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Volumn 17, Issue 10, 2016, Pages 636-651

Region-specific roles of the corticotropin-releasing factor-urocortin system in stress

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; ANTIDEPRESSANT AGENT; CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR; CORTICOTROPIN RELEASING FACTOR RECEPTOR 1; CORTICOTROPIN RELEASING FACTOR RECEPTOR 2; CYCLIC AMP DEPENDENT PROTEIN KINASE; ENDOCANNABINOID; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; UROCORTIN; CORTICOTROPIN RELEASING FACTOR RECEPTOR;

EID: 84984825577     PISSN: 1471003X     EISSN: 14710048     Source Type: Journal    
DOI: 10.1038/nrn.2016.94     Document Type: Review
Times cited : (198)

References (228)
  • 1
    • 0019782980 scopus 로고
    • Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin
    • Vale, W., Spiess, J., Rivier, C. & Rivier, J. Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin. Science 213, 1394-1397 (1981).
    • (1981) Science , vol.213 , pp. 1394-1397
    • Vale, W.1    Spiess, J.2    Rivier, C.3    Rivier, J.4
  • 2
    • 0025331354 scopus 로고
    • Is corticotropin-releasing factor a mediator of stress responses?
    • Dunn, A. J. & Berridge, C. W. Is corticotropin-releasing factor a mediator of stress responses? Ann. NY Acad. Sci. 579, 183-191 (1990).
    • (1990) Ann. NY Acad. Sci. , vol.579 , pp. 183-191
    • Dunn, A.J.1    Berridge, C.W.2
  • 3
    • 1342281225 scopus 로고    scopus 로고
    • CRF and CRF receptors: Role in stress responsivity and other behaviors
    • Bale, T. L. & Vale, W. W. CRF and CRF receptors: role in stress responsivity and other behaviors. Annu. Rev. Pharmacol. Toxicol. 44, 525-557 (2004).
    • (2004) Annu. Rev. Pharmacol. Toxicol. , vol.44 , pp. 525-557
    • Bale, T.L.1    Vale, W.W.2
  • 4
    • 0027716959 scopus 로고
    • The locus coeruleus as a site for integrating corticotropin-releasing factor and noradrenergic mediation of stress responses
    • Valentino, R. J., Foote, S. L. & Page, M. E. The locus coeruleus as a site for integrating corticotropin-releasing factor and noradrenergic mediation of stress responses. Ann. NY Acad. Sci. 697, 173-188 (1993).
    • (1993) Ann. NY Acad. Sci. , vol.697 , pp. 173-188
    • Valentino, R.J.1    Foote, S.L.2    Page, M.E.3
  • 5
    • 0020183919 scopus 로고
    • Corticotropin-releasing factor: Actions on the sympathetic nervous system and metabolism
    • Brown, M. R. et al. Corticotropin-releasing factor: actions on the sympathetic nervous system and metabolism. Endocrinology 111, 928-931 (1982).
    • (1982) Endocrinology , vol.111 , pp. 928-931
    • Brown, M.R.1
  • 6
    • 0036462444 scopus 로고    scopus 로고
    • Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression
    • Reul, J. M. & Holsboer, F. Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression. Curr. Opin. Pharmacol. 2, 23-33 (2002).
    • (2002) Curr. Opin. Pharmacol. , vol.2 , pp. 23-33
    • Reul, J.M.1    Holsboer, F.2
  • 9
    • 0028035260 scopus 로고
    • Corticotropin-releasing hormone (CRH) antisense oligodeoxynucleotide induces anxiolytic effects in rat
    • Skutella, T. et al. Corticotropin-releasing hormone (CRH) antisense oligodeoxynucleotide induces anxiolytic effects in rat. Neuroreport 5, 2181-2185 (1994).
    • (1994) Neuroreport , vol.5 , pp. 2181-2185
    • Skutella, T.1
  • 10
    • 0028625387 scopus 로고
    • Corticotropin-releasing hormone (CRH) antisense oligodeoxynucleotide treatment attenuates social defeat-induced anxiety in rats
    • Skutella, T. et al. Corticotropin-releasing hormone (CRH) antisense oligodeoxynucleotide treatment attenuates social defeat-induced anxiety in rats. Cell. Mol. Neurobiol. 14, 579-588 (1994).
    • (1994) Cell. Mol. Neurobiol. , vol.14 , pp. 579-588
    • Skutella, T.1
  • 11
    • 0021714606 scopus 로고
    • Elevated concentrations of CSF corticotropin-releasing factor-like immunoreactivity in depressed patients
    • Nemeroff, C. B. et al. Elevated concentrations of CSF corticotropin-releasing factor-like immunoreactivity in depressed patients. Science 226, 1342-1344 (1984).
    • (1984) Science , vol.226 , pp. 1342-1344
    • Nemeroff, C.B.1
  • 12
    • 0031004906 scopus 로고    scopus 로고
    • Elevated CSF corticotropin-releasing factor concentrations in posttraumatic stress disorder
    • Bremner, J. D. et al. Elevated CSF corticotropin-releasing factor concentrations in posttraumatic stress disorder. Am. J. Psychiatry 154, 624-629 (1997).
    • (1997) Am. J. Psychiatry , vol.154 , pp. 624-629
    • Bremner, J.D.1
  • 13
    • 0027503187 scopus 로고
    • Association of fluoxetine treatment with reductions in CSF concentrations of corticotropin-releasing hormone and arginine vasopressin in patients with major depression
    • De Bellis, M. D. et al. Association of fluoxetine treatment with reductions in CSF concentrations of corticotropin-releasing hormone and arginine vasopressin in patients with major depression. Am. J. Psychiatry 150, 656-657 (1993).
    • (1993) Am. J. Psychiatry , vol.150 , pp. 656-657
    • De Bellis, M.D.1
  • 14
    • 0031697426 scopus 로고    scopus 로고
    • Cerebrospinal fluid concentrations of corticotropin-releasing hormone, vasopressin, and somatostatin in depressed patients and healthy controls: Response to amitriptyline treatment
    • Heuser, I. et al. Cerebrospinal fluid concentrations of corticotropin-releasing hormone, vasopressin, and somatostatin in depressed patients and healthy controls: response to amitriptyline treatment. Depress. Anxiety 8, 71-79 (1998).
    • (1998) Depress. Anxiety , vol.8 , pp. 71-79
    • Heuser, I.1
  • 15
    • 0037131064 scopus 로고    scopus 로고
    • Effects of antalarmin, a CRF type 1 receptor antagonist, on anxiety-like behavior and motor activation in the rat
    • Zorrilla, E. P., Valdez, G. R., Nozulak, J., Koob, G. F. & Markou, A. Effects of antalarmin, a CRF type 1 receptor antagonist, on anxiety-like behavior and motor activation in the rat. Brain Res. 952, 188-199 (2002).
    • (2002) Brain Res. , vol.952 , pp. 188-199
    • Zorrilla, E.P.1    Valdez, G.R.2    Nozulak, J.3    Koob, G.F.4    Markou, A.5
  • 16
    • 0032104267 scopus 로고    scopus 로고
    • Corticotropin releasing factor receptor 1-deficient mice display decreased anxiety, impaired stress response, and aberrant neuroendocrine development
    • Smith, G. W. et al. Corticotropin releasing factor receptor 1-deficient mice display decreased anxiety, impaired stress response, and aberrant neuroendocrine development. Neuron 20, 1093-1102 (1998).
    • (1998) Neuron , vol.20 , pp. 1093-1102
    • Smith, G.W.1
  • 17
    • 17344362093 scopus 로고    scopus 로고
    • Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1
    • Timpl, P. et al. Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1. Nat. Genet. 19, 162-166 (1998).
    • (1998) Nat. Genet. , vol.19 , pp. 162-166
    • Timpl, P.1
  • 18
    • 0141542646 scopus 로고    scopus 로고
    • Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress
    • Muller, M. B. et al. Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress. Nat. Neurosci. 6, 1100-1107 (2003).
    • (2003) Nat. Neurosci. , vol.6 , pp. 1100-1107
    • Muller, M.B.1
  • 19
    • 0034127008 scopus 로고    scopus 로고
    • Mice deficient for corticotropin-releasing hormone receptor-2 display anxiety-like behaviour and are hypersensitive to stress
    • Bale, T. L. et al. Mice deficient for corticotropin-releasing hormone receptor-2 display anxiety-like behaviour and are hypersensitive to stress. Nat. Genet. 24, 410-414 (2000).
    • (2000) Nat. Genet. , vol.24 , pp. 410-414
    • Bale, T.L.1
  • 20
    • 0034087469 scopus 로고    scopus 로고
    • Abnormal adaptations to stress and impaired cardiovascular function in mice lacking corticotropin-releasing hormone receptor 2
    • Coste, S. C. et al. Abnormal adaptations to stress and impaired cardiovascular function in mice lacking corticotropin-releasing hormone receptor 2. Nat. Genet. 24, 403-409 (2000).
    • (2000) Nat. Genet. , vol.24 , pp. 403-409
    • Coste, S.C.1
  • 21
    • 0034069655 scopus 로고    scopus 로고
    • Deletion of crhr2 reveals an anxiolytic role for corticotropin-releasing hormone receptor 2
    • Kishimoto, T. et al. Deletion of Crhr2 reveals an anxiolytic role for corticotropin-releasing hormone receptor 2. Nat. Genet. 24, 415-419 (2000).
    • (2000) Nat. Genet. , vol.24 , pp. 415-419
    • Kishimoto, T.1
  • 22
    • 84930360329 scopus 로고    scopus 로고
    • Increased anxiety in corticotropin-releasing factor type 2 receptor-null mice requires recent acute stress exposure and is associated with dysregulated serotonergic activity in limbic brain areas
    • Issler, O. et al. Increased anxiety in corticotropin-releasing factor type 2 receptor-null mice requires recent acute stress exposure and is associated with dysregulated serotonergic activity in limbic brain areas. Biol. Mood Anxiety Disord. 4, 1 (2014).
    • (2014) Biol. Mood Anxiety Disord , vol.4 , pp. 1
    • Issler, O.1
  • 23
    • 78650431997 scopus 로고    scopus 로고
    • A triple urocortin knockout mouse model reveals an essential role for urocortins in stress recovery
    • Neufeld-Cohen, A. et al. A triple urocortin knockout mouse model reveals an essential role for urocortins in stress recovery. Proc. Natl Acad. Sci. USA 107, 19020-19025 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 19020-19025
    • Neufeld-Cohen, A.1
  • 24
    • 19844365569 scopus 로고    scopus 로고
    • Stressor controllability and learned helplessness: The roles of the dorsal raphe nucleus, serotonin, and corticotropin-releasing factor
    • Maier, S. F. & Watkins, L. R. Stressor controllability and learned helplessness: the roles of the dorsal raphe nucleus, serotonin, and corticotropin-releasing factor. Neurosci. Biobehav. Rev. 29, 829-841 (2005).
    • (2005) Neurosci. Biobehav. Rev. , vol.29 , pp. 829-841
    • Maier, S.F.1    Watkins, L.R.2
  • 25
    • 14644442955 scopus 로고    scopus 로고
    • Peptides that fine-tune the serotonin system
    • Valentino, R. J. & Commons, K. G. Peptides that fine-tune the serotonin system. Neuropeptides 39, 1-8 (2005).
    • (2005) Neuropeptides , vol.39 , pp. 1-8
    • Valentino, R.J.1    Commons, K.G.2
  • 26
    • 0038790172 scopus 로고    scopus 로고
    • Increased depression-like behaviors in corticotropin-releasing factor receptor-2-deficient mice: Sexually dichotomous responses
    • Bale, T. L. & Vale, W. W. Increased depression-like behaviors in corticotropin-releasing factor receptor-2-deficient mice: sexually dichotomous responses. J. Neurosci. 23, 5295-5301 (2003).
    • (2003) J. Neurosci. , vol.23 , pp. 5295-5301
    • Bale, T.L.1    Vale, W.W.2
  • 27
    • 84880574652 scopus 로고    scopus 로고
    • Is it really a matter of simple dualism? Corticotropin-releasing factor receptors in body and mental health
    • Janssen, D. & Kozicz, T. Is it really a matter of simple dualism? Corticotropin-releasing factor receptors in body and mental health. Front. Endocrinol. (Lausanne) 4, 28 (2013).
    • (2013) Front. Endocrinol. (Lausanne) , vol.4 , pp. 28
    • Janssen, D.1    Kozicz, T.2
  • 28
    • 0344142487 scopus 로고    scopus 로고
    • Modulation of learning and anxiety by corticotropin-releasing factor (CRF) and stress: Differential roles of CRF receptors 1 and 2
    • Radulovic, J., Ruhmann, A., Liepold, T. & Spiess, J. Modulation of learning and anxiety by corticotropin-releasing factor (CRF) and stress: differential roles of CRF receptors 1 and 2. J. Neurosci. 19, 5016-5025 (1999).
    • (1999) J. Neurosci. , vol.19 , pp. 5016-5025
    • Radulovic, J.1    Ruhmann, A.2    Liepold, T.3    Spiess, J.4
  • 30
    • 58149280270 scopus 로고    scopus 로고
    • Type 1 corticotropin-releasing factor receptor expression reported in BAC transgenic mice: Implications for reconciling ligand-receptor mismatch in the central corticotropin-releasing factor system
    • Justice, N. J., Yuan, Z. F., Sawchenko, P. E. & Vale, W. Type 1 corticotropin-releasing factor receptor expression reported in BAC transgenic mice: implications for reconciling ligand-receptor mismatch in the central corticotropin-releasing factor system. J. Comp. Neurol. 511, 479-496 (2008).
    • (2008) J. Comp. Neurol. , vol.511 , pp. 479-496
    • Justice, N.J.1    Yuan, Z.F.2    Sawchenko, P.E.3    Vale, W.4
  • 31
    • 84865089294 scopus 로고    scopus 로고
    • Visualizing corticotropin-releasing hormone receptor type 1 expression and neuronal connectivities in the mouse using a novel multifunctional allele
    • Kuhne, C. et al. Visualizing corticotropin-releasing hormone receptor type 1 expression and neuronal connectivities in the mouse using a novel multifunctional allele. J. Comp. Neurol. 520, 3150-3180 (2012).
