Expression, binding, and signaling properties of CRF2(a) receptors endogenously expressed in human retinoblastoma Y79 cells: Passage-dependent regulation of functional receptors

Journal of Neurochemistry

Volumn 104, Issue 4, 2008, Pages 926-936

  Gutknecht, Eric ^a,b   Hauger, Richard L ^c   Van Der Linden, Ilse ^a   Vauquelin, Georges ^b   Dautzenberg, Frank M ^a  

^a JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

^b VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Corticotropin releasing factor receptor desensitization; Corticotropin releasing factor receptor signaling; Cyclic AMP; Ligand binding; mRNA expression

Indexed keywords

5 CHLORO 4 [N (CYCLOPROPYLMETHYL) N PROPYLAMINO] 2 METHYL 6 (2,4,6 TRICHLOROANILINO)PYRIMIDINE; ANTISAUVAGINE 30; CORTICOTROPIN RELEASING FACTOR; CORTICOTROPIN RELEASING FACTOR RECEPTOR 1; CORTICOTROPIN RELEASING FACTOR RECEPTOR 2; CORTICOTROPIN RELEASING FACTOR RECEPTOR 2A; CORTICOTROPIN RELEASING FACTOR RECEPTOR 2B; CORTICOTROPIN RELEASING FACTOR RECEPTOR 2C; CYCLIC AMP; MESSENGER RNA; SAUVAGINE; UNCLASSIFIED DRUG; UROCORTIN I;

ARTICLE; CANCER CELL CULTURE; CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DESENSITIZATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IC 50; LIGAND BINDING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RETINOBLASTOMA; SIGNAL TRANSDUCTION; UPREGULATION;

CELL CULTURE TECHNIQUES; CELL LINE, TUMOR; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; PEPTIDES; PROTEIN BINDING; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; RETINOBLASTOMA; SIGNAL TRANSDUCTION;

OVIS;

EID: 38449093484     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2007.05052.x     Document Type: Article

References (51)

