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Volumn 38, Issue , 2016, Pages 99-107

Methylmercury and brain development: A review of recent literature

Author keywords

Developmental neurotoxicity; Mechanisms; Methylmercury

Indexed keywords

CALCIUM; GLUTAMIC ACID; METHYLMERCURY; METHYLMERCURY DERIVATIVE;

EID: 84984580971     PISSN: 0946672X     EISSN: 18783252     Source Type: Journal    
DOI: 10.1016/j.jtemb.2016.03.001     Document Type: Review
Times cited : (137)

References (147)
  • 1
    • 84991307012 scopus 로고    scopus 로고
    • NRC, Toxicological Effects of Methylmercury. Toxicological Effects of Methylmercury. Washington (DC), 2000
    • [1] NRC, Toxicological Effects of Methylmercury. Toxicological Effects of Methylmercury. Washington (DC), 2000.
  • 2
    • 0036177730 scopus 로고    scopus 로고
    • The three modern faces of mercury
    • [2] Clarkson, T.W., The three modern faces of mercury. Environ. Health Perspect. 110:Suppl. 1 (2002), 11–23.
    • (2002) Environ. Health Perspect. , vol.110 , pp. 11-23
    • Clarkson, T.W.1
  • 3
    • 0142213730 scopus 로고    scopus 로고
    • The toxicology of mercury-current exposures and clinical manifestations
    • [3] Clarkson, T.W., Magos, L., Myers, G.J., The toxicology of mercury-current exposures and clinical manifestations. N. Engl. J. Med. 349:18 (2003), 1731–1737.
    • (2003) N. Engl. J. Med. , vol.349 , Issue.18 , pp. 1731-1737
    • Clarkson, T.W.1    Magos, L.2    Myers, G.J.3
  • 4
    • 79952279392 scopus 로고    scopus 로고
    • Organomercurials: their formation and pathways in the environment
    • [4] Hintelmann, H., Organomercurials: their formation and pathways in the environment. Met. Ions Life Sci. 7 (2010), 365–401.
    • (2010) Met. Ions Life Sci. , vol.7 , pp. 365-401
    • Hintelmann, H.1
  • 5
    • 84984589194 scopus 로고    scopus 로고
    • Oxidative stress in MeHg-induced neurotoxicity
    • [5] Farina, M., Aschner, M., Rocha, J.B., Oxidative stress in MeHg-induced neurotoxicity. Toxicol. Appl. Pharmacol. 256:3 (2011), 405–417.
    • (2011) Toxicol. Appl. Pharmacol. , vol.256 , Issue.3 , pp. 405-417
    • Farina, M.1    Aschner, M.2    Rocha, J.B.3
  • 6
    • 84868198333 scopus 로고    scopus 로고
    • The toxicology of mercury and its compounds
    • [6] Syversen, T., Kaur, P., The toxicology of mercury and its compounds. J. Trace Elem. Med. Biol. 26:4 (2012), 215–226.
    • (2012) J. Trace Elem. Med. Biol. , vol.26 , Issue.4 , pp. 215-226
    • Syversen, T.1    Kaur, P.2
  • 7
    • 0018866764 scopus 로고
    • The relationship between blood levels and dose of methylmercury in man
    • [7] Kershaw, T.G., Clarkson, T.W., Dhahir, P.H., The relationship between blood levels and dose of methylmercury in man. Arch. Environ. Health 35:1 (1980), 28–36.
    • (1980) Arch. Environ. Health , vol.35 , Issue.1 , pp. 28-36
    • Kershaw, T.G.1    Clarkson, T.W.2    Dhahir, P.H.3
  • 9
    • 0023748960 scopus 로고
    • Uptake of methylmercury in the rat brain: effects of amino acids
    • [9] Aschner, M., Clarkson, T.W., Uptake of methylmercury in the rat brain: effects of amino acids. Brain Res. 462:1 (1988), 31–39.
    • (1988) Brain Res. , vol.462 , Issue.1 , pp. 31-39
    • Aschner, M.1    Clarkson, T.W.2
  • 11
    • 34548435560 scopus 로고    scopus 로고
    • Neurobehavioural and molecular changes induced by methylmercury exposure during development
    • [11] Johansson, C., Castoldi, A.F., Onishchenko, N., Manzo, L., Vahter, M., Ceccatelli, S., Neurobehavioural and molecular changes induced by methylmercury exposure during development. Neurotox. Res. 11:3–4 (2007), 241–260.
    • (2007) Neurotox. Res. , vol.11 , Issue.3-4 , pp. 241-260
    • Johansson, C.1    Castoldi, A.F.2    Onishchenko, N.3    Manzo, L.4    Vahter, M.5    Ceccatelli, S.6
  • 12
    • 79251473702 scopus 로고    scopus 로고
    • Methylmercury and brain development: imprecision and underestimation of developmental neurotoxicity in humans
    • [12] Grandjean, P., Herz, K.T., Methylmercury and brain development: imprecision and underestimation of developmental neurotoxicity in humans. Mt. Sinai J. Med. 78:1 (2011), 107–118.
    • (2011) Mt. Sinai J. Med. , vol.78 , Issue.1 , pp. 107-118
    • Grandjean, P.1    Herz, K.T.2
  • 15
    • 20044385396 scopus 로고    scopus 로고
    • Methylmercury: recent advances in the understanding of its neurotoxicity
    • [15] Aschner, M., Syversen, T., Methylmercury: recent advances in the understanding of its neurotoxicity. Ther. Drug Monit. 27:3 (2005), 278–283.
