Regulation of GPCR activity, trafficking and localization by GPCR-interacting proteins

British Journal of Pharmacology

Volumn 165, Issue 6, 2012, Pages 1717-1736

  Magalhaes, Ana C ^a,b   Dunn, Henry ^a,b   Ferguson, Stephen S G ^a,b  

^a ROBARTS RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

beta arrestin; calmodulin; desensitization; G protein coupled receptors; homer; PDZ proteins; RGS; signalling; small G proteins; trafficking

Indexed keywords

4 AMINOBUTYRIC ACID B RECEPTOR; ADENOSINE DIPHOSPHATE RIBOSYLATION FACTOR 1; BETA ARRESTIN; CALMODULIN; DOPAMINE RECEPTOR; G PROTEIN COUPLED RECEPTOR; GPCR ASSOCIATED SORTING PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE; MUSCARINIC RECEPTOR; OPTINEURIN; PHOSPHOLIPASE D; PHOSPHOPROTEIN PHOSPHATASE; POSTSYNAPTIC DENSITY PROTEIN 95; PROTEIN HOMER; PROTEIN SH3; PROTEIN ZO1; RAB PROTEIN; RAL PROTEIN; RAP PROTEIN; RAS PROTEIN; RECEPTOR ACTIVITY MODIFYING PROTEIN; RECEPTOR PROTEIN; RGS PROTEIN; SEROTONIN 2A AGONIST; SEROTONIN 2C AGONIST; SPINOPHILIN; UNCLASSIFIED DRUG;

ASTROCYTE; BINDING SITE; CELL COMPARTMENTALIZATION; CELL MEMBRANE TRANSPORT; CELL MIGRATION; CELL SURFACE; CELLULAR DISTRIBUTION; DENDRITIC SPINE; DRUG RECEPTOR BINDING; DRUG TARGETING; ENDOCYTOSIS; ENDOPLASMIC RETICULUM; HUMAN; INTRACELLULAR SIGNALING; INTRACELLULAR TRANSPORT; NERVE CELL; NERVE CELL PLASTICITY; NEUROPHARMACOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; RECEPTOR AFFINITY; RECEPTOR DOWN REGULATION; REVIEW; SEQUENCE HOMOLOGY;

ANIMALS; ARRESTINS; G-PROTEIN-COUPLED RECEPTOR KINASES; GTP-BINDING PROTEINS; HUMANS; PROTEIN TRANSPORT; RECEPTOR ACTIVITY-MODIFYING PROTEINS; RECEPTORS, G-PROTEIN-COUPLED; VESICULAR TRANSPORT PROTEINS;

EID: 84857471063     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2011.01552.x     Document Type: Review

References (214)

1. Abbas AI, Yadav PN, Yao WD, Arbuckle MI, Grant SG, Caron MG, et al,. (2009). PSD-95 is essential for hallucinogen and atypical antipsychotic drug actions at serotonin receptors. J Neurosci 29: 7124-7136.
2. Anborgh PH, Godin C, Pampillo M, Dhami GK, Dale LB, Cregan SP, et al,. (2005). Inhibition of metabotropic glutamate receptor signaling by the huntingtin-binding protein optineurin. J Biol Chem 280: 34840-34848.
3. Anderson GR, Posokhova E, Martemyanov KA, (2009). The R7 RGS protein family: multi-subunit regulators of neuronal G protein signaling. Cell Biochem Biophys 54: 33-46.
4. Ango F, Pin JP, Tu JC, Xiao B, Worley PF, Bockaert J, et al,. (2000). Dendritic and axonal targeting of type 5 metabotropic glutamate receptor is regulated by homer1 proteins and neuronal excitation. J Neurosci 20: 8710-8716.
5. Ango F, Prézeau L, Muller T, Tu JC, Xiao B, Worley PF, et al,. (2001). Agonist-independent activation of metabotropic glutamate receptors by the intracellular protein Homer. Nature 411: 962-965.
6. Antonescu CN, Danuser G, Schmid SL, (2010). Phosphatidic acid plays a regulatory role in clathrin-mediated endocytosis. Mol Biol Cell 21: 2944-2952.
7. Balasubramanian S, Fam SR, Hall RA, (2007). GABAB receptor association with the PDZ scaffold Mupp1 alters receptor stability and function. J Biol Chem 282: 4162-4171.
8. Ballon DR, Flanary PL, Gladue DP, Konopka JB, Dohlman HG, Thorner J, (2006). DEP-domain-mediated regulation of GPCR signaling responses. Cell 126: 1079-1093.
9. Bansal G, Druey KM, Xie Z, (2007). R4 RGS proteins: regulation of G-protein signaling and beyond. Pharmacol Ther 116: 473-495.
10. Barlic J, Andrews JD, Kelvin AA, Bosinger SE, DeVries ME, Xu L, et al,. (2001). Regulation of tyrosine kinase activation and granule release through beta-arrestin by CXCRI. Nat Immunol 1: 227-233.
11. Bartlett SE, Enquist J, Hopf FW, Lee JH, Gladher F, Kharazia V, et al,. (2005). Dopamine responsiveness is regulated by targeted sorting of D2 receptors. Proc Natl Acad Sci U S A 102: 11521-11526.
12. Becamel C, Figge A, Poliak S, Dumuis A, Peles E, Bockaert J, et al,. (2001). Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1. J Biol Chem 276: 12974-12982.
13. Bécamel C, Alonso G, Galéotti N, Demey E, Jouin P, Ullmer C, et al,. (2002). Synaptic multiprotein complexes associated with 5-HT(2C) receptors: a proteomic approach. EMBO J 21: 2332-2342.
14. Bécamel C, Gavarini S, Chanrion B, Alonso G, Galéotti N, Dumuis A, et al,. (2004). The serotonin 5-HT2A and 5-HT2C receptors interact with specific sets of PDZ proteins. J Biol Chem 279: 20257-20266.
15. Bernstein LS, Grillo AA, Loranger SS, Linder ME, (2000). RGS4 binds to membranes through an amphipathic alpha -helix. J Biol Chem 275: 18520-18526.
16. Bernstein LS, Ramineni S, Hague C, Cladman W, Chidiac P, Levey AI, et al,. (2004). RGS2 binds directly and selectively to the M1 muscarinic acetylcholine receptor third intracellular loop to modulate Gq/11alpha signaling. J Biol Chem 279: 21248-21256.