1. Bale T. L. Vale W. W. (2004) CRF and CRF receptors: role in stress responsivity and other behaviors. Annu. Rev. Toxicol. 44, 525 557.
2. Brar B. K., Chen A., Perrin M. H. Vale W. (2004) Specificity and regulation of extracellularly regulated kinase-1/2 phosphorylation through corticotropin-releasing factor (CRF) receptors 1 and 2b by the CRF/urocortin family of peptides. Endocrinology 145, 1718 1729.
3. Chalmers D. T., Lovenberg T. W. De Souza E. B. (1996) Localization of novel corticotropin-releasing factor receptor (CRF2) mRNA expression to specific subcortical nuclei in rat brain: comparison with CRF1 receptor mRNA expression. J. Neurosci. 15, 6340 6350.
4. Chen C., Dagnino R. Jr., De Souza E. B. et al. (1996) Design and synthesis of a series of non-peptide high-affinity human corticotropin-releasing factor1 receptor antagonists. J. Med. Chem. 39, 4358 4360.
5. Clark R. B., Knoll B. J. Barber R. (1999) Partial agonists and G protein-coupled receptor desensitization. Trends Pharmacol. Sci. 20, 279 286.
6. Dautzenberg F. M. Hauger R. L. (2002) The CRF peptide family and their receptors: yet more partners discovered. Trends Pharmacol. Sci. 23, 71 77.
7. Dautzenberg F. M., Dietrich K., Palchaudhuri M. R. Spiess J. (1997) Identification of two corticotropin-releasing factor receptors with high ligand selectivity from Xenopus laevis: unusual pharmacology of the type 1 receptor. J. Neurochem. 69, 1640 1649.
8. Dautzenberg F. M., Mevenkamp G., Wille S. Hauger R. L. (1999) N-terminal splice variants of the type I PACAP receptor: isolation, characterization and ligand binding/selectivity determinants. J. Neuroendocrinol. 11, 941 949.
9. Dautzenberg F. M., Higelin J. Teichert U. (2000) Functional characterization of corticotropin-releasing factor type 1 receptor endogenously expressed in human embryonic kidney 293 cells. Eur. J. Pharmacol. 390, 51 59.
10. 1 receptors: a potential mechanism regulating stress adaptation. Am. J. Physiol. Regul. Integr. Comp. Physiol. 280, R935 R946.
11. Dautzenberg F. M., Py-Lang G., Higelin J., Fischer C., Wright M. B. Huber G. (2001b) Different binding modes of amphibian and human CRF type 1 and type 2 receptors: evidence for evolutionary differences. J. Pharmacol. Exp. Ther. 296, 113 120.
12. 2 receptor mediate differential binding of CRF ligands in comparison to its human counterpart. Mol. Pharmacol. 61, 1132 1139.
13. 1 receptor desensitization. Biochem. Biophys. Res. Commun. 298, 303 308.
14. Dautzenberg F. M., Gutknecht E., Van der Linden I., Olivares-Reyes J. A., Durrenberger F. Hauger R. L. (2004a) Cell-type specific calcium signaling by corticotropin-releasing factor type 1 (CRF1) and 2a (CRF2(a)) receptors: phospholipase C-mediated responses in human embryonic kidney 293 but not SK-N-MC neuroblastoma cells. Biochem. Pharmacol. 68, 1833 1844.
15. Dautzenberg F. M., Higelin J., Wille S. Brauns O. (2004b) Molecular cloning and functional expression of the mouse CRF2(a) receptor splice variant. Regul. Pept. 121, 89 97.
16. Dermitzaki E., Tsatsanis C., Minas V. et al. (2007) Corticotropin- releasing factor (CRF) and the urocortins differentially regulate catecholamine secretion in human and rat adrenals, in a CRF receptor type-specific manner. Endocrinology 148, 1524 1538.
17. Dieterich K. D. DeSouza E. B. (1996) Functional corticotropin-releasing factor receptors in human neuroblastoma cells. Brain Res. 733, 113 118.
18. Donaldson C., Sutton S., Perrin M. H., Corrigan A. Z., Lewis K. A., Rivier J., Vaughan J. M. Vale W. W. (1996) Cloning and characterization of human urocortin. Endocrinology 137, 2167 2170.
19. Grigoriadis D. E. (2005) The corticotropin-releasing factor receptor: a novel target for the treatment of depression and anxiety-related disorders. Expert Opin. Ther. Targets 9, 651 684.
20. Gulyas J., Rivier C., Perrin M., Koerber S. C., Sutton S., Corrigan A., Lahrichi S. L., Craig A. G., Vale W. Rivier J. (1995) Potent, structurally constrained agonists and competitive antagonists of corticotropin-releasing factor. Proc. Natl Acad. Sci. USA 92, 10575 10579.
21. Harmar A. J. (2001) Family-B G-protein-coupled receptors. Genome Biol. 2, 3013 Reviews.
22. Hauger R. L., Dautzenberg F. M., Flaccus A., Liepold T. Spiess J. (1997) Regulation of corticotropin-releasing factor receptor function in human Y-79 retinoblastoma cells: rapid and reversible homologous desensitization but prolonged recovery. J. Neurochem. 68, 2308 2316.
23. Hauger R. L., Grigoriadis D. E., Dallman M. F., Plotsky P. M., Vale W. W. Dautzenberg F. M. (2003a) International union of pharmacology. XXXVI. Current status of the nomenclature for receptors for corticotropin-releasing factor and their ligands. Pharmacol. Rev. 55, 21 26.
24. 1 receptor phosphorylation and desensitization by protein kinase C: a possible role in stress adaptation. J. Pharmacol. Exp. Ther. 306, 794 806.
25. Hauger R. L., Risbrough V., Brauns O. Dautzenberg F. M. (2006) Corticotropin releasing factor (CRF) receptor signaling in the central nervous system: new molecular targets. CNS Neurol. Disord. Drug Targets. 5, 453 479.
26. 125I-antisauvagine-30; a novel and specific high-affinity radioligand for the characterization of corticotropin-releasing factor type 2 receptors. Neuropharmacology 40, 114 122.
