The CRF1 receptor antagonist SSR125543 prevents stress-induced cognitive deficit associated with hippocampal dysfunction: Comparison with paroxetine and d-cycloserine

Psychopharmacology

Volumn 228, Issue 1, 2013, Pages 97-107

  Philbert, J ^a   Belzung, C ^b   Griebel, G ^a  

^a SANOFI   (France)

^b UNIVERSITÉ DE TOURS   (France)

Author keywords

CRF1 receptor antagonist; d Cycloserine; Electrophysiology; Excitability; Hippocampus; Input output curve; Memory; Paroxetine; PTSD

Indexed keywords

4 (2 CHLORO 4 METHOXY 5 METHYLPHENYL) N [2 CYCLOPROPYL 1 (3 FLUORO 4 METHYLPHENYL)ETHYL] 5 METHYL N (2 PROPYNYL) 2 THIAZOLAMINE; CYCLOSERINE; PAROXETINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN DYSFUNCTION; CHEMOPROPHYLAXIS; COGNITIVE DEFECT; CONTROLLED STUDY; DRUG EFFECT; HIPPOCAMPAL CA1 REGION; MALE; MEMORY; MOUSE; NERVE CELL EXCITABILITY; NONHUMAN; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; SYNAPTIC TRANSMISSION; TASK PERFORMANCE;

ANIMALS; BEHAVIOR, ANIMAL; COGNITION DISORDERS; CYCLOSERINE; ELECTROSHOCK; HIPPOCAMPUS; HYDROCARBONS, HALOGENATED; MALE; MICE; PAROXETINE; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; SEROTONIN UPTAKE INHIBITORS; STRESS, PSYCHOLOGICAL; THIAZINES; TIME FACTORS;

EID: 84879202113     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-013-3020-1     Document Type: Article

References (61)