17. Bhatnagar A, Willins DL, Gray JA, Woods J, Benovic JL, Roth BL, (2001). The dynamin-dependent, arrestin-independent internalization of 5-hydroxytryptamine 2A (5-HT2A) serotonin receptors reveals differential sorting of arrestins and 5-HT2A receptors during endocytosis. J Biol Chem 276: 8269-8277.
18. Bhattacharya M, Babwah AV, Ferguson SSG, (2004). Small G protein-coupled receptors. Biochem Soc Trans 32: 1040-1044.
19. Bockaert J, Fagni L, Dumuis A, Marin P, (2004). GPCR interacting proteins (GIP). Pharmacol Ther 103: 203-221.
20. Bockaert J, Perroy J, Bécamel C, Marin P, Fagni L, (2010). GPCR interacting proteins (GIPs) in the nervous system: roles in physiology and pathologies. Annu Rev Pharmacol Toxicol 50: 89-109.
21. Boeuf J, Trigo JM, Moreau PH, Lecourtier L, Vogel E, Cassel JC, et al,. (2009). Attenuated behavioural responses to acute and chronic cocaine in GASP-1-deficient mice. Eur J Neurosci 30: 860-868.
22. Bomberger JM, Parameswaran N, Hall CS, Aiyar N, Spielman WS, (2005a). Novel function for receptor activity-modifying proteins (RAMPs) in post-endocytic receptor trafficking. J Biol Chem 280: 9297-9307.
23. Bomberger JM, Spielman WS, Hall CS, Weinman EJ, Parameswaran N, (2005b). Receptor activity-modifying protein (RAMP) isoform-specific regulation of adrenomedullin receptor trafficking by NHERF-1. J Biol Chem 280: 23926-23935.
24. Boudin H, Doan A, Xia J, Shigemoto R, Huganir RL, Worley P, et al,. (2000). Presynaptic clustering of mGluR7a requires the PICK1 PDZ domain binding site. Neuron 28: 485-497.
25. Bouschet T, Martin S, Henley JM, (2005). Receptor-activity-modifying proteins are required for forward trafficking of the calcium-sensing receptor to the plasma membrane. J Cell Sci 118: 4709-4720.
26. Bouvier M, (2001). Oligomerization of G-protein-coupled transmitter receptors. Nat Rev Neurosci 2: 274-286.
27. Brakeman PR, Lanahan AA, O'Brien R, Roche K, Barnes CA, Huganir RL, et al,. (1997). Homer: a protein that selectively binds metabotropic glutamate receptors. Nature 386: 284-288.
28. Cao TT, Deacon HW, Reczek D, Bretscher A, von Zastrow M, (1999). A kinase-regulated PDZ-domain interaction controls endocytic sorting of the beta2-adrenergic receptor. Nature 401: 286-290.
29. Cao W, Luttrell LM, Medvedev AV, Pierce KL, Daniel KW, Dixon TM, et al,. (2000). Direct binding of activated c-Src to the beta 3-adrenergic receptor is required for MAP kinase activation. J Biol Chem 275: 38131-38134.
30. Cermakian N, Sassone-Corsi P, (2000). Multilevel regulation of the circadian clock. Nat Rev Mol Cell Biol 1: 59-67.
31. Charlton JJ, Allen PB, Psifogeorgou K, Chakravarty S, Gomes I, Neve RL, et al,. (2008). Multiple actions of spinophilin regulate mu opioid receptor function. Neuron 58: 238-247.
32. Chen CK, Eversole-Cire P, Zhang HK, Mancino V, Chen YJ, He W, et al,. (2003). Instability of GGL domain-containing RGS proteins in mice lacking the G protein β-subunit Gβ5. Proc Natl Acad Sci U S A 100: 6604-6609.
33. Chen Z, Hague C, Hall RA, Minneman KP, (2006). Syntrophins regulate alpha1D-adrenergic receptors through a PDZ domain-mediated interaction. J Biol Chem 281: 12414-12420.
34. Cheng S, Zhang J, Zhu P, Ma Y, Xiong Y, Sun L, et al,. (2010). The PDZ domain protein CAL interacts with mGluR5a and modulates receptor expression. J Neurochem 112: 588-598.
35. Choi JW, Lim S, Oh YS, Kim EK, Kim SH, Kim YH, et al,. (2010). Subtype-specific role of phospholipase C-beta in bradykinin and LPA signaling through differential binding of different PDZ scaffold proteins. Cell Signal 22: 1153-1161.
36. Claing A, Chen W, Miller WE, Vitale N, Moss J, Premont RT, et al,. (2001). beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosis. J Biol Chem 276: 42509-42513.
37. Croci C, Sticht H, Brandstätter JH, Enz R, (2003). Group I metabotropic glutamate receptors bind to protein phosphatase 1C. Mapping and modeling of interacting sequences. J Biol Chem 278: 50682-50690.
38. Dev KK, Nakajima Y, Kitano J, Braithwaite SP, Henley JM, Nakanishi S, (2000). PICK1 interacts with and regulates PKC phosphorylation of mGLUR7. J Neurosci 20: 7252-7257.
39. Dhami GK, Ferguson SS, (2006). Regulation of metabotropic glutamate receptor signaling, desensitization and endocytosis. Pharmacol Ther 111: 260-271.
40. Dooley R, Baumgart S, Rasche S, Hatt H, Neuhaus EM, (2009). Olfactory receptor signaling is regulated by the post-synaptic density 95, drosophila discs large, zona-occludens 1 (PDZ) scaffold multi-PDZ domain protein 1. FEBS J 276: 7279-7290.
41. Drenan RM, Doupnik CA, Jayaraman M, Buchwalter AL, Kaltenbronn KM, Huettner JE, et al,. (2006). R7BP augments the function of RGS7*Gbeta5 complexes by a plasma membrane-targeting mechanism. J Biol Chem 281: 28222-28231.
42. Du G, Huang P, Liang BT, Frohman MA, (2004). Phospholipase D2 localizes to the plasma membrane and regulates angiotensin II receptor endocytosis. Mol Biol Cell 15: 1024-1030.
43. Esseltine JL, Dale LB, Ferguson SS, (2011). Rab GTPases bind at a common site within the angiotensin II type I receptor carboxyl-terminal tail: evidence that Rab4 regulates receptor phosphorylation, desensitization, and resensitization. Mol Pharmacol 79: 175-184.
44. Fam SR, Paquet M, Castleberry AM, Oller H, Lee CJ, Traynelis SF, et al,. (2005). P2Y1 receptor signaling is controlled by interaction with the PDZ scaffold NHERF-2. Proc Natl Acad Sci U S A 102: 8042-8047.
