Modulation of learning and anxiety by corticotropin-releasing factor (CRF) and stress: Differential roles of CRF receptors 1 and 2

Journal of Neuroscience

Volumn 19, Issue 12, 1999, Pages 5016-5025

  Radulovic, Jelena ^a   Rühmann, Andreas ^a   Liepold, Thomas ^a   Spiess, Joachim ^a  

^a MAX PLANCK INSTITUTE OF EXPERIMENTAL MEDICINE   (Germany)

Author keywords

Anxiety; CRF receptor 1; CRF receptor 2; Fear conditioning; Hippocampus; Lateral septum; Stress

Indexed keywords

CORTICOTROPIN RELEASING FACTOR; CORTICOTROPIN RELEASING FACTOR ANTAGONIST; CORTICOTROPIN RELEASING FACTOR RECEPTOR;

ANIMAL EXPERIMENT; ANXIETY; ARTICLE; CONTROLLED STUDY; FEAR; HIPPOCAMPUS; IMMOBILIZATION STRESS; LEARNING; LEARNING DISORDER; MALE; MEMORY CONSOLIDATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; STATE DEPENDENT LEARNING; STRESS;

EID: 0344142487     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.19-12-05016.1999     Document Type: Article

References (52)

1. Aiba A, Chen C, Herrup K, Rosenmund C, Stevens C F, Tonegawa (1994) Reduced hippocampal long-term potentiation and context-specific deficit in associative learning in mGluR1 mutant mice. Cell 79:366-375.
2. Behan DP, Heinrichs SC, Troncoso JC, Liu XJ, Kawas CH, Ling N, De Souza EB (1995) Displacement of corticotropin releasing factor from its binding protein as a possible treatment for Alzheimer's disease. Nature 378:284-287.
3. Behan D, Khongsaly O, Ling N, De Souza EB (1996) Urocortin interaction with corticotropin-releasing factor (CRF) binding protein (CRF-BP): a novel mechanism for elevating "free" CRF levels in human brain. Brain Res 725:263-267.
4. Cador M, Ahmed S H, Koob GF, Le Moal M, Stinus L (1992) Corticotropin-releasing factor induces a place aversion independent of its neuroendocrine role. Brain Res 597:304-309.
5. Chang CP, Pearse RV, O'Connell S, Rosenfeld MG (1993) Identification of a seven transmembrane helix receptor for corticotropin-releasing factor and sauvagine in mammalian brain. Neuron 11:1187-1195.
6. Chalmers DT, Lovenberg TW, De Souza EB (1995) Localization of novel corticotropin-releasing factor receptor (CRF2) mRNA expression to specific subcortical nuclei in rat brain: comparison with CRF1 receptor mRNA expression. J Neurosci 15:6340-6350.
7. Chen R, Lewis KA, Perrin MH, Vale WW (1993) Expression cloning of a human corticotropin-releasing-factor receptor. Proc Natl Acad Sci USA 90:8967-8971.
8. Cummings S, Elde R, Ells J, Lindall A (1983) Corticotropin-releasing factor immunoreactivity is widely distributed within the central nervous system of the rat. J Neurosci 3:1355-1368.
9. Dautzenberg FM, Wille S, Lohmann R, Spiess J (1998) Mapping of the ligand-selective domain of Xenopus laevis CRF receptor: implications for the ligand-binding site. Proc Natl Acad Sci USA 95:4941-4946.
10. De Souza EB (1995) Corticotropin-releasing factor receptors: physiology, pharmacology, biochemistry and role in central nervous system and immune disorders. Psychoneuroendocrinology 20:789-819.
11. Diamant M, de Wied D (1993) Structure-related effects of CRF and CRF-derived peptides: dissociation of behavioral, endocrine and autonomic activity. Neuroendocrinology 57:1071-1081.
12. Donaldson CJ, Sutton SW, Perrin MH, Corrigan AZ, Lewis KA, Rivier J, Vaughan JM, Vale WW (1996) Cloning and characterization of human urocortin. Endocrinology 137:2167-2170.
13. Dunn AJ, Berridge CW (1990) Physiological and behavioral responses to corticotropin-releasing factor administration: is CRF a mediator of anxiety or stress responses? Brain Res Rev 15:71-100.