1. Acheson DT, Gresack JE, Risbrough VB (2012) Hippocampal dysfunction effects on context memory: possible etiology for posttraumatic stress disorder. Neuropharmacology 62:674-685
2. Adamec R, Fougere D, Risbrough V (2010) CRF receptor blockade prevents initiation and consolidation of stress effects on affect in the predator stress model of PTSD. Int J Neuropsychopharmacol 13:747-757
3. Adamec R, Muir C, Grimes M, Pearcey K (2007) Involvement of noradrenergic and corticoid receptors in the consolidation of the lasting anxiogenic effects of predator stress. Behav Brain Res 179:192-207
4. Arnsten AF (2009) Stress signalling pathways that impair prefrontal cortex structure and function. Nat Rev Neurosci 10:410-422
5. Baker DG, West SA, Nicholson WE, Ekhator NN, Kasckow JW, Hill KK, Bruce AB, Orth DN, Geracioti TD Jr (1999) Serial CSF corticotropin-releasing hormone levels and adrenocortical activity in combat veterans with posttraumatic stress disorder. Am J Psychiatry 156:585-588
6. Benowitz LI, Routtenberg A (1997) GAP-43: an intrinsic determinant of neuronal development and plasticity. Trends Neurosci 20:84-91
7. Bremner JD, Licinio J, Darnell A, Krystal JH, Owens MJ, Southwick SM, Nemeroff CB, Charney DS (1997) Elevated CSF corticotropin-releasing factor concentrations in posttraumatic stress disorder. Am J Psychiatry 154:624-629
8. Bremner JD, Vermetten E (2004) Neuroanatomical changes associated with pharmacotherapy in posttraumatic stress disorder. Ann N Y Acad Sci 1032:154-157
9. Brewin CR, Kleiner JS, Vasterling JJ, Field AP (2007) Memory for emotionally neutral information in posttraumatic stress disorder: a meta-analytic investigation. J Abnorm Psychol 116:448-463
10. Chen Y, Dube CM, Rice CJ, Baram TZ (2008) Rapid loss of dendritic spines after stress involves derangement of spine dynamics by corticotropin-releasing hormone. J Neurosci 28:2903-2911
11. de Kleine RA, Hendriks GJ, Kusters WJ, Broekman TG, van Minnen A (2012) A Randomized placebo-controlled trial of d-cycloserine to enhance exposure therapy for posttraumatic stress disorder. Biol Psychiatry 71:962-968
12. De Kloet ER, Karst H, Joels M (2008) Corticosteroid hormones in the central stress response: quick-and-slow. Front Neuroendocrinol 29:268-272
13. De Kloet ER, Oitzl MS, Joels M (1999) Stress and cognition: are corticosteroids good or bad guys? Trends Neurosci 22:422-426
14. Donohue HS, Gabbott PL, Davies HA, Rodriguez JJ, Cordero MI, Sandi C, Medvedev NI, Popov VI, Colyer FM, Peddie CJ, Stewart MG (2006) Chronic restraint stress induces changes in synapse morphology in stratum lacunosum-moleculare CA1 rat hippocampus: a stereological and three-dimensional ultrastructural study. Neuroscience 140:597-606
15. Fujishiro J, Imanishi T, Onozawa K, Tsushima M (2002) Comparison of the anticholinergic effects of the serotonergic antidepressants, paroxetine, fluvoxamine and clomipramine. Eur J Pharmacol 454:183-188
16. Griebel G, Holsboer F (2012) Neuropeptide receptor ligands as drugs for psychiatric diseases: the end of the beginning? Nat Rev Drug Discov 11:462-478
17. 1 receptor antagonist: II. Characterization in rodent models of stress-related disorders. J Pharmacol Exp Ther 301:333-345
18. Hajszan T, Maclusky NJ, Leranth C (2005) Short-term treatment with the antidepressant fluoxetine triggers pyramidal dendritic spine synapse formation in rat hippocampus. Eur J Neurosci 21:1299-1303
19. Hofmann SG, Meuret AE, Smits JA, Simon NM, Pollack MH, Eisenmenger K, Shiekh M, Otto MW (2006) Augmentation of exposure therapy with d-cycloserine for social anxiety disorder. Arch Gen Psychiatry 63:298-304
20. Holmes A, Heilig M, Rupniak NM, Steckler T, Griebel G (2003) Neuropeptide systems as novel therapeutic targets for depression and anxiety disorders. Trends Pharmacol Sci 24:580-588
21. Holsboer F, Ising M (2008) Central CRH system in depression and anxiety - evidence from clinical studies with CRH1 receptor antagonists. Eur J Pharmacol 583:350-357
