGIC; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTORS; UP-REGULATION;

EID: 20844458651     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200525971     Document Type: Article

References (48)

1. Carreno, B. M. and Collins, M., The B7 family of ligands and its receptors: new pathways for costimulation and inhibition of immune responses. Annu. Rev. Immunol 2002. 20: 29-53.
2. Sharpe, A. H. and Freeman, G. J., The B7-CD28 superfamily. Nat. Rev. Immunol. 2002. 2: 116-126.
3. Chen, L., Co-inhibitory molecules of the B7-CD28 family in the control of T cell immunity. Nat. Rev. Immunol. 2004. 4: 336-347.
4. Borriello, F., Sethna, M. P., Boyd, S. D., Schweitzer, A. N., Tivol, E. A., Jacoby, D., Strom, T. B., Simpson, E. M., Freeman, G. J. and Sharpe, A. H., B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation. Immunity 1997. 6: 303-313.
5. Shahinian, A., Pfeffer, K., Lee, K. P., Kundig, T. M., Kishihara, K., Wakeham, A., Kawai, K., Ohashi, P. S., Thompson, C. B. and Mak, T. W., Differential T cell costimulatory requirements in CD28-deficient mice. Science 1993. 261: 609-612.
6. Ferguson, S. E., Han, S., Kelsoe, G. and Thompson, C. B., CD28 is required for germinal center formation. J. Immunol. 1996. 156: 4576-4581.
7. Nurieva, R. I., Mai, X. M., Forbush, K., Bevan, M. J. and Dong, C., B7 h is required for T cell activation, differentiation, and effector function. Proc. Natl. Acad. Sci. USA 2003. 100: 14163-14168.
8. Mak, T. W., Shahinian, A., Yoshinaga, S. K., Wakeham, A., Boucher, L. M., Pintilie, M., Duncan, G., Gajewska, B. U., Gronski, M., Eriksson, U., Odermatt, B., Ho, A., Bouchard, D., Whorisky; J. S., Jordana, M., Ohashi, P. S., Pawson, T., Bladt, F. and Tafuri, A., Costimulation through the inducible costimulator ligand is essential for both T helper and B cell functions in T cell-dependent B cell responses. Nat. Immunol. 2003. 4: 765-772.
9. Dong, C., Juedes, A. E., Temann, U. A., Shresta, S., Allison, J. P., Ruddle, N. H. and Flavell, R. A., ICOS co-stimulatory receptor is essential for T cell activation and function. Nature 2001. 409: 97-101.
10. McAdam, A. J., Greenwald, R. J., Levin, M. A., Chernova, T., Malenkovich, N., Ling, V., Freeman, G. J. and Sharpe, A. H., ICOS is critical for CD40-mediated antibody class switching. Nature 2001. 409: 102-105.
11. Tafuri, A., Shahinian, A., Bladt, F., Yoshinaga, S. K., Jordana, M., Wakeham, A., Boucher, L. M., Bouchard, D., Chan, V. S. and Duncan, G., ICOS is essential for effective T-helper-cell responses. Nature 2001. 409: 105-109.
12. Tivol, E. A., Borriello, F., Schweitzer, A. N., Lynch, W. P., Bluestone, J. A. and Sharpe, A. H., Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 1995. 3: 541-547.
13. Waterhouse, P., Penninger, J. M., Timms, E., Wakeham, A., Shahinian, A., Lee, K. P., Thompson, C. B., Griesser, H. and Mak, T. W., Lymphoproliferative disorders with early lethality in mice deficient in CTLA-4. Science 1995. 270: 985-988.
14. Nishimura, H., Nose, M., Hiai, H., Minato, N. and Honjo, T., Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. Immunity 1999. 11: 141-151.
15. Nishimura, H., Okazaki, T., Tanaka, Y., Nakatani, K., Hara, M., Matsumori, A., Sasayama, S., Mizoguchi, A., Hiai, H., Minato, N. and Honjo, T., Autoimmune dilated cardiomyopathy in PDA-1 receptor-deficient mice. Science 2001. 291: 319-322.
16. Watanabe, N., Gavrieli, M., Sedy, J. R., Yang, J., Fallarino, F., Loftin, S. K., Hurchla, M. A., Zimmerman, N., Sim, J., Zang, X., Murphy, T. L., Russell, J. H., Allison, J. P. and Murphy, K. M., BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1. Nat. Immunol. 2003. 4: 670-679.
