Inhibition of activin receptor-like kinase 5 attenuates Bleomycin-induced pulmonary fibrosis

Experimental and Molecular Pathology

Volumn 83, Issue 1, 2007, Pages 39-46

  Higashiyama, Hiroyuki ^a   Yoshimoto, Daisuke ^a   Kaise, Toshihiko ^a   Matsubara, Shigeki ^a   Fujiwara, Masatoshi ^a   Kikkawa, Hideo ^a   Asano, Satoshi ^a   Kinoshita, Mine ^a  

^a Development and Medical Affairs Division   (Japan)

Author keywords

ALK5; CTGF; Fibronectin; Myofibroblast; Smad proteins; TGF beta; Type I collagen; Type III collagen

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; BLEOMYCIN; COLLAGEN TYPE 1; COLLAGEN TYPE 3; CONNECTIVE TISSUE GROWTH FACTOR; FIBRONECTIN; MESSENGER RNA; RECEPTOR REGULATED SMAD PROTEIN; SB 525334; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG INHIBITION; EXTRACELLULAR MATRIX; GENE EXPRESSION; GENETIC ANALYSIS; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; LUNG FIBROSIS; MALE; MOUSE; MYOFIBROBLAST; NONHUMAN; PROTEIN EXPRESSION; UPREGULATION;

ACTIVE TRANSPORT, CELL NUCLEUS; ACTIVIN RECEPTORS, TYPE I; ANIMALS; BLEOMYCIN; CELL PROLIFERATION; COLLAGEN TYPE I; EXTRACELLULAR MATRIX PROTEINS; GENE EXPRESSION REGULATION; IMMEDIATE-EARLY PROTEINS; IMMUNOHISTOCHEMISTRY; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MICE; MICE, INBRED BALB C; PROTEIN KINASE INHIBITORS; PULMONARY FIBROSIS; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; RNA, MESSENGER; SMAD2 PROTEIN; SMAD3 PROTEIN;

EID: 34249666220     PISSN: 00144800     EISSN: 10960945     Source Type: Journal    
DOI: 10.1016/j.yexmp.2006.12.003     Document Type: Article

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