    • (2005) Ther. Drug Monit. , vol.27 , Issue.3 , pp. 278-283
    • Aschner, M.1    Syversen, T.2
  • 16
    • 0020338425 scopus 로고
    • Pathology of Minamata disease: with special reference to its pathogenesis
    • [16] Takeuchi, T., Pathology of Minamata disease: with special reference to its pathogenesis. Acta Pathol. Jpn. 32:Suppl. 1 (1982), 73–99.
    • (1982) Acta Pathol. Jpn. , vol.32 , pp. 73-99
    • Takeuchi, T.1
  • 19
    • 84984537116 scopus 로고    scopus 로고
    • Effects of 2,3-dimercapto-1-propanesulfonic acid (DMPS) on methylmercury-induced locomotor deficits and cerebellar toxicity in mice
    • [19] Carvalho, M.C., Franco, J.L., Ghizoni, H., Kobus, K., Nazari, E.M., Rocha, J.B., Nogueira, C.W., Dafre, A.L., Muller, Y.M., Farina, M., Effects of 2,3-dimercapto-1-propanesulfonic acid (DMPS) on methylmercury-induced locomotor deficits and cerebellar toxicity in mice. Toxicology 239:3 (2007), 195–203.
    • (2007) Toxicology , vol.239 , Issue.3 , pp. 195-203
    • Carvalho, M.C.1    Franco, J.L.2    Ghizoni, H.3    Kobus, K.4    Nazari, E.M.5    Rocha, J.B.6    Nogueira, C.W.7    Dafre, A.L.8    Muller, Y.M.9    Farina, M.10
  • 21
    • 84947034773 scopus 로고    scopus 로고
    • The effects of methylmercury exposure on behavior and biomarkers of oxidative stress in adult mice
    • [21] Kirkpatrick, M., Benoit, J., Everett, W., Gibson, J., Rist, M., Fredette, N., The effects of methylmercury exposure on behavior and biomarkers of oxidative stress in adult mice. Neurotoxicology 50 (2015), 170–178.
    • (2015) Neurotoxicology , vol.50 , pp. 170-178
    • Kirkpatrick, M.1    Benoit, J.2    Everett, W.3    Gibson, J.4    Rist, M.5    Fredette, N.6
  • 22
    • 77956458798 scopus 로고    scopus 로고
    • Methylmercury-induced neurotoxicity and apoptosis
    • [22] Ceccatelli, S., Dare, E., Moors, M., Methylmercury-induced neurotoxicity and apoptosis. Chem. Biol. Interact. 188:2 (2010), 301–308.
    • (2010) Chem. Biol. Interact. , vol.188 , Issue.2 , pp. 301-308
    • Ceccatelli, S.1    Dare, E.2    Moors, M.3
  • 23
    • 84984580627 scopus 로고    scopus 로고
    • Mechanisms of methylmercury-induced neurotoxicity: evidence from experimental studies
    • [23] Farina, M., Rocha, J.B., Aschner, M., Mechanisms of methylmercury-induced neurotoxicity: evidence from experimental studies. Life Sci. 89:15–16 (2011), 555–563.
    • (2011) Life Sci. , vol.89 , Issue.15-16 , pp. 555-563
    • Farina, M.1    Rocha, J.B.2    Aschner, M.3
  • 24
    • 84876800641 scopus 로고    scopus 로고
    • Developmental neurotoxicity: some old and new issues
    • [24] Giordano, G., Costa, L.G., Developmental neurotoxicity: some old and new issues. ISRN Toxicol., 2012, 2012, 814795.
    • (2012) ISRN Toxicol. , vol.2012 , pp. 814795
    • Giordano, G.1    Costa, L.G.2
  • 25
    • 84984577456 scopus 로고    scopus 로고
    • Involvement of glutamate and reactive oxygen species in methylmercury neurotoxicity
    • [25] Aschner, M., Syversen, T., Souza, D.O., Rocha, J.B., Farina, M., Involvement of glutamate and reactive oxygen species in methylmercury neurotoxicity. Braz. J. Med. Biol. Res. 40:3 (2007), 285–291.
    • (2007) Braz. J. Med. Biol. Res. , vol.40 , Issue.3 , pp. 285-291
    • Aschner, M.1    Syversen, T.2    Souza, D.O.3    Rocha, J.B.4    Farina, M.5
  • 26
    • 3242812890 scopus 로고    scopus 로고
    • 2+ dysregulation and neuronal death in rat cerebellar granule cells through an M3 muscarinic receptor-linked pathway
    • 2+ dysregulation and neuronal death in rat cerebellar granule cells through an M3 muscarinic receptor-linked pathway. Toxicol. Sci. 80:1 (2004), 60–68.
    • (2004) Toxicol. Sci. , vol.80 , Issue.1 , pp. 60-68
    • Limke, T.L.1    Bearss, J.J.2    Atchison, W.D.3
  • 27
    • 36248961154 scopus 로고    scopus 로고
    • Developmental mercury exposure elicits acute hippocampal cell death, reductions in neurogenesis, and severe learning deficits during puberty
    • [27] Falluel-Morel, A., Sokolowski, K., Sisti, H.M., Zhou, X., Shors, T.J., Dicicco-Bloom, E., Developmental mercury exposure elicits acute hippocampal cell death, reductions in neurogenesis, and severe learning deficits during puberty. J. Neurochem. 103:5 (2007), 1968–1981.