    • (2012) J. Comp. Neurol. , vol.520 , pp. 3150-3180
    • Kuhne, C.1
  • 33
    • 0034639339 scopus 로고    scopus 로고
    • Distribution of mRNAs encoding CRF receptors in brain and pituitary of rat and mouse
    • Van Pett, K. et al. Distribution of mRNAs encoding CRF receptors in brain and pituitary of rat and mouse. J. Comp. Neurol. 428, 191-212 (2000).
    • (2000) J. Comp. Neurol. , vol.428 , pp. 191-212
    • Van Pett, K.1
  • 34
    • 37549067014 scopus 로고    scopus 로고
    • Stress-induced intracellular trafficking of corticotropin-releasing factor receptors in rat locus coeruleus neurons
    • Reyes, B. A., Valentino, R. J. & Van Bockstaele, E. J. Stress-induced intracellular trafficking of corticotropin-releasing factor receptors in rat locus coeruleus neurons. Endocrinology 149, 122-130 (2008).
    • (2008) Endocrinology , vol.149 , pp. 122-130
    • Reyes, B.A.1    Valentino, R.J.2    Van Bockstaele, E.J.3
  • 35
    • 84908612385 scopus 로고    scopus 로고
    • Using high resolution imaging to determine trafficking of corticotropin-releasing factor receptors in noradrenergic neurons of the rat locus coeruleus
    • Reyes, B. A., Bangasser, D. A., Valentino, R. J. & Van Bockstaele, E. J. Using high resolution imaging to determine trafficking of corticotropin-releasing factor receptors in noradrenergic neurons of the rat locus coeruleus. Life Sci. 112, 2-9 (2014).
    • (2014) Life Sci. , vol.112 , pp. 2-9
    • Reyes, B.A.1    Bangasser, D.A.2    Valentino, R.J.3    Van Bockstaele, E.J.4
  • 36
    • 72049097678 scopus 로고    scopus 로고
    • Phasic versus sustained fear in rats and humans: Role of the extended amygdala in fear versus anxiety
    • Davis, M., Walker, D. L., Miles, L. & Grillon, C. Phasic versus sustained fear in rats and humans: role of the extended amygdala in fear versus anxiety. Neuropsychopharmacology 35, 105-135 (2010).
    • (2010) Neuropsychopharmacology , vol.35 , pp. 105-135
    • Davis, M.1    Walker, D.L.2    Miles, L.3    Grillon, C.4
  • 38
    • 84879785747 scopus 로고    scopus 로고
    • Differential activation of neuronal cell types in the basolateral amygdala by corticotropin releasing factor
    • Rostkowski, A. B., Leitermann, R. J. & Urban, J. H. Differential activation of neuronal cell types in the basolateral amygdala by corticotropin releasing factor. Neuropeptides 47, 273-280 (2013).
    • (2013) Neuropeptides , vol.47 , pp. 273-280
    • Rostkowski, A.B.1    Leitermann, R.J.2    Urban, J.H.3
  • 39
    • 0026464694 scopus 로고
    • Differential actions of corticotropin releasing factor on basolateral and central amygdaloid neurones, in vitro
    • Rainnie, D. G., Fernhout, B. J. & Shinnick-Gallagher, P. Differential actions of corticotropin releasing factor on basolateral and central amygdaloid neurones, in vitro. J. Pharmacol. Exp. Ther. 263, 846-858 (1992).
    • (1992) J. Pharmacol. Exp. Ther. , vol.263 , pp. 846-858
    • Rainnie, D.G.1    Fernhout, B.J.2    Shinnick-Gallagher, P.3
  • 40
    • 80053365601 scopus 로고    scopus 로고
    • Glutamatergic and dopaminergic neurons mediate anxiogenic and anxiolytic effects of CRHR1
    • Refojo, D. et al. Glutamatergic and dopaminergic neurons mediate anxiogenic and anxiolytic effects of CRHR1. Science 333, 1903-1907 (2011).
    • (2011) Science , vol.333 , pp. 1903-1907
    • Refojo, D.1
  • 42
    • 0032997184 scopus 로고    scopus 로고
    • Role of corticotropin-releasing factor and urocortin within the basolateral amygdala of rats in anxiety and panic responses
    • Sajdyk, T. J., Schober, D. A., Gehlert, D. R. & Shekhar, A. Role of corticotropin-releasing factor and urocortin within the basolateral amygdala of rats in anxiety and panic responses. Behav. Brain Res. 100, 207-215 (1999).
    • (1999) Behav. Brain Res. , vol.100 , pp. 207-215
    • Sajdyk, T.J.1    Schober, D.A.2    Gehlert, D.R.3    Shekhar, A.4
  • 43
    • 33644833973 scopus 로고    scopus 로고
    • Injections of urocortin 1 into the basolateral amygdala induce anxiety-like behavior and c-fos expression in brainstem serotonergic neurons
    • Spiga, F., Lightman, S. L., Shekhar, A. & Lowry, C. A. Injections of urocortin 1 into the basolateral amygdala induce anxiety-like behavior and c-Fos expression in brainstem serotonergic neurons. Neuroscience 138, 1265-1276 (2006).
    • (2006) Neuroscience , vol.138 , pp. 1265-1276
    • Spiga, F.1    Lightman, S.L.2    Shekhar, A.3    Lowry, C.A.4
  • 44
    • 78650679210 scopus 로고    scopus 로고
    • Local repeated corticotropin-releasing factor infusion exacerbates anxiety- and fear-related behavior: Differential involvement of the basolateral amygdala and medial prefrontal cortex
    • Bijlsma, E. Y., van Leeuwen, M. L., Westphal, K. G., Olivier, B. & Groenink, L. Local repeated corticotropin-releasing factor infusion exacerbates anxiety- and fear-related behavior: differential involvement of the basolateral amygdala and medial prefrontal cortex. Neuroscience 173, 82-92 (2011).
    • (2011) Neuroscience , vol.173 , pp. 82-92
    • Bijlsma, E.Y.1    Van Leeuwen, M.L.2    Westphal, K.G.3    Olivier, B.4    Groenink, L.5
  • 45
    • 84903647624 scopus 로고    scopus 로고
    • Fear extinction learning can be impaired or enhanced by modulation of the CRF system in the basolateral nucleus of the amygdala
    • Abiri, D. et al. Fear extinction learning can be impaired or enhanced by modulation of the CRF system in the basolateral nucleus of the amygdala. Behav. Brain Res. 271, 234-239 (2014).
    • (2014) Behav. Brain Res. , vol.271 , pp. 234-239
    • Abiri, D.1
  • 46
    • 0037108954 scopus 로고    scopus 로고
    • Involvement of stress-released corticotropin-releasing hormone in the basolateral amygdala in regulating memory consolidation
    • Roozendaal, B., Brunson, K. L., Holloway, B. L., McGaugh, J. L. & Baram, T. Z. Involvement of stress-released corticotropin-releasing hormone in the basolateral amygdala in regulating memory consolidation. Proc. Natl Acad. Sci. USA 99, 13908-13913 (2002).
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 13908-13913
    • Roozendaal, B.1    Brunson, K.L.2    Holloway, B.L.3    McGaugh, J.L.4    Baram, T.Z.5
  • 47
    • 48549094903 scopus 로고    scopus 로고
    • Corticotropin-releasing factor in the basolateral amygdala enhances memory consolidation via an interaction with the β-adrenoceptor-cAMP pathway: Dependence on glucocorticoid receptor activation
    • Roozendaal, B., Schelling, G. & McGaugh, J. L. Corticotropin-releasing factor in the basolateral amygdala enhances memory consolidation via an interaction with the β-adrenoceptor-cAMP pathway: dependence on glucocorticoid receptor activation. J. Neurosci. 28, 6642-6651 (2008).
    • (2008) J. Neurosci. , vol.28 , pp. 6642-6651
    • Roozendaal, B.1    Schelling, G.2    McGaugh, J.L.3
  • 48
    • 36849084573 scopus 로고    scopus 로고
    • Activation of basolateral amygdala corticotropin-releasing factor 1 receptors modulates the consolidation of contextual fear
    • Hubbard, D. T., Nakashima, B. R., Lee, I. & Takahashi, L. K. Activation of basolateral amygdala corticotropin-releasing factor 1 receptors modulates the consolidation of contextual fear. Neuroscience 150, 818-828 (2007).
    • (2007) Neuroscience , vol.150 , pp. 818-828
    • Hubbard, D.T.1    Nakashima, B.R.2    Lee, I.3    Takahashi, L.K.4
  • 49
    • 77956440516 scopus 로고    scopus 로고
    • The anxiolytic effect of environmental enrichment is mediated via amygdalar CRF receptor type 1
    • Sztainberg, Y., Kuperman, Y., Tsoory, M., Lebow, M. & Chen, A. The anxiolytic effect of environmental enrichment is mediated via amygdalar CRF receptor type 1. Mol. Psychiatry 15, 905-917 (2010).
    • (2010) Mol. Psychiatry , vol.15 , pp. 905-917
    • Sztainberg, Y.1    Kuperman, Y.2    Tsoory, M.3    Lebow, M.4    Chen, A.5
  • 50
    • 84924787952 scopus 로고    scopus 로고
    • Corticotropin-releasing hormone drives anandamide hydrolysis in the amygdala to promote anxiety
    • Gray, J. M. et al. Corticotropin-releasing hormone drives anandamide hydrolysis in the amygdala to promote anxiety. J. Neurosci. 35, 3879-3892 (2015).
    • (2015) J. Neurosci. , vol.35 , pp. 3879-3892
    • Gray, J.M.1
  • 51
    • 0021180072 scopus 로고
    • The organization of projections from the central nucleus of the amygdala to brainstem sites involved in central autonomic regulation: A combined retrograde transport-immunohistochemical study
    • Veening, J. G., Swanson, L. W. & Sawchenko, P. E. The organization of projections from the central nucleus of the amygdala to brainstem sites involved in central autonomic regulation: a combined retrograde transport-immunohistochemical study. Brain Res. 303, 337-357 (1984).
    • (1984) Brain Res. , vol.303 , pp. 337-357
    • Veening, J.G.1    Swanson, L.W.2    Sawchenko, P.E.3
  • 52
    • 0023677407 scopus 로고
    • Different projections of the central amygdaloid nucleus mediate autonomic and behavioral correlates of conditioned fear
    • LeDoux, J. E., Iwata, J., Cicchetti, P. & Reis, D. J. Different projections of the central amygdaloid nucleus mediate autonomic and behavioral correlates of conditioned fear. J. Neurosci. 8, 2517-2529 (1988).
    • (1988) J. Neurosci. , vol.8 , pp. 2517-2529
    • LeDoux, J.E.1    Iwata, J.2    Cicchetti, P.3    Reis, D.J.4
  • 53
    • 84929290391 scopus 로고    scopus 로고
    • Ethanol and corticotropin releasing factor receptor modulation of central amygdala neurocircuitry: An update and future directions
    • Silberman, Y. & Winder, D. G. Ethanol and corticotropin releasing factor receptor modulation of central amygdala neurocircuitry: an update and future directions. Alcohol 49, 179-184 (2015).
    • (2015) Alcohol , vol.49 , pp. 179-184
    • Silberman, Y.1    Winder, D.G.2
  • 54
    • 0031886769 scopus 로고    scopus 로고
    • Corticotropin-releasing factor increases dihydropyridine- and neurotoxin-resistant calcium currents in neurons of the central amygdala
    • Yu, B. & Shinnick-Gallagher, P. Corticotropin-releasing factor increases dihydropyridine- and neurotoxin-resistant calcium currents in neurons of the central amygdala. J. Pharmacol. Exp. Ther. 284, 170-179 (1998).
    • (1998) J. Pharmacol. Exp. Ther. , vol.284 , pp. 170-179
    • Yu, B.1    Shinnick-Gallagher, P.2
  • 55
    • 84876963129 scopus 로고    scopus 로고
    • Corticotropin releasing factor and catecholamines enhance glutamatergic neurotransmission in the lateral subdivision of the central amygdala
    • Silberman, Y. & Winder, D. G. Corticotropin releasing factor and catecholamines enhance glutamatergic neurotransmission in the lateral subdivision of the central amygdala. Neuropharmacology 70, 316-323 (2013).
    • (2013) Neuropharmacology , vol.70 , pp. 316-323
    • Silberman, Y.1    Winder, D.G.2
  • 56
    • 41049105860 scopus 로고    scopus 로고
    • Pro- and anti-nociceptive effects of corticotropin-releasing factor (CRF) in central amygdala neurons are mediated through different receptors
    • Ji, G. & Neugebauer, V. Pro- and anti-nociceptive effects of corticotropin-releasing factor (CRF) in central amygdala neurons are mediated through different receptors. J. Neurophysiol. 99, 1201-1212 (2008).
    • (2008) J. Neurophysiol. , vol.99 , pp. 1201-1212
    • Ji, G.1    Neugebauer, V.2
  • 57
    • 43049164381 scopus 로고    scopus 로고
    • Differential mechanisms of CRF1 and CRF2 receptor functions in the amygdala in pain-related synaptic facilitation and behavior
    • Fu, Y. & Neugebauer, V. Differential mechanisms of CRF1 and CRF2 receptor functions in the amygdala in pain-related synaptic facilitation and behavior. J. Neurosci. 28, 3861-3876 (2008).
    • (2008) J. Neurosci. , vol.28 , pp. 3861-3876
    • Fu, Y.1    Neugebauer, V.2
  • 58
    • 2142814332 scopus 로고    scopus 로고
    • Corticotropin-releasing factor and urocortin I modulate excitatory glutamatergic synaptic transmission
    • Liu, J. et al. Corticotropin-releasing factor and urocortin I modulate excitatory glutamatergic synaptic transmission. J. Neurosci. 24, 4020-4029 (2004).
    • (2004) J. Neurosci. , vol.24 , pp. 4020-4029
    • Liu, J.1
  • 59
    • 1542377428 scopus 로고    scopus 로고
    • Ethanol augments GABAergic transmission in the central amygdala via CRF1 receptors
    • Nie, Z. et al. Ethanol augments GABAergic transmission in the central amygdala via CRF1 receptors. Science 303, 1512-1514 (2004).