45. Feng W, Tu J, Yang T, Vernon PS, Allen PD, Worley PF, et al,. (2002). Homer regulates gain of ryanodine receptor type 1 channel complex. J Biol Chem 277: 44722-44730.
46. Ferguson SS, (2001). Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling. Pharmacol Rev 53: 1-24.
47. Ferguson SS, (2007). Phosphorylation-independent attenuation of GPCR signalling. Trends Pharmacol Sci 28: 173-179.
48. Ferguson SS, Zhang J, Barak LS, Caron MG, (1996). G-protein-coupled receptor kinases and arrestins: regulators of G-protein-coupled receptor sequestration. Biochem Soc Trans 24: 953-959.
49. Flajolet M, Rakhilin S, Wang H, Starkova N, Nuangchamnong N, Nairn AC, et al,. (2003). Protein phosphatase 2C binds selectively to and dephosphorylates metabotropic glutamate receptor 3. Proc Natl Acad Sci U S A 100: 16006-16011.
50. Gage RM, Matveeva EA, Whiteheart SW, von Zastrow M, (2005). Type I PDZ ligands are sufficient to promote rapid recycling of G Protein-coupled receptors independent of binding to N-ethylmaleimide-sensitive factor. J Biol Chem 280: 3305-3313.
51. Gainetdinov RR, Premont RT, Bohn LM, Lefkowitz RJ, Caron MG, (2004). Desensitization of G protein-coupled receptors and neuronal functions. Annu Rev Neurosci 27: 107-144.
52. Galandrin S, Oligny-Longpré G, Bouvier M, (2007). The evasive nature of drug efficacy: implications for drug discovery. Trends Pharmacol Sci 28: 423-430.
53. Gardner LA, Naren AP, Bahouth SW, (2007). Assembly of an SAP97-AKAP79-cAMP-dependent protein kinase scaffold at the type 1 PSD-95/DLG/ZO1 motif of the human beta(1)-adrenergic receptor generates a receptosome involved in receptor recycling and networking. J Biol Chem 282: 5085-5099.
54. Gavarini S, Becamel C, Altier C, Lory P, Poncet J, Wijnholds J, et al,. (2006). Opposite effects of PSD-95 and MPP3 PDZ proteins on serotonin 5-hydroxytryptamine2C receptor desensitization and membrane stability. Mol Biol Cell 17: 4619-4631.
55. Gee HY, Kim YW, Jo MJ, Namkung W, Kim JY, Park HW, et al,. (2009). Synaptic scaffolding molecule binds to and regulates vasoactive intestinal polypeptide type-1 receptor in epithelial cells. Gastroenterology 137: 607-617.
56. Gesty-Palmer D, Luttrell LM, (2008). Heptahelical terpsichory. Who calls the tune? J Recept Signal Transduct Res 28: 39-58.
57. Giuffrida R, Musumeci S, D'Antoni S, Bonaccorso CM, Giuffrida-Stella AM, Oostra BA, et al,. (2005). A reduced number of metabotropic glutamate subtype 5 receptors are associated with constitutive homer proteins in a mouse model of fragile X syndrome. J Neurosci 25: 8908-8916.
58. Godin CM, Ferreira LT, Dale LB, Gros R, Cregan SP, Ferguson SS, (2010). The small GTPase Ral couples the angiotensin II type 1 receptor to the activation of phospholipase C-delta 1. Mol Pharmacol 77: 388-395.
59. Goehler H, Lalowski M, Stelzl U, Waelter S, Stroedicke M, Worm U, et al,. (2004). A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease. Mol Cell 15: 853-865.
60. Gold SJ, Ni YG, Dohlman HG, Nestler EJ, (1997). Regulators of G-protein signaling (RGS) proteins: region specific expression of nine subtypes in rat brain. J Neurosci 17: 8024-8037.
61. Goodman OB Jr, Krupnick JG, Santini F, Gurevich VV, Penn RB, Gagnon AW, et al,. (1996). Beta-arrestin acts as a clathrin adaptor in endocytosis of the beta2-adrenergic receptor. Nature 383: 447-450.
62. Gray NW, Fourgeaud L, Huang B, Chen J, Cao H, Oswald BJ, et al,. (2003). Dynamin 3 is a component of the postsynapse, where it interacts with mGluR5 and Homer. Curr Biol 13: 510-515.
63. Guillaume JL, Daulat AM, Maurice P, Levoye A, Migaud M, Brydon L, et al,. (2008). The PDZ protein mupp1 promotes Gi coupling and signaling of the Mt1 melatonin receptor. J Biol Chem 283: 16762-16771.
64. Gullapalli A, Wolfe BL, Griffin CT, Magnuson T, Trejo J, (2006). An essential role for SNX1 in lysosomal sorting of protease-activated receptor-1: evidence for retromer-, Hrs-, and Tsg101-independent functions of sorting nexins. Mol Biol Cell 17: 1228-1238.
65. Hague C, Bernstein LS, Ramineni S, Chen Z, Minneman KP, Hepler JR, (2005). Selective inhibition of alpha1Adrenergic receptor signaling by RGS2 association with the receptor third intracellular loop. J Biol Chem 280: 27289-27295.
66. Hall RA, Premont RT, Chow CW, Blitzer JT, Pitcher JA, Claing A, et al,. (1998). The beta2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange. Nature 392: 626-630.
67. Hamelin E, Thériault C, Laroche G, Parent JL, (2005). The intracellular trafficking of the G protein-coupled receptor TPβ depends on a direct interaction with Rab11. J Biol Chem 280: 36195-36205.
68. Harjes P, Wanker EE, (2003). The hunt for huntingtin function: interaction partners tell many different stories. Trends Biochem Sci 28: 425-433.
69. Hayashi MK, Ames HM, Hayashi Y, (2006). Tetrameric hub structure of postsynaptic scaffolding protein homer. J Neurosci 26: 8492-8501.
70. He J, Bellini M, Xu J, Castleberry AM, Hall RA, (2004). Interaction with cystic fibrosis transmembrane conductance regulator-associated ligand (CAL) inhibits beta1-adrenergic receptor surface expression. J Biol Chem 279: 50190-50196.
71. He J, Bellini M, Inuzuka H, Xu J, Xiong Y, Yang X, et al,. (2006). Proteomic analysis of beta1-adrenergic receptor interactions with PDZ scaffold proteins. J Biol Chem 281: 2820-2827.