17. Sica, G. L., Choi, I. H., Zhu, G., Tamada, K., Wang, S. D., Tamura, H., Chapoval, A. I., Flies, D. B., Bajorath, J. and Chen, L. B7-H4, a molecule of the B7 family, negatively regulates T cell immunity. Immunity 2003. 18: 849-861.
18. Liu, X., Gao, J. X., Wen, J., Yin, L., Li, O., Zuo, T., Gajewski, T. F., Fu, Y. X., Zheng, P. and Liu, Y., B7DC/PDL2 promotes tumor immunity by a PD-1-independent mechanism. J. Exp. Med. 2003. 197: 1721-1730.
19. Gett, A. V., Sallusto, F., Lanzavecchia, A. and Geginat, J., T cell fitness determined by signal strength. Nat. Immunol. 2003. 4: 355-360.
20. Beutler, B., Innate immunity: an overview. Mol. Immunol. 2004. 40: 845-859.
21. Akira, S. and Takeda, K., Toll-like receptor signalling. Nat. Rev. Immunol. 2004. 4: 499-511.
22. Akira, S., Takeda, K. and Kaisho, T., Toll-like receptors: critical proteins linking innate and acquired immunity. Nat. Immunol. 2001. 2: 675-680.
23. Schnare, M., Barton, G. M., Holt, A. C., Takeda, K., Akira, S. and Medzhitov, R., Toll-like receptors control activation of adaptive immune responses. Nat. Immunol. 2001. 2: 947-950.
24. Hoebe, K., Janssen, E. M., Kim, S. O., Alexopoulou, L., Flavell, R. A., Han, J. and Beutler, B., Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways. Nat. Immunol. 2003. 4: 1223-1229.
25. Yamamoto, M., Sato, S., Hemmi, H., Uematsu, S., Hoshino, K., Kaisho, T., Takeuchi, O., Takeda, K. and Akira, S., TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway. Nat. Immunol. 2003. 4: 1144-1150.
26. Fitzgerald, K. A., Rowe, D. C., Barnes, B. J., Caffrey, D. R., Visintin, A., Latz, E., Monks, B., Pitha, P. M. and Golenbock, D. T., LPS-TLR4 signaling to IRF-3/7 and NF-kB involves the Toll adapters TRAM and TRIF. J. Exp. Med. 2003. 198: 1043-1055.
27. Hoebe, K., Du, X., Georgel, P., Janssen, E., Tabeta, K., Kim, S. O., Goode, J., Lin, P., Mann, N., Mudd, S., Crozat, K., Sovath, S., Han, J. and Beutler, B., Identification of Lps2 as a key transducer of MyD88-independent TIR signalling. Nature 2003. 424: 743-738.
28. Yamamoto, M., Sato, S., Hemmi, H., Hoshino, K., Kaisho, T., Sanjo, H., Takeuchi, O., Sugiyama, M., Okabe, M., Takeda, K. and Akira, S., Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science 2003. 301: 640-643.
29. Dalod, M., Hamilton, T., Salomon, R., Salazart-Mather, T. P., Henry, S. C., Hamilton, J. D. and Biron, C. A., Dendritic cell responses to early routine cytomegalovirus infection: subset functional specialization and differential regulation by interferon α/β. J. Exp. Med. 2003. 197: 885-898.
30. + T cell expansion with variable dependence on type I IFN. J. Exp. Med. 2004. 199: 775-784.
31. Doyle, S., Vaidya, S., O'Connell, R., Dadgostar, H., Dempsey, P., Wu, T., Rao, G., Sun, R., Haberland, M., Modlin, R. and Cheng, G., IRF3 mediates a TLR3/TLR4-specific antiviral gene program. Immunity 2002. 17: 251-263.
32. Toshchakov, V., Jones, B. W., Perera, P. Y., Thomas, K., Cody, M. J., Zhang, S., Williams, B. R., Major, J., Hamilton, T. A., Fenton, M. J. and Vogel, S. N., TLR4, but not TLR2, mediates IFN-beta-induced STAT1alpha/beta-dependent gene expression in macrophages. Nat. Immunol. 2002. 3: 392-398.
33. Yoshinaga, S. K., Whoriskey, J. S. and Khare, S. D., T cell co-stimulation through B7RP-1 and ICOS. Nature 1999. 402: 827-832.
