Reduced anxiety-like and cognitive performance in mice lacking the corticotropin-releasing factor receptor 1

Brain Research

Volumn 835, Issue 1, 1999, Pages 1-9

  Contarino, Angelo ^a   Dellu, Françoise ^a   Koob, George F ^a   Smith, George W ^b   Lee, Kuo Fen ^b   Vale, Wylie ^b   Gold, Lisa H ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

Author keywords

Anxiety; CRF receptor type 1; Memory; Null mutant mice

Indexed keywords

CORTICOTROPIN RELEASING FACTOR; CORTICOTROPIN RELEASING FACTOR RECEPTOR;

ANIMAL EXPERIMENT; ANXIETY NEUROSIS; COGNITION; COGNITIVE DEFECT; CONFERENCE PAPER; CONTROLLED STUDY; EXPLORATORY BEHAVIOR; GENE DELETION; MAZE TEST; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPATIAL MEMORY;

ANIMALS; ANXIETY; BEHAVIOR, ANIMAL; COGNITION; FEMALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; TIME FACTORS;

EID: 0033578240     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(98)01158-5     Document Type: Conference Paper

References (52)

1. Baldwin H.A., Rassnick S., Rivier J., Koob G.F., Britton K.T. CRF antagonist reverses the "anxiogenic" response to ethanol withdrawal in the rat. Psychopharmacology. 103:1991;227-232.
2. Behan D.P., Grigoriadis D.E., Lovenberg T., Chalmers D., Heinrichs S., Liaw C., De Souza E.B. Neurobiology of corticotropin releasing factor (CRF) receptors and CRF-binding protein: implications for the treatment of CNS disorders. Mol. Psychiatry. 1:1996;265-277.
3. Behan D.P., Heinrichs S.C., Troncoso J.C., Liu X.J., Kawas C.H., Ling N., De Souza E.B. Displacement of corticotropin releasing factor from its binding protein as a possible treatment for Alzheimer's disease. Nature. 378:1995;284-287.
4. Berridge C.W., Dunn A.J. CRF and restraint-stress decrease exploratory behavior in hypophysectomized mice. Pharmacol. Biochem. Behav. 34:1989;517-519.
5. Britton D.R., Varela M., Garcia A., Rosenthal M. Dexamethasone suppresses pituitary-adrenal but not behavioral effects of centrally administered CRF. Life Sci. 38:1986;211-216.
6. Britton D.T., Lee G., Dana R., Risch S.C., Koob G.F. Activating and "anxiogenic" effects of corticotropin releasing factor are not inhibited by blockade of the pituitary-adrenal system with dexamethasone. Life Sci. 39:1986;1281-1286.
7. Britton K.T., Lee G., Vale W., Rivier J., Koob G.F. Corticotropin releasing factor (CRF) receptor antagonist blocks activating and "anxiogenic" actions of CRF in the rat. Brain Res. 369:1986;303-306.
8. Butler P.D., Weiss J.M., Stout J.C., Nemeroff C.B. Corticotropin-releasing factor produces fear-enhancing and behavioral activating effects following infusion into the locus coeruleus. J. Neurosci. 10:1990;176-183.
9. 1 receptor mRNA expression. J. Neurosci. 15:1995;6340-6350.
10. Chen R., Lewis K.A., Perrin M.H., Vale W.W. Expression cloning of a human corticotropin-releasing factor receptor. Proc. Natl. Acad. Sci. USA. 90:1993;8967-8971.
11. Cole B.J., Koob G.F. Propranolol antagonizes the enhanced conditioned fear produced by corticotropin releasing factor. J. Pharmacol. Exp. Ther. 247:1988;902-910.
12. Conrad C.D., Galea L.A.M., Kuroda Y., McEwen B.S. Chronic stress impairs rat spatial memory on the Y maze, and this effect is blocked by tianeptine pretreatment. Behav. Neurosci. 110:1996;1321-1334.
13. Conrad C.D., Lupien S.J., Thanasoulis L.C., McEwen B.S. The effects of type I and type II corticosteroid receptor agonists on exploratory behavior and spatial memory in the Y-maze. Brain Res. 759:1997;76-83.
14. Crawley J.N. Neuropharmacologic specificity of a simple animal model for the behavioral actions of benzodiazepines. Pharmacol. Biochem. Behav. 15:1981;695-699.
15. Dellu F., Fauchey V., Le Moal M., Simon H. Extension of a new two-trial memory task in the rat: influence of environmental context on recognition processes. Neurobiol. Learn. and Mem. 67:1997;112-120.