72. He W, Lu LS, Zhang X, El Hodiri HM, Chen CK, Slep KC, et al,. (2000). Modules in the photoreceptor RGS9-1.Gβ5L GTPase-accelerating protein complex control effector coupling, GTPase acceleration, protein folding, and stability. J Biol Chem 275: 37093-37100.
73. Heo K, Ha SH, Chae YC, Lee S, Oh YS, Kim YH, et al,. (2006). RGS2 promotes formation of neurites by stimulating microtubule polymerization. Cell Signal 18: 2182-2192.
74. Heydorn A, Sondergaard BP, Ersboll B, Holst B, Nielsen FC, Haft CR, et al,. (2004). A library of 7TM receptor C-terminal tails. Interactions with the proposed post-endocytic sorting proteins ERM-binding phosphoprotein 50 (EBP50), N-ethylmaleimide- sensitive factor (NSF), sorting nexin 1 (SNX1), and G protein-coupled receptor-associated sorting protein (GASP). J Biol Chem 279: 54291-54303.
75. Hirakawa T, Galet C, Kishi M, Ascoli M, (2003). GIPC binds to the human lutropin receptor (hLHR) through an unusual PDZ domain binding motif, and it regulates the sorting of the internalized human choriogonadotropin and the density of cell surface hLHR. J Biol Chem 278: 49348-49357.
76. Holmes KD, Babwah AV, Dale LB, Poulter MO, Ferguson SS, (2006). Differential regulation of corticotropin releasing factor 1alpha receptor endocytosis and trafficking by beta-arrestins and Rab GTPases. J Neurochem 96: 934-949.
77. Houndolo T, Boulay PL, Claing A, (2005). G protein-coupled receptor endocytosis in ADP-ribosylation factor 6-depleted cells. J Biol Chem 280: 5598-5604.
78. Hu LA, Tang Y, Miller WE, Cong M, Lau AG, Lefkowitz RJ, et al,. (2000). beta 1-adrenergic receptor association with PSD-95. Inhibition of receptor internalization and facilitation of beta 1-adrenergic receptor interaction with N-methyl-D-aspartate receptors. J Biol Chem 275: 38659-38666.
79. Hu LA, Chen W, Martin NP, Whalen EJ, Premont RT, Lefkowitz RJ, (2003). GIPC interacts with the beta1-adrenergic receptor and regulates beta1-adrenergic receptor-mediated ERK activation. J Biol Chem 278: 26295-26301.
80. Inglese J, Koch WJ, Caron MG, Lefkowitz RJ, (1992). Isoprenylation in regulation of signal transduction by G-protein-coupled receptor kinases. Nature 359: 147-150.
81. Irminger-Finger I, Jefford CE, (2006). Is there more to BARD1 than BRCA1? Nat Rev Cancer 6: 382-391.
82. Jakab RL, Goldman-Rakic PS, (1998). 5-Hydroxytryptamine2A serotonin receptors in the primate cerebral cortex: possible site of action of hallucinogenic and antipsychotic drugs in pyramidal cell apical dendrites. Proc Natl Acad Sci U S A 95: 735-740.
83. Jayaraman M, Zhou H, Jia L, Cain MD, Blumer KJ, (2009). R9AP and R7BP: traffic cops for the RGS7 family in phototransduction and neuronal GPCR signaling. Trends Pharmacol Sci 30: 17-24.
84. Jeanneteau F, Diaz J, Sokoloff P, Griffon N, (2004). Interactions of GIPC with dopamine D2, D3 but not D4 receptors define a novel mode of regulation of G protein-coupled receptors. Mol Biol Cell 15: 696-705.
85. Jones KA, Srivastava DP, Allen JA, Strachan RT, Roth BL, Penzes P, (2009). Rapid modulation of spine morphology by the 5-HT2A serotonin receptor through kalirin-7 signaling. Proc Natl Acad Sci U S A 106: 19575-19580.
86. Joubert L, Hanson B, Barthet G, Sebben M, Claeysen S, Hong W, et al,. (2004). New sorting nexin (SNX27) and NHERF specifically interact with the 5-HT4a receptor splice variant: roles in receptor targeting. J Cell Sci 117: 5367-5379.
87. Kammermeier PJ, Worley PF, (2007). Homer 1a uncouples metabotropic glutamate receptor 5 from postsynaptic effectors. Proc Natl Acad Sci U S A 104: 6055-6060.
88. Kammermeier PJ, Xiao B, Tu JC, Worley PF, Ikeda SR, (2000). Homer proteins regulate coupling of group I metabotropic glutamate receptors to N-type calcium and M-type potassium channels. J Neurosci 20: 7238-7245.
89. Kato A, Ozawa F, Saitoh Y, Fukazawa Y, Sugiyama H, Inokuchi K, (1998). Novel members of the Vesl/Homer family of PDZ proteins that bind metabotropic glutamate receptors. J Biol Chem 273: 23969-23975.
90. Kenakin T, (2007). Functional selectivity through protean and biased agonism: who steers the ship? Mol Pharmacol 72: 1393-1401.
91. Kimple RJ, De Vries L, Tronche're H, Behe CI, Morris RA, Gist Farquhar M, et al,. (2001). RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity. J Biol Chem 276: 29275-29281.
92. Kitano J, Kimura K, Yamazaki Y, Soda T, Shigemoto R, Nakajima Y, et al,. (2002). Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins. J Neurosci 22: 1280-1289.
93. Koch T, Brandenburg LO, Schulz S, Liang Y, Klein J, Hollt V, (2003). ADP-ribosylation factor-dependent phospholipase D2 activation is required for agonist-induced mu-opioid receptor endocytosis. J Biol Chem 278: 9979-9985.
94. Koch WJ, Inglese J, Stone WC, Lefkowitz RJ, (1993). The binding site for the beta gamma subunits of heterotrimeric G proteins on the beta-adrenergic receptor kinase. J Biol Chem 268: 8256-8260.
95. 2-adrenergic receptor dephosphorylation by vesicular acidification. J Biol Chem 272: 5-8.
96. Krupnick JG, Benovic JL, (1998). The role of receptor kinases and arrestins in G protein-coupled receptor regulation. Annu Rev Pharmacol Toxicol 38: 289-319.
97. Krupnick JG, Goodman OB Jr, Keen JH, Benovic JL, (1997). Arrestin/clathrin interaction. Localization of the clathrin binding domain of nonvisual arrestins to the carboxy terminus. J Biol Chem 272: 15011-15016.