34. Liang, L., Porter, E. M. and Sha, W. C., Constitutive expression of the B7 h ligand for inducible costimulator on naive B cells is extinguished after activation by distinct B cell receptor and interleukin 4 receptor-mediated pathways and can be rescued by CD40 signaling. J. Exp. Med. 2002. 196: 97-108.
35. Aicher, A., Hayden-Ledbetter, M., Brad, W. A., Pezzutto, A., Richter, G., Magaletti, D., Buckwalter, S., Ledbetter, J. A. and Clark, E. A., Characterization of human inducible costimulator ligand expression and function. J. Immunol. 2000. 164: 4689-4696.
36. Sato, S., Nomura, F., Kawai, T., Takeuchi, O., Muhlradt, P. F., Takeda, K. and Akira, S., Synergy and cross-tolerance between toll-like receptor (TLR) 2- and TLR4-mediated signaling pathways. J. Immunol. 2000. 165: 7096-7101.
37. Nurieva, R. I., Duong, J., Kishikawa, H., Dianzani, U., Rojo, J. M., Ho, I., Flavell, R. A. and Dong, C., Transcriptional regulation of Th2 differentiation by inducible costimulator. Immunity 2003. 18: 801-811.
38. Mandelbrot, D., McAdam, A. J. and Sharpe, A. H., B7-1 or B7-2 is required to produce the lymphoproliferative phenotype in mice lacking cytotoxic T lymphocyte-associated antigen (CTLA-4). J. Exp. Med. 1999. 189: 435-440.
39. Dong, H., Strome, S. E., Salomao, D. R., Tamura, H., Hirano, F., Flies, D. B., Roche, P. C., Lu, J., Zhu, G., Tamada, K., Lennon, V. A., Celis, E. and Chen, L., Tumor-associated B7-H1 promotes T cell apoptosis: a potential mechanism of immune evasion. Nat. Med. 2002. 8: 793-800.
40. Dong, H., Zhu, G., Tamada, K. and Chen, L., B7-H1, a third member of the B7 family, co-stimulates T cell proliferation and interleukin-10 secretion. Nat. Med. 1999. 5: 1365-1369.
41. Tseng, S. Y., Otsuji, M., Gorski, K., Huang, X., Slansky, J. E., Pai, S. I., Shalabi, A., Shin, T., Pardoll, D. M. and Tsuchiya, H., B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells. J. Exp. Med. 2001. 193: 839-846.
42. Redecke, V., Häcker, H., Datta, S. K., Fermin, A., Pitha, P. M., Broide, D. H. and Raz, E., Activation of Toll-like receptor 2 induces a Th2 immune response and promotes experimental asthma. J. Immunol. 2004. 172: 2739-2743.
43. Eder, W., Klimecki, W., Yu, L., Von Mutius, E., Riedler, J., Braun-Fahrlander, C., Nowak, D. and Martinez, F. D., Toll-like receptor 2 as a major gene for asthma in children of European farmers. J. Allergy Clin. Immunol. 2004. 113: 482-488.
44. Dillon, S., Agrawal, A., Van Dyke, T., Landreth, G., McCauley, L., Koh, A., Maliszewski, C., Akira, S. and Pulendran, B., A Toll-like receptor 2 ligand stimulates Th2 responses in vivo, via induction of extracellular signal-regulated kinase mitogen-activated protein kinase and c-Fos in dendritic cells. J. Immunol. 2004. 172: 4733-4743.
45. Agrawal, S., Agrawal, A., Doughty, B., Gerwitz, A., Blenis, J., Van Dyke, T. and Pulendran, B., Cutting edge: different Toll-like receptor agonists instruct dendritic cells to induce distinct Th responses via differential modulation of extracellular signal-regulated kinase-mitogen-activated protein kinase and c-Fos. J. Immunol. 2003. 171: 4984-4989.
46. Chu, R. S., Targoni, O. S., Krieg, A. M., Lehmann, P. V. and Harding, C. V., CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity. J. Exp. Med. 1997. 186: 1623-1631.
47. Brazolot Millan, C. L., Weeratna, R., Krieg, A. M., Siegrist, C. A. and Davis, H. L., CpG DNA can induce strong Th1 humoral and cell-mediated immune responses against hepatitis B surface antigen in young mice. Proc. Natl. Acad. Sci. USA 1998. 95: 15553-15558.
48. Liu, X., Ohnishi, N., Ni, N., Akira, L. S. and Bacon, K. B., CpG directly induce T-bet expression and inhibits IgG1 and IgE switching in B cells. Nat. Immunol. 2003. 4: 687-693.