Cutting edge: Inducible costimulator protein regulates both Th1 and Th2 responses to cutaneous Leishmaniasis

Journal of Immunology

Volumn 168, Issue 3, 2002, Pages 991-995

  Greenwald, Rebecca J ^a   McAdam, Alexander J ^a   Van der Woude, Diane ^a   Satoskar, Abhay R ^a   Sharpe, Arlene H ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; FEMALE; IMMUNOGLOBULIN PRODUCTION; IMMUNOREGULATION; IMMUNOSTIMULATION; INFECTION CONTROL; LEISHMANIA MEXICANA; MOUSE; NONHUMAN; PRIORITY JOURNAL; SKIN LEISHMANIASIS; TH1 CELL; TH2 CELL;

EID: 0036467340     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.168.3.991     Document Type: Article

References (30)

1. ICOS is an inducible T-cell costimulator structurally and functionally related to CD28
2. ICOS is critical for CD40mediated antibody class switching
3. ICOS co-stimulatory receptor is essential for T-cell activation and function
4. + T cells
5. B7h, a novel costimulatory homolog of B7.1 and B7.2. is induced by TNFα
6. T-cell co-stimulation through B7RP-1 and ICOS
7. Characterization of human inducible costimulator ligand expression and function
8. ICOS is essential for effective T-helper-cell responses
9. The CD28-related molecule ICOS is required for effective T cell-dependent immune responses
10. Inducible costimulator regulates Th2-mediated inflammation, but not Th2 differentiation, in a model of allergic airway disease
11. ICOS is critical for T helper cell-mediated lung mucosal inflammatory responses
12. Importance of ICOS-B7RP-1 costimulation in acute and chronic allograft rejection
13. The costimulatory molecule ICOS plays an important role in the immunopathogenesis of EAE
14. ICOS ligand costimulation is required for T-cell encephalitogenicity
15. Mice with STAT6-targeted gene disruption develop a Th1 response and control cutaneous leishmaniasis
16. Disruption of the murine interleukin-4 gene inhibits disease progression during Leishmania mexicana infection but does not increase control of Leishmania donovani infection
17. Immune responses associated with susceptibility of C57BL/10 mice to Leishmania amazonensis
18. Experimental infection of BALB/c mice with Leishmania panamensis and Leishmania mexicana: Induction of early IFN-γ but not IL-4 is associated with the development of cutaneous lesions
19. Reciprocal expression of interferon γ or interleukin 4 during the resolution or progression of murine leishmaniasis: Evidence for expansion of distinct helper T cell subsets
20. IL-4-deficient BALB/c mice resist infection with Leishmania major
21. TNF-α synergizes with IFN-γ in mediating killing of Leishmania major through the induction of nitric oxide
22. A quick, simple method for purifying Leishmania mexicana amastigotes in large numbers
23. Role of costimulators in T cell differentiation: Studies using APCs lacking expression of CD80 or CD86
24. Internalization of Leishmania mexicana complex amastigotes via the Fc receptor is required to sustain infection in murine cutaneous leishmaniasis
25. Differential T cell costimulatory requirements in CD28-deficient mice
26. Duration of TCR stimulation determines costimulatory requirement of T cells
27. Limited role of CD28-mediated signals in T helper subset differentiation
28. CD28 dependence of T cell differentiation to IL-4 production varies with the particular type 2 immune response
29. Th1- and Th2-cell commitment during infectious disease: Asymmetry in divergent pathways
30. Inducible costimulator protein (ICOS) controls T helper cell subset polarization after virus and parasite infection