메뉴 건너뛰기




Volumn 34, Issue 3, 2000, Pages 171-181

Effects of the high-affinity corticotropin-releasing hormone receptor 1 antagonist R121919 in major depression: the first 20 patients treated

Author keywords

[No Author keywords available]

Indexed keywords

3 (6 DIMETHYLAMINO 4 METHYL 3 PYRIDINYL) 7 DIPROPYLAMINO 2,5 DIMETHYLPYRAZOLO[1,5 A]PYRIMIDINE; CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR ANTAGONIST; CORTICOTROPIN RELEASING FACTOR RECEPTOR; HYDROCORTISONE; UNCLASSIFIED DRUG;

EID: 0034193881     PISSN: 00223956     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-3956(00)00016-9     Document Type: Article
Times cited : (666)

References (41)
  • 2
    • 0027489208 scopus 로고
    • Expression cloning of a human corticotropin-releasing factor receptor
    • Chen R., Lewis K.A., Perrin M.H., Vale W.W. Expression cloning of a human corticotropin-releasing factor receptor. Proc. Natl. Acad. Sci. USA. 90:1993;8967-8971.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 8967-8971
    • Chen, R.1    Lewis, K.A.2    Perrin, M.H.3    Vale, W.W.4
  • 3
    • 0029928064 scopus 로고    scopus 로고
    • Persistent elevations of cerebrospinal fluid concentrations of corticotropin-releasing factor in adult nonhuman primates exposed to early-life stressors: Implications for the pathophysiology of mood and anxiety disorders
    • Coplan J.D., Andrews M.W., Rosenblum L.A., Owens M.J., Friedman S., Gorman J.M., Nemeroff C.B. Persistent elevations of cerebrospinal fluid concentrations of corticotropin-releasing factor in adult nonhuman primates exposed to early-life stressors: implications for the pathophysiology of mood and anxiety disorders. Proc. Natl. Acad. Sci. USA. 93:1996;1619-1623.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 1619-1623
    • Coplan, J.D.1    Andrews, M.W.2    Rosenblum, L.A.3    Owens, M.J.4    Friedman, S.5    Gorman, J.M.6    Nemeroff, C.B.7
  • 4
    • 0026535166 scopus 로고
    • The role of the amygdala in fear and axiety
    • Davis M. The role of the amygdala in fear and axiety. Ann. Rev. Neurosci. 15:1992;353-375.
    • (1992) Ann. Rev. Neurosci. , vol.15 , pp. 353-375
    • Davis, M.1
  • 5
    • 0025966328 scopus 로고
    • Repeated stress-induced activation of corticotropin-releasing factor neurons enhances vasopressin stores and colocalization with corticotropin-releasing factor in the median eminence of rats
    • De Goeij D.C.E., Kvetnansky R., Whitnall M.H., Jezova D., Berkenbosch F., Tilders F.J.H. Repeated stress-induced activation of corticotropin-releasing factor neurons enhances vasopressin stores and colocalization with corticotropin-releasing factor in the median eminence of rats. Neuroendocrinology. 53:1991;150-159.
    • (1991) Neuroendocrinology , vol.53 , pp. 150-159
    • De Goeij, D.C.E.1    Kvetnansky, R.2    Whitnall, M.H.3    Jezova, D.4    Berkenbosch, F.5    Tilders, F.J.H.6
  • 9
    • 0001970461 scopus 로고
    • Neuroendocrinology of mood disorders
    • F.E. Bloom, & D.J. Kupfer. New York: Raven Press
    • Holsboer F. Neuroendocrinology of mood disorders. Bloom F.E., Kupfer D.J. Psychopharmacology: The fourth generation of progress. 1995;957-969 Raven Press, New York.
    • (1995) Psychopharmacology: The Fourth Generation of Progress , pp. 957-969
    • Holsboer, F.1
  • 10
    • 0032895726 scopus 로고    scopus 로고
    • The rationale for corticotropin-releasing hormone receptor (CRH-R) antagonists to treat depression and anxiety
    • Holsboer F. The rationale for corticotropin-releasing hormone receptor (CRH-R) antagonists to treat depression and anxiety. J. Psychiat. Res. 33:1999;181-214.
    • (1999) J. Psychiat. Res. , vol.33 , pp. 181-214