98. Kunapuli P, Gurevich VV, Benovic JL, (1994). Phospholipid-stimulated autophosphorylation activates the G protein-coupled receptor kinase GRK5. J Biol Chem 269: 10209-10212.
99. Kuwasako K, Cao YN, Chu CP, Iwatsubo S, Eto T, Kitamura K, (2006). Functions of the cytoplasmic tails of the human receptor activity-modifying protein components of calcitonin gene-related peptide and adrenomedullin receptors. J Biol Chem 281: 7205-7213.
100. Labasque M, Reiter E, Becamel C, Bockaert J, Marin P, (2008). Physical interaction of calmodulin with the 5-hydroxytryptamine2C receptor C-terminus is essential for G protein-independent, arrestin-dependent receptor signaling. Mol Biol Cell 19: 4640-4650.
101. Laporte SA, Roy SF, Escher E, Guillemette G, Leduc R, (1998). Essential role of leucine222 in mediating signal transduction of the human angiotensin II type 1 receptor. Receptors Channels 5: 103-112.
102. Laporte SA, Oakley RH, Holt JA, Barak LS, Caron MG, (2000). The interaction of beta-arrestin with the AP-2 adaptor is required for the clustering of beta 2-adrenergic receptor into clathrin-coated pits. J Biol Chem 275: 23120-23126.
103. Lee JH, Lee J, Choi KY, Hepp R, Lee JY, Lim MK, et al,. (2008). Calmodulin dynamically regulates the trafficking of the metabotropic glutamate receptor mGluR5. Proc Natl Acad Sci U S A 105: 12575-12580.
104. Lefkowitz RJ, (1998). G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor signaling and desensitization. J Biol Chem 273: 18677-18680.
105. Lefkowitz RJ, Shenoy SK, (2005). Transduction of receptor signals by β-arrestins. Science 308: 512-517.
106. Lefkowitz RJ, Rajagopal K, Whalen EJ, (2006). New roles for beta-arrestins in cell signaling: not just for seven-transmembrane receptors. Mol Cell 24: 643-652.
107. Li JG, Chen C, Liu-Chen LY, (2002). Ezrin-radixin-moesin-binding phosphoprotein-50/Na+/H+ exchanger regulatory factor (EBP50/ NHERF) blocks U50,488H-induced down-regulation of the human kappa opioid receptor by enhancing its recycling rate. J Biol Chem 277: 27545-27552.
108. Lin SHS, Arai AC, Wang Z, Nothacker HP, Civelli O, (2001). The carboxyl terminus of the prolactin-releasing peptide receptor interacts with PDZ domain proteins involved in alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor clustering. Mol Pharmacol 60: 916-924.
109. Luttrell LM, (2008). Reviews in molecular biology and biotechnology: transmembrane signalling by G protein-coupled receptors. Mol Biotechnol 39: 239-264.
110. Luttrell LM, Gesty-Palmer D, (2010). Beyond desensitization: physiological relevance of arrestin-dependent signaling. Pharmacol Rev 62: 305-330.
111. Luttrell LM, Ferguson SS, Daaka Y, Miller WE, Maudsley S, Della Rocca GJ, et al,. (1999). Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. Science 283: 655-661.
112. Magalhaes AC, Holmes KD, Dale LB, Comps-Agrar L, Lee D, Yadav PN, et al,. (2010). CRF receptor 1 regulates anxiety behavior via sensitization of 5-HT2 receptor signaling. Nat Neurosci 13: 622-629.
113. Mahon MJ, Shimada M, (2005). Calmodulin interacts with the cytoplasmic tails of the parathyroid hormone 1 receptor and a sub-set of class b G-protein coupled receptors. FEBS Lett 579: 803-807.
114. Mahon MJ, Donowitz M, Yun CC, Segre GV, (2002). Na(+)/H(+) exchanger regulatory factor 2 directs parathyroid hormone 1 receptor signalling. Nature 417: 858-861.
115. Makino ER, Handy JW, Li TS, Arshavsky VY, (1999). The GTPase activating factor for transducin in rod photoreceptors is the complex between RGS9 and type 5 G protein β subunit. Proc Natl Acad Sci U S A 96: 1947-1952.
116. Mao L, Yang L, Tang Q, Samdani S, Zhang G, Wang JQ, (2005a). The scaffold protein Homer1b/c links metabotropic glutamate receptor 5 to extracellular signal-regulated protein kinase cascades in neurons. J Neurosci 25: 2741-2752.
117. Mao L, Yang L, Arora A, Choe ES, Zhang G, Liu Z, et al,. (2005b). Role of protein phosphatase 2A in mGluR5-regulated MEK/ERK phosphorylation in neurons. J Biol Chem 280: 12602-12610.
118. Marchese A, Paing MM, Temple BR, Trejo J, (2008). G protein-coupled receptor sorting to endosomes and lysosomes. Annu Rev Pharmacol Toxicol 48: 601-629.
119. Martin-McCaffrey L, Hains MD, Pritchard GA, Pajak A, Dagnino L, Siderovski DP, et al,. (2005). Differential expression of regulator of G-protein signaling R12 subfamily members during mouse development. Dev Dyn 234: 438-444.
120. Matsuki T, Kiyama A, Kawabuchi M, Okada M, Nagai K, (2001). A novel protein interacts with a clock-related protein, rPer1. Brain Res 916: 1-10.
121. McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, et al,. (1998). RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. Nature 393: 333-339.
122. Minakami R, Jinnai N, Sugiyama H, (1997). Phosphorylation and calmodulin binding of the metabotropic glutamate receptor subtype 5 (mGluR5) are antagonistic in vitro. J Biol Chem 272: 20291-20298.
123. Mitchell R, McCulloch D, Lutz E, Johnson M, MacKenzie C, Fennell M, et al,. (1998). Rhodopsin-family receptors associate with small G proteins to activate phospholipase D. Nature 392: 411-414.
124. Neer EJ, (1995). Heterotrimeric G proteins: organizers of transmembrane signals. Cell 80: 249-257.
125. Nunn C, Mao H, Chidiac P, Albert PR, (2006). RGS17/RGSZ2 and the RZ/A family of regulators of G-protein signaling. Semin Cell Dev Biol 17: 390-399.
126. Oakley RH, Laporte SA, Holt JA, Caron MG, Barak LS, (2000). Differential affinities of visual arrestin, β arrestin1, and β arrestin2 for G protein-coupled receptors delineate two major classes of receptors. J Biol Chem 275: 17201-17210.
