Corticotropin releasing factor receptor 1-deficient mice display decreased anxiety, impaired stress response, and aberrant neuroendocrine development

Neuron

Volumn 20, Issue 6, 1998, Pages 1093-1102

  Smith, George W ^a,c   Aubry, Jean Michel ^a   Dellu, Francoise ^b   Contarino, Angelo ^b   Bilezikjian, Louise M ^a   Gold, Lisa H ^b   Chen, Ruoping ^a   Marchuk, Yelena ^a   Hauser, Chris ^a   Bentley, Cornelia A ^a   Sawchenko, Paul E ^a   Koob, George F ^b   Vale, Wylie ^a   Lee, Kuo Fen ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTERONE; CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR RECEPTOR; MESSENGER RNA; RECEPTOR SUBTYPE;

AGENESIS; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ANXIETY; ARTICLE; CONTROLLED STUDY; CORTICOTROPIN DEFICIENCY; DEVELOPMENT; FEMALE; GENE; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IMMUNOHISTOCHEMISTRY; MALE; MORTALITY; MOUSE; NEUROENDOCRINE SYSTEM; NEWBORN; NONHUMAN; PRIORITY JOURNAL; SOUTHERN BLOTTING; STRESS; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0032104267     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0896-6273(00)80491-2     Document Type: Article

References (46)