    • Holsboer, F.1
  • 11
    • 0029926722 scopus 로고    scopus 로고
    • Antidepressants and HPA regulation
    • Holsboer F., Barden N. Antidepressants and HPA regulation. Endocrine Rev. 17:1996;187-205.
    • (1996) Endocrine Rev. , vol.17 , pp. 187-205
    • Holsboer, F.1    Barden, N.2
  • 12
    • 1842606918 scopus 로고
    • Blunted corticotropin and normal cortisol response to human corticotropin-releasing factor in depression
    • Holsboer F., von Bardeleben U., Gerken A., Stalla G.K., Müller O.A. Blunted corticotropin and normal cortisol response to human corticotropin-releasing factor in depression. N. Engl. J. Med. 311:1984;1127.
    • (1984) N. Engl. J. Med. , vol.311 , pp. 1127
    • Holsboer, F.1    Von Bardeleben, U.2    Gerken, A.3    Stalla, G.K.4    Müller, O.A.5
  • 14
    • 0026621815 scopus 로고
    • The role of corticotropin-releasing hormone in the pathogenesis of Cushing's disease, anorexia nervosa, alcoholism, affective disorders and dementia
    • Holsboer F., Spengler D., Heuser I. The role of corticotropin-releasing hormone in the pathogenesis of Cushing's disease, anorexia nervosa, alcoholism, affective disorders and dementia. Prog. Brain Res. 93:1992;385-417.
    • (1992) Prog. Brain Res. , vol.93 , pp. 385-417
    • Holsboer, F.1    Spengler, D.2    Heuser, I.3
  • 15
    • 0021995208 scopus 로고
    • Biological effects of corticotropin-releasing hormone administered to rhesus monkeys
    • Kalin N.H. Biological effects of corticotropin-releasing hormone administered to rhesus monkeys. Fed. Proc. 44:1985;249-253.
    • (1985) Fed. Proc. , vol.44 , pp. 249-253
    • Kalin, N.H.1
  • 16
    • 0006128151 scopus 로고    scopus 로고
    • Hyperactivity of CRH neuronal circuits as a target for therapeutic interventions in affective disorders
    • (In press)
    • Keck FE, Holsboer F (2000): Hyperactivity of CRH neuronal circuits as a target for therapeutic interventions in affective disorders. Peptides (In press).
    • (2000) Peptides
    • Keck, F.E.1    Holsboer, F.2
  • 18
    • 0031595180 scopus 로고    scopus 로고
    • Behavioural profiles of two Wistar rat lines selectively bred for high or low anxiety-related behaviour
    • Liebsch G., Montkowski A., Holsboer F., Landgraf R. Behavioural profiles of two Wistar rat lines selectively bred for high or low anxiety-related behaviour. Behav. Brain Res. 94:1998;301-310.
    • (1998) Behav. Brain Res. , vol.94 , pp. 301-310
    • Liebsch, G.1    Montkowski, A.2    Holsboer, F.3    Landgraf, R.4
  • 20
    • 0033305069 scopus 로고    scopus 로고
    • Composite glucocorticoid regulation at a functionally defined negative glucocorticoid response element of the human corticotropin-releasing hormone gene
    • Malkoski S.P., Dorin R.I. Composite glucocorticoid regulation at a functionally defined negative glucocorticoid response element of the human corticotropin-releasing hormone gene. Mol. Endocrinol. 13:1999;1629-1644.
    • (1999) Mol. Endocrinol. , vol.13 , pp. 1629-1644
    • Malkoski, S.P.1    Dorin, R.I.2
  • 22
    • 0023927320 scopus 로고
    • Reduced corticotropin-releasing factor binding sites in the frontal cortex of suicide victims
    • Nemeroff C.B., Owens M.J., Bissette G., Andorn A.C., Stanley M. Reduced corticotropin-releasing factor binding sites in the frontal cortex of suicide victims. Arch. Gen. Psychiatry. 45:1988;577-579.
    • (1988) Arch. Gen. Psychiatry , vol.45 , pp. 577-579
    • Nemeroff, C.B.1    Owens, M.J.2    Bissette, G.3    Andorn, A.C.4    Stanley, M.5
  • 23
    • 0026332080 scopus 로고
    • The physiology and pharmacology of corticotropin-releasing factor