127. Oh YS, Jo NW, Choi JW, Kim HS, Seo SW, Kang KO, et al,. (2004). NHERF2 specifically interacts with LPA2 receptor and defines the specificity and efficiency of receptor-mediated phospholipase C-beta3 activation. Mol Cell Biol 24: 5069-5079.
128. Oldenhof J, Vickery R, Anafi M, Oak J, Ray A, Schoots O, et al,. (1998). SH3 binding domains in the dopamine D4 receptor. Biochemistry 37: 15726-15736.
129. Overington JP, Al-Lazikani B, Hopkins AL, (2006). How many drug targets are there? Nat Rev Drug Discov 5: 993-996.
130. Pak Y, Pham N, Rotin D, (2002). Direct binding of the beta1 adrenergic receptor to the cyclic AMP-dependent guanine nucleotide exchange factor CNrasGEF leads to ras activation. Mol Cell Biol 22: 7942-7952.
131. Paquet M, Asay MJ, Fam SR, Inuzuka H, Castleberry AM, Oller H, et al,. (2006). The PDZ scaffold NHERF-2 interacts with mGluR5 and regulates receptor activity. J Biol Chem 281: 29949-29961.
132. Parameswaran N, Spielman WS, (2006). RAMPs: the past, present and future. Trends Biochem Sci 31: 631-638.
133. 2-adrenergic receptor through a direct interaction. Biochem J 418: 163-172.
134. Parker LL, Backstrom JR, Sanders-Bush E, Shieh BH, (2003). Agonist-induced phosphorylation of the serotonin 5-HT2C receptor regulates its interaction with multiple PDZ protein 1. J Biol Chem 278: 21576-21583.
135. Penela P, Ribas C, Mayor FJ, (2003). Mechanisms of regulation of the expression and function of G protein-coupled receptor kinases. Cell Signal 15: 973-981.
136. 2-adrenergic receptors permit resensitization. Mol Pharmacol 47: 666-676.
137. Pitcher JA, Touhara K, Payne ES, Lefkowitz RJ, (1995). Pleckstrin homology domain-mediated membrane association and activation of the beta-adrenergic receptor kinase requires coordinate interaction with G beta gamma subunits and lipid. J Biol Chem 270: 11707-11710.
138. Pitcher JA, Freedman NJ, Lefkowitz RJ, (1998). G protein-coupled receptor kinases. Annu Rev Biochem 67: 653-692.
139. Polese D, de Serpis AA, Ambesi-Impiombato A, Muscettola G, de Bartolomeis A, (2002). Homer 1a gene expression modulation by antipsychotic drugs: involvement of the glutamate metabotropic system and effects of d-cycloserine. Neuropsychopharmacology 27: 906-913.
140. Potschka H, Krupp E, Ebert U, Gümbel C, Leichtlein C, Lorch B, et al,. (2002). Kindling-induced overexpression of Homer 1A and its functional implications for epileptogenesis. Eur J Neurosci 16: 2157-2165.
141. Poupart ME, Fessart D, Cotton M, Laporte SA, Claing A, (2007). ARF6 regulates angiotensin II type 1 receptor endocytosis by controlling the recruitment of AP-2 and clathrin. Cell Signal 19: 2370-2378.
142. Premont RT, Gainetdinov RR, (2007). Physiological roles of G protein-coupled receptor kinases and arrestins. Annu Rev Physiol 69: 511-534.
143. Premont RT, Koch WJ, Inglese J, Lefkowitz RJ, (1994). Identification, purification, and characterization of GRK5, a member of the family of G protein-coupled receptor kinases. J Biol Chem 269: 6832-6841.
144. Premont RT, Inglese J, Lefkowitz RJ, (1995). Protein kinases that phosphorylate activated G protein-coupled receptors. FASEB J 9: 175-182.
145. Premont RT, Macrae AD, Stoffel RH, Chung N, Pitcher JA, Ambrose C, et al,. (1996). Characterization of the G protein-coupled receptor kinase GRK4. Identification of four splice variants. J Biol Chem 271: 6403-6410.
146. Rajagopal S, Rajagopal K, Lefkowitz RJ, (2010). Teaching old receptors new tricks: biasing seven-transmembrane receptors. Nat Rev Drug Discov 9: 373-386.
147. Reid HM, Mulvaney EP, Turner EC, Kinsella BT, (2010). Interaction of the human prostacyclin receptor with Rab11: characterization of a novel Rab11 binding domain (RBD) within α-helix 8 that is regulated by palmitoylation. J Biol Chem 285: 18709-18726.
148. Reiter E, Lefkowitz RJ, (2006). GRKs and beta-arrestins: roles in receptor silencing, trafficking and signaling. Trends Endocrinol Metab 17: 159-165.
149. Rezaie T, Child A, Hitchings R, Brice G, Miller L, Coca-Prados M, et al,. (2002). Adult-onset primary open-angle glaucoma caused by mutations in optineurin. Science 295: 1077-1079.
150. Ribeiro FM, Paquet M, Ferreira LT, Cregan T, Swan P, Cregan SP, et al,. (2010). Metabotropic glutamate receptor-mediated cell signaling pathways are altered in a mouse model of Huntington's disease. J Neurosci 30: 316-324.
151. Richman JG, Brady AE, Wang Q, Hensel JL, Colbran RJ, Limbird LE, (2001). Agonist-regulated Interaction between alpha2-adrenergic receptors and spinophilin. J Biol Chem 276: 15003-15008.
152. Richman RW, Strock J, Hains MD, Cabanilla NJ, Lau KK, Siderovski DP, et al,. (2005). RGS12 interacts with the SNARE-binding region of the Cav2.2 calcium channel. J Biol Chem 280: 1521-1528.
153. Rochdi MD, Parent JL, (2003). Galphaq-coupled receptor internalization specifically induced by galphaq signaling. Regulation by EBP50. J Biol Chem 278: 17827-17837.
154. Roche KW, Tu JC, Petralia RS, Xiao B, Wenthold RJ, Worley PF, (1999). Homer 1b regulates the trafficking of group I metabotropic glutamate receptors. J Biol Chem 274: 25953-25957.
155. Ronesi JA, Huber KM, (2008). Homer interactions are necessary for metabotropic glutamate receptor-induced long-term depression and translational activation. J Neurosci 28: 543-547.
156. Rong R, Ahn JY, Huang H, Nagata E, Kalman D, Kapp JA, et al,. (2003). PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis. Nat Neurosci 6: 1153-1161.
