Elevated CSF corticotropin-releasing factor concentrations in posttraumatic stress disorder

American Journal of Psychiatry

Volumn 154, Issue 5, 1997, Pages 624-629

  Bremner, J Douglas ^a   Licinio, Julio ^b   Darnell, Adam ^b   Krystal, John H ^b   Owens, Michael J ^b   Southwick, Steven M ^b   Nemeroff, Charles B ^b   Charney, Dennis S ^b  

^a Yale New Haven Psychiatric Hospital   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOTROPIN RELEASING FACTOR; SOMATOSTATIN;

ADULT; AROUSAL; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CORTICOTROPIN RELEASE; DRUG CEREBROSPINAL FLUID LEVEL; HUMAN; LUMBAR PUNCTURE; MALE; MENTAL STRESS; NEUROTRANSMISSION; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL;

EID: 0031004906     PISSN: 0002953X     EISSN: None     Source Type: Journal    
DOI: 10.1176/ajp.154.5.624     Document Type: Article

References (58)

1. Delbende C, Delarue C, Lefebvre H, Bunel DT, Szafarczyk A, Mocaer E, Kamoun A, Jegou S, Vaudry H: Glucocorticoids, transmitters and stress. Br J Psychiatry 1992; 160:24-34
2. Chappell PB, Smith MA, Kilts CD, Bissette G, Ritchie J, Nemeroff CB: Alterations in corticotropin-releasing factor-like immunoreactivity in discrete rat brain regions after acute and chronic stress. J Neurosci 1986; 6:2908-2914
3. Owens MJ, Nemeroff CB: Physiology and pharmacology of corticotropin-releasing factor. Pharmacol Rev 1991; 425-473
4. Ottenweller JE, Natelson BH, Pitman DL, Drastal SD: Adrenocortical and behavioral responses to repeated stressors: toward an animal model of chronic stress and stress-related mental illness. Biol Psychiatry 1989; 26:829-841
5. Dallman MF, Jones MT: Corticosteroid feedback control of ACTH secretion: effect of stress-induced corticosterone secretion on subsequent stress responses in the rat. Endocrinology 1973; 92:1367-1375
6. Caggiula AR, Antelman SM, Aul E, Knopf S, Edwards DJ: Prior stress attenuates the analgesic response but sensitizes the corticosterone and cortical dopamine responses to stress 10 days later. Psychopharmacology (Berl) 1989; 99:233-237
7. Owens MJ, Nemeroff CB: The neurobiology of CRF: implications for the affective disorders, in The Hypothalamic-Pituitary-Adrenal Axis: Physiology, Pathophysiology, and Psychiatric Implications. Edited by Schatzberg AF, Nemeroff CB. New York, Raven Press, 1988, pp 1-36
8. Ehlers CL, Henriksen SS, Wang M, Rivier J, Vale W, Bloom FE: CRF production in the brain: excitation and cortical seizures in the rat. Brain Res 1983; 278:332-336
9. Brown MR, Fisher LA: Central nervous system effects of corticotropin releasing factor on the dog. Brain Res 1983; 280:75-79
10. Brown MR, Fisher LA, Rivier J, Spiess S, Rivier C, Vale W: Corticotropin-releasing factor: effects on the sympathetic nervous system and oxygen consumption. Life Sci 1982; 30:207-210
11. Valentino RJ, Foote SL, Aston-Jones G: Corticotropin-releasing factor activates noradrenergic neurons of the locus coeruleus. Brain Res 1983; 270:363-367
12. Sutton RE, Koob GF, Le Moal M, Rivier J, Vale W: Corticotropin releasing factor produces behavioral activation in rats. Nature 1982; 297:331-333
13. Britton DR, Koob G, Vale W: Intraventricular corticotropin-releasing factor enhances behavioral effects of novelty. Life Sci 1982; 31:363-367
14. Britton KT, Koob GF: Behavioral effects of CRF, in The Hypothalamic-Pituitary-Adrenal Axis: Physiology, Pathophysiology, and Psychiatric Implications. Edited by Schatzberg AF, Nemeroff CB. New York, Raven Press, 1988, pp 55-66
15. Swerdlow NR, Britton KT, Koob GF: Potentiation of acoustic startle by corticotropine releasing factor and fear are both reversed by alpha-helical CRF (9-41). Neuropsychopharmacology 1989; 2:285-292
16. Heinrichs SC, Pich EM, Miczek KA, Britton KT, Koob GF: Corticotropin-releasing factor antagonist reduces emotionality in socially defeated rats via direct neurotropic action. Brain Res 1992; 581:190-197
17. Owens MJ, Nemeroff CB: The role of corticotropin-releasing factor in the pathophysiology of affective and anxiety disorders: laboratory and clinical studies. Ciba Found Symp 1993; 172: 296-316
