Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress

Nature Neuroscience

Volumn 6, Issue 10, 2003, Pages 1100-1107

  Müller, Marianne B ^a   Zimmermann, Stephan ^a   Sillaber, Inge ^a   Hagemeyer, Thomas P ^a   Deussing, Jan M ^a   Timpl, Peter ^a   Kormann, Michael S D ^a   Droste, Susanne K ^a   Kühn, Ralf ^b   Reul, Johannes M H M ^a   Holsboer, Florian ^a   Wurst, Wolfgang ^a,b  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOTROPIN RELEASING FACTOR RECEPTOR; CORTICOTROPIN RELEASING FACTOR RECEPTOR 1; UNCLASSIFIED DRUG;

ADAPTATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANXIETY; ARTICLE; BRAIN FUNCTION; CONTROLLED STUDY; FOREBRAIN; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; KNOCKOUT MOUSE; LIMBIC CORTEX; MALE; MOOD DISORDER; MOUSE; NEUROENDOCRINOLOGY; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN FUNCTION; STRESS;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; ANXIETY DISORDERS; BEHAVIOR, ANIMAL; CORTICOTROPIN-RELEASING HORMONE; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; LIMBIC SYSTEM; MALE; MICE; MICE, KNOCKOUT; MUTATION; NEURAL PATHWAYS; PITUITARY-ADRENAL SYSTEM; PROSENCEPHALON; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; RECEPTORS, MINERALOCORTICOID; RNA, MESSENGER; STRESS;

EID: 0141542646     PISSN: 10976256     EISSN: None     Source Type: Journal    
DOI: 10.1038/nn1123     Document Type: Article

References (44)

