Corticotropin-releasing hormone drives anandamide hydrolysis in the amygdala to promote anxiety

Journal of Neuroscience

Volumn 35, Issue 9, 2015, Pages 3879-3892

  Megan Gray, J ^a,b,c   Vecchiarelli, Haley A ^a,b,d   Morena, Maria ^a,b,c   Lee, Tiffany T Y ^a,e   Hermanson, Daniel J ^f   Kim, Alexander B ^a,d   McLaughlin, Ryan J ^h   Hassan, Kowther I ^a   Kuhne, Claudia ⁱ   Wotjak, Carsten T ⁱ   Deussing, Jan M ⁱ   Patel, Sachin ^g   Hill, Matthew N ^a,b,c  

^a UNIVERSITY OF CALGARY   (Canada)

^b Mathison Centre for Mental Health Research and Education   (Canada)

^c Departments of Cell Biology and Anatomy and Psychiatry   (Canada)

^d UNIVERSITY OF CALGARY   (Canada)

^e UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^f Department of Chemistry ^*  (United States)

^g VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^h WASHINGTON STATE UNIVERSITY   (United States)

ⁱ MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

Author keywords

Anxious behavior; Basolateral amygdala; Endocannabinoid signaling; HPA axis; Stress

Indexed keywords

ANANDAMIDE; ANTALARMIN; CORTAGINE; CORTICOSTERONE; CORTICOTROPIN RELEASING FACTOR; FATTY ACID AMIDASE; MIFEPRISTONE; UNCLASSIFIED DRUG; UROCORTIN II; AMIDASE; AMIDE; ARACHIDONIC ACID DERIVATIVE; CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR RECEPTOR; CORTICOTROPIN RELEASING FACTOR RECEPTOR 1; ENDOCANNABINOID; FATTY-ACID AMIDE HYDROLASE;

ACUTE STRESS; AMYGDALOID NUCLEUS; ANIMAL MODEL; ANIMAL TISSUE; ANXIETY; ARTICLE; BLOOD SAMPLING; CANNULATION; CELL ACTIVATION; CHEMICAL REACTION KINETICS; CONTROLLED STUDY; ELEVATED PLUS MAZE TEST; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENCE IN SITU HYBRIDIZATION; IMMUNOHISTOCHEMISTRY; LIQUID CHROMATOGRAPHY; MALE; MOUSE; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN HYDROLYSIS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TANDEM MASS SPECTROMETRY; WESTERN BLOTTING; AMYGDALA; ANIMAL; GENETICS; HYDROLYSIS; KNOCKOUT MOUSE; MENTAL STRESS; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; PSYCHOLOGY; SPRAGUE DAWLEY RAT;

ADRENOCORTICOTROPIC HORMONE; AMIDOHYDROLASES; AMYGDALA; ANIMALS; ANXIETY; ARACHIDONIC ACIDS; CORTICOTROPIN-RELEASING HORMONE; ENDOCANNABINOIDS; HYDROLYSIS; MALE; MICE; MICE, KNOCKOUT; POLYUNSATURATED ALKAMIDES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; STRESS, PSYCHOLOGICAL;

EID: 84924787952     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2737-14.2015     Document Type: Article

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