157. Ross EM, Wilkie TM, (2000). GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins. Annu Rev Biochem 69: 795-827.
158. Sala C, PiÃch V, Wilson NR, Passafaro M, Liu G, Sheng M, (2001). Regulation of dendritic spine morphology and synaptic function by Shank and Homer. Neuron 31: 115-130.
159. Sarrouilhe D, di Tommaso A, Métayé T, Ladeveze V, (2006). Spinophilin: from partners to functions. Biochimie 88: 1099-1113.
160. Schiff ML, Siderovski DP, Jordan JD, Brothers G, Snow B, De Vries L, et al,. (2000). Tyrosine-kinase-dependent recruitment of RGS12 to the N-type calcium channel. Nature 408: 723-727.
161. 2-Adrenergic receptor internalization, endosomal sorting and plasma membrane recycling are regulated by Rab GTPases. J Biol Chem 275: 27221-27228.
162. Seachrist JL, Laporte SA, Dale LB, Babwah AV, Caron MG, Anborgh PH, et al,. (2002). Rab5 association with the angiotensin II type 1A receptor promotes Rab5 GTP binding and vesicular fusion. J Biol Chem 277: 679-685.
163. Sethakorn N, Yau DM, Dulin NO, (2010). Non-canonical functions of RGS proteins. Cell Signal 22: 1274-1281.
164. Sheng M, Sala C, (2001). PDZ domains and the organization of
165. Shenoy SK, McDonald PH, Kohout TA, Lefkowitz RJ, (2001). Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin. Science 294: 1307-1313.
166. Shiraishi Y, Mizutani A, Bito H, Fujisawa K, Narumiya S, Mikoshiba K, et al,. (1999). Cupidin, an isoform of Homer/Vesl, interacts with the actin cytoskeleton and activated rho family small GTPases and is expressed in developing mouse cerebellar granule cells. J Neurosci 19: 8389-8400.
167. Siderovski DP, Willard FS, (2005). The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits. Int J Biol Sci 1: 51-66.
168. Sjögren B, Neubig RR, (2010). Thinking outside of the 'RGS box': new approaches to therapeutic targeting of regulators of G protein signaling. Mol Pharmacol 78: 550-557.
169. Skiba NP, Martemyanov KA, Elfenbein A, Hopp JA, Bohm A, Simonds WF, et al,. (2001). RGS9-Gβ5 substrate selectivity in photoreceptors-opposing effects of constituent domains yield high affinity of RGS interaction with the G protein-effector complex. J Biol Chem 276: 37365-37372.
170. Smith FD, Oxford GS, Milgram SL, (1999). Association of the D2 dopamine receptor third cytoplasmic loop with spinophilin, a protein phosphatase-1- interacting protein. J Biol Chem 274: 19894-19900.
171. Snow BE, Krumins AM, Brothers GM, Lee SF, Wall MA, Chung S, et al,. (1998a). A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gβ5 subunits. Proc Natl Acad Sci U S A 95: 13307-13312.
172. Snow BE, Hall RA, Krumins AM, Brothers GM, Bouchard D, Brothers CA, et al,. (1998b). GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain. J Biol Chem 273: 17749-17755.
173. Spellmann I, Rujescu D, Musil R, Mayr A, Giegling I, Genius J, et al,. (2011). Homer-1 polymorphisms are associated with psychopathology and response to treatment in schizophrenic patients. J Psychiatr Res 45: 234-241.
174. Stoffel RH, Randall RR, Premont RT, Lefkowitz RJ, Inglese J, (1994). Palmitoylation of G protein-coupled receptor kinase, GRK6. Lipid modification diversity in the GRK family. J Biol Chem 269: 27791-27794.
175. Stoffel RH, Inglese J, Macrae AD, Lefkowitz RJ, Premont RT, (1998). Palmitoylation increases the kinase activity of the G protein-coupled receptor kinase, GRK6. Biochemistry 37: 16053-16059.
176. Sun P, Wang J, Gu W, Cheng W, Jin GZ, Friedman E, et al,. (2009). PSD-95 regulates D1 dopamine receptor resensitization, but not receptor-mediated gs-protein activation. Cell Res 19: 612-624.
177. Swanson CJ, Baker DA, Carson D, Worley PF, Kalivas PW, (2001). Repeated cocaine administration attenuates group I metabotropic glutamate receptor-mediated glutamate release and behavioral activation: a potential role for Homer. J Neurosci 21: 9043-9052.
178. Szumlinski KK, Dehoff MH, Kang SH, Frys KA, Lominac KD, Klugmann M, et al,. (2004). Homer proteins regulate sensitivity to cocaine. Neuron 43: 401-413.
179. Tadokoro S, Tachibana T, Imanaka T, Nishida W, Sobue K, (1999). Involvement of unique leucine-zipper motif of PSD-Zip45 (Homer 1c/vesl-1L) in group 1 metabotropic glutamate receptor clustering. Proc Natl Acad Sci U S A 96: 13801-13806.
180. Takai Y, Sasaki T, Matozaki T, (2001). Small GTP-binding proteins. Physiol Rev 81: 153-208.
181. Tang Y, Hu LA, Miller WE, Ringstad N, Hall RA, Pitcher JA, et al,. (1999). Identification of the endophilins (SH3p4/p8/p13) as novel binding partners for the beta1-adrenergic receptor. Proc Natl Acad Sci U S A 96: 12559-12564.
182. Terrillon S, Bouvier M, (2004). Roles of G-protein-coupled receptor dimerization. EMBO Rep 5: 30-34.
183. Thompson MD, Cole DE, Jose PA, (2008). Pharmacogenomics of G protein-coupled receptor signaling: insights from health and disease. Methods Mol Biol 448: 77-107.
184. Tobin AB, Butcher AJ, Kong KC, (2008). Location, location, location. site-specific GPCR phosphorylation offers a mechanism for cell-type-specific signalling. Trends Pharmacol Sci 29: 413-420.
185. Touhara K, Inglese J, Pitcher JA, Shaw G, Lefkowitz RJ, (1994). Binding of G protein beta gamma-subunits to pleckstrin homology domains. J Biol Chem 269: 10217-10220.
186. Trejo J, Hammes SR, Coughlin SR, (1998). Termination of signaling by protease-activated receptor-1 is linked to lysosomal sorting. Proc Natl Acad Sci U S A 95: 13698-13702.
187. Tu JC, Xiao B, Yuan JP, Lanahan AA, Leoffert K, Li M, et al,. (1998). Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors. Neuron 21: 717-726.