    • (2007) J. Neurochem. , vol.103 , Issue.5 , pp. 1968-1981
    • Falluel-Morel, A.1    Sokolowski, K.2    Sisti, H.M.3    Zhou, X.4    Shors, T.J.5    Dicicco-Bloom, E.6
  • 28
    • 0027948358 scopus 로고
    • Increases in the number of reactive glia in the visual cortex of Macaca fascicularis following subclinical long-term methyl mercury exposure
    • [28] Charleston, J.S., Bolender, R.P., Mottet, N.K., Body, R.L., Vahter, M.E., Burbacher, T.M., Increases in the number of reactive glia in the visual cortex of Macaca fascicularis following subclinical long-term methyl mercury exposure. Toxicol. Appl. Pharmacol. 129:2 (1994), 196–206.
    • (1994) Toxicol. Appl. Pharmacol. , vol.129 , Issue.2 , pp. 196-206
    • Charleston, J.S.1    Bolender, R.P.2    Mottet, N.K.3    Body, R.L.4    Vahter, M.E.5    Burbacher, T.M.6
  • 29
    • 0029943154 scopus 로고    scopus 로고
    • Changes in the number of astrocytes and microglia in the thalamus of the monkey Macaca fascicularis following long-term subclinical methylmercury exposure
    • [29] Charleston, J.S., Body, R.L., Bolender, R.P., Mottet, N.K., Vahter, M.E., Burbacher, T.M., Changes in the number of astrocytes and microglia in the thalamus of the monkey Macaca fascicularis following long-term subclinical methylmercury exposure. Neurotoxicology 17:1 (1996), 127–138.
    • (1996) Neurotoxicology , vol.17 , Issue.1 , pp. 127-138
    • Charleston, J.S.1    Body, R.L.2    Bolender, R.P.3    Mottet, N.K.4    Vahter, M.E.5    Burbacher, T.M.6
  • 30
    • 0027480552 scopus 로고
    • Methylmercury-induced alterations in excitatory amino acid transport in rat primary astrocyte cultures
    • [30] Aschner, M., Du, Y.L., Gannon, M., Kimelberg, H.K., Methylmercury-induced alterations in excitatory amino acid transport in rat primary astrocyte cultures. Brain Res. 602:2 (1993), 181–186.
    • (1993) Brain Res. , vol.602 , Issue.2 , pp. 181-186
    • Aschner, M.1    Du, Y.L.2    Gannon, M.3    Kimelberg, H.K.4
  • 31
    • 0033953122 scopus 로고    scopus 로고
    • Glia maintain follower neuron survival during Drosophila CNS development
    • [31] Booth, G.E., Kinrade, E.F., Hidalgo, A., Glia maintain follower neuron survival during Drosophila CNS development. Development 127:2 (2000), 237–244.
    • (2000) Development , vol.127 , Issue.2 , pp. 237-244
    • Booth, G.E.1    Kinrade, E.F.2    Hidalgo, A.3
  • 33
    • 84876668625 scopus 로고    scopus 로고
    • Emerging roles of astrocytes in neural circuit development
    • [33] Clarke, L.E., Barres, B.A., Emerging roles of astrocytes in neural circuit development. Nat. Rev. Neurosci. 14:5 (2013), 311–321.
    • (2013) Nat. Rev. Neurosci. , vol.14 , Issue.5 , pp. 311-321
    • Clarke, L.E.1    Barres, B.A.2
  • 34
    • 85037357104 scopus 로고    scopus 로고
    • Glia and neurodevelopment: focus on fetal alcohol spectrum disorders
    • [34] Guizzetti, M., Zhang, X., Goeke, C., Gavin, D.P., Glia and neurodevelopment: focus on fetal alcohol spectrum disorders. Front. Pediatr., 2, 2014, 123.
    • (2014) Front. Pediatr. , vol.2 , pp. 123
    • Guizzetti, M.1    Zhang, X.2    Goeke, C.3    Gavin, D.P.4
  • 35
    • 0024458542 scopus 로고
    • Role of glial cells in the regulation of the brain ion microenvironment
    • [35] Walz, W., Role of glial cells in the regulation of the brain ion microenvironment. Prog. Neurobiol. 33:4 (1989), 309–333.
    • (1989) Prog. Neurobiol. , vol.33 , Issue.4 , pp. 309-333
    • Walz, W.1
  • 36
    • 0027093677 scopus 로고
    • In vitro evidence for the role of glutamate in the CNS toxicity of mercury
    • [36] Brookes, N., In vitro evidence for the role of glutamate in the CNS toxicity of mercury. Toxicology 76:3 (1992), 245–256.
    • (1992) Toxicology , vol.76 , Issue.3 , pp. 245-256
    • Brookes, N.1
  • 37
    • 0028606987 scopus 로고
    • Astrocytes as mediators of methylmercury neurotoxicity: effects on D-aspartate and serotonin uptake
    • [37] Dave, V., Mullaney, K.J., Goderie, S., Kimelberg, H.K., Aschner, M., Astrocytes as mediators of methylmercury neurotoxicity: effects on D-aspartate and serotonin uptake. Dev. Neurosci. 16:3-4 (1994), 222–231.