14. Franklin KBJ, Paxinos G (1997) The mouse brain in stereotaxic coordinates. San Diego: Academic.
15. Garcia R, Jaffard R (1996) Changes in synaptic excitability in the lateral septum associated with contextual and auditory fear conditioning in mice. Eur J Neurosci 8:809-815.
16. Heinrichs SC, Vale EA, Lapsansky J, Behan DP, Mcclure LV, Ling N, De Souza EB, Schulteis G (1997) Enhancement of performance in multiple learning tasks by corticotropin-releasing factor-binding protein ligand inhibitors. Peptides 18:711-716.
17. Henke PG (1990) Hippocampal pathway to the amygdala and stress ulcer development. Brain Res Bull 25:691-696.
18. Kim JJ, Fanselow MS (1992) Modality-specific retrograde amnesia of fear. Science 256:675-677.
19. Kishimoto T, Pearse RV, Lin CR, Rosenfeld MG (1995) A sauvagine/ corticotropin-releasing factor receptor expressed in heart and skeletal muscle. Proc Natl Acad Sci USA 92:1108-1112.
20. Koob G, Heinrichs SC, Menzaghi F, Pich EM, Britton KT (1994) Corticotropin releasing factor, stress and behavior. Semin Neurosci 6:221-229.
21. Koob GF, Bloom FE (1985) Corticotropin-releasing factor and behavior. Fed Proc 44:259-263.
22. Kozicz T, Yanaihara H, Arimura A (1998) Distribution of urocortin-like immunoreactivity in the central nervous system of the rat. J Comp Neurol 391:1-10.
23. Liang KC, Lee EHY (1988) Intra-amygdala injections of corticotropin-releasing factor facilitate inhibitory avoidance learning and reduce exploratory behavior in mice. Psychopharmacology 96:232-236.
24. Lovenberg TW, Liaw CW, Grigoriadis DE, Clevenger W, Chalmers DT, De Souza EB, Oltersdorf T (1995) Cloning and characterization of a functionally distinct corticotropin-releasing factor receptor subtype from rat brain. Proc Natl Acad Sci USA 92:836-840.
25. Maren S, Aharonov G, Fanselow MS (1997) Neurotoxic lesions of the dorsal hippocampus and Pavlovian fear conditioning in rats. Behav Brain Res 88:261-274.
26. Menard J, Treit D (1996) Lateral and medial septal lesions reduce anxiety in the plus-maze and probe-burying tests. Physiol Behav 60:845-853.
27. Olschowka JA, O'Donohue TL, Mueller GP, Jacobowitz DM (1982) The distribution of corticotropin releasing factor-like immunoreactive neurons in rat brain. Peptides 3:995-1015.
28. Perrin M, Donaldson C, Chen R, Blount A, Berggren T, Bilezikjian L, Sawchenko P, Vale W (1995) Identification of a second corticotropin-releasing factor receptor gene and characterization of a cDNA expressed in heart. Proc Natl Acad Sci USA 92:2969-2973.
29. Phillips RG, LeDoux JE (1992) Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. Behav Neurosci 106:274-285.
30. Potter E, Behan DP, Fischer WH, Linton EA, Lowry PJ, Vale WW (1991) Cloning and characterization of the cDNAs for human and rat corticotropin releasing factor-binding proteins. Nature 349:423-426.
31. Potter E, Behan DP, Linton EA, Lowry PJ, Sawchenko PE, Vale WW (1992) The central distribution of a corticotropin releasing factor (CRF)-binding protein predicts multiple sites and modes of action. Proc Natl Acad Sci USA 89:4192-4196.
32. Radulovic J, Sydow S, Spiess J (1998a) Characterization of native corticotropin-releasing factor receptor type 1 (CRFR1) in the rat and mouse central nervous system. J Neurosci Res 54:507-521.
33. Radulovic J, Kammermeier J, Spiess J (1998b) Relationship between FOS production and classical fear conditioning: effects of novelty, latent inhibition and unconditioned stimulus preexposure. J Neurosci 18:7452-7461.