    • (2004) Science , vol.303 , pp. 1512-1514
    • Nie, Z.1
  • 60
    • 65549137542 scopus 로고    scopus 로고
    • 1 receptors mediate the ethanol enhancement of GABAergic transmission in the mouse central amygdala
    • 1 receptors mediate the ethanol enhancement of GABAergic transmission in the mouse central amygdala. ScientificWorldJournal 9, 68-85 (2009).
    • (2009) ScientificWorldJournal , vol.9 , pp. 68-85
    • Nie, Z.1
  • 61
    • 84928742257 scopus 로고    scopus 로고
    • The central amygdala as an integrative hub for anxiety and alcohol use disorders
    • Gilpin, N. W., Herman, M. A. & Roberto, M. The central amygdala as an integrative hub for anxiety and alcohol use disorders. Biol. Psychiatry 77, 859-869 (2015).
    • (2015) Biol. Psychiatry , vol.77 , pp. 859-869
    • Gilpin, N.W.1    Herman, M.A.2    Roberto, M.3
  • 62
    • 84946592951 scopus 로고    scopus 로고
    • Glutamatergic transmission in the central nucleus of the amygdala is selectively altered in marchigian sardinian alcohol-preferring rats: Alcohol and CRF effects
    • Herman, M. A. et al. Glutamatergic transmission in the central nucleus of the amygdala is selectively altered in Marchigian Sardinian alcohol-preferring rats: alcohol and CRF effects. Neuropharmacology 102, 21-31 (2016).
    • (2016) Neuropharmacology , vol.102 , pp. 21-31
    • Herman, M.A.1
  • 63
    • 33748510588 scopus 로고    scopus 로고
    • The effect of lateral septum corticotropin-releasing factor receptor 2 activation on anxiety is modulated by stress
    • Henry, B., Vale, W. & Markou, A. The effect of lateral septum corticotropin-releasing factor receptor 2 activation on anxiety is modulated by stress. J. Neurosci. 26, 9142-9152 (2006).
    • (2006) J. Neurosci. , vol.26 , pp. 9142-9152
    • Henry, B.1    Vale, W.2    Markou, A.3
  • 64
    • 0028973118 scopus 로고
    • 1 receptor antisense oligodeoxynucleotide into the central nucleus of the amygdala reduced anxiety-related behavior in socially defeated rats
    • 1 receptor antisense oligodeoxynucleotide into the central nucleus of the amygdala reduced anxiety-related behavior in socially defeated rats. Regul. Pept. 59, 229-239 (1995).
    • (1995) Regul. Pept. , vol.59 , pp. 229-239
    • Liebsch, G.1
  • 65
    • 84873744252 scopus 로고    scopus 로고
    • Non pain-related CRF1 activation in the amygdala facilitates synaptic transmission and pain responses
    • Ji, G., Fu, Y., Adwanikar, H. & Neugebauer, V. Non pain-related CRF1 activation in the amygdala facilitates synaptic transmission and pain responses. Mol. Pain 9, 2 (2013).
    • (2013) Mol. Pain , vol.9 , pp. 2
    • Ji, G.1    Fu, Y.2    Adwanikar, H.3    Neugebauer, V.4
  • 66
    • 34250665463 scopus 로고    scopus 로고
    • Pain-related anxiety-like behavior requires CRF1 receptors in the amygdala
    • Ji, G., Fu, Y., Ruppert, K. A. & Neugebauer, V. Pain-related anxiety-like behavior requires CRF1 receptors in the amygdala. Mol. Pain 3, 13 (2007).
    • (2007) Mol. Pain , vol.3 , pp. 13
    • Ji, G.1    Fu, Y.2    Ruppert, K.A.3    Neugebauer, V.4
  • 67
    • 80053634170 scopus 로고    scopus 로고
    • MicroRNA as repressors of stress-induced anxiety: The case of amygdalar MIR 34
    • Haramati, S. et al. MicroRNA as repressors of stress-induced anxiety: the case of amygdalar miR 34. J. Neurosci. 31, 14191-14203 (2011).
    • (2011) J. Neurosci. , vol.31 , pp. 14191-14203
    • Haramati, S.1
  • 68
    • 9244261036 scopus 로고    scopus 로고
    • Tissue plasminogen activator promotes the effects of corticotropin-releasing factor on the amygdala and anxiety-like behavior
    • Matys, T. et al. Tissue plasminogen activator promotes the effects of corticotropin-releasing factor on the amygdala and anxiety-like behavior. Proc. Natl Acad. Sci. USA 101, 16345-16350 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 16345-16350
    • Matys, T.1
  • 69
    • 0037314824 scopus 로고    scopus 로고
    • Tissue plasminogen activator in the amygdala is critical for stress-induced anxiety-like behavior
    • Pawlak, R., Magarinos, A. M., Melchor, J., McEwen, B. & Strickland, S. Tissue plasminogen activator in the amygdala is critical for stress-induced anxiety-like behavior. Nat. Neurosci. 6, 168-174 (2003).
    • (2003) Nat. Neurosci. , vol.6 , pp. 168-174
    • Pawlak, R.1    Magarinos, A.M.2    Melchor, J.3    McEwen, B.4    Strickland, S.5
  • 70
    • 0032535291 scopus 로고    scopus 로고
    • Are different parts of the extended amygdala involved in fear versus anxiety?
    • Davis, M. Are different parts of the extended amygdala involved in fear versus anxiety? Biol. Psychiatry 44, 1239-1247 (1998).
    • (1998) Biol. Psychiatry , vol.44 , pp. 1239-1247
    • Davis, M.1
  • 71
    • 58149388202 scopus 로고    scopus 로고
    • Dopamine enhances fast excitatory synaptic transmission in the extended amygdala by a CRF-R1-dependent process
    • Kash, T. L., Nobis, W. P., Matthews, R. T. & Winder, D. G. Dopamine enhances fast excitatory synaptic transmission in the extended amygdala by a CRF-R1-dependent process. J. Neurosci. 28, 13856-13865 (2008).
    • (2008) J. Neurosci. , vol.28 , pp. 13856-13865
    • Kash, T.L.1    Nobis, W.P.2    Matthews, R.T.3    Winder, D.G.4
  • 72
    • 84872354497 scopus 로고    scopus 로고
    • A corticotropin releasing factor pathway for ethanol regulation of the ventral tegmental area in the bed nucleus of the stria terminalis
    • Silberman, Y., Matthews, R. T. & Winder, D. G. A corticotropin releasing factor pathway for ethanol regulation of the ventral tegmental area in the bed nucleus of the stria terminalis. J. Neurosci. 33, 950-960 (2013).
    • (2013) J. Neurosci. , vol.33 , pp. 950-960
    • Silberman, Y.1    Matthews, R.T.2    Winder, D.G.3
  • 73
    • 33646350005 scopus 로고    scopus 로고
    • Anxiogenic and aversive effects of corticotropin-releasing factor (CRF) in the bed nucleus of the stria terminalis in the rat: Role of CRF receptor subtypes
    • Sahuque, L. L. et al. Anxiogenic and aversive effects of corticotropin-releasing factor (CRF) in the bed nucleus of the stria terminalis in the rat: role of CRF receptor subtypes. Psychopharmacol. (Berl.) 186, 122-132 (2006).
    • (2006) Psychopharmacol. (Berl.) , vol.186 , pp. 122-132
    • Sahuque, L.L.1
  • 74
    • 79955751301 scopus 로고    scopus 로고
    • β-adrenergic receptors enhance excitatory transmission in the bed nucleus of the stria terminalis through a corticotrophin-releasing factor receptor-dependent and cocaine-regulated mechanism
    • Nobis, W. P., Kash, T. L., Silberman, Y. & Winder, D. G. β-Adrenergic receptors enhance excitatory transmission in the bed nucleus of the stria terminalis through a corticotrophin-releasing factor receptor-dependent and cocaine-regulated mechanism. Biol. Psychiatry 69, 1083-1090 (2011).
    • (2011) Biol. Psychiatry , vol.69 , pp. 1083-1090
    • Nobis, W.P.1    Kash, T.L.2    Silberman, Y.3    Winder, D.G.4
  • 75
    • 84922723193 scopus 로고    scopus 로고
    • Importance of CRF receptor-mediated mechanisms of the bed nucleus of the stria terminalis in the processing of anxiety and pain
    • Tran, L., Schulkin, J. & Greenwood-Van Meerveld, B. Importance of CRF receptor-mediated mechanisms of the bed nucleus of the stria terminalis in the processing of anxiety and pain. Neuropsychopharmacology 39, 2633-2645 (2014).
    • (2014) Neuropsychopharmacology , vol.39 , pp. 2633-2645
    • Tran, L.1    Schulkin, J.2    Greenwood-Van Meerveld, B.3
  • 76
    • 73949139173 scopus 로고    scopus 로고
    • Corticotropin-releasing factor (CRF) sensitization of ethanol withdrawal-induced anxiety-like behavior is brain site specific and mediated by CRF-1 receptors: Relation to stress-induced sensitization
    • Huang, M. M. et al. Corticotropin-releasing factor (CRF) sensitization of ethanol withdrawal-induced anxiety-like behavior is brain site specific and mediated by CRF-1 receptors: relation to stress-induced sensitization. J. Pharmacol. Exp. Ther. 332, 298-307 (2010).
    • (2010) J. Pharmacol. Exp. Ther. , vol.332 , pp. 298-307
    • Huang, M.M.1
  • 77
    • 84859478648 scopus 로고    scopus 로고
    • Sculpting the hippocampus from within: Stress, spines, and CRH
    • Maras, P. M. & Baram, T. Z. Sculpting the hippocampus from within: stress, spines, and CRH. Trends Neurosci. 35, 315-324 (2012).
    • (2012) Trends Neurosci. , vol.35 , pp. 315-324
    • Maras, P.M.1    Baram, T.Z.2
  • 78
    • 84859462955 scopus 로고    scopus 로고
    • Tuning synaptic transmission in the hippocampus by stress: The CRH system
    • Chen, Y., Andres, A. L., Frotscher, M. & Baram, T. Z. Tuning synaptic transmission in the hippocampus by stress: the CRH system. Front. Cell. Neurosci. 6, 13 (2012).
    • (2012) Front. Cell. Neurosci. , vol.6 , pp. 13
    • Chen, Y.1    Andres, A.L.2    Frotscher, M.3    Baram, T.Z.4
  • 79
    • 0020629374 scopus 로고
    • Corticotropin releasing factor decreases postburst hyperpolarizations and excites hippocampal neurons
    • Aldenhoff, J. B., Gruol, D. L., Rivier, J., Vale, W. & Siggins, G. R. Corticotropin releasing factor decreases postburst hyperpolarizations and excites hippocampal neurons. Science 221, 875-877 (1983).
    • (1983) Science , vol.221 , pp. 875-877
    • Aldenhoff, J.B.1    Gruol, D.L.2    Rivier, J.3    Vale, W.4    Siggins, G.R.5
  • 80
    • 0036581331 scopus 로고    scopus 로고
    • Priming of long-term potentiation in mouse hippocampus by corticotropin-releasing factor and acute stress: Implications for hippocampus-dependent learning
    • Blank, T., Nijholt, I., Eckart, K. & Spiess, J. Priming of long-term potentiation in mouse hippocampus by corticotropin-releasing factor and acute stress: implications for hippocampus-dependent learning. J. Neurosci. 22, 3788-3794 (2002).
    • (2002) J. Neurosci. , vol.22 , pp. 3788-3794
    • Blank, T.1    Nijholt, I.2    Eckart, K.3    Spiess, J.4
  • 81
    • 0026548437 scopus 로고
    • CRF increases protein phosphorylation and enhances retention performance in rats
    • Hung, H. C., Chou, C. K., Chiu, T. H. & Lee, E. H. CRF increases protein phosphorylation and enhances retention performance in rats. Neuroreport 3, 181-184 (1992).
    • (1992) Neuroreport , vol.3 , pp. 181-184
    • Hung, H.C.1    Chou, C.K.2    Chiu, T.H.3    Lee, E.H.4
  • 82
    • 0033617820 scopus 로고    scopus 로고
    • Corticotropin-releasing factor enhances brain-derived neurotrophic factor gene expression to facilitate memory retention in rats
    • Ma, Y. L., Chen, K. Y., Wei, C. L. & Lee, E. H. Corticotropin-releasing factor enhances brain-derived neurotrophic factor gene expression to facilitate memory retention in rats. Chin. J. Physiol. 42, 73-81 (1999).
    • (1999) Chin. J. Physiol. , vol.42 , pp. 73-81
    • Ma, Y.L.1    Chen, K.Y.2    Wei, C.L.3    Lee, E.H.4
  • 83
    • 67349139864 scopus 로고    scopus 로고
    • Effects of acidic-astressin and ovine-CRF microinfusions into the ventral hippocampus on defensive behaviors in rats
    • Pentkowski, N. S. et al. Effects of acidic-astressin and ovine-CRF microinfusions into the ventral hippocampus on defensive behaviors in rats. Horm. Behav. 56, 35-43 (2009).
    • (2009) Horm. Behav. , vol.56 , pp. 35-43
    • Pentkowski, N.S.1
  • 84
    • 0033578240 scopus 로고    scopus 로고
    • Reduced anxiety-like and cognitive performance in mice lacking the corticotropin-releasing factor receptor 1
    • Contarino, A. et al. Reduced anxiety-like and cognitive performance in mice lacking the corticotropin-releasing factor receptor 1. Brain Res. 835, 1-9 (1999).
    • (1999) Brain Res. , vol.835 , pp. 1-9
    • Contarino, A.1
  • 85
    • 0034730451 scopus 로고    scopus 로고
    • Role of corticotropin-releasing factor, vasopressin and the autonomic nervous system in learning and memory
    • Croiset, G., Nijsen, M. J. & Kamphuis, P. J. Role of corticotropin-releasing factor, vasopressin and the autonomic nervous system in learning and memory. Eur. J. Pharmacol. 405, 225-234 (2000).
    • (2000) Eur. J. Pharmacol. , vol.405 , pp. 225-234
    • Croiset, G.1    Nijsen, M.J.2    Kamphuis, P.J.3
  • 86
    • 80052463843 scopus 로고    scopus 로고
    • Corticotropin-releasing factor and urocortin I activate CREB through functionally selective Gβγ signaling in hippocampal pyramidal neurons
    • Stern, C. M., Meitzen, J. & Mermelstein, P. G. Corticotropin-releasing factor and urocortin I activate CREB through functionally selective Gβγ signaling in hippocampal pyramidal neurons. Eur. J. Neurosci. 34, 671-681 (2011).
