Selective Activation of Corticotropin-Releasing Factor-2 Receptors on Neurochemically Identified Neurons in the Rat Dorsal Raphe Nucleus Reveals Dual Actions

Journal of Neuroscience

Volumn 24, Issue 6, 2004, Pages 1305-1311

  Pernar, Luise ^a   Curtis, Andre L ^a   Vale, Wylie W ^b   Rivier, Jean E ^b   Valentino, Rita J ^a  

^a CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^b SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

Author keywords

Antalarmin; Antisauvagine 30; Juxtacellular labeling; Neurobiotin; Serotonin; Stress; Urocortin II

Indexed keywords

ANTALARMIN; ANTISAUVAGINE 30; BIOTIN; CORTICOTROPIN RELEASING FACTOR; CORTICOTROPIN RELEASING FACTOR R1 RECEPTOR; CORTICOTROPIN RELEASING FACTOR R2 RECEPTOR; CORTICOTROPIN RELEASING FACTOR RECEPTOR; HALOTHANE; LIGAND; NEUROBIOTIN; UNCLASSIFIED DRUG; UROCORTIN; UROCORTIN 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL LABELING; CLASSIFICATION; CONTROLLED STUDY; DENSITY; DORSAL RAPHE NUCLEUS; DOSE RESPONSE; HORMONE RECEPTOR INTERACTION; INHIBITION KINETICS; INNERVATION; LIGAND BINDING; MALE; MENTAL DISEASE; NERVE CELL; NEUROCHEMISTRY; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; SEROTONIN RELEASE; STRESS;

ANIMALS; AREA UNDER CURVE; CORTICOTROPIN-RELEASING HORMONE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION ROUTES; IONTOPHORESIS; LIGANDS; MALE; NEURAL INHIBITION; NEURONS; PEPTIDE FRAGMENTS; PYRIMIDINES; PYRROLES; RAPHE NUCLEI; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; SEROTONIN;

EID: 1242291760     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2885-03.2004     Document Type: Article

References (34)