    • (1994) Dev. Neurosci. , vol.16 , Issue.3-4 , pp. 222-231
    • Dave, V.1    Mullaney, K.J.2    Goderie, S.3    Kimelberg, H.K.4    Aschner, M.5
  • 38
    • 0035947014 scopus 로고    scopus 로고
    • Methylmercury-mediated inhibition of 3H-D-aspartate transport in cultured astrocytes is reversed by the antioxidant catalase
    • [38] Allen, J.W., Mutkus, L.A., Aschner, M., Methylmercury-mediated inhibition of 3H-D-aspartate transport in cultured astrocytes is reversed by the antioxidant catalase. Brain Res. 902:1 (2001), 92–100.
    • (2001) Brain Res. , vol.902 , Issue.1 , pp. 92-100
    • Allen, J.W.1    Mutkus, L.A.2    Aschner, M.3
  • 39
    • 0035831238 scopus 로고    scopus 로고
    • Methylmercury inhibits the in vitro uptake of the glutathione precursor, cystine, in astrocytes, but not in neurons
    • [39] Allen, J.W., Shanker, G., Aschner, M., Methylmercury inhibits the in vitro uptake of the glutathione precursor, cystine, in astrocytes, but not in neurons. Brain Res. 894:1 (2001), 131–140.
    • (2001) Brain Res. , vol.894 , Issue.1 , pp. 131-140
    • Allen, J.W.1    Shanker, G.2    Aschner, M.3
  • 40
    • 0035369252 scopus 로고    scopus 로고
    • The uptake of cysteine in cultured primary astrocytes and neurons
    • [40] Shanker, G., Allen, J.W., Mutkus, L.A., Aschner, M., The uptake of cysteine in cultured primary astrocytes and neurons. Brain Res. 902:2 (2001), 156–163.
    • (2001) Brain Res. , vol.902 , Issue.2 , pp. 156-163
    • Shanker, G.1    Allen, J.W.2    Mutkus, L.A.3    Aschner, M.4
  • 41
    • 0037474157 scopus 로고    scopus 로고
    • Methylmercury-induced reactive oxygen species formation in neonatal cerebral astrocytic cultures is attenuated by antioxidants
    • [41] Shanker, G., Aschner, M., Methylmercury-induced reactive oxygen species formation in neonatal cerebral astrocytic cultures is attenuated by antioxidants. Brain Res. Mol. Brain Res. 110:1 (2003), 85–91.
    • (2003) Brain Res. Mol. Brain Res. , vol.110 , Issue.1 , pp. 85-91
    • Shanker, G.1    Aschner, M.2
  • 42
    • 48749086761 scopus 로고    scopus 로고
    • Possible involvement of cathepsin B released by microglia in methylmercury-induced cerebellar pathological changes in the adult rat
    • [42] Sakamoto, M., Miyamoto, K., Wu, Z., Nakanishi, H., Possible involvement of cathepsin B released by microglia in methylmercury-induced cerebellar pathological changes in the adult rat. Neurosci. Lett. 442:3 (2008), 292–296.
    • (2008) Neurosci. Lett. , vol.442 , Issue.3 , pp. 292-296
    • Sakamoto, M.1    Miyamoto, K.2    Wu, Z.3    Nakanishi, H.4
  • 43
    • 0018256847 scopus 로고
    • Abnormal neuronal migration, deranged cerebral cortical organization, and diffuse white matter astrocytosis of human fetal brain: a major effect of methylmercury poisoning in utero
    • [43] Choi, B.H., Lapham, L.W., Amin-Zaki, L., Saleem, T., Abnormal neuronal migration, deranged cerebral cortical organization, and diffuse white matter astrocytosis of human fetal brain: a major effect of methylmercury poisoning in utero. J. Neuropathol. Exp. Neurol. 37:6 (1978), 719–733.
    • (1978) J. Neuropathol. Exp. Neurol. , vol.37 , Issue.6 , pp. 719-733
    • Choi, B.H.1    Lapham, L.W.2    Amin-Zaki, L.3    Saleem, T.4
  • 44
    • 0022978595 scopus 로고
    • Methylmercury poisoning of the developing nervous system: I. Pattern of neuronal migration in the cerebral cortex
    • [44] Choi, B.H., Methylmercury poisoning of the developing nervous system: I. Pattern of neuronal migration in the cerebral cortex. Neurotoxicology 7:2 (1986), 591–600.
    • (1986) Neurotoxicology , vol.7 , Issue.2 , pp. 591-600
    • Choi, B.H.1
  • 47
    • 0028821638 scopus 로고
    • Minamata disease: methylmercury poisoning in Japan caused by environmental pollution
    • [47] Harada, M., Minamata disease: methylmercury poisoning in Japan caused by environmental pollution. Crit. Rev. Toxicol. 25:1 (1995), 1–24.
    • (1995) Crit. Rev. Toxicol. , vol.25 , Issue.1 , pp. 1-24
    • Harada, M.1
  • 48
    • 35348998910 scopus 로고    scopus 로고
    • The effects of methylmercury on motor activity are sex- and age-dependent, and modulated by genetic deletion of adenosine receptors and caffeine administration
    • [52] Bjorklund, O., Kahlstrom, J., Salmi, P., Ogren, S.O., Vahter, M., Chen, J.F., Fredholm, B.B., Dare, E., The effects of methylmercury on motor activity are sex- and age-dependent, and modulated by genetic deletion of adenosine receptors and caffeine administration. Toxicology 241:3 (2007), 119–133.