1. Owens, M.J. & Nemeroff, C.B. Physiology and pharmacology of corticotropin releasing factor. Pharmacol. Rev. 43, 425-473 (1991).
2. Holsboer, F. The rationale for the corticotropin-releasing hormone receptor (CRH-R) antagonists to treat depression and anxiety. J. Psychiatr. Res. 33, 181-214 (1999).
3. Brunson, K.L., Avishai-Eliner, S., Hatalski, C.G. & Baram, T.Z. Neurobiology of the stress response early in life: evolution of a concept and the role of corticotropin-releasing hormone. Mol. Psychiatry 6, 647-656 (2001).
4. Avishai-Eliner, S., Brunson, K.L., Sandman, C.A. & Baram, T.Z. Stressed-out, or in (utero)? Trends Neurosci. 25, 518-524 (2002).
5. Caldji, C., Diorio, J. & Meaney, M.J. Variations of maternal care in infancy regulate the development of stress reactivity. Biol. Psychiatry 48, 1164-1174 (2000).
6. Liu, D. et al. Maternal care, hippocampal glucocorticoid receptors, and the hypothalamic-pituitary-adrenal response to stress. Science 277, 1659-1662 (1997).
7. Zobel, A.W. et al. Effects of the high-affinity corticotropin-releasing hormone receptor antagonist R121919 in major depression: the first 20 patients treated. J. Psychiatr. Res. 34, 171-181 (2000).
8. Timpl, P. et al. Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1. Nat. Genet. 19, 162-166 (1998).
9. Preil, J. et al. Regulation of the hypothalamic-pituitary-adrenocortical system in mice deficient for CRH receptors 1 and 2. Endocrinology 142, 4946-4955 (2001).
10. Müller, M.B. et al. Selective activation of the hypothalamic vasopressinergic system in mice deficient for the corticotropin-releasing hormone receptor 1 is dependent on glucocorticoids. Endocrinology 141, 4262-4269 (2000).
11. Dunn, A.J. & Berridge, C.W. Physiological and behavioral responses to corticotropin-releasing factor administration: is CRF a mediator of anxiety or stress responses? Brain Res. Rev. 15, 71-100 (1990).
12. Sillaber, I. et al. Enhanced and delayed stress-induced alcohol drinking in mice lacking functional CRH 1 receptors. Science 296, 931-933 (2002).
13. Liebsch, G. et al. Chronic infusion of a CRH1 receptor antisense oligodeoxynucleotide into the central nucleus of the amygdala reduced anxiety-related behavior in socially defeated rats. Reg. Peptides 59, 229-239 (1995).
14. Smith, G.W. et al. Corticotropin releasing factor receptor 1-deficient mice display decreased anxiety, impaired stress response, and aberrant neuroendocrine development. Neuron 20, 1093-1102 (1998).
15. Joels, M. & de Kloet, E.R. Control of neuronal excitability by corticosteroid hormones. Trends Neurosci. 15, 25-30 (1992).
16. Korte, S.M., Korte-Bouws, G.A., Koob, G.F., De Kloet, E.R. & Bohus, B. Mineralocorticoid and glucocorticoid receptor antagonists in animal models of anxiety. Pharmacol. Biochem. Behav. 54, 261-267 (1996).
17. Korte, S.M. Corticosteroids in relation to fear, anxiety and psychopathology. Neurosci. Biobehav. Rev. 25, 117-142 (2001).
18. Tronche, F. et al. Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety. Nat. Genet. 23, 99-103 (1999).
19. Lewandoski, M. Conditional control of gene expression in the mouse. Nat. Rev. Genet. 2, 743-755 (2001).
20. Minichiello, L. et al. Essential role of trkB receptors in hippocampus-mediated learning. Neuron 24, 401-414 (1999).
21. Solà, C., Tusell, J.M. & Serratosa, J. Comparative study of the distribution of calmodulin kinase II and calcineurin in the mouse brain. J. Neurosci. Res. 57, 651-662 (1999).
22. Chen, Y., Brunson, K., Müller, M.B., Cariaga, W. & Baram, T.Z. Immunocytochemical distribution of corticotropin-releasing hormone type-1 (CRF1)-like immunoreactivity in the mouse brain: light microscopy analysis usingan antibody directed against the C-terminus. J. Comp. Neurol. 420, 305-323 (2000).
23. Davis, M. & Whalen, P.J. The amygdala: vigilance and emotion. Mol. Psychiatry 6, 13-34 (2001).
24. Lobe, C.G. et al. Z/AP, a double reporter for Cre-mediated recombination. Dev. Biol. 208, 281-292 (1999).
25. Van Pett, K. et al. Distribution of mRNAs encoding CRF receptors in brain and pituitary of rat and mouse. J. Comp. Neurol. 428, 191-212 (2000).
26. Hascoet, M., Bourin, M. & Dhonnchadhda, B.A.N. The mouse light-dark paradigm: a review. Prog. Neurosychopharmacol. Biol. Psychiatry 25, 141-166 (2001).
27. Rodgers, J.I. & Dalvi, A. Anxiety, defence and the elevated plus-maze. Neurosci. Biobehav. Rev. 21, 801-810 (1997).
28. Cole, J.C. & Rodgers, R.J. Ethological comparison of the effects of diazepam and acute/chronic imipramine on the behaviour of mice in the elevated plus-maze. Pharmacol. Biochem. Behav. 52, 473-478 (1995).
29. Liebsch, G., Landgraf, R., Engelmann, M., Lorscher, P. & Holsboer, F. Differential behavioural effects of chronic infusion of CRH1 and CRH2 receptor antisense oligonucleotides into the rat brain. J. Psychiatr. Res. 33, 153-163 (1999).
30. Keck, M.E. et al. The anxiolytic effect of the CRH1 receptor antagonist R121919 depends on innate emotionality in rats. Eur. J. Neurosci. 13, 373-380 (2001).
31. Joels, M. Corticosteroid actions in the hippocampus. J. Neuroendocrinol. 13, 657-669 (2001).
32. Gray, T.S. & Bingaman, E.W. The amygdala: corticotropin-releasing factor, steroids and stress. Crit. Rev. Neurobiol. 10, 155-168 (1996).
33. López, J.F., Akil, H. & Watson, S. Neural circuits mediating stress. Biol. Psychiatry 46, 1461-1471 (1999).
34. Herman, J.P. & Cullinan, W.E. Neurocircuitry of stress: central control of the hypothalamic-pituitary-adrenocortical axis. Trends Neurosci. 20, 78-84 (1997).
35. Herman, J.P., Schafer, M.K., Young, E.A., Akil, H. & Watson, S.J. Selective forebrain fiber tract lesions implicate ventral hippocampal structures in tonic regulation of paraventricular nucleus corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) mRNA expression. Brain Res. 592, 228-238 (1992).
36. de Kloet, E.R. & Reul, J.M.H.M. Feedback action and tonic influence of corticosteroids on brain function: a concept arising from the heterogeneity of brain receptor systems. Psychoneuroendocrinology 12, 83-105 (1987).
37. Gesing, A. et at. Psychological stress increases hippocampal mineralocorticoid receptor levels: involvement of corticotropin-releasing hormone. J. Neurosci. 21, 4822-4829 (2001).
38. Raadsheer, F.C., Hoogendijk, W.J.G., Stam, F.C., Tilders, F.J.H. & Swaab, D.F. Increased number of corticotropin-releasing hormone expressing neurons in the hypothalamic paraventricular nucleus of depressed patients. Neuroendocrinology 60, 436-444 (1994).
39. Raadsheer, F.C. et al. Corticotropin-releasing hormone levels in the paraventricular nucleus of patients with Alzheimer's disease and depression. Am. J. Psychiatry 152, 1372-1376 (1995).
40. 1A, glucocorticoid and mineralocorticoid receptor in rat and human hippocampus: implications for the neurobiology of depression. Biol. Psychiatry 43, 547-573 (1998).
41. Holsboer, F. The corticosteroid receptor hypothesis of depression. Neuropsychopharmacology 23, 477-501 (2000).
42. Hanks, M., Wurst, W., Anson-Cartwright, L., Auerbach, A.B. & Joyner, A.L. Rescue of the En-1 mutant phenotype by replacement of En-1 with En-2. Science 269, 679-682 (1995).
43. Hill, D.P. & Wurst, W. Screening for novel pattern formation genes using gene trap approaches. Methods Enzymol. 225, 664-668 (1993).
44. Kresse, A., Jacobowitz, D.M. & Skofitsch, G. Detailed mapping of CGRP mRNA expression in the rat central nervous system: comparison with previous immunocytochemical findings. Brain Res. Bull. 36, 261-274 (1995).