188. Tu JC, Xiao B, Naisbitt S, Yuan JP, Petralia RS, Brakeman P, et al,. (1999). Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins. Neuron 23: 583-592.
189. Turner JH, Raymond JR, (2005). Interaction of calmodulin with the serotonin 5-hydroxytryptamine2A receptor. A putative regulator of G protein coupling and receptor phosphorylation by protein kinase C. J Biol Chem 280: 30741-30750.
190. Turner JH, Gelasco AK, Raymond JR, (2004). Calmodulin interacts with the third intracellular loop of the serotonin 5-hydroxytryptamine1A receptor at two distinct sites: putative role in receptor phosphorylation by protein kinase C. J Biol Chem 279: 17027-17037.
191. Ullmer C, Schmuck K, Figge A, Lübbert H, (1998). Cloning and characterization of MUPP1, a novel PDZ domain protein. FEBS Lett 424: 63-68.
192. Wang B, Bisello A, Yang Y, Romero GG, Friedman PA, (2007). NHERF1 regulates parathyroid hormone receptor membrane retention without affecting recycling. J Biol Chem 282: 36214-36222.
193. Wang B, Yang Y, Abou-Samra AB, Friedman PA, (2009). NHERF1 regulates parathyroid hormone receptor desensitization: interference with beta-arrestin binding. Mol Pharmacol 75: 1189-1197.
194. Wang B, Ardura JA, Romero G, Yang Y, Hall RA, Friedman PA, (2010). Na/H exchanger regulatory factors control parathyroid hormone receptor signaling by facilitating differential activation of G(alpha) protein subunits. J Biol Chem 285: 26976-26986.
195. Wang D, Sadée W, Quillan JM, (1999). Calmodulin binding to G protein-coupling domain of opioid receptors. J Biol Chem 274: 22081-22088.
196. Wang D, Surratt CK, Sadée W, (2000). Calmodulin regulation of basal and agonist-stimulated G protein coupling by the mu-opioid receptor (OP(3)) in morphine-pretreated cell. J Neurochem 75: 763-771.
197. Wang D, Quillan JM, Winans K, Lucas JL, Sadée W, (2001). Single nucleotide polymorphisms in the human mu opioid receptor gene alter basal G protein coupling and calmodulin binding. J Biol Chem 276: 34624-34630.
198. Wang Q, Zhao J, Brady AE, Feng J, Allen PB, Lefkowitz RJ, et al,. (2004). Spinophilin blocks arrestin actions in vitro and in vivo at G protein-coupled receptors. Science 304: 1940-1944.
199. Wang X, Zeng W, Soyombo AA, Tang W, Ross EM, Barnes AP, et al,. (2005). Spinophilin regulates Ca2+ signalling by binding the N-terminal domain of RGS2 and the third intracellular loop of G-protein-coupled receptors. Nat Cell Biol 7: 405-411.
200. Wente W, Stroh T, Beaudet A, Richter D, Kreienkamp HJ, (2005). Interactions with PDZ domain proteins PIST/GOPC and PDZK1 regulate intracellular sorting of the somatostatin receptor subtype 5. J Biol Chem 280: 32419-32425.
201. Wheeler D, Garrido JL, Bisello A, Kim YK, Friedman PA, Romero G, (2008). Regulation of parathyroid hormone type 1 receptor dynamics, traffic, and signaling by the Na+/H+ exchanger regulatory factor-1 in rat osteosarcoma ROS 17/2.8 cells. Mol Endocrinol 22: 1163-1170.
202. Whistler JL, Enquist J, Marley A, Fong J, Gladher F, Tsuruda P, et al,. (2002). Modulation of postendocytic sorting of G protein-coupled receptors. Science 297: 615-620.
203. Xia Z, Hufeisen SJ, Gray JA, Roth BL, (2003a). The PDZ-binding domain is essential for the dendritic targeting of 5-HT2A serotonin receptors in cortical pyramidal neurons in vitro. Neuroscience 122: 907-920.
204. Xia Z, Gray JA, Compton-Toth BA, Roth BL, (2003b). A direct interaction of PSD-95 with 5-HT2A serotonin receptors regulates receptor trafficking and signal transduction. J Biol Chem 278: 21901-21908.
205. Xiao B, Tu JC, Petralia RS, Yuan JP, Doan A, Breder CD, et al,. (1998). Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins. Neuron 21: 707-716.
206. Xu J, Paquet M, Lau AG, Wood JD, Ross CA, Hall RA, (2001). beta 1-adrenergic receptor association with the synaptic scaffolding protein membrane-associated guanylate kinase inverted-2 (MAGI-2). Differential regulation of receptor internalization by MAGI-2 and PSD-95. J Biol Chem 276: 41310-41317.
207. Yang L, Seifert A, Wu D, Wang X, Rankovic V, Schröder H, et al,. (2010a). Role of phospholipase D2/phosphatidic acid signal transduction in micro- and delta-opioid receptor endocytosis. Mol Pharmacol 78: 105-113.
208. Yang X, Zheng J, Xiong Y, Shen H, Sun L, Huang Y, et al,. (2010b). Beta-2 adrenergic receptor mediated ERK activation is regulated by interaction with MAGI-3. FEBS Lett 584: 2207-2212.
209. Yuan JP, Kiselyov K, Shin DM, Chen J, Shcheynikov N, Kang SH, et al,. (2003). Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors. Cell 114: 777-789.
210. Zeng W, Xu X, Popov S, Mukhopadhyay S, Chidiac P, Swistok J, et al,. (1998). The N-terminal domain of RGS4 confers receptor-selective inhibition of G protein signaling. J Biol Chem 273: 34687-34690.
211. Zerial M, McBride H, (2001). Rab proteins as membrane organizers. Nat Rev Mol Cell Biol 2: 107-117.
212. Zhang J, Vinuela A, Neely MH, Hallett PJ, Grant SG, Miller GM, et al,. (2007). Inhibition of the dopamine D1 receptor signaling by PSD-95. J Biol Chem 282: 15778-15789.
213. Zhang J, Cheng S, Xiong Y, Ma Y, Luo D, Jeromin A, et al,. (2008). A novel association of mGluR1a with the PDZ scaffold protein CAL modulates receptor activity. FEBS Lett 582: 4117-4124.
214. Zimmerman B, Simaan M, Lee MH, Luttrell LM, Laporte SA, (2009). c-Src-mediated phosphorylation of AP-2 reveals a general mechanism for receptors internalizing through the clathrin pathway. Cell Signal 21: 103-110.