Loss of integrin αvβ6-mediated TGF-β activation causes Mmp 12-dependent emphysema

Nature

Volumn 422, Issue 6928, 2003, Pages 169-173

  Morris, David G ^a,b   Huang, Xiaozhu ^a   Kaminski, Naftali ^c   Wang, Yanli ^a   Shapiro, Steven D ^d   Dolganov, Gregory ^b   Gllck, Adam ^e   Sheppard, Dean ^a,b  

^a SAN FRANCISCO GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

^e NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; GENES; PULMONARY DISEASES;

CELL GROWTH;

PROTEINS;

ALPHA5 INTEGRIN; BETA6 INTEGRIN; CELL SURFACE PROTEIN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

BIOLOGY;

ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL MIGRATION; CELL SURVIVAL; CHRONIC LUNG DISEASE; CONTROLLED STUDY; DIMERIZATION; EMPHYSEMA; EXTRACELLULAR MATRIX; GENE EXPRESSION REGULATION; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING;

AGING; ANIMALS; ANTIGENS, NEOPLASM; DISEASE PROGRESSION; DISEASE SUSCEPTIBILITY; GENE DELETION; HUMANS; INFLAMMATION; INTEGRIN BETA CHAINS; INTEGRINS; MACROPHAGES, ALVEOLAR; MATRIX METALLOPROTEINASE 12; METALLOENDOPEPTIDASES; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; PULMONARY EMPHYSEMA; TRANSFORMING GROWTH FACTOR BETA;

ANIMALIA;

EID: 0037435009     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature01413     Document Type: Article

References (27)

1. Munger, J. S. et al. The integrin αvβ6 binds and activates latent TGFβ1: a mechanism for regulating pulmonary inflammation and fibrosis. Cell 96, 319-328 (1999).
2. Pittet, J. F. et al. TGF-β is a critical mediator of acute lung injury. J. Clin. Invest. 107, 1537-1544 (2001).
3. Kaminski, N. et al. Global analysis of gene expression in pulmonary fibrosis reveals distinct programs regulating lung inflammation and fibrosis. Proc. Natl. Acad. Sci. USA 97, 1778-1783 (2000).
4. Werb, Z. & Gordon, S. Elastase secretion by stimulated macrophages. Characterization and regulation. J. Exp. Med. 142, 361-377 (1975).
5. Shapiro, S. D. et al. Molecular cloning, chromosomal localization, and bacterial expression of a murine macrophage metalloelastase. J. Biol. Chem. 267, 4664-4671 (1992).
6. Belaaouaj, A. et al. Human macrophage metalloelastase. Genomic organization, chromosomal location, gene linkage, and tissue-specific expression. J. Biol. Chem. 270, 14568-14575 (1995).
7. Hautamaki, R. D., Kobayashi, D. K., Senior, R. M. & Shapiro, S. D. Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice. Science 277, 2002-2004 (1997).
8. Agrez, M., Chen, A., Cone, R. I., Pytela, R. & Sheppard, D. The αvβ6 integrin promotes proliferation of colon carcinoma cells through a unique region of the beta 6 cytoplasmic domain. J. Cell Biol. 127, 547-556 (1994).
9. Huang, X. Z., Chen, A., Agrez, M. & Sheppard, D. A point mutation in the integrin β6 subunit abolishes both αvβ6 binding to fibronectin and receptor localization to focal contacts. Am. J. Respir. Cell. Mol. Biol. 13, 245-251 (1995).
10. Huang, X., Wu, J., Zhu, W., Pytela, R. & Sheppard, D. Expression of the human integrin β6 subunit in alveolar type II cells and bronchiolar epithelial cells reverses lung inflammation in β6 knockout mice. Am. J. Respir. Cell. Mol. Biol. 19, 636-642 (1998).
11. Feinberg, M. W. et al. Transforming growth factor-β I inhibits cytokine-mediated induction of human metalloelastase in macrophages. J. Biol. Chem. 275, 25766-25773 (2000).
12. Werner, F. et al. Transforming growth factor-β I inhibition of macrophage activation is mediated via Smad3. J. Biol. Chem. 275, 36653-36658 (2000).
13. Huang, X. Z. et al. Inactivation of the integrin β6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin. J. Cell Biol. 153, 921-928 (1996).
14. Wang, Z. et al. Interferon gamma induction of pulmonary emphysema in the adult murine lung. J. Exp. Med. 192, 1587-1600 (2000).
15. Fujita, M. et al. Overexpression of tumour necrosis factor-α produces an increase in lung volumes and pulmonary hypertension. Am. J. Physiol. Lung Cell Mol. Physiol. 280, L39-L49 (2001).
16. Zheng, T. et al. Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase- and cathepsin-dependent emphysema. J. Clin. Invest. 106, 1081-1093 (2000).
17. Wert, S. E. et al. Increased metalloproteinase activity, oxidant production, and emphysema in surfactant protein D gene-inactivated mice. Proc. Natl Acad. Sci. USA 97, 5972-5977 (2000).
18. Leco, K. J. et al. Spontaneous air space enlargement in the lungs of mice lacking tissue inhibitor of metalloproteinases-3 (TIMP-3). J. Clin. Invest. 108, 817-829 (2001).
19. Kasahara, Y. et al. Inhibition of VEGF receptors causes lung cell apoptosis and emphysema. J. Clin. Invest. 106, 1311-1319 (2000).
20. Niewoehner, D. E., Kleinerman, J. & Rice, D. B. Pathologic changes in the peripheral airways of young cigarette smokers. N. Engl. J. Med. 291, 755-758 (1974).
21. Silverman, E. K. et al. Genetic epidemiology of severe, early-onset chronic obstructive pulmonary disease. Risk to relatives for airflow obstruction and chronic bronchitis. Am. J. Respir. Crit. Care Med. 157, 1770-1778 (1998).
22. Wikenheiser, K. A., Clark, J. C., Linnoila, R. I., Stahlman, M. T. & Whitsett, J. A. Simian virus 40 large T antigen directed by transcriptional elements of the human surfactant protein C gene produces pulmonary adenocarcinomas in transgenic mice. Cancer Res. 52, 5342-5352 (1992).
23. Cone, R. I., Weinacker, A., Chen, A. Sheppard, D. Effects of beta subunit cytoplasmic domain deletions on the recruitment of the integrin αvβ6 to focal contacts. Cell Adhes. Commun. 2, 101-113 (1994).
24. Clark, J. C. et al. FGF-10 disrupts lung morphogenesis and causes pulmonary adenomas in vivo. Am. J. Physiol. Lung. Cell. Mol. Physiol. 280, L705-L715 (2001).
25. Liu, X. et al. Conditional epidermal expression of TGF beta I blocks neonatal lethality but causes a reversible hyperplasia and alopecia. Proc. Natl Acad. Sci. USA 98, 9139-9144 (2001).
26. - cotransporter (NKCC1) in asthmatic subjects. Genome Res. 11, 1473-1483 (2001).
27. Dunnill, M. S. Quantitative methods in the study of pulmonary pathology. Thorax 17, 320-328 (1962).