    • (2007) Toxicology , vol.241 , Issue.3 , pp. 119-133
    • Bjorklund, O.1    Kahlstrom, J.2    Salmi, P.3    Ogren, S.O.4    Vahter, M.5    Chen, J.F.6    Fredholm, B.B.7    Dare, E.8
  • 50
    • 0037782283 scopus 로고    scopus 로고
    • Effects of prenatal exposure to methylmercury on dopamine-mediated locomotor activity and dopamine D2 receptor binding
    • [54] Dare, E., Fetissov, S., Hokfelt, T., Hall, H., Ogren, S.O., Ceccatelli, S., Effects of prenatal exposure to methylmercury on dopamine-mediated locomotor activity and dopamine D2 receptor binding. Naunyn Schmiedebergs Arch. Pharmacol. 367:5 (2003), 500–508.
    • (2003) Naunyn Schmiedebergs Arch. Pharmacol. , vol.367 , Issue.5 , pp. 500-508
    • Dare, E.1    Fetissov, S.2    Hokfelt, T.3    Hall, H.4    Ogren, S.O.5    Ceccatelli, S.6
  • 51
    • 0037072564 scopus 로고    scopus 로고
    • Evaluation of changes in methylmercury accumulation in the developing rat brain and its effects: a study with consecutive and moderate dose exposure throughout gestation and lactation periods
    • [55] Sakamoto, M., Kakita, A., Wakabayashi, K., Takahashi, H., Nakano, A., Akagi, H., Evaluation of changes in methylmercury accumulation in the developing rat brain and its effects: a study with consecutive and moderate dose exposure throughout gestation and lactation periods. Brain Res. 949:1–2 (2002), 51–59.
    • (2002) Brain Res. , vol.949 , Issue.1-2 , pp. 51-59
    • Sakamoto, M.1    Kakita, A.2    Wakabayashi, K.3    Takahashi, H.4    Nakano, A.5    Akagi, H.6
  • 52
    • 32844467864 scopus 로고    scopus 로고
    • Gestational exposure to methylmercury and n-3 fatty acids: effects on high- and low-rate operant behavior in adulthood
    • [56] Paletz, E.M., Craig-Schmidt, M.C., Newland, M.C., Gestational exposure to methylmercury and n-3 fatty acids: effects on high- and low-rate operant behavior in adulthood. Neurotoxicol. Teratol. 28:1 (2006), 59–73.
    • (2006) Neurotoxicol. Teratol. , vol.28 , Issue.1 , pp. 59-73
    • Paletz, E.M.1    Craig-Schmidt, M.C.2    Newland, M.C.3
  • 54
    • 0021690949 scopus 로고
    • Mitotic arrest in the developing CNS after prenatal exposure to methylmercury
    • [58] Rodier, P.M., Aschner, M., Sager, P.R., Mitotic arrest in the developing CNS after prenatal exposure to methylmercury. Neurobehav. Toxicol. Teratol. 6:5 (1984), 379–385.
    • (1984) Neurobehav. Toxicol. Teratol. , vol.6 , Issue.5 , pp. 379-385
    • Rodier, P.M.1    Aschner, M.2    Sager, P.R.3
  • 55
    • 33751508327 scopus 로고    scopus 로고
    • Methylmercury elicits rapid inhibition of cell proliferation in the developing brain and decreases cell cycle regulator, cyclin E
    • [59] Burke, K., Cheng, Y., Li, B., Petrov, A., Joshi, P., Berman, R.F., Reuhl, K.R., DiCicco-Bloom, E., Methylmercury elicits rapid inhibition of cell proliferation in the developing brain and decreases cell cycle regulator, cyclin E. Neurotoxicology 27:6 (2006), 970–981.
    • (2006) Neurotoxicology , vol.27 , Issue.6 , pp. 970-981
    • Burke, K.1    Cheng, Y.2    Li, B.3    Petrov, A.4    Joshi, P.5    Berman, R.F.6    Reuhl, K.R.7    DiCicco-Bloom, E.8
  • 56
    • 82455162364 scopus 로고    scopus 로고
    • Methylmercury (MeHg) elicits mitochondrial-dependent apoptosis in developing hippocampus and acts at low exposures
    • [60] Sokolowski, K., Falluel-Morel, A., Zhou, X., DiCicco-Bloom, E., Methylmercury (MeHg) elicits mitochondrial-dependent apoptosis in developing hippocampus and acts at low exposures. Neurotoxicology 32:5 (2011), 535–544.
    • (2011) Neurotoxicology , vol.32 , Issue.5 , pp. 535-544
    • Sokolowski, K.1    Falluel-Morel, A.2    Zhou, X.3    DiCicco-Bloom, E.4
  • 57
    • 0001301702 scopus 로고
    • Alkyl mercury poisoning
    • [61] Engleson, G., Herner, T., Alkyl mercury poisoning. Acta Paediatr. 41:3 (1952), 289–294.
    • (1952) Acta Paediatr. , vol.41 , Issue.3 , pp. 289-294
    • Engleson, G.1    Herner, T.2
  • 58
    • 0018078910 scopus 로고
    • Congenital Minamata disease: intrauterine methylmercury poisoning
    • [62] Harada, M., Congenital Minamata disease: intrauterine methylmercury poisoning. Teratology 18:2 (1978), 285–288.