1. Adell A, Casanovas JM, Artigas F (1997) Comparative study in the rat of the actions of different types of stress on the release of 5-HT in raphe nuclei and forebrain areas. Neuropharmacology 36:735-741.
2. Akaoka H, Saunier C-F, Chergui K, Charlety P, Buda M, Chouvet G (1992) Combining in vivo volume-controlled pressure microejection with extracellular unit recording. J Neurosci Methods 42:119-128.
3. Briscoe RJ, Cabrera CL, Baird TJ, Rice KC, Woods JH (2000) Antalarmin blockade of corticotropin-releasing hormone-induced hypertension in rats. Brain Res 881:204-207.
4. Chalmers DT, Lovenberg TW, De Souza EB (1995) Localization of novel corticotropin-releasing factor receptor (CRF2) mRNA expression to specific subcortical nuclei in rat brain: comparison with CRF1 receptor mRNA expression. J Neurosci 15:6340-6350.
5. Chen R, Lewis KA, Perrin MH, Vale WW (1993) Expression cloning of a human corticotropin-releasing factor receptor. Proc Natl Acad Sci USA 90:8967-8971.
6. Curtis AL, Grigoradis D, Page ME, Rivier J, Valentino RJ (1994) Pharmacological comparison of two corticotropin-releasing factor antagonists: in vivo and in vitro studies. J Pharmacol Exp Ther 268:359-365.
7. Dautzenberg FM, Kilpatrick GJ, Hauger RL, Moreau J-L (2001) Molecular biology of the CRH receptors-in the mood. Peptides 22:753-760.
8. Grahn RE, Maswood S, McQueen MB, Watkins LR, Maier SF (1999) Activation of serotonin-immunoreactive cells in the dorsal raphe nucleus in rats exposed to an uncontrollable stressor. Brain Res 826:35-43.
9. Hammack SE, Richey KJ, Schmid MJ, LoPresti ML, Watkins LR, Maier SF (2002) The role of corticotropin-releasing hormone in the dorsal raphe nucleus in mediating the behavioral consequences of uncontrollable stress. J Neurosci 22:1020-1026.
10. Hammack SE, Schmid MJ, LoPresti ML, Der-Avakian A, Pellymounter MA, Foster AC, Watkins LR, Maier SF (2003) Corticotropin-releasing hormone type 2 receptors in the dorsal raphe nucleus mediate the behavioral consequences of uncontrollable stress. J Neurosci 23:1019-1025.
11. Hsu SY, Hsueh AJW (2001) Human stresscopin and stresscopin-related peptide are selective ligands for the corticotropin-releasing hormone receptor. Nat Med 7:605-611.
12. Jacobs BL, Azmitia EC (1992) Structure and function of the brain serotonin system. Physiol Rev 72:165-228.
13. Kirby LG, Allen AR, Lucki I (1995) Regional differences in the effects of forced swimming on extracellular levels of 5-hydroxytryptamine and 5-hydroxyindoleacetic acid. Brain Res 682:189-196.
14. Kirby LG, Chou-Green JM, Davis K, Lucki I (1997) The effects of different stressors on extracellular 5-hydroxytryptamine and 5-hydroxyindoleacetic acid. Brain Res 760:218-230.
15. Kirby LG, Rice K, Valentino RJ (2000) Effects of corticotropin-releasing factor on neuronal activity in the serotonergic dorsal raphe nucleus. Neuropsychopharmacology 22:148-162.
16. Linthorst ACE, Flachskamm C, Hopkins SJ, Hoadley ME, Labeur MS, Holsboer F, Reul JMHM (1997) Long-term intracerebroventricular infusion of corticotropin-releasing hormone alters neuroendocrine, neurochemical, autonomic, behavioral, and cytokine responses to a systemic inflammatory challenge. J Neurosci 17:4448-4460.
17. Lowry CA, Rodda JE, Lightman SL, Ingram CD (2000) Corticotropin-releasing factor increases in vitro firing rates of serotonergic neurons in the dorsal raphe nucleus: evidence for activation of a topographically organized mesolimbocortical serotonergic system. J Neurosci 20:7728-7736.
18. Mann JJ (1999) Role of the serotonergic system in the pathogenesis of major depression and suicidal behavior. Neuropsychopharmacology 21:99S-105S.
19. Molliver ME (1987) Serotonergic neuronal systems: what their anatomic organization tells us about function. J Clin Psychopharmacol 7:3S-23S.
20. Nutt D (2002) The neuropharmacology of serotonin and noradrenaline in depression. Int Clin Psychopharmacol 17 [Suppl]1:S1-S12.
21. Paxinos G, Watson C (1998) The rat brain in stereotaxic coordinates. North Ryde, UK: Academic.
22. Pinault D (1996) A novel single-cell staining procedure performed in vivo under electrophysiological control: morpho-functional features of juxtacellularly labeled thalamic cells and other central neurons with biocytin or neurobiotin. J Neurosci Methods 65:113-136.
23. Price ML, Lucki I (2001) Regulation of serotonin release in the lateral septum and striatum by corticotropin-releasing factor. J Neurosci 21:2833-2841.
24. Price ML, Curtis AL, Kirby LG, Valentino RJ, Lucki I (1998) Effects of corticotropin-releasing factor on brain serotonergic activity. Neuropsychopharmacology 18:492-502.
25. Price ML, Kirby LG, Valentino RJ, Lucki I (2002) Evidence for corticotropin-releasing factor regulation of serotonin in the lateral septum during acute swim stress: adaptation produced by repeated swim. Psychopharmacology 162:406-414.
26. Radulovic J, Ruhmann A, Liepold T, Spiess J (1999) Modulation of learning and anxiety by corticotropin-releasing factor (CRF) and stress: differential roles of CRF receptors 1 and 2. J Neurosci 19:5016-5025.
27. Reyes TM, Lewis K, Perrin MH, Kunitake KS, Vaughan J, Arias CA, Hogenesch JB, Gulyas J, Rivier J, Vale WW, Sawchenko PE (2001) Urocortin II: a member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors. Proc Natl Acad Sci USA 98:2843-2848.
28. Roche M, Commons KG, Peoples A, Valentino RJ (2003) Circuitry underlying regulation of the serotonergic system by swim stress. J Neurosci 23:970-977.
29. 125I] sauvagine binding to CRH2 receptors: membrane homogenate and autoradiographic studies. J Pharmacol Exp Ther 286:459-468.
30. Rueter LE, Fornal CA, Jacobs BL (1997) A critical review of 5-HT brain microdialysis and behavior. Rev Neurosci 8:117-137.
31. Schreihofer AM, Guyenet PG (1997) Identification of C1 presympathetic neurons in rat rostral ventrolateral medulla by juxtacellular labeling in vivo. J Comp Neurol 387:524-536.
32. Valentino RJ, Liouterman L, Van Bockstaele EJ (2001) Evidence for regional heterogeneity in corticotropin-releasing factor interactions in the dorsal raphe nucleus. J Comp Neurol 435:450-463.
33. Waselus M, Valentino RJ, Van Bockstaele EJ (2003) Synaptic interactions between axon terminals containing corticotropin-releasing factor (CRF) and somatodendritic processes containing serotonin in the rat dorsal raphe nucleus (DRN). Soc Neurosci Abstr 712.4.
34. Zorrilla EP, Valdez GR, Nozulak J, Koob GF, Markou A (2002) Effects of antalarmin, a CRF type 1 receptor antagonist, on anxiety-like behavior and motor activation in the rat. Brain Res 952:188-199.