Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression

Current Opinion in Pharmacology

Volumn 2, Issue 1, 2002, Pages 23-33

  Reul, Johannes M H M ^a   Holsboer, Florian ^a  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOTROPIN RELEASING FACTOR; CORTICOTROPIN RELEASING FACTOR ANTAGONIST; CORTICOTROPIN RELEASING FACTOR RECEPTOR; CORTICOTROPIN RELEASING FACTOR RECEPTOR 1; CORTICOTROPIN RELEASING FACTOR RECEPTOR 2; CRF RECEPTOR TYPE 1; CRF RECEPTOR TYPE 2; NEUROPEPTIDE; R 1219191; RECEPTORS, CORTICOTROPIN RELEASING HORMONE; UNCLASSIFIED DRUG; UROCORTIN;

ANIMAL; ANXIETY; ANXIETY NEUROSIS; ARTICLE; BRAIN; CHEMISTRY; COPING BEHAVIOR; DEPRESSION; DRUG RESEARCH; HUMAN; HYPOPHYSIS ADRENAL SYSTEM; HYPOTHALAMUS HYPOPHYSIS SYSTEM; METABOLISM; NEUROANATOMY; PANIC; PHOBIA; PHYSIOLOGY; POSTTRAUMATIC STRESS DISORDER; PROTEIN FAMILY; PROTEIN LOCALIZATION; STRESS; TRANQUILIZING ACTIVITY; REVIEW;

ANIMALS; ANXIETY; DEPRESSION; HUMANS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; PITUITARY-ADRENAL SYSTEM; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE;

EID: 0036462444     PISSN: 14714892     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1471-4892(01)00117-5     Document Type: Review

References (83)

1. Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin
2. Elevated concentrations of CSF corticotropin-releasing factor-like immunoreactivity in depressed patients
3. Reduced corticotropin-releasing factor binding sites in the frontal cortex of suicide victims
4. Blunted corticotropin and normal cortisol response to human corticotropin-releasing factor in depression
5. Serial assessment of corticotropin-releasing hormone response after dexamethasone in depression implications for pathophysiology of DST nonsuppression
6. Long-term intracerebroventricular infusion of corticotropin-releasing hormone alters neuroendocrine, neurochemical, autonomic, behavioral, and cytokine responses to a systemic inflammatory challenge
7. Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor
8. Urotensin I - A novel CRF-like peptide in catostomus commersoni urophysis
9. Isolation and amino acid composition of sauvagine. An active polypeptide from methanol extracts of the skin of the south american frog phyllomedusa
10. Expression cloning of a human corticotropin-releasing-factor receptor
11. Cloning and characterization of a functionally distinct corticotropin-releasing factor receptor subtype from rat brain
12. 1 receptor mRNA expression
13. 2β receptor mRNAs are differentially distributed between the rat central nervous system and peripheral tissues
14. Urocortin II: A member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors
15. Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor
16. Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor
17. Mouse models of altered CRH-binding protein expression
18. Urocortin expression in rat brain: Evidence against a pervasive relationship of urocortin-containing projections with targets bearing type 2 CRF receptors
19. Do centrally administered neuropeptides access cognate receptors? An analysis in the central corticotropin-releasing factor system
20. Distribution of mRNAs encoding CRF receptors in brain and pituitary of rat and mouse
21. Hypothalamic integration: Organization of the paraventricular and supraoptic nuclei
22. Noradrenergic mechanisms in stress and anxiety: I. preclinical studies
23. Unraveling the central nervous system pathways underlying responses to leptin
24. Organization of ovine corticotropin-releasing factor immunoreactive cells and fibers in the rat brain: An immunohistochemical study
25. Physiology and pharmacology of corticotropin-releasing factor
26. The rationale for corticotropin-releasing hormone receptor (CRH-R) antagonists to treat depression and anxiety
27. Corticotropin-releasing hormone receptor subtypes and emotion
28. Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1
29. Corticotropin releasing factor receptor 1-deficient mice display decreased anxiety, impaired stress response, and aberrant neuroendocrine development
30. Overproduction of corticotropin-releasing factor in transgenic mice: A genetic model of anxiogenic behavior
31. Corticotropin-releasing factor CRF1, but not CRF2, receptors mediate anxiogenic-like behavior
32. 1 receptor antisense oligodeoxynucleotide into the central nucleus of the amygdala reduced anxiety-related behavior in socially defeated rats
33. Differential behavioural effects of chronic infusion of CRH 1 and CRH 2 receptor antisense oligonucleotides into the rat brain
34. Corticotropin-releasing hormone receptor (type 1) antisense targeting reduces anxiety
35. The role of CRF receptor subtypes in stress-induced behavioral responses
36. Receptor binding, behavioral, and electrophysiological profiles of nonpeptide corticotropin-releasing factor subtype 1 receptor antagonists CRA 1000 and CRA 1001
37. CRHR1 Antagonists as novel treatment strategies
38. Brain penetrance, receptor occupancy and anti-stress in vivo efficacy of a small molecule corticotropin-releasing factor, receptor selective antagonist
39. The impact of the nonpeptide corticotropin-releasing hormone antagonist antalamin on behavioral and endocrine responses to stress
40. The CRF receptor 1 antagonist, antalarmin, decreases anxiety as assessed by the shock-probe burying test in rats
41. 1) antagonist
42. Corticotropin releasing factor (CRF) receptor modulators: Progress and opportunities for new therapeutic agents
43. 1 receptor antagonist
44. The development of a potential single photon emission computed tomography (SPECT) imaging agent for the corticotropin-releasing hormone receptor type 1
45. Synthesis and biological activity of flouro-substituted Pyrrolo[2,3-d]pyrimidines: The development of potential positron emission tomography imaging agents for the corticotropin-releasing hormone type 1 receptor
46. Abnormal adaptions to stress and impaired cardiovascular function in mice-lacking corticotropin-releasing hormone receptor-2
47. Mice deficient for corticotropin-releasing hormone receptor-2 display anxiety-like behaviour and are hypersensitive to stress
48. Deletion of Crhr2 reveals an anxiolytic role for corticotropin-releasing hormone receptor-2
49. Behavioral phenotyping of transgenic and knockout mice: Experimental design and evaluation of general health sensory functions, motor abilities, and specific behavioral tests
50. Modulation of learning and anxiety by corticotropin-releasing factor (CRF) and stress: Differential roles of CRF receptors 1 and 2
51. Human urocortin II: Effects of a novel, selective CRF-R2 receptor agonist on anxiety and motor activation in rats
52. The corticosteroid receptor hypothesis of depression
53. Glucocorticoids and depression
54. Cortisol response in the combined dexamethasone/CRH test as predictor of relapse in patients with remitted depression: A prospective study
55. Hyperactivity of CRH neuronal circuits as a target for therapeutic interventions in affective disorders
56. Corticotropin-releasing hormone in depression and post-traumatic stress disorder
57. Hypothalamic peptides in human brain diseases
58. Brain corticosteroid receptor balance in health and disease
59. The brain mineralocorticoid receptor: Greedy for ligand, mysterious in function
60. Expression of corticotropin releasing hormone receptors type I and type II mRNA in suicide victims and controls
61. Corticotropin-releasing hormone receptor type 1 -deficiency enhances hippocampal serotonergic neurotransmission: An in vivo microdialysis study in mutant mice
62. Selective activation of the hypothalamic vasopressinergic system in mice deficient for the corticotropin-releasing hormone receptor 1 is dependent on glucocorticoids
63. Stress-specific regulation of corticotropin releasing hormone receptor expression in the paraventricular and supraoptic nuclei of the hypothalamus in the rat
64. Immune challenge and immobilization stress induce transcription of the gene encoding the CRT receptor in selective nuclei of the rat hypothalamus
65. Regulation of corticotropin-releasing hormone receptor messenger ribonucleic acid in the rat brain and pituitary by glucocorticoids and stress
66. Expression of corticotropin-releasing hormone type 1 receptor in paraventricular nucleus after acute stress
67. Regulation of corticotropin-releasing factor type 1 (CRF1) receptor messenger ribonucleic acid in the paraventricular nucleus of rat hypothalamus by exogenous CRF
68. Regulation of the hypothalamic-pituitary-adrenocortical system in mice deficient for CRH receptors 1 and 2
69. Two receptor systems for corticosterone in rat brain: Microdistribution and differential occupation
70. Psychological stress increases hippocampal mineralocorticoid receptor levels: Involvement of corticotropin-releasing hormone
71. Pituitary and adrenocortical responses to the ovine corticotropin releasing hormone in depressed patients and healthy volunteers
72. Induction of corticotropin-releasing hormone gene expression by glucocorticoids: Implication for understanding the states of fear and anxiety and allostatic load
73. The role of the amygdala in conditioned fear
74. The organization and possible function of amygdaloid corticotropin-releasing factor pathways
75. Effects of the high-affinity corticotropin-releasing hormone receptor I antagonist R121919 in major depression: The first 20 patients treated
76. Role of CRF receptor 1 in central CRF-induced stimulation of colonic propulsion in rats
77. Antalarmin blockade of corticotropin releasing hormone-induced hypertension in rats
78. A polymorphic genomic duplication on human chromosome 15 is a susceptibility factor for panic and phobic disorders
79. Molecular biology of the CRH receptors - In the mood
80. Distribution of corticotropin-releasing factor receptor mRNA expression in the rat brain and pituitary
81. Neuroanatomical basis for facilitation of hypothalamic-pituitary-adrenal responses to a novel stressor after chronic stress
82. 1A glucocorticoid, and mineralocorticoid receptor in rat and human hippocampus - Implications for the neurobiology of depression
83. A cholecystokinin-mediated pathway to the paraventricular thalamus is recruited in chronically stressed rats and regulates hypothalamic-pituitary-adrenal function