    • (1978) Teratology , vol.18 , Issue.2 , pp. 285-288
    • Harada, M.1
  • 62
    • 0024540448 scopus 로고
    • The effects of methylmercury on the developing brain
    • [66] Choi, B.H., The effects of methylmercury on the developing brain. Prog. Neurobiol. 32:6 (1989), 447–470.
    • (1989) Prog. Neurobiol. , vol.32 , Issue.6 , pp. 447-470
    • Choi, B.H.1
  • 63
    • 0030909239 scopus 로고    scopus 로고
    • Migration of granule neurons in cerebellar organotypic cultures is impaired by methylmercury
    • [67] Kunimoto, M., Suzuki, T., Migration of granule neurons in cerebellar organotypic cultures is impaired by methylmercury. Neurosci. Lett. 226:3 (1997), 183–186.
    • (1997) Neurosci. Lett. , vol.226 , Issue.3 , pp. 183-186
    • Kunimoto, M.1    Suzuki, T.2
  • 64
    • 0034461819 scopus 로고    scopus 로고
    • Effects of methylmercury and inorganic mercury on the growth of nerve fibers in cultured chick dorsal root ganglia
    • [68] Miura, K., Himeno, S., Koide, N., Imura, N., Effects of methylmercury and inorganic mercury on the growth of nerve fibers in cultured chick dorsal root ganglia. Tohoku J. Exp. Med. 192:3 (2000), 195–210.
    • (2000) Tohoku J. Exp. Med. , vol.192 , Issue.3 , pp. 195-210
    • Miura, K.1    Himeno, S.2    Koide, N.3    Imura, N.4
  • 66
    • 6844241966 scopus 로고    scopus 로고
    • A review of experimental methylmercury toxicity in rats: neuropathology and evidence for apoptosis
    • [70] Nagashima, K., A review of experimental methylmercury toxicity in rats: neuropathology and evidence for apoptosis. Toxicol. Pathol. 25:6 (1997), 624–631.
    • (1997) Toxicol. Pathol. , vol.25 , Issue.6 , pp. 624-631
    • Nagashima, K.1
  • 67
    • 0034653128 scopus 로고    scopus 로고
    • Early acute necrosis, delayed apoptosis and cytoskeletal breakdown in cultured cerebellar granule neurons exposed to methylmercury
    • [71] Castoldi, A.F., Barni, S., Turin, I., Gandini, C., Manzo, L., Early acute necrosis, delayed apoptosis and cytoskeletal breakdown in cultured cerebellar granule neurons exposed to methylmercury. J. Neurosci. Res. 59:6 (2000), 775–787.
    • (2000) J. Neurosci. Res. , vol.59 , Issue.6 , pp. 775-787
    • Castoldi, A.F.1    Barni, S.2    Turin, I.3    Gandini, C.4    Manzo, L.5
  • 68
    • 0023499798 scopus 로고
    • Mechanism of methylmercury cytotoxicity
    • [72] Miura, K., Imura, N., Mechanism of methylmercury cytotoxicity. Crit. Rev. Toxicol. 18:3 (1987), 161–188.
    • (1987) Crit. Rev. Toxicol. , vol.18 , Issue.3 , pp. 161-188
    • Miura, K.1    Imura, N.2
  • 70
    • 0032442625 scopus 로고    scopus 로고
    • Methylmercury antagonizes the survival-promoting activity of insulin-like growth factor on developing cerebellar granule neurons
    • [74] Bulleit, R.F., Cui, H., Methylmercury antagonizes the survival-promoting activity of insulin-like growth factor on developing cerebellar granule neurons. Toxicol. Appl. Pharmacol. 153:2 (1998), 161–168.
    • (1998) Toxicol. Appl. Pharmacol. , vol.153 , Issue.2 , pp. 161-168
    • Bulleit, R.F.1    Cui, H.2
  • 71
    • 0036836070 scopus 로고    scopus 로고
    • Translocation of apoptosis-inducing factor in cerebellar granule cells exposed to neurotoxic agents inducing oxidative stress
    • [75] Fonfria, E., Dare, E., Benelli, M., Sunol, C., Ceccatelli, S., Translocation of apoptosis-inducing factor in cerebellar granule cells exposed to neurotoxic agents inducing oxidative stress. Eur. J. Neurosci. 16:10 (2002), 2013–2016.
    • (2002) Eur. J. Neurosci. , vol.16 , Issue.10 , pp. 2013-2016
    • Fonfria, E.1    Dare, E.2    Benelli, M.3    Sunol, C.4    Ceccatelli, S.5
  • 72
    • 33644956003 scopus 로고    scopus 로고
    • High susceptibility of neural stem cells to methylmercury toxicity: effects on cell survival and neuronal differentiation
    • [76] Tamm, C., Duckworth, J., Hermanson, O., Ceccatelli, S., High susceptibility of neural stem cells to methylmercury toxicity: effects on cell survival and neuronal differentiation. J. Neurochem. 97:1 (2006), 69–78.
    • (2006) J. Neurochem. , vol.97 , Issue.1 , pp. 69-78
    • Tamm, C.1    Duckworth, J.2    Hermanson, O.3    Ceccatelli, S.4
  • 73
    • 78650527416 scopus 로고    scopus 로고
    • Cell death mechanisms and their implications in toxicology
    • [77] Orrenius, S., Nicotera, P., Zhivotovsky, B., Cell death mechanisms and their implications in toxicology. Toxicol. Sci. 119:1 (2011), 3–19.
