CRF receptor 1 regulates anxiety behavior via sensitization of 5-HT2 receptor signaling

Nature Neuroscience

Volumn 13, Issue 5, 2010, Pages 622-629

  Magalhaes, Ana C ^a   Holmes, Kevin D ^a   Dale, Lianne B ^a   Comps Agrar, Laetitia ^b   Lee, Dennis ^a   Yadav, Prem N ^c   Drysdale, Linsay ^a   Poulter, Michael O ^a   Roth, Bryan L ^c   Pin, Jean Philippe ^b   Anisman, Hymie ^d   Ferguson, Stephen S G ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b INSTITUT DE GÉNOMIQUE FONCTIONNELLE   (France)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^d CARLETON UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

4 IODO 2,5 DIMETHOXYAMPHETAMINE; CORTICOTROPIN RELEASING FACTOR; CORTICOTROPIN RELEASING FACTOR RECEPTOR 1; INOSITOL PHOSPHATE; MONENSIN; RAB PROTEIN; RAB11 PROTEIN; SEROTONIN 2 RECEPTOR; VOLINANSERIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY; ARTICLE; CELL STRAIN HEK293; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DOSE RESPONSE; ENDOCYTOSIS; ENDOSOME; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; INTERNALIZATION; MAZE TEST; MOUSE; NONHUMAN; PDZ DOMAIN; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; STRESS; WESTERN BLOTTING;

AMPHETAMINES; ANIMALS; ANXIETY; BEHAVIOR, ANIMAL; BIOTINYLATION; CELLS, CULTURED; CORTICOTROPIN-RELEASING HORMONE; CYCLIC AMP; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYO, MAMMALIAN; FLUOROBENZENES; HORMONES; HUMANS; INOSITOL PHOSPHATES; IONOPHORES; MALE; MAZE LEARNING; MICE; MONENSIN; MUTATION; NEURONS; PIPERIDINES; PREFRONTAL CORTEX; RATS; REACTION TIME; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; RECEPTORS, SEROTONIN, 5-HT2; SEROTONIN; SEROTONIN AGENTS; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 77951667861     PISSN: 10976256     EISSN: None     Source Type: Journal    
DOI: 10.1038/nn.2529     Document Type: Article

References (14)

1. Anisman, H., Merali, Z. & Hayley, S. Neurotransmitter, peptide and cytokine processes in relation to depressive disorder: comorbidity of depression with neurodegenerative disorders. Prog. Neurobiol. 85, 1-74 (2008).
2. 2A serotonin receptors in cortical pyramidal neurons in vitro. Neuroscience 122, 907-920 (2003).
3. Doherty, M.D. & Pickel, V.M. Ultrastructural localization of the serotonin 2A receptor in dopaminergic neurons in the ventral tegmental area. Brain Res. 864, 176-185 (2000).
4. Gray, J.A. et al. Cell type-specifc effects of endocytosis inhibitors on 5-hydroxytryptamine (2A) receptor desensitization and resensitization reveal an arrestin-, GRK2-and GRK5-independent mode of regulation in human embryonic kidney 293 cells. Mol. Pharmacol. 60, 1020-1030 (2001).
5. 2C receptor internalization. J. Pharmacol. Exp. Ther. 310, 865-870 (2004).
6. Marion, S., Weiner, D.M. & Caron, M.G. RNA editing induces variation in desensitization and traffcking of 5-hydroxytryptamine 2c receptor isoforms. J. Biol. Chem. 279, 2945-2954 (2004).
7. Collingridge, G.L., Isaac, J.T. & Wang, Y.T. Receptor traffcking and synaptic plasticity. Nat. Rev. Neurosci. 5, 952-962 (2004).
8. Hu, L.A. et al. β1-adrenergic receptor association with PSD-95. Inhibition of receptor internalization and facilitation of β1-adrenergic receptor interaction with N-methyl-D-aspartate receptors. J. Biol. Chem. 275, 38659-38666 (2000).
9. Ferguson, S.S.G. Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling. Pharmacol. Rev. 53, 1-24 (2001).
10. 2-adrenergic receptor internalization, endosomal sorting and plasma membrane recycling are regulated by Rab GTPases. J. Biol. Chem. 275, 27221-27228 (2000).
11. Ferguson, S.S.G. & Caron, M.G. Green fuorescent protein tagged β-arrestin translocation as a measure of G protein-coupled receptor activation. Methods Mol. Biol. 237, 121-126 (2004).
12. Dhami, G.K. et al. Protein-coupled receptor kinase 2 RGS homology domain binds to both metabotropic glutamate receptor 1a and Gαq to attenuate signaling. J. Biol. Chem. 279, 16614-16620 (2004).
13. Conn, P.J. & Sanders-Bush, E. Serotonin-stimulated phosphoinositide turnover: mediation by the S2 binding site in rat cerebral cortex, but not in subcortical regions. J. Pharmacol. Exp. Ther. 234, 195-203 (1985).
14. Franklin, K.B.J. & Paxinos, G. The Mouse Brain in Stereotaxic Coordinates (Academic Press, San Diego, 1997).