18. Nemeroff CB, Widerlov E, Bissette G, Walleus H, Karlsson I, Eklund K, Kilts CD, Loosen PT, Vale W: Elevated concentrations of CSF corticotropin-releasing factor-like immunoreactivity in depressed patients. Science 1984; 226:1342-1343
19. Banki CM, Bissette G, Arato M, O'Connor L, Nemeroff CB: CSF corticotropin-releasing factor-like immunoreactivity in depression and schizophrenia. Am J Psychiatry 1987; 144:873-877
20. Bremner JD, Davis M, Southwick SM, Krystal JH, Charney DS: The neurobiology of posttraumatic stress disorder, in American Psychiatric Press Review of Psychiatry, vol 12. Edited by Oldham JM, Riba MB, Tasman A. Washington, DC, American Psychiatric Press, 1993, pp 182-204
21. Charney DS, Deutch AY, Krystal JH, Southwick SM, Davis M: Psychobiologic mechanisms of posttraumatic stress disorder. Arch Gen Psychiatry 1993; 50:294-299
22. Benyassi A, Roussel JP, Rougeot C, Gavalda A, Astier H, Arancibia S: Chronic stress affects in vivo hypothalamic somatostatin release but not in vitro GH responsiveness to somatostatin in rats. Neurosci Lett 1993; 159:166-170
23. Deutch AY, Bean AJ, Bissette G, Nemeroff CB, Robbins RJ, Roth RH: Stress-induced alterations in neurotensin, somatostatin and corticotropin-releasing factor in mesotelencephalic dopamine system regions. Brain Res 1987; 417:350-354
24. Wallace JL, Boichot E, Sidoti C, Brecx A, Paubert-Braquet M: Protective effects of somatostatin against gastric damage induced by hemorrhagic shock, stress, and PAF in the rat. Regul Pept 1993; 47:195-203
25. Agren H, Lundquist G: Low levels of somatostatin in human CSF marks depressive episodes. Psychoneuroendocrinology 1984; 9: 233-248
26. Rubinow DR, Gold PW, Post RM, Ballenger JC, Cowdry RW: Somatostatin in patients with affective illness and in normal volunteers, in Neurobiology of Mood Disorders. Edited by Post RM, Ballenger JC. Baltimore, Williams & Wilkins, 1984, pp 369-387
27. Doran AR, Rubinow DR, Roy A, Pickar D: CSF somatostatin and abnormal response to dexamethasone administration in schizophrenic and depressed patients. Arch Gen Psychiatry 1986; 43:365-369
28. Banki CM, Karmacsi L, Bissette G, Nemeroff CB: Cerebrospinal fluid neuropeptides in mood disorders and dementia. J Affect Disord 1992; 25:39-46
29. Sharma RP, Bissette G, Janicak PG, Davis JM, Nemeroff CB: Elevation of CSF somatostatin concentrations in mania. Am J Psychiatry 1995; 152:1807-1809
30. Spitzer RL, Williams JBW, Gibbon M: Structured Clinical Interview for DSM-III-R (SCID). New York, New York State Psychiatric Institute, Biometrics Research, 1987
31. Licinio J, Seibyl JP, Altemus M, Charney DS, Krystal JH: Elevated CSF levels of interleukin-2 in neuroleptic-free schizophrenic patients. Am J Psychiatry 1993; 150:1408-1410
32. Keane TM, Caddell JM, Taylor KL: Mississippi Scale for Combat-Related Posttraumatic Stress Disorder: three studies in reliability and validity. J Consult Clin Psychol 1988; 56:85-90
33. Keane TM, Fairbank JA, Caddell JM: Clinical evaluation of a scale to measure combat exposure. Psychol Assess 1989; 1:53-55
34. Cook LL, Bissette G, Dole K, Nemeroff CB: A critical evaluation of cysteamine as a tool to deplete somatostatin in the rat central nervous system. Endocrinology 1989; 124:855-860
35. Bissette G, Widerlov E, Walleus H, Karlsson I, Eklund K, Forsman A, Nemeroff CB: Alterations in cerebrospinal fluid concentrations of somatostatinlike immunoreactivity in neuropsychiatric disorders. Arch Gen Psychiatry 1986; 43:1148-1151
36. Post RM, Gold P, Rubinow DR, Ballenger JC, Bunney WE, Goodwin FK: Peptides in cerebrospinal fluid of neuropsychiatric patients: an approach to central nervous system peptide function. Life Sci 1982; 31:1-15
37. Smith MA, Davidson J, Ritchie JC, Kudler H, Lipper S, Chappell P, Nemeroff CB: The corticotropin-releasing hormone test in patients with posttraumatic stress disorder. Biol Psychiatry 1989; 26:349-355
38. Mason JW, Giller EL, Kosten TR, Ostroff RB, Podd L: Urinary free cortisol levels in post-traumatic stress disorder patients. J Nerv Ment Dis 1986; 174:145-149
39. Pitman R, Orr S: Twenty-four hour urinary cortisol and catecholamine excretion in combat-related posttraumatic stress disorder. Biol Psychiatry 1990; 27:245-247