    • (2011) Toxicol. Sci. , vol.119 , Issue.1 , pp. 3-19
    • Orrenius, S.1    Nicotera, P.2    Zhivotovsky, B.3
  • 74
  • 75
    • 0031309785 scopus 로고    scopus 로고
    • Pathways mediating Ca2+ entry in rat cerebellar granule cells following in vitro exposure to methyl mercury
    • [79] Marty, M.S., Atchison, W.D., Pathways mediating Ca2+ entry in rat cerebellar granule cells following in vitro exposure to methyl mercury. Toxicol. Appl. Pharmacol. 147:2 (1997), 319–330.
    • (1997) Toxicol. Appl. Pharmacol. , vol.147 , Issue.2 , pp. 319-330
    • Marty, M.S.1    Atchison, W.D.2
  • 76
    • 0031595962 scopus 로고    scopus 로고
    • Elevations of intracellular Ca2+ as a probable contributor to decreased viability in cerebellar granule cells following acute exposure to methylmercury
    • [80] Marty, M.S., Atchison, W.D., Elevations of intracellular Ca2+ as a probable contributor to decreased viability in cerebellar granule cells following acute exposure to methylmercury. Toxicol. Appl. Pharmacol. 150:1 (1998), 98–105.
    • (1998) Toxicol. Appl. Pharmacol. , vol.150 , Issue.1 , pp. 98-105
    • Marty, M.S.1    Atchison, W.D.2
  • 77
    • 0034663064 scopus 로고    scopus 로고
    • Methylmercury affects multiple subtypes of calcium channels in rat cerebellar granule cells
    • [81] Sirois, J.E., Atchison, W.D., Methylmercury affects multiple subtypes of calcium channels in rat cerebellar granule cells. Toxicol. Appl. Pharmacol. 167:1 (2000), 1–11.
    • (2000) Toxicol. Appl. Pharmacol. , vol.167 , Issue.1 , pp. 1-11
    • Sirois, J.E.1    Atchison, W.D.2
  • 78
    • 0029670179 scopus 로고    scopus 로고
    • Protective effects of Ca2+ channel blockers against methyl mercury toxicity
    • [82] Sakamoto, M., Ikegami, N., Nakano, A., Protective effects of Ca2+ channel blockers against methyl mercury toxicity. Pharmacol. Toxicol. 78:3 (1996), 193–199.
    • (1996) Pharmacol. Toxicol. , vol.78 , Issue.3 , pp. 193-199
    • Sakamoto, M.1    Ikegami, N.2    Nakano, A.3
  • 79
    • 0027194712 scopus 로고
    • Methyl mercury increases intracellular Ca2+ and inositol phosphate levels in cultured cerebellar granule neurons
    • [83] Sarafian, T.A., Methyl mercury increases intracellular Ca2+ and inositol phosphate levels in cultured cerebellar granule neurons. J. Neurochem. 61:2 (1993), 648–657.
    • (1993) J. Neurochem. , vol.61 , Issue.2 , pp. 648-657
    • Sarafian, T.A.1
  • 80
    • 0035476890 scopus 로고    scopus 로고
    • Antioxidant compounds and Ca(2+) pathway blockers differentially protect against methylmercury and mercuric chloride neurotoxicity
    • [84] Gasso, S., Cristofol, R.M., Selema, G., Rosa, R., Rodriguez-Farre, E., Sanfeliu, C., Antioxidant compounds and Ca(2+) pathway blockers differentially protect against methylmercury and mercuric chloride neurotoxicity. J. Neurosci. Res. 66:1 (2001), 135–145.
    • (2001) J. Neurosci. Res. , vol.66 , Issue.1 , pp. 135-145
    • Gasso, S.1    Cristofol, R.M.2    Selema, G.3    Rosa, R.4    Rodriguez-Farre, E.5    Sanfeliu, C.6
  • 81
    • 0030880491 scopus 로고    scopus 로고
    • Fluorescent estimation on cytotoxicity of methylmercury in dissociated rat cerebellar neurons: its comparison with ionomycin
    • [85] Okazaki, E., Oyama, Y., Chikahisa, L., Nagano, T., Katayama, N., Sakamoto, M., Fluorescent estimation on cytotoxicity of methylmercury in dissociated rat cerebellar neurons: its comparison with ionomycin. Environ. Toxicol. Pharmacol. 3:4 (1997), 237–244.
    • (1997) Environ. Toxicol. Pharmacol. , vol.3 , Issue.4 , pp. 237-244
    • Okazaki, E.1    Oyama, Y.2    Chikahisa, L.3    Nagano, T.4    Katayama, N.5    Sakamoto, M.6
  • 82
    • 0028058666 scopus 로고
    • Methylmercury-induced augmentation of oxidative metabolism in cerebellar neurons dissociated from the rats: its dependence on intracellular Ca2+
    • [86] Oyama, Y., Tomiyoshi, F., Ueno, S., Furukawa, K., Chikahisa, L., Methylmercury-induced augmentation of oxidative metabolism in cerebellar neurons dissociated from the rats: its dependence on intracellular Ca2+. Brain Res. 660:1 (1994), 154–157.
    • (1994) Brain Res. , vol.660 , Issue.1 , pp. 154-157
    • Oyama, Y.1    Tomiyoshi, F.2    Ueno, S.3    Furukawa, K.4    Chikahisa, L.5
  • 83
    • 0035577791 scopus 로고    scopus 로고
    • Identification and characterization of uptake systems for cystine and cysteine in cultured astrocytes and neurons: evidence for methylmercury-targeted disruption of astrocyte transport
    • [87] Shanker, G., Aschner, M., Identification and characterization of uptake systems for cystine and cysteine in cultured astrocytes and neurons: evidence for methylmercury-targeted disruption of astrocyte transport. J. Neurosci. Res. 66:5 (2001), 998–1002.