    • (2011) Eur. J. Neurosci. , vol.34 , pp. 671-681
    • Stern, C.M.1    Meitzen, J.2    Mermelstein, P.G.3
  • 87
    • 56049086401 scopus 로고    scopus 로고
    • Corticotropin-releasing hormone stimulates SGK-1 kinase expression in cultured hippocampal neurons via CRH R1
    • Sheng, H. et al. Corticotropin-releasing hormone stimulates SGK-1 kinase expression in cultured hippocampal neurons via CRH R1. Am. J. Physiol. Endocrinol. Metab. 295, E938-E946 (2008).
    • (2008) Am. J. Physiol. Endocrinol. Metab. , vol.295 , pp. E938-E946
    • Sheng, H.1
  • 88
    • 58049190148 scopus 로고    scopus 로고
    • Role of orexin/hypocretin and CRF in the formation of drug-dependent synaptic plasticity in the mesolimbic system
    • Bonci, A. & Borgland, S. Role of orexin/hypocretin and CRF in the formation of drug-dependent synaptic plasticity in the mesolimbic system. Neuropharmacology 56, 107-111 (2009).
    • (2009) Neuropharmacology , vol.56 , pp. 107-111
    • Bonci, A.1    Borgland, S.2
  • 89
    • 75449117472 scopus 로고    scopus 로고
    • A ventral tegmental CRF-glutamate-dopamine interaction in addiction
    • Wise, R. A. & Morales, M. A ventral tegmental CRF-glutamate-dopamine interaction in addiction. Brain Res. 1314, 38-43 (2010).
    • (2010) Brain Res. , vol.1314 , pp. 38-43
    • Wise, R.A.1    Morales, M.2
  • 90
    • 84896138011 scopus 로고    scopus 로고
    • Corticotropin releasing factor: A key role in the neurobiology of addiction
    • Zorrilla, E. P., Logrip, M. L. & Koob, G. F. Corticotropin releasing factor: a key role in the neurobiology of addiction. Front. Neuroendocrinol. 35, 234-244 (2014).
    • (2014) Front. Neuroendocrinol. , vol.35 , pp. 234-244
    • Zorrilla, E.P.1    Logrip, M.L.2    Koob, G.F.3
  • 91
    • 33744500233 scopus 로고    scopus 로고
    • Effects of arousal- and feeding-related neuropeptides on dopaminergic and GABAergic neurons in the ventral tegmental area of the rat
    • Korotkova, T. M., Brown, R. E., Sergeeva, O. A., Ponomarenko, A. A. & Haas, H. L. Effects of arousal- and feeding-related neuropeptides on dopaminergic and GABAergic neurons in the ventral tegmental area of the rat. Eur. J. Neurosci. 23, 2677-2685 (2006).
    • (2006) Eur. J. Neurosci. , vol.23 , pp. 2677-2685
    • Korotkova, T.M.1    Brown, R.E.2    Sergeeva, O.A.3    Ponomarenko, A.A.4    Haas, H.L.5
  • 92
    • 84905054536 scopus 로고    scopus 로고
    • CRF R2 and the heterosynaptic regulation of VTA glutamate during reinstatement of cocaine seeking
    • Williams, C. L., Buchta, W. C. & Riegel, A. C. CRF R2 and the heterosynaptic regulation of VTA glutamate during reinstatement of cocaine seeking. J. Neurosci. 34, 10402-10414 (2014).
    • (2014) J. Neurosci. , vol.34 , pp. 10402-10414
    • Williams, C.L.1    Buchta, W.C.2    Riegel, A.C.3
  • 93
    • 42149150944 scopus 로고    scopus 로고
    • Corticotropin-releasing factor increases mouse ventral tegmental area dopamine neuron firing through a protein kinase C-dependent enhancement of Ih
    • Wanat, M. J., Hopf, F. W., Stuber, G. D., Phillips, P. E. & Bonci, A. Corticotropin-releasing factor increases mouse ventral tegmental area dopamine neuron firing through a protein kinase C-dependent enhancement of Ih. J. Physiol. 586, 2157-2170 (2008).
    • (2008) J. Physiol. , vol.586 , pp. 2157-2170
    • Wanat, M.J.1    Hopf, F.W.2    Stuber, G.D.3    Phillips, P.E.4    Bonci, A.5
  • 94
    • 0023232365 scopus 로고
    • Neurochemical and behavioral effects of corticotropin-releasing factor in the ventral tegmental area of the rat
    • Kalivas, P. W., Duffy, P. & Latimer, L. G. Neurochemical and behavioral effects of corticotropin-releasing factor in the ventral tegmental area of the rat. J. Pharmacol. Exp. Ther. 242, 757-763 (1987).
    • (1987) J. Pharmacol. Exp. Ther. , vol.242 , pp. 757-763
    • Kalivas, P.W.1    Duffy, P.2    Latimer, L.G.3
  • 95
    • 20044391431 scopus 로고    scopus 로고
    • Cocaine experience establishes control of midbrain glutamate and dopamine by corticotropin-releasing factor: A role in stress-induced relapse to drug seeking
    • Wang, B. et al. Cocaine experience establishes control of midbrain glutamate and dopamine by corticotropin-releasing factor: a role in stress-induced relapse to drug seeking. J. Neurosci. 25, 5389-5396 (2005).
    • (2005) J. Neurosci. , vol.25 , pp. 5389-5396
    • Wang, B.1
  • 96
    • 84884987977 scopus 로고    scopus 로고
    • Binge ethanol-drinking potentiates corticotropin releasing factor R1 receptor activity in the ventral tegmental area
    • Sparta, D. R. et al. Binge ethanol-drinking potentiates corticotropin releasing factor R1 receptor activity in the ventral tegmental area. Alcohol Clin. Exp. Res. 37, 1680-1687 (2013).
    • (2013) Alcohol Clin. Exp. Res. , vol.37 , pp. 1680-1687
    • Sparta, D.R.1
  • 97
    • 66249089037 scopus 로고    scopus 로고
    • Chronic cocaine enhances corticotropin-releasing factor-dependent potentiation of excitatory transmission in ventral tegmental area dopamine neurons
    • Hahn, J., Hopf, F. W. & Bonci, A. Chronic cocaine enhances corticotropin-releasing factor-dependent potentiation of excitatory transmission in ventral tegmental area dopamine neurons. J. Neurosci. 29, 6535-6544 (2009).
    • (2009) J. Neurosci. , vol.29 , pp. 6535-6544
    • Hahn, J.1    Hopf, F.W.2    Bonci, A.3
  • 98
  • 99
    • 79961236775 scopus 로고    scopus 로고
    • Augmented cocaine seeking in response to stress or CRF delivered into the ventral tegmental area following long-access self-administration is mediated by CRF receptor type 1 but not CRF receptor type 2
    • Blacktop, J. M. et al. Augmented cocaine seeking in response to stress or CRF delivered into the ventral tegmental area following long-access self-administration is mediated by CRF receptor type 1 but not CRF receptor type 2. J. Neurosci. 31, 11396-11403 (2011).
    • (2011) J. Neurosci. , vol.31 , pp. 11396-11403
    • Blacktop, J.M.1
  • 100
    • 84926203391 scopus 로고    scopus 로고
    • VTA CRF neurons mediate the aversive effects of nicotine withdrawal and promote intake escalation
    • Grieder, T. E. et al. VTA CRF neurons mediate the aversive effects of nicotine withdrawal and promote intake escalation. Nat. Neurosci. 17, 1751-1758 (2014).
    • (2014) Nat. Neurosci. , vol.17 , pp. 1751-1758
    • Grieder, T.E.1
  • 101
    • 84899838919 scopus 로고    scopus 로고
    • Social stress and CRF-dopamine interactions in the VTA: Role in long-term escalation of cocaine self-administration
    • Boyson, C. O. et al. Social stress and CRF-dopamine interactions in the VTA: role in long-term escalation of cocaine self-administration. J. Neurosci. 34, 6659-6667 (2014).
    • (2014) J. Neurosci. , vol.34 , pp. 6659-6667
    • Boyson, C.O.1
  • 103
    • 84906568749 scopus 로고    scopus 로고
    • Knockdown of CRF1 receptors in the ventral tegmental area attenuates cue- and acute food deprivation stress-induced cocaine seeking in mice
    • Chen, N. A. et al. Knockdown of CRF1 receptors in the ventral tegmental area attenuates cue- and acute food deprivation stress-induced cocaine seeking in mice. J. Neurosci. 34, 11560-11570 (2014).
    • (2014) J. Neurosci. , vol.34 , pp. 11560-11570
    • Chen, N.A.1
  • 104
    • 84875651899 scopus 로고    scopus 로고
    • CRF acts in the midbrain to attenuate accumbens dopamine release to rewards but not their predictors
    • Wanat, M. J., Bonci, A. & Phillips, P. E. CRF acts in the midbrain to attenuate accumbens dopamine release to rewards but not their predictors. Nat. Neurosci. 16, 383-385 (2013).
    • (2013) Nat. Neurosci. , vol.16 , pp. 383-385
    • Wanat, M.J.1    Bonci, A.2    Phillips, P.E.3
  • 106
    • 0020555603 scopus 로고
    • Nucleus locus ceruleus: New evidence of anatomical and physiological specificity
    • Foote, S. L., Bloom, F. E. & Aston-Jones, G. Nucleus locus ceruleus: new evidence of anatomical and physiological specificity. Physiol. Rev. 63, 844-914 (1983).
    • (1983) Physiol. Rev. , vol.63 , pp. 844-914
    • Foote, S.L.1    Bloom, F.E.2    Aston-Jones, G.3
  • 107
    • 84951985777 scopus 로고    scopus 로고
    • Control of arousal through neuropeptide afferents of the locus coeruleus
    • Zitnik, G. A. Control of arousal through neuropeptide afferents of the locus coeruleus. Brain Res. 1641, 338-350 (2015).
    • (2015) Brain Res. , vol.1641 , pp. 338-350
    • Zitnik, G.A.1
  • 108
    • 0019855733 scopus 로고
    • Activity of norepinephrine-containing locus coeruleus neurons in behaving rats anticipates fluctuations in the sleep-waking cycle
    • Aston-Jones, G. & Bloom, F. E. Activity of norepinephrine-containing locus coeruleus neurons in behaving rats anticipates fluctuations in the sleep-waking cycle. J. Neurosci. 1, 876-886 (1981).
    • (1981) J. Neurosci. , vol.1 , pp. 876-886
    • Aston-Jones, G.1    Bloom, F.E.2
  • 109
    • 0019732445 scopus 로고
    • Norepinephrine-containing locus coeruleus neurons in behaving rats exhibit pronounced responses to non-noxious environmental stimuli
    • Aston-Jones, G. & Bloom, F. E. Norepinephrine-containing locus coeruleus neurons in behaving rats exhibit pronounced responses to non-noxious environmental stimuli. J. Neurosci. 1, 887-900 (1981).
    • (1981) J. Neurosci. , vol.1 , pp. 887-900
    • Aston-Jones, G.1    Bloom, F.E.2
  • 110
    • 0031969592 scopus 로고    scopus 로고
    • Injection of corticotropin-releasing hormone into the locus coeruleus or foot shock increases neuronal fos expression
    • Rassnick, S., Hoffman, G. E., Rabin, B. S. & Sved, A. F. Injection of corticotropin-releasing hormone into the locus coeruleus or foot shock increases neuronal Fos expression. Neuroscience 85, 259-268 (1998).
    • (1998) Neuroscience , vol.85 , pp. 259-268
    • Rassnick, S.1    Hoffman, G.E.2    Rabin, B.S.3    Sved, A.F.4
  • 111
    • 0030992727 scopus 로고    scopus 로고
    • Activation of the locus coeruleus noradrenergic system by intracoerulear microinfusion of corticotropin-releasing factor: Effects on discharge rate, cortical norepinephrine levels and cortical electroencephalographic activity
    • Curtis, A. L., Lechner, S. M., Pavcovich, L. A. & Valentino, R. J. Activation of the locus coeruleus noradrenergic system by intracoerulear microinfusion of corticotropin-releasing factor: effects on discharge rate, cortical norepinephrine levels and cortical electroencephalographic activity. J. Pharmacol. Exp. Ther. 281, 163-172 (1997).
    • (1997) J. Pharmacol. Exp. Ther. , vol.281 , pp. 163-172
    • Curtis, A.L.1    Lechner, S.M.2    Pavcovich, L.A.3    Valentino, R.J.4
  • 112
    • 23244432007 scopus 로고    scopus 로고
    • An integrative theory of locus coeruleus-norepinephrine function: Adaptive gain and optimal performance
    • Aston-Jones, G. & Cohen, J. D. An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performance. Annu. Rev. Neurosci. 28, 403-450 (2005).
    • (2005) Annu. Rev. Neurosci. , vol.28 , pp. 403-450
    • Aston-Jones, G.1    Cohen, J.D.2
  • 113
    • 40849118482 scopus 로고    scopus 로고
    • Convergent regulation of locus coeruleus activity as an adaptive response to stress
    • Valentino, R. J. & Van Bockstaele, E. Convergent regulation of locus coeruleus activity as an adaptive response to stress. Eur. J. Pharmacol. 583, 194-203 (2008).
    • (2008) Eur. J. Pharmacol. , vol.583 , pp. 194-203
    • Valentino, R.J.1    Van Bockstaele, E.2
  • 114
    • 84863988242 scopus 로고    scopus 로고
    • Corticotropin-releasing factor acting at the locus coeruleus disrupts thalamic and cortical sensory-evoked responses
    • Devilbiss, D. M., Waterhouse, B. D., Berridge, C. W. & Valentino, R. Corticotropin-releasing factor acting at the locus coeruleus disrupts thalamic and cortical sensory-evoked responses. Neuropsychopharmacology 37, 2020-2030 (2012).
