Cutting edge: Critical role of inducible costimulator in germinal center reactions

Journal of Immunology

Volumn 166, Issue 6, 2001, Pages 3659-3662

  Dong, C ^a   Temann, U A ^a   Flavell, R A ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; IMMUNOGLOBULIN CLASS; IMMUNOGLOBULIN G1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; EFFECTOR CELL; GENE REARRANGEMENT; GERMINAL CENTER; HUMORAL IMMUNITY; IMMUNIZATION; IMMUNOHISTOCHEMISTRY; IMMUNOSTIMULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; SPLEEN; T LYMPHOCYTE ACTIVATION;

EID: 0035869525     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.166.6.3659     Document Type: Article

References (11)

1. CD40 and CD154 in cell-mediated immunity
2. Impaired mucosal immune responses in interleukin 4-targeted mice
3. Absence of interleukin-4 enhances germinal center reaction in secondary immune response
4. + T cells
5. CD28 is required for germinal center formation
6. ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28
7. T-cell co-stimulation through B7RP-1 and ICOS
8. B7h, a novel costimulatory homolog of B7.1 and B7.2, is induced by TNFα
9. ICOS costimulatory receptor is essential for T-cell activation and function
10. The CD28-related molecule ICOS is required for effective T cell-dependent immune responses
11. Identification of murine germinal center B cell subsets defined by the expression of surface isotypes and differentiation antigens