40. Kudler H, Davidson J, Meador K, Lipper S, Ely T: The DST and posttraumatic stress disorder. Am J Psychiatry 1987; 144:1068-1071
41. Yehuda R, Southwick SM, Krystal JH, Bremner JD, Charney DS, Mason JW: Enhanced suppression of cortisol with low dose dexamethasone in posttraumatic stress disorder. Am J Psychiatry 1993; 150:83-86
42. Yehuda R, Lowy MT, Southwick SM, Shaffer D, Giller EL Jr: Lymphocyte glucocorticoid receptor number in posttraumatic stress disorder. Am J Psychiatry 1991; 148:499-504
43. McEwen BS, Gould EA, Sakai RR: The vulnerability of the hippocampus to protective and destructive effects of glucocorticoids in relation to stress. Br J Psychiatry 1992; 160:18-24
44. Sapolsky RM, McEwen BS: Why dexamethasone resistance? two possible neuroendocrine mechanisms, in The Hypothalamic-Pituitary-Adrenal Axis: Physiology, Pathophysiology, and Psychiatric Implications. Edited by Schatzberg AF, Nemeroff CB. New York, Raven Press, 1988, pp 155-169
45. Herman JP, Schafer MK, Young EA, Thompson R, Douglass J, Akil H, Watson SJ: Evidence for hippocampal regulation of neuroendocrine neurons of hypothalamo-pituitary-adrenocortical axis. J Neurosci 1989; 9:3072-3082
46. Feldman S, Conforti N: Participation of the dorsal hippocampus in the glucocorticoid feedback effect on adrenocortical activity. Neuroendocrinology 1980; 30:52-55
47. Magarinos A, Somoza G, DeNicola A: Glucocorticoid negative feedback and glucocorticoid receptors after hippocampectomy in rats. Horm Metab Res 1987; 19:105-109
48. Bremner JD, Randall PR, Scott TM, Bronen RA, Seibyl JP, Southwick SM, Delaney RC, McCarthy G, Charney DS, Innis RB: MRI-based measurement of hippocampal volume in patients with combat-related posttraumatic stress disorder. Am J Psychiatry 1995; 152:973-981
49. Geracioti TD Jr, Orth DN, Ekhator NN, Blumenkopf B, Loosen PT: Serial cerebrospinal fluid corticotropin-releasing hormone concentrations in healthy and depressed humans. J Clin Endocrinol Metab 1992; 74:1325-1330
50. Coplan JD, Andrews MW, Rosenblum LA, Owens MJ, Friedman S, Gorman JM, Nemeroff CB: Persistent elevations of cerebrospinal fluid concentrations of corticotropin-releasing factor in adult nonhuman primates exposed to early-life stressors: implications for the pathophysiology of mood and anxiety disorders. Proc Natl Acad Sci USA 1996; 93:1619-1623
51. Fossey MD, Lydiard RB, Ballenger JC, Laraia MT, Bissette G, Nemeroff CB: Cerebrospinal fluid corticotropin-releasing factor concentrations in patients with anxiety disorders and normal comparison subjects. Biol Psychiatry 1996; 39:703-707
52. Jolkonen J, Lepola U, Bissette G, Nemeroff CB, Riekkinen P: CSF corticotropin-releasing factor is not affected in panic disorder. Biol Psychiatry 1993; 33:136-138
53. Plotsky PM, Owens MJ, Nemeroff CB: Neuropeptide alterations in mood disorders, in Psychopharmacology: The Fourth Generation of Progress. Edited by Bloom FE, Kupfer DJ. New York, Raven Press, 1995, pp 971-981
54. Hawley RJ, Nemeroff CB, Bissette G, Guidotti A, Rawlings R, Linnoila M: Neurochemical correlates of sympathetic activation during severe alcohol withdrawal. Alcohol Clin Exp Res 1994; 18:1312-1316
55. Shibasaki T, Yamauchi N, Kato Y, Masuda A, Imaki T, Hotta M, Demura H, Oono H, Ling N, Shizume K: Involvement of corticotropin-releasing factor in restraint stress-induced anorexia and reversion of the anorexia by somatostatin in the rat. Life Sci 1988; 43:1103-1110
56. Rivier C, Vale W: Involvement of corticotropin-releasing factor and somatostatin in stress-induced inhibition of growth hormone secretion in the rat. Endocrinology 1985; 117:2478-2482
57. Kling MA, Rubinow DR, Doran AR, Roy A, Davis CL, Calabrese JR, Nieman LK, Post RM, Chrousos GP, Gold PW: Cerebrospinal fluid immunoreactive somatostatin concentrations in patients with Cushing's disease and major depression: relationship to indices of corticotropin-releasing hormone and cortisol secretion. Neuroendocrinology 1993; 57:79-88
58. Doran AR, Rubinow DR, Roy A, Pickar D: CSF somatostatin and abnormal response to dexamethasone administration in schizophrenia and depressed patients. Arch Gen Psychiatry 1986; 43:365-369