34. Radulovic J, Kammermeier J, Spiess J (1998c) Generalization of fear responses in C57BL/6N mice subjected to one-trial foreground contextual fear conditioning. Behav Brain Res 95:179-189.
35. Reul JMHM, De Kloet ER (1985) Two receptor systems for corticosterone in rat brain: microdistribution and differential occupation. Endocrinology 117:2505-2511.
36. Rudy JW, Morledge P (1994) Ontogeny of contextual fear conditioning in rats: implications for consolidation, infantile amnesia, and hippocampal system function. Behav Neurosci 108:227-234.
37. Rühmann A, Köpke AKE, Dautzenberg FM, Spiess J (1996) Synthesis and characterization of a photoactivable analog of corticotropin-releasing factor for specific receptor labeling. Proc Natl Acad Sci USA 93:10609-10613.
38. Rühmann A, Bonk I, Lin CR, Rosenfeld MG, Spiess J (1998) Structural requirements for peptidic antagonists of the corticotropin-releasing factor receptor (CRFR): development of CRFR2β selective antisauvagine-30. Proc Natl Acad Sci USA 95:15264-15269.
39. Schulkin J, Gold PW, McEwen BS (1998) Induction of corticotropin-releasing hormone gene expression by glucocorticoids: implication for understanding the states of fear and anxiety and allostatic load. Psychoneuroendocrinology 23:219-243.
40. Smith GW, Aubry J-M, Dellu F, Contarino A, Bilezikjian LM, Gold LH, Chen R, Marchuk Y, Hauser C, Bentley CA, Sawchenko PE, Koob GF, Vale W, Lee K-F (1998) Corticotropin releasing factor receptor 1-deficient mice display decreased anxiety, impaired stress response, and aberrant neuroendocrine development. Neuron 20:1093-1102.
41. Smith MA, Makino S, Kvetnansky R, Post RM (1995) Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus. J Neurosci 15:1961-1970.
42. Spiess J, Rivier J, Rivier C, Vale W (1981) Primary structure of corticotropin-releasing factor from ovine hypothalamus. Proc Natl Acad Sci USA 78:6517-6521.
43. Stenzel P, Kesterson R, Yeung W, Cone RD, Rittenberg MB, Stenzel-Poore MP (1995) Identification of a novel murine receptor for corticotropin-releasing hormone expressed in heart. Mol Endocrinol 9:637-645.
44. Stiedl O, Spiess J (1997) Effect of tone-dependent fear conditioning on heart rate and behavior of C57BL/6N mice. Behav Neurosci 111:703-711.
45. Sutton RE, Koob GF, Je Moal M, Rivier J, Vale W (1982) Corticotropin releasing factor produces behavioural activation in rats. Nature 297:331-333.
46. Thomas E, Yadin E (1980) Multiple unit activity in the septum during Pavlovian aversive conditioning: evidence for an inhibitory role for the septum. Exp Neurol 69:50-60.
47. Timpl P, Spanagel R, Sillaber I, Kresse A, Reul JMHM, Stalla GK, Blanquet V, Sleckler T, Holsboer F, Wurst W (1998) Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1. Nat Genet 19:162-166.
48. Tsien JZ, Huerta PT, Tonegawa S (1996) The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory. Cell 87:1327-1338.
49. Vale W, Spiess J, Rivier C, Rivier J (1981) Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and β-endorphin. Science 213:1394-1397.
50. Vaughan J, Donaldson C, Bittencourt J, Perrin MH, Lewis K, Sutton S, Chan R, Turnbull AV, Lovejoy D, Rivier C, Rivier J, Sawchenko PE, Vale W (1995) Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor. Nature 378:287-292.
51. Vita N, Laurent P, Lefort S, Chalon P, Lelias J-M, Kaghad M, Le Fur G, Caput D, Ferrara P (1993) Primary structure and functional expression of mouse pituitary and human brain corticotrophin releasing factor receptors. FEBS Lett:335:1-5.
52. Yadin E, Thomas E (1981) Septal correlates of conditioned inhibition and excitation. J Comp Physiol Psychol 95:331-340.