    • (2012) Neuropsychopharmacology , vol.37 , pp. 2020-2030
    • Devilbiss, D.M.1    Waterhouse, B.D.2    Berridge, C.W.3    Valentino, R.4
  • 115
    • 84856030643 scopus 로고    scopus 로고
    • Corticotropin-releasing factor in the norepinephrine nucleus, locus coeruleus, facilitates behavioral flexibility
    • Snyder, K., Wang, W. W., Han, R., McFadden, K. & Valentino, R. J. Corticotropin-releasing factor in the norepinephrine nucleus, locus coeruleus, facilitates behavioral flexibility. Neuropsychopharmacology 37, 520-530 (2012).
    • (2012) Neuropsychopharmacology , vol.37 , pp. 520-530
    • Snyder, K.1    Wang, W.W.2    Han, R.3    McFadden, K.4    Valentino, R.J.5
  • 116
    • 33745066419 scopus 로고    scopus 로고
    • Agonist-induced internalization of corticotropin-releasing factor receptors in noradrenergic neurons of the rat locus coeruleus
    • Reyes, B. A., Fox, K., Valentino, R. J. & Van Bockstaele, E. J. Agonist-induced internalization of corticotropin-releasing factor receptors in noradrenergic neurons of the rat locus coeruleus. Eur. J. Neurosci. 23, 2991-2998 (2006).
    • (2006) Eur. J. Neurosci. , vol.23 , pp. 2991-2998
    • Reyes, B.A.1    Fox, K.2    Valentino, R.J.3    Van Bockstaele, E.J.4
  • 117
    • 7444233045 scopus 로고    scopus 로고
    • Corticotropin-releasing hormone directly activates noradrenergic neurons of the locus ceruleus recorded in vitro
    • Jedema, H. P. & Grace, A. A. Corticotropin-releasing hormone directly activates noradrenergic neurons of the locus ceruleus recorded in vitro. J. Neurosci. 24, 9703-9713 (2004).
    • (2004) J. Neurosci. , vol.24 , pp. 9703-9713
    • Jedema, H.P.1    Grace, A.A.2
  • 118
    • 0037454130 scopus 로고    scopus 로고
    • 1 receptor antagonist, DMP695, abolishes activation of locus coeruleus noradrenergic neurones by CRF in anesthetized rats
    • 1 receptor antagonist, DMP695, abolishes activation of locus coeruleus noradrenergic neurones by CRF in anesthetized rats. Eur. J. Pharmacol. 464, 127-133 (2003).
    • (2003) Eur. J. Pharmacol. , vol.464 , pp. 127-133
    • Lejeune, F.1    Millan, M.J.2
  • 119
    • 84938749925 scopus 로고    scopus 로고
    • CRH engagement of the locus coeruleus noradrenergic system mediates stress-induced anxiety
    • McCall, J. G. et al. CRH engagement of the locus coeruleus noradrenergic system mediates stress-induced anxiety. Neuron 87, 605-620 (2015).
    • (2015) Neuron , vol.87 , pp. 605-620
    • McCall, J.G.1
  • 120
    • 84882450298 scopus 로고    scopus 로고
    • Social stress engages opioid regulation of locus coeruleus norepinephrine neurons and induces a state of cellular and physical opiate dependence
    • Chaijale, N. N. et al. Social stress engages opioid regulation of locus coeruleus norepinephrine neurons and induces a state of cellular and physical opiate dependence. Neuropsychopharmacology 38, 1833-1843 (2013).
    • (2013) Neuropsychopharmacology , vol.38 , pp. 1833-1843
    • Chaijale, N.N.1
  • 121
    • 79952792916 scopus 로고    scopus 로고
    • 1 receptor levels in learned helpless and non-helpless rats: A potential link to stress resilience
    • 1 receptor levels in learned helpless and non-helpless rats: a potential link to stress resilience. Behav. Brain Res. 221, 25-33 (2011).
    • (2011) Behav. Brain Res. , vol.221 , pp. 25-33
    • Taneja, M.1
  • 122
    • 0028878225 scopus 로고
    • Previous stress alters corticotropin-releasing factor neurotransmission in the locus coeruleus
    • Curtis, A. L., Pavcovich, L. A., Grigoriadis, D. E. & Valentino, R. J. Previous stress alters corticotropin-releasing factor neurotransmission in the locus coeruleus. Neuroscience 65, 541-550 (1995).
    • (1995) Neuroscience , vol.65 , pp. 541-550
    • Curtis, A.L.1    Pavcovich, L.A.2    Grigoriadis, D.E.3    Valentino, R.J.4
  • 123
    • 0033033053 scopus 로고    scopus 로고
    • Long-term regulation of locus ceruleus sensitivity to corticotropin-releasing factor by swim stress
    • Curtis, A. L., Pavcovich, L. A. & Valentino, R. J. Long-term regulation of locus ceruleus sensitivity to corticotropin-releasing factor by swim stress. J. Pharmacol. Exp. Ther. 289, 1211-1219 (1999).
    • (1999) J. Pharmacol. Exp. Ther. , vol.289 , pp. 1211-1219
    • Curtis, A.L.1    Pavcovich, L.A.2    Valentino, R.J.3
  • 124
    • 77956448518 scopus 로고    scopus 로고
    • Sex differences in corticotropin-releasing factor receptor signaling and trafficking: Potential role in female vulnerability to stress-related psychopathology
    • Bangasser, D. A. et al. Sex differences in corticotropin-releasing factor receptor signaling and trafficking: potential role in female vulnerability to stress-related psychopathology. Mol. Psychiatry 877, 896-904 (2010).
    • (2010) Mol. Psychiatry , vol.877 , pp. 896-904
    • Bangasser, D.A.1
  • 125
    • 84906748280 scopus 로고    scopus 로고
    • Chronic alcohol exposure differentially affects activation of female locus coeruleus neurons and the subcellular distribution of corticotropin releasing factor receptors
    • Retson, T. A., Reyes, B. A. & Van Bockstaele, E. J. Chronic alcohol exposure differentially affects activation of female locus coeruleus neurons and the subcellular distribution of corticotropin releasing factor receptors. Prog. Neuropsychopharmacol. Biol. Psychiatry 56, 66-74 (2015).
    • (2015) Prog. Neuropsychopharmacol. Biol. Psychiatry , vol.56 , pp. 66-74
    • Retson, T.A.1    Reyes, B.A.2    Van Bockstaele, E.J.3
  • 126
    • 0037319203 scopus 로고    scopus 로고
    • Circuitry underlying regulation of the serotonergic system by swim stress
    • Roche, M., Commons, K. G., Peoples, A. & Valentino, R. J. Circuitry underlying regulation of the serotonergic system by swim stress. J. Neurosci. 23, 970-977 (2003).
    • (2003) J. Neurosci. , vol.23 , pp. 970-977
    • Roche, M.1    Commons, K.G.2    Peoples, A.3    Valentino, R.J.4
  • 127
    • 67349251529 scopus 로고    scopus 로고
    • Stress-induced redistribution of corticotropin-releasing factor receptor subtypes in the dorsal raphe nucleus
    • Waselus, M., Nazzaro, C., Valentino, R. J. & Van Bockstaele, E. J. Stress-induced redistribution of corticotropin-releasing factor receptor subtypes in the dorsal raphe nucleus. Biol. Psychiatry 66, 76-83 (2009).
    • (2009) Biol. Psychiatry , vol.66 , pp. 76-83
    • Waselus, M.1    Nazzaro, C.2    Valentino, R.J.3    Van Bockstaele, E.J.4
  • 128
    • 0034141638 scopus 로고    scopus 로고
    • Effects of corticotropin-releasing factor on neuronal activity in the serotonergic dorsal raphe nucleus
    • Kirby, L. G., Rice, K. C. & Valentino, R. J. Effects of corticotropin-releasing factor on neuronal activity in the serotonergic dorsal raphe nucleus. Neuropsychopharmacology 22, 148-162 (2000).
    • (2000) Neuropsychopharmacology , vol.22 , pp. 148-162
    • Kirby, L.G.1    Rice, K.C.2    Valentino, R.J.3
  • 129
    • 37349126918 scopus 로고    scopus 로고
    • Corticotropin-releasing factor 1 and 2 receptors in the dorsal raphe differentially affect serotonin release in the nucleus accumbens
    • Lukkes, J. L., Forster, G. L., Renner, K. J. & Summers, C. H. Corticotropin-releasing factor 1 and 2 receptors in the dorsal raphe differentially affect serotonin release in the nucleus accumbens. Eur. J. Pharmacol. 578, 185-193 (2008).
    • (2008) Eur. J. Pharmacol. , vol.578 , pp. 185-193
    • Lukkes, J.L.1    Forster, G.L.2    Renner, K.J.3    Summers, C.H.4
  • 131
    • 0035871328 scopus 로고    scopus 로고
    • Regulation of serotonin release in the lateral septum and striatum by corticotropin-releasing factor
    • Price, M. L. & Lucki, I. Regulation of serotonin release in the lateral septum and striatum by corticotropin-releasing factor. J. Neurosci. 21, 2833-2841 (2001).
    • (2001) J. Neurosci. , vol.21 , pp. 2833-2841
    • Price, M.L.1    Lucki, I.2
  • 133
    • 84901496570 scopus 로고    scopus 로고
    • Corticotropin-releasing factor-related peptides, serotonergic systems, and emotional behavior
    • Fox, J. H. & Lowry, C. A. Corticotropin-releasing factor-related peptides, serotonergic systems, and emotional behavior. Front. Neurosci. 7, 169 (2013).
    • (2013) Front. Neurosci. , vol.7 , pp. 169
    • Fox, J.H.1    Lowry, C.A.2
  • 134
    • 0141798674 scopus 로고    scopus 로고
    • Membrane and synaptic effects of corticotropin-releasing factor on periaqueductal gray neurons of the rat
    • Bowers, L. K., Swisher, C. B. & Behbehani, M. M. Membrane and synaptic effects of corticotropin-releasing factor on periaqueductal gray neurons of the rat. Brain Res. 981, 52-57 (2003).
    • (2003) Brain Res. , vol.981 , pp. 52-57
    • Bowers, L.K.1    Swisher, C.B.2    Behbehani, M.M.3
  • 135
    • 0033752761 scopus 로고    scopus 로고
    • Anxiolytic effect of a CRH receptor antagonist in the dorsal periaqueductal gray
    • Martins, A. P., Marras, R. A. & Guimaraes, F. S. Anxiolytic effect of a CRH receptor antagonist in the dorsal periaqueductal gray. Depress. Anxiety 12, 99-101 (2000).
    • (2000) Depress. Anxiety , vol.12 , pp. 99-101
    • Martins, A.P.1    Marras, R.A.2    Guimaraes, F.S.3
  • 136
    • 84922430809 scopus 로고    scopus 로고
    • Effects of dorsal periaqueductal gray CRF1- and CRF2 receptor stimulation in animal models of panic
    • Sergio Tde, O., Spiacci, A. Jr & Zangrossi, H. Jr. Effects of dorsal periaqueductal gray CRF1- and CRF2 receptor stimulation in animal models of panic. Psychoneuroendocrinology 49, 321-330 (2014).
    • (2014) Psychoneuroendocrinology , vol.49 , pp. 321-330
    • Sergio Tde, O.1    Spiacci, A.2    Zangrossi, H.3
  • 137
    • 34447621212 scopus 로고    scopus 로고
    • CRF type 1 receptors in the dorsal periaqueductal gray modulate anxiety-induced defensive behaviors
    • Litvin, Y., Pentkowski, N. S., Blanchard, D. C. & Blanchard, R. J. CRF type 1 receptors in the dorsal periaqueductal gray modulate anxiety-induced defensive behaviors. Horm. Behav. 52, 244-251 (2007).
    • (2007) Horm. Behav. , vol.52 , pp. 244-251
    • Litvin, Y.1    Pentkowski, N.S.2    Blanchard, D.C.3    Blanchard, R.J.4
  • 138
    • 79960562237 scopus 로고    scopus 로고
    • Anxiogenic and antinociceptive effects induced by corticotropin-releasing factor (CRF) injections into the periaqueductal gray are modulated by CRF1 receptor in mice
    • Miguel, T. T. & Nunes-de-Souza, R. L. Anxiogenic and antinociceptive effects induced by corticotropin-releasing factor (CRF) injections into the periaqueductal gray are modulated by CRF1 receptor in mice. Horm. Behav. 60, 292-300 (2011).
    • (2011) Horm. Behav. , vol.60 , pp. 292-300
    • Miguel, T.T.1    Nunes-De-Souza, R.L.2
  • 139
    • 34250669398 scopus 로고    scopus 로고
    • Differential effects of CRF1 and CRF2 receptor antagonists on pain-related sensitization of neurons in the central nucleus of the amygdala
    • Ji, G. & Neugebauer, V. Differential effects of CRF1 and CRF2 receptor antagonists on pain-related sensitization of neurons in the central nucleus of the amygdala. J. Neurophysiol. 97, 3893-3904 (2007).
    • (2007) J. Neurophysiol. , vol.97 , pp. 3893-3904
    • Ji, G.1    Neugebauer, V.2
  • 140
    • 84887230082 scopus 로고    scopus 로고
    • Overexpression of corticotropin-releasing factor receptor type 2 in the bed nucleus of stria terminalis improves posttraumatic stress disorder-like symptoms in a model of incubation of fear
    • Elharrar, E. et al. Overexpression of corticotropin-releasing factor receptor type 2 in the bed nucleus of stria terminalis improves posttraumatic stress disorder-like symptoms in a model of incubation of fear. Biol. Psychiatry 74, 827-836 (2013).
    • (2013) Biol. Psychiatry , vol.74 , pp. 827-836
    • Elharrar, E.1
  • 141
    • 84861148331 scopus 로고    scopus 로고
    • Susceptibility to PTSD-like behavior is mediated by corticotropin-releasing factor receptor type 2 levels in the bed nucleus of the stria terminalis
    • Lebow, M. et al. Susceptibility to PTSD-like behavior is mediated by corticotropin-releasing factor receptor type 2 levels in the bed nucleus of the stria terminalis. J. Neurosci. 32, 6906-6916 (2012).
    • (2012) J. Neurosci. , vol.32 , pp. 6906-6916
    • Lebow, M.1
  • 142
    • 34547741600 scopus 로고    scopus 로고
    • Differential expression of intrinsic membrane currents in defined cell types of the anterolateral bed nucleus of the stria terminalis
    • Hammack, S. E., Mania, I. & Rainnie, D. G. Differential expression of intrinsic membrane currents in defined cell types of the anterolateral bed nucleus of the stria terminalis. J. Neurophysiol. 98, 638-656 (2007).