1. Archer, J. (1973). Tests for emotionality in mice and rats: a review. Anim. Behav. 21, 205-235.
2. Avishai-Eliner, S., Yi, S.J., and Baram, T.Z. (1996). Developmental profile of messenger RNA for corticotropin-releasing hormone in the rat limbic system. Brain Res. Dev. Brain. Res. 91, 159-163.
3. Ballard, P.L. (1989). Hormonal regulation of pulmonary surfactant. Endocr. Rev. 10, 165-181.
4. Britton, K.T., Lee, G., Dana, R., Risch, S.C., and Koob, G.F. (1986). Activating and 'anxiogenic-like' effects of corticotropin releasing factor are not inhibited by blockade of the pituitary-adrenal system with dexamethasone. Life Sci. 39, 1281-1286.
5. Chalmers, D.T., Lovenberg, T.W., and De Souza, E.B. (1995). Localization of novel corticotropin-releasing factor receptor (CRF2) mRNA expression to specific subcortical nuclei in rat brain: comparison with CRF1 receptor mRNA expression. J. Neurosci. 15, 6340-6350.
6. Chan, R.K., Brown, E.R., Ericsson, A., Kovacs, K.J., and Sawchenko, P.E. (1993). A comparison of two immediate-early genes, c-fos and NGFI-B, as markers for functional activation in stress-related neuroendocrine circuitry. J. Neurosci. 13, 5126-5138.
7. Chrousos, G.P., and Gold, P.W. (1992). The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis. JAMA 267, 1244-1252.
8. Cole, T.J., Blendy, J.A., Monaghan, A.P., Krieglstein, K., Schmid, W., Aguzzi, A., Fantuzzi, G., Hummler, E., Unsicker, K., and Schutz, G. (1995). Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation. Genes Dev. 9, 1608-1621.
9. Crawley, J., and Goodwin, F.K. (1980). Preliminary report of a simple animal behavior model for the anxiolytic effects of benzodiazepines. Pharmacol. Biochem. Behav. 13, 167-170.
10. Daikoku, S., Kinutani, M., and Sako, M. (1976). Ultrastructural study on the hypothalamic-hypophysial-adrenal axis in fetal rats. Cell Tissue Res. 168, 549-559.
11. Denenberg, V. (1967). Stimulation in infancy, emotional reactivity and exploratory behavior. In Biology and Behavior: Neurophysiology and Emotion, D. Glass, ed. (New York: Rockefeller University Press and Russell Sage Foundation), pp. 161-190.
12. Gertz, B.J., Contreras, L.N., McComb, D.J., Kovacs, K., Tyrrell, J.B., and Dallman, M.F. (1987). Chronic administration of corticotropin-releasing factor increases pituitary corticotrope number. Endocrinology 120, 381-388.
13. Grigoriadis, D.E., Lovenberg, T.W., Chalmers, D.T., Liaw, C., and De Souza, E.B. (1996). Characterization of corticotropin releasing factor receptor subtypes. Ann. N.Y. Acad. Sci. 780, 60-80.
14. Heinrichs, S.C., Lapsansky, J., Lovenberg, T.W., De Souza, E.B., and Chalmers, D.T. (1997). Corticotropin-releasing factor CRF1, but not CRF2, receptors mediate anxiogenic-like behavior. Regul. Pept. 71, 15-21.
15. Idelman, S. (1970). Ultrastructure of the mammalian adrenal cortex. Int. Rev. Cytol. 27, 181-281.
16. Keller Wood, M.E., and Dallman, M.F. (1984). Corticosteroid inhibition of ACTH secretion. Endocr. Rev. 5, 1-24.
17. Kishimoto, T., Pearse, R.V., Jr., Lin, C.R., and Rosenfeld, M.G. (1995). A sauvagine/corticotropin-releasing factor receptor expressed in heart and skeletal muscle. Proc. Natl. Acad. Sci. USA 92, 1108-1112.
18. Koob, G., Heinrichs, S.C., Menzaghi, F., Pich, E.M., and Britton, K.T. (1994). Corticotropin releasing factor, stress and behavior. Semin Neurosci 6, 221-229.
19. Lee, K.F., Li, E., Huber, L.J., Landis, S.C., Sharpe, A.H., Chao, M.V., and Jaenisch, R. (1992). Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system. Cell 69, 737-749.
20. Lister, R.G. (1987). The use of a plus-maze to measure anxiety in the mouse. Psychopharmacology 92, 180-185.
21. Lovenberg, T.W., Liaw, C.W., Grigoriadis, D.E., Clevenger, W., Chalmers, D.T., De Souza, E.B., and Oltersdorf, T. (1995). Cloning and characterization of a functionally distinct corticotropin-releasing factor receptor subtype from rat brain. Proc. Natl. Acad. Sci. USA 92, 836-840.
22. Mansi, J.A., Rivest, S., and Drolet, G. (1996). Regulation of corticotro-pin-releasing factor type 1 (CRF1) receptor messenger ribonucleic acid in the paraventricular nucleus of rat hypothalamus by exogenous CRF. Endocrinology 137, 4619-4629.
23. Martinez, V., Rivier, J., Wang, L., and Tache, Y. (1997). Central injection of a new corticotropin-releasing factor (CRF) antagonist, astressin, blocks CRF-and stress-related alterations of gastric and colonic motor function. J. Pharmacol. Exp. Ther. 280, 754-760.
24. Misslin, R., Belzung, C., and Vogel, E. (1989). Behavioral validation of a light-dark choice procedure for testing anti-anxiety agents. Behav. Process. 18, 119-132.