22. Hubbard DT, Nakashima BR, Lee I, Takahashi LK (2007) Activation of basolateral amygdala corticotropin-releasing factor 1 receptors modulates the consolidation of contextual fear. Neuroscience 150:818-828
23. Ivy AS, Rex CS, Chen Y, Dube C, Maras PM, Grigoriadis DE, Gall CM, Lynch G, Baram TZ (2010) Hippocampal dysfunction and cognitive impairments provoked by chronic early-life stress involve excessive activation of CRH receptors. J Neurosci 30:13005-13015
24. Kerr DS, Campbell LW, Applegate MD, Brodish A, Landfield PW (1991) Chronic stress-induced acceleration of electrophysiologic and morphometric biomarkers of hippocampal aging. J Neurosci 11:1316-1324
25. Kohda K, Harada K, Kato K, Hoshino A, Motohashi J, Yamaji T, Morinobu S, Matsuoka N, Kato N (2007) Glucocorticoid receptor activation is involved in producing abnormal phenotypes of single-prolonged stress rats: a putative post-traumatic stress disorder model. Neuroscience 148:22-33
26. Ledgerwood L, Richardson R, Cranney J (2004) d-Cycloserine and the facilitation of extinction of conditioned fear: consequences for reinstatement. Behav Neurosci 118:505-513
27. Ledgerwood L, Richardson R, Cranney J (2005) d-Cycloserine facilitates extinction of learned fear: effects on reacquisition and generalized extinction. Biol Psychiatry 57:841-847
28. Li F, Tsien JZ (2009) Memory and the NMDA receptors. N Engl J Med 361:302-303
29. Li X, Han F, Liu D, Shi Y (2010) Changes of Bax, Bcl-2 and apoptosis in hippocampus in the rat model of post-traumatic stress disorder. Neurol Res 32:579-586
30. Litz BT, Salters-Pedneault K, Steenkamp MM, Hermos JA, Bryant RA, Otto MW, Hofmann SG (2012) A randomized placebo-controlled trial of d-cycloserine and exposure therapy for posttraumatic stress disorder. J Psychiatr Res 46:1184-1190
31. McEwen BS (2000) Effects of adverse experiences for brain structure and function. Biol Psychiatry 48:721-731
32. McEwen BS, Sapolsky RM (1995) Stress and cognitive function. Curr Opin Neurobiol 5:205-216
33. Naudon L, Hotte M, Jay TM (2007) Effects of acute and chronic antidepressant treatments on memory performance: a comparison between paroxetine and imipramine. Psychopharmacology (Berl) 191:353-364
34. Nemeroff CB, Owens MJ (2004) Pharmacologic differences among the SSRIs: focus on monoamine transporters and the HPA axis. CNS Spectr 9:23-31
35. Overstreet DH, Griebel G (2004) Antidepressant-like effects of CRF1 receptor antagonist SSR125543 in an animal model of depression. Eur J Pharmacol 497:49-53
36. Philbert J, Pichat P, Beeske S, Decobert M, Belzung C, Griebel G (2011) Acute inescapable stress exposure induces long-term sleep disturbances and avoidance behavior: a mouse model of post-traumatic stress disorder (PTSD). Behav Brain Res 221:149-154
37. 1 receptor antagonist SSR125543 attenuates long-term cognitive deficit induced by acute inescapable stress in mice, independently from the hypothalamic pituitary adrenal axis. Pharmacol Biochem Behav 102:415-422
38. Pichat P, Bergis OE, Terranova JP, Urani A, Duarte C, Santucci V, Gueudet C, Voltz C, Steinberg R, Stemmelin J, Oury-Donat F, Avenet P, Griebel G, Scatton B (2007) SSR180711, a novel selective alpha7 nicotinic receptor partial agonist: (II) efficacy in experimental models predictive of activity against cognitive symptoms of schizophrenia. Neuropsychopharmacology 32:17-34
39. Poleszak E, Wlaz P, Wrobel A, Fidecka S, Nowak G (2008) NMDA/glutamate mechanism of magnesium-induced anxiolytic-like behavior in mice. Pharmacol Rep 60:655-663
40. Rebaudo R, Melani R, Balestrino M, Izvarina N (2001) Electrophysiological effects of sustained delivery of CRF and its receptor agonists in hippocampal slices. Brain Res 922:112-117
41. Ressler KJ, Rothbaum BO, Tannenbaum L, Anderson P, Graap K, Zimand E, Hodges L, Davis M (2004) Cognitive enhancers as adjuncts to psychotherapy: use of d-cycloserine in phobic individuals to facilitate extinction of fear. Arch Gen Psychiatry 61:1136-1144