    • Owens M.J., Nemeroff C.B. The physiology and pharmacology of corticotropin-releasing factor. Pharmacol. Rev. 43:1991;425-473.
    • (1991) Pharmacol. Rev. , vol.43 , pp. 425-473
    • Owens, M.J.1    Nemeroff, C.B.2
  • 24
    • 0025979621 scopus 로고
    • Pathways to the secretion of adrenocorticotropin: A view from the portal
    • Plotsky P.M. Pathways to the secretion of adrenocorticotropin: a view from the portal. J. Neuroendocrinol. 3:1991;1-9.
    • (1991) J. Neuroendocrinol. , vol.3 , pp. 1-9
    • Plotsky, P.M.1
  • 26
    • 0027936468 scopus 로고
    • Increased numbers of corticotropin-releasing hormone expressing neurons in the hypothalamic paraventricular nucleus of depressed patients
    • Raadsheer F.C., Hoogendijk W.J.G., Stam F.C., Tilders F.J.H., Swaab D.F. Increased numbers of corticotropin-releasing hormone expressing neurons in the hypothalamic paraventricular nucleus of depressed patients. Neuroendocrinology. 60:1994;433-436.
    • (1994) Neuroendocrinology , vol.60 , pp. 433-436
    • Raadsheer, F.C.1    Hoogendijk, W.J.G.2    Stam, F.C.3    Tilders, F.J.H.4    Swaab, D.F.5
  • 27
    • 0043281643 scopus 로고    scopus 로고
    • Autoradiographic and in situ hybridization localization of corticotropin-releasing factor 1 and 2 receptors in nonhuman primate brain
    • Sánchez M.M., Young L.J., Plotsky P.M., Insel T.R. Autoradiographic and in situ hybridization localization of corticotropin-releasing factor 1 and 2 receptors in nonhuman primate brain. J. Comp. Neurol. 408:1999;365-377.
    • (1999) J. Comp. Neurol. , vol.408 , pp. 365-377
    • Sánchez, M.M.1    Young, L.J.2    Plotsky, P.M.3    Insel, T.R.4
  • 28
    • 0031859325 scopus 로고    scopus 로고
    • Induction of corticotropin-releasing hormone gene expression by glucocorticoids: Implication for understanding the states of fear and anxiety and allostatic load
    • Schulkin J., Gold P.W., McEwen B.S. Induction of corticotropin-releasing hormone gene expression by glucocorticoids: implication for understanding the states of fear and anxiety and allostatic load. Psychoneuroendocrinology. 23:1998;219-243.
    • (1998) Psychoneuroendocrinology , vol.23 , pp. 219-243
    • Schulkin, J.1    Gold, P.W.2    McEwen, B.S.3
  • 30
    • 0031960095 scopus 로고    scopus 로고
    • 1 receptor attenuates stress-induced relapse to drug seeking in cocaine- And heroine-trained rats
    • 1 receptor attenuates stress-induced relapse to drug seeking in cocaine- and heroine-trained rats. Psychopharmacology. 137:1998;184-190.
    • (1998) Psychopharmacology , vol.137 , pp. 184-190
    • Shaham, Y.1    Erb, S.2    Leung, S.3    Buczek, Y.4    Stewart, J.5
  • 31
    • 0028035260 scopus 로고
    • Antisense oligodeoxynucleotide complementary to corticotropin-releasing hormone mRNA reduces anxiety in shuttlebox performance
    • Skutella T., Probst J.C., Criswell H., Moy C., Breese G., Jirikowski G.F., Holsboer F. Antisense oligodeoxynucleotide complementary to corticotropin-releasing hormone mRNA reduces anxiety in shuttlebox performance. Neuroreport. 5:1994;2181-2185.
    • (1994) Neuroreport , vol.5 , pp. 2181-2185
    • Skutella, T.1    Probst, J.C.2    Criswell, H.3    Moy, C.4    Breese, G.5    Jirikowski, G.F.6    Holsboer, F.7
  • 32
    • 0031925646 scopus 로고    scopus 로고
    • Corticotropin-releasing hormone receptor (type 1) antisense targeting reduces anxiety
    • Skutella T., Probst J.C., Renner U., Holsboer F., Behl C. Corticotropin-releasing hormone receptor (type 1) antisense targeting reduces anxiety. Neuroscience. 85:1998;795-805.
    • (1998) Neuroscience , vol.85 , pp. 795-805
    • Skutella, T.1    Probst, J.C.2    Renner, U.3    Holsboer, F.4    Behl, C.5
  • 34