    • (2007) J. Neurophysiol. , vol.98 , pp. 638-656
    • Hammack, S.E.1    Mania, I.2    Rainnie, D.G.3
  • 143
    • 84958093037 scopus 로고    scopus 로고
    • Overshadowed by the amygdala: The bed nucleus of the stria terminalis emerges as key to psychiatric disorders
    • Lebow, M. A. & Chen, A. Overshadowed by the amygdala: the bed nucleus of the stria terminalis emerges as key to psychiatric disorders. Mol. Psychiatry 21, 450-463 (2016).
    • (2016) Mol. Psychiatry , vol.21 , pp. 450-463
    • Lebow, M.A.1    Chen, A.2
  • 144
    • 84904353796 scopus 로고    scopus 로고
    • Central stress-integrative circuits: Forebrain glutamatergic and GABAergic projections to the dorsomedial hypothalamus, medial preoptic area, and bed nucleus of the stria terminalis
    • Myers, B., Mark Dolgas, C., Kasckow, J., Cullinan, W. E. & Herman, J. P. Central stress-integrative circuits: forebrain glutamatergic and GABAergic projections to the dorsomedial hypothalamus, medial preoptic area, and bed nucleus of the stria terminalis. Brain Struct. Funct. 219, 1287-1303 (2014).
    • (2014) Brain Struct. Funct. , vol.219 , pp. 1287-1303
    • Myers, B.1    Mark Dolgas, C.2    Kasckow, J.3    Cullinan, W.E.4    Herman, J.P.5
  • 145
    • 84893452899 scopus 로고    scopus 로고
    • Control of stress-induced persistent anxiety by an extra-amygdala septohypothalamic circuit
    • Anthony, T. E. et al. Control of stress-induced persistent anxiety by an extra-amygdala septohypothalamic circuit. Cell 156, 522-536 (2014).
    • (2014) Cell , vol.156 , pp. 522-536
    • Anthony, T.E.1
  • 147
    • 12744268344 scopus 로고    scopus 로고
    • 2 receptor-mediated depression to facilitation of glutamatergic transmission in the lateral septum
    • 2 receptor-mediated depression to facilitation of glutamatergic transmission in the lateral septum. J. Neurosci. 25, 577-583 (2005).
    • (2005) J. Neurosci. , vol.25 , pp. 577-583
    • Liu, J.1
  • 149
    • 0035906266 scopus 로고    scopus 로고
    • Attenuation of fear conditioning by antisense inhibition of brain corticotropin releasing factor-2 receptor
    • Ho, S. P. et al. Attenuation of fear conditioning by antisense inhibition of brain corticotropin releasing factor-2 receptor. Brain Res. Mol. Brain Res. 89, 29-40 (2001).
    • (2001) Brain Res. Mol. Brain Res. , vol.89 , pp. 29-40
    • Ho, S.P.1
  • 150
    • 34249901008 scopus 로고    scopus 로고
    • Differential activation of CRF receptor subtypes removes stress-induced memory deficit and anxiety
    • Todorovic, C. et al. Differential activation of CRF receptor subtypes removes stress-induced memory deficit and anxiety. Eur. J. Neurosci. 25, 3385-3397 (2007).
    • (2007) Eur. J. Neurosci. , vol.25 , pp. 3385-3397
    • Todorovic, C.1
  • 151
    • 0043198359 scopus 로고    scopus 로고
    • Corticotropin-releasing factor requires CRF binding protein to potentiate NMDA receptors via CRF receptor 2 in dopamine neurons
    • Ungless, M. A. et al. Corticotropin-releasing factor requires CRF binding protein to potentiate NMDA receptors via CRF receptor 2 in dopamine neurons. Neuron 39, 401-407 (2003).
    • (2003) Neuron , vol.39 , pp. 401-407
    • Ungless, M.A.1
  • 152
    • 2642582531 scopus 로고    scopus 로고
    • 1b adrenergic, CRF-R1, and CRF-R2 receptor mRNA in serotonergic, γ-aminobutyric acidergic, and catecholaminergic cells of the rat dorsal raphe nucleus
    • 1b adrenergic, CRF-R1, and CRF-R2 receptor mRNA in serotonergic, γ-aminobutyric acidergic, and catecholaminergic cells of the rat dorsal raphe nucleus. J. Comp. Neurol. 474, 364-378 (2004).
    • (2004) J. Comp. Neurol. , vol.474 , pp. 364-378
    • Day, H.E.1
  • 153
    • 1242291760 scopus 로고    scopus 로고
    • Selective activation of corticotropin-releasing factor-2 receptors on neurochemically identified neurons in the rat dorsal raphe nucleus reveals dual actions
    • Pernar, L., Curtis, A. L., Vale, W. W., Rivier, J. E. & Valentino, R. J. Selective activation of corticotropin-releasing factor-2 receptors on neurochemically identified neurons in the rat dorsal raphe nucleus reveals dual actions. J. Neurosci. 24, 1305-1311 (2004).
    • (2004) J. Neurosci. , vol.24 , pp. 1305-1311
    • Pernar, L.1    Curtis, A.L.2    Vale, W.W.3    Rivier, J.E.4    Valentino, R.J.5
  • 154
    • 0034667548 scopus 로고    scopus 로고
    • Corticotropin-releasing factor increases in vitro firing rates of serotonergic neurons in the rat dorsal raphe nucleus: Evidence for activation of a topographically organized mesolimbocortical serotonergic system
    • Lowry, C. A., Rodda, J. E., Lightman, S. L. & Ingram, C. D. Corticotropin-releasing factor increases in vitro firing rates of serotonergic neurons in the rat dorsal raphe nucleus: evidence for activation of a topographically organized mesolimbocortical serotonergic system. J. Neurosci. 20, 7728-7736 (2000).
    • (2000) J. Neurosci. , vol.20 , pp. 7728-7736
    • Lowry, C.A.1    Rodda, J.E.2    Lightman, S.L.3    Ingram, C.D.4
  • 155
    • 84866644737 scopus 로고    scopus 로고
    • 2C receptors in the basolateral amygdala and dorsal striatum are a novel target for the anxiolytic and antidepressant effects of exercise
    • 2C receptors in the basolateral amygdala and dorsal striatum are a novel target for the anxiolytic and antidepressant effects of exercise. PLoS ONE 7, e46118 (2012).
    • (2012) PLoS ONE , vol.7 , pp. e46118
    • Greenwood, B.N.1
  • 156
    • 0345714770 scopus 로고    scopus 로고
    • Serotonin 2C receptors within the basolateral amygdala induce acute fear-like responses in an open-field environment
    • Campbell, B. M. & Merchant, K. M. Serotonin 2C receptors within the basolateral amygdala induce acute fear-like responses in an open-field environment. Brain Res. 993, 1-9 (2003).
    • (2003) Brain Res. , vol.993 , pp. 1-9
    • Campbell, B.M.1    Merchant, K.M.2
  • 157
    • 48249090408 scopus 로고    scopus 로고
    • Corticotropin-releasing factor in the dorsal raphe nucleus increases medial prefrontal cortical serotonin via type 2 receptors and median raphe nucleus activity
    • Forster, G. L. et al. Corticotropin-releasing factor in the dorsal raphe nucleus increases medial prefrontal cortical serotonin via type 2 receptors and median raphe nucleus activity. Eur. J. Neurosci. 28, 299-310 (2008).
    • (2008) Eur. J. Neurosci. , vol.28 , pp. 299-310
    • Forster, G.L.1
  • 158
    • 0036469375 scopus 로고    scopus 로고
    • The role of corticotropin-releasing hormone in the dorsal raphe nucleus in mediating the behavioral consequences of uncontrollable stress
    • Hammack, S. E. et al. The role of corticotropin-releasing hormone in the dorsal raphe nucleus in mediating the behavioral consequences of uncontrollable stress. J. Neurosci. 22, 1020-1026 (2002).
    • (2002) J. Neurosci. , vol.22 , pp. 1020-1026
    • Hammack, S.E.1
  • 159
    • 0037321309 scopus 로고    scopus 로고
    • Corticotropin releasing hormone type 2 receptors in the dorsal raphe nucleus mediate the behavioral consequences of uncontrollable stress
    • Hammack, S. E. et al. Corticotropin releasing hormone type 2 receptors in the dorsal raphe nucleus mediate the behavioral consequences of uncontrollable stress. J. Neurosci. 23, 1019-1025 (2003).
    • (2003) J. Neurosci. , vol.23 , pp. 1019-1025
    • Hammack, S.E.1
  • 161
    • 84893363363 scopus 로고    scopus 로고
    • Central CRF neurons are not created equal: Phenotypic differences in CRF-containing neurons of the rat paraventricular hypothalamus and the bed nucleus of the stria terminalis
    • Dabrowska, J., Hazra, R., Guo, J. D., Dewitt, S. & Rainnie, D. G. Central CRF neurons are not created equal: phenotypic differences in CRF-containing neurons of the rat paraventricular hypothalamus and the bed nucleus of the stria terminalis. Front. Neurosci. 7, 156 (2013).
    • (2013) Front. Neurosci. , vol.7 , pp. 156
    • Dabrowska, J.1    Hazra, R.2    Guo, J.D.3    Dewitt, S.4    Rainnie, D.G.5
  • 162
    • 84954513450 scopus 로고    scopus 로고
    • A transgenic rat for investigating the anatomy and function of corticotrophin releasing factor circuits
    • Pomrenze, M. B. et al. A transgenic rat for investigating the anatomy and function of corticotrophin releasing factor circuits. Front. Neurosci. 9, 487 (2015).
    • (2015) Front. Neurosci. , vol.9 , pp. 487
    • Pomrenze, M.B.1
  • 163
    • 84962719618 scopus 로고    scopus 로고
    • Stress increases GABAergic neurotransmission in CRF neurons of the central amygdala and bed nucleus stria terminalis
    • Partridge, J. G. et al. Stress increases GABAergic neurotransmission in CRF neurons of the central amygdala and bed nucleus stria terminalis. Neuropharmacology 107, 239-250 (2016).
    • (2016) Neuropharmacology , vol.107 , pp. 239-250
    • Partridge, J.G.1
  • 164
    • 2942587062 scopus 로고    scopus 로고
    • Hippocampal corticotropin releasing hormone: Pre- and postsynaptic location and release by stress
    • Chen, Y. et al. Hippocampal corticotropin releasing hormone: pre- and postsynaptic location and release by stress. Neuroscience 126, 533-540 (2004).
    • (2004) Neuroscience , vol.126 , pp. 533-540
    • Chen, Y.1
  • 165
    • 0022351793 scopus 로고
    • Behavioral investigation of the coexistence of substance P, corticotropin releasing factor, and acetylcholinesterase in lateral dorsal tegmental neurons projecting to the medial frontal cortex of the rat
    • Crawley, J. N., Olschowka, J. A., Diz, D. I. & Jacobowitz, D. M. Behavioral investigation of the coexistence of substance P, corticotropin releasing factor, and acetylcholinesterase in lateral dorsal tegmental neurons projecting to the medial frontal cortex of the rat. Peptides 6, 891-901 (1985).
    • (1985) Peptides , vol.6 , pp. 891-901
    • Crawley, J.N.1    Olschowka, J.A.2    Diz, D.I.3    Jacobowitz, D.M.4
  • 166
    • 84928397130 scopus 로고    scopus 로고
    • Increased CRF signalling in a ventral tegmental area-interpeduncular nucleus-medial habenula circuit induces anxiety during nicotine withdrawal
    • Zhao-Shea, R. et al. Increased CRF signalling in a ventral tegmental area-interpeduncular nucleus-medial habenula circuit induces anxiety during nicotine withdrawal. Nat. Commun. 6, 6770 (2015).
    • (2015) Nat. Commun. , vol.6 , pp. 6770
    • Zhao-Shea, R.1
  • 167
    • 77951667861 scopus 로고    scopus 로고
    • CRF receptor 1 regulates anxiety behavior via sensitization of 5 HT2 receptor signaling
    • Magalhaes, A. C. et al. CRF receptor 1 regulates anxiety behavior via sensitization of 5 HT2 receptor signaling. Nat. Neurosci. 13, 622-629 (2010).
    • (2010) Nat. Neurosci. , vol.13 , pp. 622-629
    • Magalhaes, A.C.1
  • 168
    • 0032895726 scopus 로고    scopus 로고
    • The rationale for corticotropin-releasing hormone receptor (CRH-R) antagonists to treat depression and anxiety
    • Holsboer, F. The rationale for corticotropin-releasing hormone receptor (CRH-R) antagonists to treat depression and anxiety. J. Psychiatr. Res. 33, 181-214 (1999).
    • (1999) J. Psychiatr. Res. , vol.33 , pp. 181-214
    • Holsboer, F.1
  • 169
    • 74949083784 scopus 로고    scopus 로고
    • Injection of urocortin 3 into the ventromedial hypothalamus modulates feeding, blood glucose levels, and hypothalamic POMC gene expression but not the HPA axis
    • Chen, P., Vaughan, J., Donaldson, C., Vale, W. & Li, C. Injection of urocortin 3 into the ventromedial hypothalamus modulates feeding, blood glucose levels, and hypothalamic POMC gene expression but not the HPA axis. Am. J. Physiol. Endocrinol. Metab. 298, E337-E345 (2010).
    • (2010) Am. J. Physiol. Endocrinol. Metab. , vol.298 , pp. E337-E345
    • Chen, P.1    Vaughan, J.2    Donaldson, C.3    Vale, W.4    Li, C.5
  • 170
    • 77954515779 scopus 로고    scopus 로고
    • Urocortin 3 modulates social discrimination abilities via corticotropin-releasing hormone receptor type 2
    • Deussing, J. M. et al. Urocortin 3 modulates social discrimination abilities via corticotropin-releasing hormone receptor type 2. J. Neurosci. 30, 9103-9116 (2010).
    • (2010) J. Neurosci. , vol.30 , pp. 9103-9116
    • Deussing, J.M.1
  • 171
    • 0035912712 scopus 로고    scopus 로고
    • Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor
    • Lewis, K. et al. Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor. Proc. Natl Acad. Sci. USA 98, 7570-7575 (2001).