42. Rey M, Carlier E, Soumireu-Mourat B (1987) Effects of corticosterone on hippocampal slice electrophysiology in normal and adrenalectomized BALB/c mice. Neuroendocrinology 46:424-429
43. Roozendaal B, McEwen BS, Chattarji S (2009) Stress, memory and the amygdala. Nat Rev Neurosci 10:423-433
44. Rorick-Kehn LM, Hart JC, McKinzie DL (2005) Pharmacological characterization of stress-induced hyperthermia in DBA/2 mice using metabotropic and ionotropic glutamate receptor ligands. Psychopharmacology 1-15
45. Rouaud E, Billard JM (2003) d-Cycloserine facilitates synaptic plasticity but impairs glutamatergic neurotransmission in rat hippocampal slices. Br J Pharmacol 140:1051-1056
46. Sairanen M, O'Leary OF, Knuuttila JE, Castren E (2007) Chronic antidepressant treatment selectively increases expression of plasticity-related proteins in the hippocampus and medial prefrontal cortex of the rat. Neuroscience 144:368-374
47. Sapolsky RM (2000) Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders. Arch Gen Psychiatry 57:925-935
48. Schuff N, Neylan TC, Fox-Bosetti S, Lenoci M, Samuelson KW, Studholme C, Kornak J, Marmar CR, Weiner MW (2008) Abnormal N-acetylaspartate in hippocampus and anterior cingulate in posttraumatic stress disorder. Psychiatry Res 162:147-157
49. Siegmund A, Wotjak CT (2006) Toward an animal model of posttraumatic stress disorder. Ann N Y Acad Sci 1071:324-334
50. Sousa N, Lukoyanov NV, Madeira MD, Almeida OF, Paula-Barbosa MM (2000) Reorganization of the morphology of hippocampal neurites and synapses after stress-induced damage correlates with behavioral improvement. Neuroscience 97:253-266
51. Surget A, Wang Y, Leman S, Ibarguen-Vargas Y, Edgar N, Griebel G, Belzung C, Sibille E (2009) Corticolimbic transcriptome changes are state-dependent and region-specific in a rodent model of depression and of antidepressant reversal. Neuropsychopharmacology 34:1363-1380
52. Tokarski K, Czyrak A, Mackowiak M, Wedzony K, Bijak M (1996) Prolonged treatment with antidepressants increases the 5-HT1A-mediated inhibition of hippocampal neurons without changing the 5-HT1A receptor binding. Acta Physiol Hung 84:343-344
53. Urani A, Philbert J, Cohen C, Griebel G (2011) The corticotropin- releasing factor 1 receptor antagonist, SSR125543, and the vasopressin 1b receptor antagonist, SSR149415, prevent stress-induced cognitive impairment in mice. Pharmacol Biochem Behav 98:425-431
54. Van PK, Viau V, Bittencourt JC, Chan RK, Li HY, Arias C, Prins GS, Perrin M, Vale W, Sawchenko PE (2000) Distribution of mRNAs encoding CRF receptors in brain and pituitary of rat and mouse. J Comp Neurol 428:191-212
55. Vermetten E, Vythilingam M, Southwick SM, Charney DS, Bremner JD (2003) Long-term treatment with paroxetine increases verbal declarative memory and hippocampal volume in posttraumatic stress disorder. Biol Psychiatry 54:693-702
56. Vidal C, Jordan W, Zieglgansberger W (1986) Corticosterone reduces the excitability of hippocampal pyramidal cells in vitro. Brain Res 383:54-59
57. Wang H, Zuo D, He B, Qiao F, Zhao M, Wu Y (2012) Conditioned fear stress combined with single-prolonged stress: a new PTSD mouse model. Neurosci Res 73:142-152
58. Woon FL, Sood S, Hedges DW (2010) Hippocampal volume deficits associated with exposure to psychological trauma and posttraumatic stress disorder in adults: a meta-analysis. Prog Neuropsychopharmacol Biol Psychiatry 34:1181-1188
59. Yamamoto S, Morinobu S, Fuchikami M, Kurata A, Kozuru T, Yamawaki S (2008) Effects of single prolonged stress and d-cycloserine on contextual fear extinction and hippocampal NMDA receptor expression in a rat model of PTSD. Neuropsychopharmacology 33:2108-2116
60. Youssef FF, Addae JI, Stone TW (2006) NMDA-induced preconditioning attenuates synaptic plasticity in the rat hippocampus. Brain Res 1073-1074:183-189
61. Zahorodna A, Tokarski K, Hess G (2006) Imipramine treatment ameliorates corticosterone-induced alterations in the effects of 5-HT1A and 5-HT4 receptor activation in the CA1 area of rat hippocampus. Eur Neuropsychopharmacol 16:383-390