    • 0032751399 scopus 로고    scopus 로고
    • Corticotropin-releasing hormone receptor subtypes and emotion
    • Steckler T., Holsboer F. Corticotropin-releasing hormone receptor subtypes and emotion. Biological Psychiatry. 46:1999;1480-1508.
    • (1999) Biological Psychiatry , vol.46 , pp. 1480-1508
    • Steckler, T.1    Holsboer, F.2
  • 35
    • 0028324921 scopus 로고
    • Overproduction of corticotropin-releasing factor in transgenic mice: A genetic model of anxiogenic behavior
    • Stenzel-Poore M.P., Heinrichs S.C., Rivest S., Koob G.F., Vale W.W. Overproduction of corticotropin-releasing factor in transgenic mice: a genetic model of anxiogenic behavior. J. Neurosci. 14:1994;2579-2584.
    • (1994) J. Neurosci. , vol.14 , pp. 2579-2584
    • Stenzel-Poore, M.P.1    Heinrichs, S.C.2    Rivest, S.3    Koob, G.F.4    Vale, W.W.5
  • 36
    • 0024332335 scopus 로고
    • Differential steroid hormone and neural influences on peptide mRNA levels in CRH cells of the parventricular nucleus: A hybridization histochemical study in the rat
    • Swanson L.W., Simmons D.M. Differential steroid hormone and neural influences on peptide mRNA levels in CRH cells of the parventricular nucleus: a hybridization histochemical study in the rat. J. Comp. Neurol. 285:1989;415-435.
    • (1989) J. Comp. Neurol. , vol.285 , pp. 415-435
    • Swanson, L.W.1    Simmons, D.M.2
  • 38
    • 0019782980 scopus 로고
    • Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and β-endorphin
    • Vale W., Spiess J., Rivier C., Rivier J. Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and β-endorphin. Science. 213:1981;1394-1397.
    • (1981) Science , vol.213 , pp. 1394-1397
    • Vale, W.1    Spiess, J.2    Rivier, C.3    Rivier, J.4
  • 39
    • 0027716959 scopus 로고
    • The locus coeruleus as a site for integrating corticotropin-releasing factor and noradrenergic mediation of stress responses
    • Valentino R.J., Foote S.L., Page M.E. The locus coeruleus as a site for integrating corticotropin-releasing factor and noradrenergic mediation of stress responses. Ann. NY Acad. Sci. 697:1993;173-188.
    • (1993) Ann. NY Acad. Sci. , vol.697 , pp. 173-188
    • Valentino, R.J.1    Foote, S.L.2    Page, M.E.3
  • 40
    • 0030445812 scopus 로고    scopus 로고
    • In vivo and in vitro characterization of antalarmin, a non-peptide corticotropin-releasing hormone (CRH) receptor antagonist: Suppression of pituitary ACTH release and peripheral inflammation
    • Webster E.L., Lewis D.B., Torpy D.J., Zachman E.K., Rice K.C., Chrousos G.P. In vivo and in vitro characterization of antalarmin, a non-peptide corticotropin-releasing hormone (CRH) receptor antagonist: suppression of pituitary ACTH release and peripheral inflammation. Endocrinology. 137:1996;5747-5750.
    • (1996) Endocrinology , vol.137 , pp. 5747-5750
    • Webster, E.L.1    Lewis, D.B.2    Torpy, D.J.3    Zachman, E.K.4    Rice, K.C.5    Chrousos, G.P.6
  • 41
    • 0029860680 scopus 로고    scopus 로고
    • Release of vasopressin within the rat paraventricular nucleus in response to emotional stress: A novel mechanism of regulating adrenocorticotropic hormone secretion?
    • Wotjak C.T., Kubota M., Liebsch G., Montkowski A., Holsboer F., Neumann I., Landgraf R. Release of vasopressin within the rat paraventricular nucleus in response to emotional stress: a novel mechanism of regulating adrenocorticotropic hormone secretion? J. Neuroscience. 16:1996;7725-7732.
    • (1996) J. Neuroscience , vol.16 , pp. 7725-7732
    • Wotjak, C.T.1    Kubota, M.2    Liebsch, G.3    Montkowski, A.4    Holsboer, F.5    Neumann, I.6    Landgraf, R.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.