16. Dellu F., Mayo W., Cherkaoui J., Le Moal M., Simon H. A two-trial memory task with automated recording: study in young and aged rats. Brain Res. 588:1992;132-139.
17. De Souza E.B., Whitehouse P.J., Kuhar M.J., Price D.L., Vale W.W. Reciprocal changes in corticotropin-releasing factor (CRF)-like immunoreactivity and CRF receptors in cerebral cortex of Alzheimer's disease. Nature. 319:1986;593-595.
18. De Souza E.B., Whitehouse P.J., Price D.L., Vale W.W. Abnormalities in corticotropin-releasing hormone (CRH) in Alzheimer's disease and other human disorders. Ann. N.Y. Acad. Sci. 512:1987;237-247.
19. Ehlers C.L., Henriksen S.J., Wang M., Rivier J., Vale W., Bloom F.E. Corticotropin releasing factor produces increases in brain excitability and convulsive seizures in rats. Brain Res. 278:1983;332-336.
20. 2, receptors mediate anxiogenic-like behavior. Reg. Peptides. 71:1997;15-21.
21. Heinrichs S.C., Min H., Tamraz S., Carmouche M., Boehme S.A., Vale W.W. Anti-sexual and anxiogenic behavioral consequences of corticotropin-releasing factor overexpression are centrally mediated. Psychoneuroendocrinology. 22:1997;215-224.
22. Heinrichs S.C., Pich E.M., Miczek K.A., Britton K.T., Koob G.F. Corticotropin-releasing factor antagonist reduces emotionality in socially defeated rats via direct neurotropic action. Brain Res. 581:1992;190-197.
23. Heinrichs S.C., Stenzel-Poore M.P., Gold L.H., Battenberg E., Bloom F.E., Koob G.F., Vale W.W., Pich E.M. Learning impairment in transgenic mice with central overexpression of corticotropin-releasing factor. Neuroscience. 74:1996;303-311.
24. Hulsey M.G., Pless C.M., Martin R.J. ICV administration of anti-corticotropin-releasing factor antisense oligonucleotide: effects on feeding behavior and body weight. Reg. Peptides. 59:1995;241-246.
25. G.F. Koob, Arousal, stress, and inverted U-shaped curves: implications for cognitive function, in: H. Weingartener, R. Lister (Eds.), Cognitive Neuroscience, Oxford University Press, Oxford, 1991, pp. 300-313.
26. G.F. Koob, Behavioral responses to stress: Focus on Corticotropin-Releasing Factor, in: M.R. Brown, G.F. Koob, C. Rivier (Eds.), Stress: Neurobiology and Neuroendocrinology, Marcel Dekker, New York, 1991, pp. 255-271.
27. Koob G.F., Bloom F.E. Corticotropin-releasing factor and behavior. Fed. Proc. 44:1985;259-263.
28. Koob G.F., Heinrichs S.C., Menzaghi F., Pich E.M., Britton K.T. Corticotropin releasing factor, stress and behavior. Sem. in the Neurosci. 6:1994;221-229.
29. Lee K.F., Li E., Huber L.J., Landis S.C., Sharpe A.H., Chao M.V., Jaenisch R. Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system. Cell. 69:1992;737-749.
30. Liaw C.W., Lovenberg T.W., Barry G., Oltersdorf T., Grigoriadis D.E., De Souza E.B. Cloning and characterization of the human corticotropin-releasing factor-2 receptor complementary deoxyribonucleic acid. Endocrinology. 137:1996;72-77.
31. 1 receptor antisense oligodeoxynucleotide into the central nucleus of the amygdala reduced anxiety-related behavior in socially defeated rats. Reg. Peptides. 59:1995;229-239.
32. Lister R.G. The use of a plus-maze to measure anxiety in the mouse. Psychopharmacology (Berl). 92:1987;180-185.
33. Lovenberg T.W., Liaw C.W., Grigoriadis D.E., Clevenger W., Chalmers D.T., De Souza E.B., Oltersdorf T. Cloning and characterization of a functionally distinct corticotropin-releasing factor receptor subtype from rat brain. Proc. Natl. Acad. Sci. USA. 92:1995;836-840.
34. Lundkvist J., Chai Z., Teheranian R., Hasanvan H., Bartfai T., Jenck F., Widmer U., Moreau J.L. A non-peptidic corticotropin releasing factor receptor antagonist attenuates fever and exhibits anxiolytic-like activity. Eur. J. Pharmacol. 309:1996;195-200.
35. 1 receptor antagonist. Eur. J. Pharmacol. 323:1997;21-26.