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 7570-7575
    • Lewis, K.1
  • 172
    • 0020416041 scopus 로고
    • Immunocytochemical localization of corticotropin-releasing factor (CRF) in the rat brain
    • Merchenthaler, I., Vigh, S., Petrusz, P. & Schally, A. V. Immunocytochemical localization of corticotropin-releasing factor (CRF) in the rat brain. Am. J. Anat. 165, 385-396 (1982).
    • (1982) Am. J. Anat. , vol.165 , pp. 385-396
    • Merchenthaler, I.1    Vigh, S.2    Petrusz, P.3    Schally, A.V.4
  • 173
    • 0035956938 scopus 로고    scopus 로고
    • Urocortin II: A member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors
    • Reyes, T. M. et al. Urocortin II: a member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors. Proc. Natl Acad. Sci. USA 98, 2843-2848 (2001).
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 2843-2848
    • Reyes, T.M.1
  • 174
    • 0035142855 scopus 로고    scopus 로고
    • Rat cerebral cortex corticotropin-releasing hormone receptors: Evidence for receptor coupling to multiple G-proteins
    • Grammatopoulos, D. K., Randeva, H. S., Levine, M. A., Kanellopoulou, K. A. & Hillhouse, E. W. Rat cerebral cortex corticotropin-releasing hormone receptors: evidence for receptor coupling to multiple G-proteins. J. Neurochem. 76, 509-519 (2001).
    • (2001) J. Neurochem. , vol.76 , pp. 509-519
    • Grammatopoulos, D.K.1    Randeva, H.S.2    Levine, M.A.3    Kanellopoulou, K.A.4    Hillhouse, E.W.5
  • 175
    • 0038407615 scopus 로고    scopus 로고
    • Functional characteristics of CRH receptors and potential clinical applications of CRH-receptor antagonists
    • Grammatopoulos, D. K. & Chrousos, G. P. Functional characteristics of CRH receptors and potential clinical applications of CRH-receptor antagonists. Trends Endocrinol. Metab. 13, 436-444 (2002).
    • (2002) Trends Endocrinol. Metab. , vol.13 , pp. 436-444
    • Grammatopoulos, D.K.1    Chrousos, G.P.2
  • 176
    • 1642423789 scopus 로고    scopus 로고
    • Specificity and regulation of extracellularly regulated kinase1/2 phosphorylation through corticotropin-releasing factor (CRF) receptors 1 and 2β by the CRF/urocortin family of peptides
    • Brar, B. K., Chen, A., Perrin, M. H. & Vale, W. Specificity and regulation of extracellularly regulated kinase1/2 phosphorylation through corticotropin-releasing factor (CRF) receptors 1 and 2β by the CRF/urocortin family of peptides. Endocrinology 145, 1718-1729 (2004).
    • (2004) Endocrinology , vol.145 , pp. 1718-1729
    • Brar, B.K.1    Chen, A.2    Perrin, M.H.3    Vale, W.4
  • 178
    • 40849120814 scopus 로고    scopus 로고
    • Intracellular mechanisms regulating corticotropin-releasing hormone receptor 2β endocytosis and interaction with extracellularly regulated kinase 1/2 and p38 mitogen-activated protein kinase signaling cascades
    • Markovic, D., Punn, A., Lehnert, H. & Grammatopoulos, D. K. Intracellular mechanisms regulating corticotropin-releasing hormone receptor 2β endocytosis and interaction with extracellularly regulated kinase 1/2 and p38 mitogen-activated protein kinase signaling cascades. Mol. Endocrinol. 22, 689-706 (2008).
    • (2008) Mol. Endocrinol. , vol.22 , pp. 689-706
    • Markovic, D.1    Punn, A.2    Lehnert, H.3    Grammatopoulos, D.K.4
  • 179
    • 0035500377 scopus 로고    scopus 로고
    • Distribution of G-protein-coupled receptor kinase (GRK) isoforms 2, 3, 5 and 6 mRNA in the rat brain
    • Erdtmann-Vourliotis, M., Mayer, P., Ammon, S., Riechert, U. & Hollt, V. Distribution of G-protein-coupled receptor kinase (GRK) isoforms 2, 3, 5 and 6 mRNA in the rat brain. Brain Res. Mol. Brain Res. 95, 129-137 (2001).
    • (2001) Brain Res. Mol. Brain Res. , vol.95 , pp. 129-137
    • Erdtmann-Vourliotis, M.1    Mayer, P.2    Ammon, S.3    Riechert, U.4    Hollt, V.5
  • 180
    • 0037074928 scopus 로고    scopus 로고
    • Arrestin2 and arrestin3 are differentially expressed in the rat brain during postnatal development
    • Gurevich, E. V., Benovic, J. L. & Gurevich, V. V. Arrestin2 and arrestin3 are differentially expressed in the rat brain during postnatal development. Neuroscience 109, 421-436 (2002).
    • (2002) Neuroscience , vol.109 , pp. 421-436
    • Gurevich, E.V.1    Benovic, J.L.2    Gurevich, V.V.3
  • 181
    • 84867681411 scopus 로고    scopus 로고
    • Severe stress switches CRF action in the nucleus accumbens from appetitive to aversive
    • Lemos, J. C. et al. Severe stress switches CRF action in the nucleus accumbens from appetitive to aversive. Nature 490, 402-406 (2012).
    • (2012) Nature , vol.490 , pp. 402-406
    • Lemos, J.C.1
  • 182
    • 67349151166 scopus 로고    scopus 로고
    • The neuro-symphony of stress
    • Joels, M. & Baram, T. Z. The neuro-symphony of stress. Nat. Rev. Neurosci. 10, 459-466 (2009).
    • (2009) Nat. Rev. Neurosci. , vol.10 , pp. 459-466
    • Joels, M.1    Baram, T.Z.2
  • 183
    • 0036468517 scopus 로고    scopus 로고
    • The CRF peptide family and their receptors: Yet more partners discovered
    • Dautzenberg, F. M. & Hauger, R. L. The CRF peptide family and their receptors: yet more partners discovered. Trends Pharmacol. Sci. 23, 71-77 (2002).
    • (2002) Trends Pharmacol. Sci. , vol.23 , pp. 71-77
    • Dautzenberg, F.M.1    Hauger, R.L.2
  • 184
    • 0032801846 scopus 로고    scopus 로고
    • Corticotropin releasing factor receptors and their ligand family
    • Perrin, M. H. & Vale, W. W. Corticotropin releasing factor receptors and their ligand family. Ann. NY Acad. Sci. 885, 312-328 (1999).
    • (1999) Ann. NY Acad. Sci. , vol.885 , pp. 312-328
    • Perrin, M.H.1    Vale, W.W.2
  • 185
    • 0028800601 scopus 로고
    • Cloning and characterization of a functionally distinct corticotropin-releasing factor receptor subtype from rat brain
    • Lovenberg, T. W. et al. Cloning and characterization of a functionally distinct corticotropin-releasing factor receptor subtype from rat brain. Proc. Natl Acad. Sci. USA 92, 836-840 (1995).
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 836-840
    • Lovenberg, T.W.1
  • 186
    • 0028914020 scopus 로고
    • Identification of a second corticotropin-releasing factor receptor gene and characterization of a cDNA expressed in heart
    • Perrin, M. et al. Identification of a second corticotropin-releasing factor receptor gene and characterization of a cDNA expressed in heart. Proc. Natl Acad. Sci. USA 92, 2969-2973 (1995).
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 2969-2973
    • Perrin, M.1
  • 187
    • 0029010906 scopus 로고
    • Identification of a novel murine receptor for corticotropin-releasing hormone expressed in the heart
    • Stenzel, P. et al. Identification of a novel murine receptor for corticotropin-releasing hormone expressed in the heart. Mol. Endocrinol. 9, 637-645 (1995).
    • (1995) Mol. Endocrinol. , vol.9 , pp. 637-645
    • Stenzel, P.1
  • 188
    • 0028819695 scopus 로고
    • Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor
    • Vaughan, J. et al. Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor. Nature 378, 287-292 (1995).
    • (1995) Nature , vol.378 , pp. 287-292
    • Vaughan, J.1
  • 189
    • 0028802780 scopus 로고
    • Corticotropin releasing factor (CRF) binding protein: A novel regulator of CRF and related peptides
    • Behan, D. P. et al. Corticotropin releasing factor (CRF) binding protein: a novel regulator of CRF and related peptides. Front. Neuroendocrinol. 16, 362-382 (1995).
    • (1995) Front. Neuroendocrinol. , vol.16 , pp. 362-382
    • Behan, D.P.1
  • 190
    • 0036802966 scopus 로고    scopus 로고
    • Corticotropin-releasing hormone-binding protein: Biochemistry and function from fishes to mammals
    • Seasholtz, A. F., Valverde, R. A. & Denver, R. J. Corticotropin-releasing hormone-binding protein: biochemistry and function from fishes to mammals. J. Endocrinol. 175, 89-97 (2002).
    • (2002) J. Endocrinol. , vol.175 , pp. 89-97
    • Seasholtz, A.F.1    Valverde, R.A.2    Denver, R.J.3
  • 191
    • 84963745868 scopus 로고    scopus 로고
    • CRF binding protein facilitates the presence of CRF type 2α receptor on the cell surface
    • Slater, P. G., Cerda, C. A., Pereira, L. A., Andres, M. E. & Gysling, K. CRF binding protein facilitates the presence of CRF type 2α receptor on the cell surface. Proc. Natl Acad. Sci. USA 113, 4075-4080 (2016).
    • (2016) Proc. Natl Acad. Sci. USA , vol.113 , pp. 4075-4080
    • Slater, P.G.1    Cerda, C.A.2    Pereira, L.A.3    Andres, M.E.4    Gysling, K.5
  • 192
    • 33746998914 scopus 로고    scopus 로고
    • Corticotropin releasing factor (CRF) receptor signaling in the central nervous system: New molecular targets
    • Hauger, R. L., Risbrough, V., Brauns, O. & Dautzenberg, F. M. Corticotropin releasing factor (CRF) receptor signaling in the central nervous system: new molecular targets. CNS Neurol. Disord. Drug Targets 5, 453-479 (2006).
    • (2006) CNS Neurol. Disord. Drug Targets , vol.5 , pp. 453-479
    • Hauger, R.L.1    Risbrough, V.2    Brauns, O.3    Dautzenberg, F.M.4
  • 193
    • 62149101953 scopus 로고    scopus 로고
    • Molecular mechanisms of corticotropin-releasing factor receptor-induced calcium signaling
    • Gutknecht, E. et al. Molecular mechanisms of corticotropin-releasing factor receptor-induced calcium signaling. Mol. Pharmacol. 75, 648-657 (2009).
    • (2009) Mol. Pharmacol. , vol.75 , pp. 648-657
    • Gutknecht, E.1
  • 194
    • 40349114499 scopus 로고    scopus 로고
    • Agonist-selective mechanisms of GPCR desensitization
    • Kelly, E., Bailey, C. P. & Henderson, G. Agonist-selective mechanisms of GPCR desensitization. Br. J. Pharmacol. 153, S379-S388 (2008).
    • (2008) Br. J. Pharmacol. , vol.153 , pp. S379-S388
    • Kelly, E.1    Bailey, C.P.2    Henderson, G.3
  • 195
    • 0037223063 scopus 로고    scopus 로고
    • Regulation of G protein-coupled receptor kinases and arrestins during receptor desensitization
    • Kohout, T. A. & Lefkowitz, R. J. Regulation of G protein-coupled receptor kinases and arrestins during receptor desensitization. Mol. Pharmacol. 63, 9-18 (2003).
    • (2003) Mol. Pharmacol. , vol.63 , pp. 9-18
    • Kohout, T.A.1    Lefkowitz, R.J.2
  • 196
    • 33947314576 scopus 로고    scopus 로고
    • Regulation of receptor trafficking by GRKs and arrestins
    • Moore, C. A., Milano, S. K. & Benovic, J. L. Regulation of receptor trafficking by GRKs and arrestins. Annu. Rev. Physiol. 69, 451-482 (2007).
    • (2007) Annu. Rev. Physiol. , vol.69 , pp. 451-482
    • Moore, C.A.1    Milano, S.K.2    Benovic, J.L.3
  • 197
    • 15744379282 scopus 로고    scopus 로고
    • 2 adrenergic receptor requires both receptor phosphorylation and receptor activation
    • 2 adrenergic receptor requires both receptor phosphorylation and receptor activation. J. Biol. Chem. 280, 9528-9535 (2005).
    • (2005) J. Biol. Chem. , vol.280 , pp. 9528-9535
    • Krasel, C.1    Bunemann, M.2    Lorenz, K.3    Lohse, M.J.4
  • 198
    • 84944721801 scopus 로고    scopus 로고
    • Corticotropin-releasing hormone receptor type 1 (CRHR1) clustering with MAGUKs is mediated via its C-terminal PDZ binding motif
    • Bender, J. et al. Corticotropin-releasing hormone receptor type 1 (CRHR1) clustering with MAGUKs is mediated via its C-terminal PDZ binding motif. PLoS ONE 10, e0136768 (2015).
    • (2015) PLoS ONE , vol.10 , pp. e0136768
    • Bender, J.1
  • 199
    • 84922593740 scopus 로고    scopus 로고
    • PDZK1/NHERF3 differentially regulates corticotropin-releasing factor receptor 1 and serotonin 2A receptor signaling and endocytosis
    • Walther, C., Caetano, F. A., Dunn, H. A. & Ferguson, S. S. PDZK1/NHERF3 differentially regulates corticotropin-releasing factor receptor 1 and serotonin 2A receptor signaling and endocytosis. Cell. Signal. 27, 519-531 (2015).
    • (2015) Cell. Signal. , vol.27 , pp. 519-531
    • Walther, C.1    Caetano, F.A.2    Dunn, H.A.3    Ferguson, S.S.4
  • 200
    • 84857471063 scopus 로고    scopus 로고
    • Regulation of GPCR activity, trafficking and localization by GPCR-interacting proteins
    • Magalhaes, A. C., Dunn, H. & Ferguson, S. S. Regulation of GPCR activity, trafficking and localization by GPCR-interacting proteins. Br. J. Pharmacol. 165, 1717-1736 (2012).