27. Hoare S. R., Sullivan S. K., Fan J., Khongsaly K. Grigoriadis D. E. (2005) Peptide ligand binding properties of the corticotropin-releasing factor (CRF) type 2 receptor: pharmacology of endogenously expressed receptors, G-protein-coupling sensitivity and determinants of CRF2 receptor selectivity. Peptides 26, 457 470.
28. Hsu S. Y. Hsueh A. J. W. (2001) Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor. Nat. Med. 7, 605 611.
29. Iredale P. A. Duman R. S. (1997) Glucocorticoid regulation of corticotropin-releasing factor1 receptor expression in pituitary-derived AtT-20 cells. Mol. Pharmacol. 51, 794 799.
30. Iredale P. A, Terwilliger R., Widnell K. L., Nestler E. J. Duman R. S. (1996) Differential regulation of corticotropin-releasing factor1 receptor expression by stress and agonist treatments in brain and cultured cells. Mol. Pharmacol. 50, 1103 1110.
31. Kenakin T. (1997) Differences between natural and recombinant G protein-coupled receptor systems with varying receptor/G protein stoichiometry. Trends Pharmacol. Sci. 18, 456 464.
32. Kiang J. G., Ding X. Z., Gist I. D., Jones R. R. Tsokos G. C. (1998) Corticotropin-releasing factor induces phosphorylation of phospholipase C-gamma at tyrosine residues via its receptor 2beta in human epidermoid A-431 cells. Eur. J. Pharmacol. 363, 203 210.
33. 2γ receptor. Mol. Endocrinol. 12, 1077 1085.
34. Lewis K., Li C., Perrin M. H. et al. (2001) Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor. Proc. Natl Acad. Sci. USA 98, 7570 7575.
35. von Mentzer B., Murata Y., Ahlstedt I., Lindstrom E. Martinez V. (2007) Functional CRF receptors in BON cells stimulate serotonin release. Biochem. Pharmacol. 73, 805 813.
36. Nanda S. A., Roseboom P. H., Nash G. A., Speers J. M. Kalin N. H. (2004) Characterization of the human corticotropin-releasing factor2(a) receptor promoter: regulation by glucocorticoids and the cyclic adenosine 5′-monophosphate pathway. Endocrinology 145, 5605 5615.
37. Nemoto T., Mano-Otagiri A. Shibasaki T. (2005) Urocortin 2 induces tyrosine hydroxylase phosphorylation in PC12 cells. Biochem. Biophys. Res. Commun. 330, 821 831.
38. 1 receptor phosphorylation and β-arrestin2 recruitment: a mechanism regulating stress and anxiety responses. Am. J. Physiol. Regul. Integr. Comp. Physiol. 293, R209 R222.
39. Palchaudhuri M. R., Hauger R. L., Wille S., Fuchs E. Dautzenberg F. M. (1999) Isolation and pharmacological characterization of two functional splice variants of corticotropin-releasing factor type 2 receptor from Tupaia belangeri. J. Neuroendocrinol. 11, 419 428.
40. Parham K.L., Zervou S., Karteris E., Catalano R. D., Old R. W. Hillhouse E.W. (2004) Promoter analysis of human corticotropin-releasing factor (CRF) type 1 receptor and regulation by CRF and urocortin. Endocrinology 145, 3971 3983.
41. Perrin M. H. Vale W. (2002) Chapter 25: corticotropin-releasing factor receptors, in Understanding G Protein-Coupled Receptors and Their Role in the CNS (Pangalos M. N. Davies C. H., eds pp. 505 526. Oxford University Press, New York.
42. Perrin M. H., Sutton S. W., Cervini L. A., Rivier J. E. Vale W. W. (1999) Comparison of an agonist, urocortin, and an antagonist, astressin, as radioligands for characterization of corticotropin-releasing factor receptors. J. Pharmacol. Exp. Ther. 288, 729 734.
43. Radulovic M., Hippel C. Spiess J. (2003) Corticotropin-releasing factor (CRF) rapidly suppresses apoptosis by acting upstream of the activation of caspases. J. Neurochem. 84, 1074 1085.
44. Reyes T. M., Lewis K., Perrin M. H. et al. (2001) Urocortin II: a member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors. Proc. Natl Acad. Sci. USA 98, 2843 2848.
45. Ruhmann A., Kopke A. K., Dautzenberg F. M. Spiess J. (1996) Synthesis and characterization of a photoactivatable analog of corticotropin-releasing factor for specific receptor labeling. Proc. Natl Acad. Sci. USA. 93, 10609 10613.
46. Ruhmann A., Bonk I., Lin C. R., Rosenfeld M. G. Spiess J. (1998) Structural requirements for peptidic antagonists of the corticotropin-releasing factor receptor (CRFR): development of CRFR2beta-selective antisauvagine-30. Proc. Natl Acad. Sci. USA 95, 15264 15269.
47. Sahuque L. L., Kullberg E. F., Mcgeehan A. J., Kinder J. R., Hicks M. P., Blanton M.G., Janak P. H. Olive M. F. (2006) Anxiogenic and aversive effects of corticotropin-releasing factor (CRF) in the bed nucleus of the stria terminalis in the rat: role of CRF receptor subtypes. Psychopharmacology (Berl.) 186, 122 132.
48. Sanchez M. M., Young L. J., Plotsky P. M. Insel T. R. (1999) Autoradiographic and in situ hybridization localization of corticotropin- releasing factor 1 and 2 receptors in nonhuman primate brain. J. Comp. Neurol. 408, 365 377.
49. Steckler T. Dautzenberg F. M. (2006) Corticotropin-releasing factor receptor antagonists in affective disorders and drug dependence - an update. CNS Neurol. Disord. Drug Targets 5, 147 165.
50. Vita N., Laurent P., Lefort S., Chalon P., Lelias J. M., Kaghad M., Le Fur G., Caput D. Ferrara P. (1993) Primary structure and functional expression of mouse pituitary and human brain corticotrophin releasing factor receptors. FEBS Lett. 335, 1 5.
51. Xu G., Rabadan-Diehl C., Nikodemova M., Wynn P., Spiess J. Aguilera G. (2001) Inhibition of corticotropin releasing hormone type-1 receptor translation by an upstream AUG triplet in the 5′ untranslated region. Mol. Pharmacol. 59, 485 492.