25. Muglia, L., Jacobson, L., Dikkes, P., and Majzoub, J.A. (1995). Corticotropin-releasing hormone deficiency reveals major fetal but not adult glucocorticoid need. Nature 373, 427-432.
26. Orth, D.N. (1992). Corticotropin-releasing hormone in humans. Endocr. Rev. 13, 164-191.
27. Owens, M.J., and Nemeroff, C.B. (1991). Physiology and pharmacology of corticotropin releasing factor. Pharmacol. Rev. 43, 425-473.
28. Pellow, S., Chopin, P., File, S.E., and Briley, M. (1985). Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J. Neurosci. Methods 14, 149-167.
29. Perrin, M., Donaldson, C., Chen, R., Blount, A., Berggren,T., Bilezikjian, L., Sawchenko, P., and Vale, W. (1995). Identification of a second corticotropin-releasing factor receptor gene and characterization of a cDNA expressed in heart. Proc. Natl. Acad. Sci. USA 92, 2969-2973.
30. Potter, E., Sutton, S., Donaldson, C., Chen, R., Perrin, M., Lewis, K., Sawchenko, P.E., and Vale, W. (1994). Distribution of corticotropin releasing factor receptor mRNA expression in the rat brain and pituitary. Proc. Natl. Acad. Sci. USA 91, 8777-8781.
31. Pozzoli, G., Bilezikjian, L.M., Perrin, M.H., Blount, A.L., and Vale, W.W. (1996). Corticotropin-releasing factor (CRF) and glucocorticoids modulate the expression of type 1 CRF receptor messenger ribonucleic acid in rat anterior pituitary cell cultures. Endocrinology 137, 65-71.
32. Rabadan-Diehl, C., Kiss, A., Camacho, C., and Aguilera, G. (1996). Regulation of messenger ribonucleic acid for corticotropin releasing hormone receptor in the pituitary during stress. Endocrinology 137, 3808-3814.
33. Rivest, S., Laflamme, N., and Nappi, R.E. (1995). Immune challenge and immobilization stress induce transcription of the gene encoding the CRF receptor in selective nuclei of the rat hypothalamus. J. Neurosci. 15, 2680-2695.
34. Sawchenko, P.E. (1987). Adrenalectomy-induced enhancement of CRF and vasopressin immunoreactivity in parvocellular neurosecretory neurons: anatomic, peptide, and steroid specificity. J. Neurosci. 7, 1093-1106.
35. Sawchenko, P.E., Swanson, L.W., and Vale, W.W. (1984). Co-expression of corticotropin releasing factor and vasopressin immunoreactivity in parvocellular neurosecretory neurons of the adrenalectomized rat. Proc. Natl. Acad. Sci. USA 81, 1883-1887.
36. Schulz, D.W., Mansbach, R.S., Sprouse, J., Braselton, J.P., Collins, J., Corman, M., Dunaiskis, A., Faraci, S., Schmidt, A.W., Seeger, T., Seymour, P., Tingley, F.D., III, Winston, E.N., Chen, Y.L., and Heym, J. (1996). CP-154,526: apotent and selective nonpeptide antagonist of corticotropin releasing factor receptors. Proc. Natl. Acad. Sci. USA 93, 10477-10482.
37. Skutella, T., Criswell, H., Moy, S., Probst, J.C., Breese, G.R., Jirikowski, G.F., and Holsboer, F. (1994). Corticotropin-releasing hormone (CRH) antisense oligodeoxynucleotide induces anxiolytic effects in rat. Neuroreport 5, 2181-2185.
38. Stenzel, P., Kesterson, R., Yeung, W., Cone, R.D., Rittenberg, M.B., and Stenzel Poore, M.P. (1995). Identification of a novel murine receptor for corticotropin-releasing hormone expressed in the heart. Mol. Endocrinol. 9, 637-645.
39. Swiergiel, A.H., Takahashi, L.K., and Kalin, N.H. (1993). Attenuation of stress-induced behavior by antagonism of corticotropin releasing factor receptors in the central amygdala in the rat. Brain Res. 623, 229-234.
40. Takahashi, L.K., Kalin, N.H., Vanden Burgt, J.A., and Sherman, J.E. (1989). Corticotropin-releasing factor modulates defensive-withdrawal and exploratory behavior in rats. Behav. Neurosci. 103, 648-654.
41. Vale, W., Spiess, J., Rivier, C., and Rivier, J. (1981). Characterization of a41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin. Science 213, 1394-1397.
42. Vale, W., Vaughan, J., Yamamoto, G., Bruhn, T., Douglas, C., Dalton, D., Rivier, C., and Rivier, J. (1983). Assay of corticotropin releasing factor. In Methods in Enzymology: Neuroendocrine Peptides, P.M. Conn, ed. (New York: Academic Press), pp. 565-577.
43. Vale, W., Vaughan, J., and Perrin, M. (1997). Corticotropin-releasing factor family of ligands and their receptors. The Endocrinologist 7, 3S-9S.
44. Vaughan, J., Donaldson, C., Bittencourt, J., Perrin, M.H., Lewis, K., Sutton, S., Chan, R., Turnbull, A.V., Lovejoy, D., Rivier, C., et al. (1995). Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor. Nature 378, 287-292.
45. Wyllie, A.H., Kerr, J.F., Macaskill, I.A., and Currie, A.R. (1973). Adrenocortical cell deletion: the role of ACTH. J. Pathol. 111, 85-94.
46. Xu, M., Moratalla, R., Gold, L.H., Hiroi, N., Koob, G.F., Graybiel, A.M., and Tonegawa, S. (1994). Dopamine D1 receptor mutant mice are deficient in striatal expression of dynorphin and in dopamine-mediated behavioral responses. Cell 79, 729-742.