    • (2012) Br. J. Pharmacol. , vol.165 , pp. 1717-1736
    • Magalhaes, A.C.1    Dunn, H.2    Ferguson, S.S.3
  • 201
    • 84959094933 scopus 로고    scopus 로고
    • PSD 95 regulates CRFR1 localization, trafficking and β arrestin2 recruitment
    • Dunn, H. A. et al. PSD 95 regulates CRFR1 localization, trafficking and β arrestin2 recruitment. Cell. Signal. 28, 531-540 (2016).
    • (2016) Cell. Signal. , vol.28 , pp. 531-540
    • Dunn, H.A.1
  • 202
    • 84861850317 scopus 로고    scopus 로고
    • Neuropeptide receptor ligands as drugs for psychiatric diseases: The end of the beginning?
    • Griebel, G. & Holsboer, F. Neuropeptide receptor ligands as drugs for psychiatric diseases: the end of the beginning? Nat. Rev. Drug Discov. 11, 462-478 (2012).
    • (2012) Nat. Rev. Drug Discov. , vol.11 , pp. 462-478
    • Griebel, G.1    Holsboer, F.2
  • 203
    • 3042608066 scopus 로고    scopus 로고
    • Effect of comorbid anxiety disorders on the hypothalamic-pituitary-adrenal axis response to a social stressor in major depression
    • Young, E. A., Abelson, J. L. & Cameron, O. G. Effect of comorbid anxiety disorders on the hypothalamic-pituitary-adrenal axis response to a social stressor in major depression. Biol. Psychiatry 56, 113-120 (2004).
    • (2004) Biol. Psychiatry , vol.56 , pp. 113-120
    • Young, E.A.1    Abelson, J.L.2    Cameron, O.G.3
  • 204
    • 34547907098 scopus 로고    scopus 로고
    • 1 receptor antagonist NBI 34041: Preclinical and clinical data suggest safety and efficacy in attenuating elevated stress response
    • 1 receptor antagonist NBI 34041: preclinical and clinical data suggest safety and efficacy in attenuating elevated stress response. Neuropsychopharmacology 32, 1941-1949 (2007).
    • (2007) Neuropsychopharmacology , vol.32 , pp. 1941-1949
    • Ising, M.1
  • 205
    • 0034193881 scopus 로고    scopus 로고
    • Effects of the high-affinity corticotropin-releasing hormone receptor 1 antagonist R121919 in major depression: The first 20 patients treated
    • Zobel, A. W. et al. Effects of the high-affinity corticotropin-releasing hormone receptor 1 antagonist R121919 in major depression: the first 20 patients treated. J. Psychiatr. Res. 34, 171-181 (2000).
    • (2000) J. Psychiatr. Res. , vol.34 , pp. 171-181
    • Zobel, A.W.1
  • 206
    • 1642578880 scopus 로고    scopus 로고
    • 1 receptor-antagonist R121919 improves sleep-EEG in patients with depression
    • 1 receptor-antagonist R121919 improves sleep-EEG in patients with depression. J. Psychiatr. Res. 38, 129-136 (2004).
    • (2004) J. Psychiatr. Res. , vol.38 , pp. 129-136
    • Held, K.1
  • 207
    • 43949134527 scopus 로고    scopus 로고
    • 1 antagonist) in the treatment of major depression
    • 1 antagonist) in the treatment of major depression. Am. J. Psychiatry 165, 617-620 (2008).
    • (2008) Am. J. Psychiatry , vol.165 , pp. 617-620
    • Binneman, B.1
  • 208
    • 75549091827 scopus 로고    scopus 로고
    • Conditional corticotropin-releasing hormone overexpression in the mouse forebrain enhances rapid eye movement sleep
    • Kimura, M. et al. Conditional corticotropin-releasing hormone overexpression in the mouse forebrain enhances rapid eye movement sleep. Mol. Psychiatry 15, 154-165 (2010).
    • (2010) Mol. Psychiatry , vol.15 , pp. 154-165
    • Kimura, M.1
  • 209
    • 77449090704 scopus 로고    scopus 로고
    • Stress hormone regulation: Biological role and translation into therapy
    • Holsboer, F. & Ising, M. Stress hormone regulation: biological role and translation into therapy. Annu. Rev. Psychol. 61, 81-109 (2010).
    • (2010) Annu. Rev. Psychol. , vol.61 , pp. 81-109
    • Holsboer, F.1    Ising, M.2
  • 210
    • 84881123234 scopus 로고    scopus 로고
    • Sex-specific cell signaling: The corticotropin-releasing factor receptor model
    • Valentino, R. J., Van Bockstaele, E. & Bangasser, D. Sex-specific cell signaling: the corticotropin-releasing factor receptor model. Trends Pharmacol. Sci. 34, 437-444 (2013).
    • (2013) Trends Pharmacol. Sci. , vol.34 , pp. 437-444
    • Valentino, R.J.1    Van Bockstaele, E.2    Bangasser, D.3
  • 211
    • 33645105247 scopus 로고    scopus 로고
    • Differential regulation of corticotropin releasing factor 1α receptor endocytosis and trafficking by β-arrestins and rab GTPases
    • Holmes, K. D., Babwah, A. V., Dale, L. B., Poulter, M. O. & Ferguson, S. S. Differential regulation of corticotropin releasing factor 1α receptor endocytosis and trafficking by β-arrestins and Rab GTPases. J. Neurochem. 96, 934-949 (2006).
    • (2006) J. Neurochem. , vol.96 , pp. 934-949
    • Holmes, K.D.1    Babwah, A.V.2    Dale, L.B.3    Poulter, M.O.4    Ferguson, S.S.5
  • 212
    • 34447622268 scopus 로고    scopus 로고
    • 1 receptor phosphorylation and β-arrestin-2 recruitment: A mechanism regulating stress and anxiety responses
    • 1 receptor phosphorylation and β-arrestin-2 recruitment: a mechanism regulating stress and anxiety responses. Am. J. Physiol. Regul. Integr. Comp. Physiol. 293, R209-R222 (2007).
    • (2007) Am. J. Physiol. Regul. Integr. Comp. Physiol. , vol.293 , pp. R209-R222
    • Oakley, R.H.1
  • 213
    • 58049215517 scopus 로고    scopus 로고
    • Continuous expression of corticotropin-releasing factor in the central nucleus of the amygdala emulates the dysregulation of the stress and reproductive axes
    • Keen-Rhinehart, E. et al. Continuous expression of corticotropin-releasing factor in the central nucleus of the amygdala emulates the dysregulation of the stress and reproductive axes. Mol. Psychiatry 14, 37-50 (2009).
    • (2009) Mol. Psychiatry , vol.14 , pp. 37-50
    • Keen-Rhinehart, E.1
  • 214
    • 79959584954 scopus 로고    scopus 로고
    • Prolonged and site-specific over-expression of corticotropin-releasing factor reveals differential roles for extended amygdala nuclei in emotional regulation
    • Regev, L. et al. Prolonged and site-specific over-expression of corticotropin-releasing factor reveals differential roles for extended amygdala nuclei in emotional regulation. Mol. Psychiatry 16, 714-728 (2011).
    • (2011) Mol. Psychiatry , vol.16 , pp. 714-728
    • Regev, L.1
  • 215
    • 84884211361 scopus 로고    scopus 로고
    • Impairment of synaptic plasticity by the stress mediator CRH involves selective destruction of thin dendritic spines via RhoA signaling
    • Chen, Y. et al. Impairment of synaptic plasticity by the stress mediator CRH involves selective destruction of thin dendritic spines via RhoA signaling. Mol. Psychiatry 18, 485-496 (2013).
    • (2013) Mol. Psychiatry , vol.18 , pp. 485-496
    • Chen, Y.1
  • 216
    • 84886940349 scopus 로고    scopus 로고
    • NMDA receptor activation and calpain contribute to disruption of dendritic spines by the stress neuropeptide CRH
    • Andres, A. L. et al. NMDA receptor activation and calpain contribute to disruption of dendritic spines by the stress neuropeptide CRH. J. Neurosci. 33, 16945-16960 (2013).
    • (2013) J. Neurosci. , vol.33 , pp. 16945-16960
    • Andres, A.L.1
  • 217
    • 79954630809 scopus 로고    scopus 로고
    • Forebrain CRHR1 deficiency attenuates chronic stress-induced cognitive deficits and dendritic remodeling
    • Wang, X. D. et al. Forebrain CRHR1 deficiency attenuates chronic stress-induced cognitive deficits and dendritic remodeling. Neurobiol. Dis. 42, 300-310 (2011).
    • (2011) Neurobiol. Dis. , vol.42 , pp. 300-310
    • Wang, X.D.1
  • 218
    • 77957355154 scopus 로고    scopus 로고
    • Hippocampal dysfunction and cognitive impairments provoked by chronic early-life stress involve excessive activation of CRH receptors
    • Ivy, A. S. et al. Hippocampal dysfunction and cognitive impairments provoked by chronic early-life stress involve excessive activation of CRH receptors. J. Neurosci. 30, 13005-13015 (2010).
    • (2010) J. Neurosci. , vol.30 , pp. 13005-13015
    • Ivy, A.S.1
  • 219
    • 34548838826 scopus 로고    scopus 로고
    • Memory for emotionally neutral information in posttraumatic stress disorder: A meta-analytic investigation
    • Brewin, C. R., Kleiner, J. S., Vasterling, J. J. & Field, A. P. Memory for emotionally neutral information in posttraumatic stress disorder: a meta-analytic investigation. J. Abnorm Psychol. 116, 448-463 (2007).
    • (2007) J. Abnorm Psychol. , vol.116 , pp. 448-463
    • Brewin, C.R.1    Kleiner, J.S.2    Vasterling, J.J.3    Field, A.P.4
  • 220
    • 84879202113 scopus 로고    scopus 로고
    • 1 receptor antagonist SSR125543 prevents stress-induced cognitive deficit associated with hippocampal dysfunction: Comparison with paroxetine and D cycloserine
    • 1 receptor antagonist SSR125543 prevents stress-induced cognitive deficit associated with hippocampal dysfunction: comparison with paroxetine and D cycloserine. Psychopharmacol. (Berl.) 228, 97-107 (2013).
    • (2013) Psychopharmacol. (Berl.) , vol.228 , pp. 97-107
    • Philbert, J.1    Belzung, C.2    Griebel, G.3
  • 222
    • 0035859205 scopus 로고    scopus 로고
    • Detection of corticotropin-releasing hormone receptor 1 immunoreactivity in cholinergic, dopaminergic and noradrenergic neurons of the murine basal forebrain and brainstem nuclei - potential implication for arousal and attention
    • Sauvage, M. & Steckler, T. Detection of corticotropin-releasing hormone receptor 1 immunoreactivity in cholinergic, dopaminergic and noradrenergic neurons of the murine basal forebrain and brainstem nuclei - potential implication for arousal and attention. Neuroscience 104, 643-652 (2001).
    • (2001) Neuroscience , vol.104 , pp. 643-652
    • Sauvage, M.1    Steckler, T.2
  • 223
    • 33748889105 scopus 로고    scopus 로고
    • Cocaine withdrawal enhances long-term potentiation induced by corticotropin-releasing factor at central amygdala glutamatergic synapses via CRF, NMDA receptors and PKA
    • Pollandt, S. et al. Cocaine withdrawal enhances long-term potentiation induced by corticotropin-releasing factor at central amygdala glutamatergic synapses via CRF, NMDA receptors and PKA. Eur. J. Neurosci. 24, 1733-1743 (2006).
    • (2006) Eur. J. Neurosci. , vol.24 , pp. 1733-1743
    • Pollandt, S.1
  • 224
    • 33749532648 scopus 로고    scopus 로고
    • Neuropeptide y and corticotropin-releasing factor bi-directionally modulate inhibitory synaptic transmission in the bed nucleus of the stria terminalis
    • Kash, T. L. & Winder, D. G. Neuropeptide Y and corticotropin-releasing factor bi-directionally modulate inhibitory synaptic transmission in the bed nucleus of the stria terminalis. Neuropharmacology 51, 1013-1022 (2006).
    • (2006) Neuropharmacology , vol.51 , pp. 1013-1022
    • Kash, T.L.1    Winder, D.G.2
  • 225
    • 23044437038 scopus 로고    scopus 로고
    • Acute and chronic corticotropin-releasing factor 1 receptor blockade inhibits cocaine-induced dopamine release: Correlation with dopamine neuron activity
    • Lodge, D. J. & Grace, A. A. Acute and chronic corticotropin-releasing factor 1 receptor blockade inhibits cocaine-induced dopamine release: correlation with dopamine neuron activity. J. Pharmacol. Exp. Ther. 314, 201-206 (2005).
    • (2005) J. Pharmacol. Exp. Ther. , vol.314 , pp. 201-206
    • Lodge, D.J.1    Grace, A.A.2
  • 226
    • 0032449451 scopus 로고    scopus 로고
    • Corticotrophin-releasing factor produces a long-lasting enhancement of synaptic efficacy in the hippocampus
    • Wang, H. L., Wayner, M. J., Chai, C. Y. & Lee, E. H. Corticotrophin-releasing factor produces a long-lasting enhancement of synaptic efficacy in the hippocampus. Eur. J. Neurosci. 10, 3428-3437 (1998).
    • (1998) Eur. J. Neurosci. , vol.10 , pp. 3428-3437
    • Wang, H.L.1    Wayner, M.J.2    Chai, C.Y.3    Lee, E.H.4
  • 227
    • 80053035683 scopus 로고    scopus 로고
    • 1 modulates early-life stress-programmed cognitive deficits
    • 1 modulates early-life stress-programmed cognitive deficits. J. Neurosci. 31, 13625-13634 (2011).
    • (2011) J. Neurosci. , vol.31 , pp. 13625-13634
    • Wang, X.D.1
  • 228
    • 56349169785 scopus 로고    scopus 로고
    • The behavioural and electrophysiological effects of CRF in rat frontal cortex
    • Zieba, B. et al. The behavioural and electrophysiological effects of CRF in rat frontal cortex. Neuropeptides 42, 513-523 (2008).
    • (2008) Neuropeptides , vol.42 , pp. 513-523
    • Zieba, B.1


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