36. McGaugh J.L., Introini-Collison I.B., Nagahara A.H., Cahill L., Brioni J.D., Castellano C. Involvement of the amygdaloid complex in neuromodulatory influences on memory storage. Neurosci. Biobehav. Rev. 14:1990;425-431.
37. Nemeroff C.B. New vistas in neuropeptide research in neuropsychiatry: focus on corticotropin-releasing factor. Neuropsychopharmacology. 6:1992;69-75.
38. Nemeroff C.B., Bissette G., Akil H., Fink M. Neuropeptide concentrations in the cerebrospinal fluid of depressed patients treated with electroconvulsive therapy. Corticotropin-releasing factor, beta-endorphin and somatostatin. Br. J. Psychiatry. 158:1991;59-63.
39. Nemeroff C.B., Widerlov E., Bissette G., Walleus H., Karlsson I., Eklund K., Kilts C.D., Loosen P.T., Vale W. Elevated concentrations of CSF corticotropin-releasing factor-like immunoreactivity in depressed patients. Science. 226:1984;1342-1344.
40. Pomara N., Singh R.R., Deptula D., LeWitt P.A., Bissette G., Stanley M., Nemeroff C.B. CSF Corticotropin-Releasing Factor (CRF) in Alzheimer's disease: Its relationship to severity of dementia and monoamine metabolites. Biol. Psychiatry. 26:1989;500-504.
41. Potter E., Sutton S., Donaldson C., Chen R., Perrin M., Lewis K., Sawchenko P.E., Vale W. Distribution of corticotropin-releasing factor receptor mRNA expression in the rat brain and pituitary. Proc. Natl. Acad. Sci. USA. 91:1994;8777-8781.
42. Rassnick S., Heinrichs S.C., Britton K.T., Koob G.F. Microinjection of a corticotropin-releasing factor antagonist into the central nucleus of the amygdala reverses anxiogenic-like effects of ethanol withdrawal. Brain Res. 605:1993;25-32.
43. Rivier C., Vale W. Modulation of stress-induced ACTH release by corticotropin-releasing factor, catecholamines and vasopressin. Nature. 305:1983;325-327.
44. Sawchenko P.E., Swanson L.W. Localization, colocalization, and plasticity of corticotropin-releasing factor immunoreactivity in rat brain. Fed. Proc. 44:1985;221-227.
45. Schulz D.W., Mansbach R.S., Sprouse J., Braselton J.P., Collins J., Corman M., Dunaiskis A., Faraci S., Schmidt A.W., Seeger T., Seymour P., Tingley III F.D., Winston E.N., Chen Y.L., Heym J. CP-154,526: A potent and selective non-peptide antagonist of corticotropin releasing factor receptors. Proc. Natl. Acad. Sci. USA. 93:1996;10477-10482.
46. Sirinathsinghji D.J., Rees L.H., Rivier J., Vale W. Corticotropin-releasing factor is a potent inhibitor of sexual receptivity in the female rat. Nature. 305:1983;232-235.
47. Skutella T., Montkowski A., Stohr T., Probst J.C., Landgraf R., Holsboer F., Jirikowski G.F. Corticotropin-releasing hormone (CRH) antisense oligodeoxynucleotide treatment attenuates social defeat-induced anxiety in rats. Cell Mol. Neurobiol. 14:1994;579-588.
48. Smith G.W., Aubry J.M., Dellu F., Contarino A., Bilezikjian L.M., Gold L.H., Chen R., Marchuk Y., Hauser C., Bentley C.A., Sawchenko P.E., Koob G.F., Vale W., Lee K.F. Corticotropin releasing factor receptor 1 deficient mice display decreased anxiety, impaired stress response, and aberrant neuroendocrine development. Neuron. 20:1998;1093-1102.
49. Spina M., Pich E.M., Chan R.K.W., Basso A.M., Rivier J., Vale W., Koob G.F. Appetite-suppressing effects of urocortin, a CRF-related neuropeptide. Science. 273:1996;1561-1564.
50. Stenzel-Poore M.P., Heinrichs S.C., Rivest S., Koob G.F., Vale W.W. Overproduction of corticotropin-releasing factor in transgenic mice: a genetic model of anxiogenic behavior. J. Neurosci. 14:1994;2579-2584.
51. Swanson L.W., Sawchenko P.E., Rivier J., Vale W.W. Organization of ovine corticotropin-releasing factor immunoreactive cells and fibers in the rat brain: an immunohistochemical study. Neuroendocrinology. 36:1983;165-186.
52. Timpl P., Spanagel R., Sillaber I., Kresse A., Reul J.M.H.M., Stalla G.K., Blanquet V., Steckler T., Holsboer F., Wurst W. Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1. Nature Genetics. 19:1998;162-166.