    • (2001) J. Neurosci. Res. , vol.66 , Issue.5 , pp. 998-1002
    • Shanker, G.1    Aschner, M.2
  • 85
    • 0035906526 scopus 로고    scopus 로고
    • Involvement of enhanced sensitivity of N-methyl-D-aspartate receptors in vulnerability of developing cortical neurons to methylmercury neurotoxicity
    • [89] Miyamoto, K., Nakanishi, H., Moriguchi, S., Fukuyama, N., Eto, K., Wakamiya, J., Murao, K., Arimura, K., Osame, M., Involvement of enhanced sensitivity of N-methyl-D-aspartate receptors in vulnerability of developing cortical neurons to methylmercury neurotoxicity. Brain Res. 901:1–2 (2001), 252–258.
    • (2001) Brain Res. , vol.901 , Issue.1-2 , pp. 252-258
    • Miyamoto, K.1    Nakanishi, H.2    Moriguchi, S.3    Fukuyama, N.4    Eto, K.5    Wakamiya, J.6    Murao, K.7    Arimura, K.8    Osame, M.9
  • 86
    • 0029064518 scopus 로고
    • Glutamate induces the production of reactive oxygen species in cultured forebrain neurons following NMDA receptor activation
    • [90] Reynolds, I.J., Hastings, T.G., Glutamate induces the production of reactive oxygen species in cultured forebrain neurons following NMDA receptor activation. J. Neurosci. 15:Pt 1 (5) (1995), 3318–3327.
    • (1995) J. Neurosci. , vol.15 , pp. 3318-3327
    • Reynolds, I.J.1    Hastings, T.G.2
  • 89
    • 84859476053 scopus 로고    scopus 로고
    • Rescue of neuronal migration deficits in a mouse model of fetal Minamata disease by increasing neuronal Ca2+ spike frequency
    • [93] Fahrion, J.K., Komuro, Y., Li, Y., Ohno, N., Littner, Y., Raoult, E., Galas, L., Vaudry, D., Komuro, H., Rescue of neuronal migration deficits in a mouse model of fetal Minamata disease by increasing neuronal Ca2+ spike frequency. Proc. Natl. Acad. Sci. U. S. A. 109:13 (2012), 5057–5062.
    • (2012) Proc. Natl. Acad. Sci. U. S. A. , vol.109 , Issue.13 , pp. 5057-5062
    • Fahrion, J.K.1    Komuro, Y.2    Li, Y.3    Ohno, N.4    Littner, Y.5    Raoult, E.6    Galas, L.7    Vaudry, D.8    Komuro, H.9
  • 90
    • 0034874731 scopus 로고    scopus 로고
    • Methylmercury-induced decrement in neuronal migration may involve cytokine-dependent mechanisms: a novel method to assess neuronal movement in vitro
    • [94] Sass, J.B., Haselow, D.T., Silbergeld, E.K., Methylmercury-induced decrement in neuronal migration may involve cytokine-dependent mechanisms: a novel method to assess neuronal movement in vitro. Toxicol. Sci. 63:1 (2001), 74–81.
    • (2001) Toxicol. Sci. , vol.63 , Issue.1 , pp. 74-81
    • Sass, J.B.1    Haselow, D.T.2    Silbergeld, E.K.3
  • 91
    • 61849149397 scopus 로고    scopus 로고
    • Continuous exposure to low concentrations of methylmercury impairs cerebellar granule cell migration in organotypic slice culture
    • [95] Mancini, J.D., Autio, D.M., Atchison, W.D., Continuous exposure to low concentrations of methylmercury impairs cerebellar granule cell migration in organotypic slice culture. Neurotoxicology 30:2 (2009), 203–208.
    • (2009) Neurotoxicology , vol.30 , Issue.2 , pp. 203-208
    • Mancini, J.D.1    Autio, D.M.2    Atchison, W.D.3
  • 92
    • 0036146443 scopus 로고    scopus 로고
    • Acute exposure to methylmercury opens the mitochondrial permeability transition pore in rat cerebellar granule cells
    • [96] Limke, T.L., Atchison, W.D., Acute exposure to methylmercury opens the mitochondrial permeability transition pore in rat cerebellar granule cells. Toxicol. Appl. Pharmacol. 178:1 (2002), 52–61.
    • (2002) Toxicol. Appl. Pharmacol. , vol.178 , Issue.1 , pp. 52-61
    • Limke, T.L.1    Atchison, W.D.2
  • 93
    • 0028969025 scopus 로고
    • Methylmercury mobilizes Ca++ from intracellular stores sensitive to inositol 1,4,5-trisphosphate in NG108-15 cells
    • [97] Hare, M.F., Atchison, W.D., Methylmercury mobilizes Ca++ from intracellular stores sensitive to inositol 1,4,5-trisphosphate in NG108-15 cells. J. Pharmacol. Exp. Ther. 272:3 (1995), 1016–1023.
    • (1995) J. Pharmacol. Exp. Ther. , vol.272 , Issue.3 , pp. 1016-1023
    • Hare, M.F.1    Atchison, W.D.2
  • 94
    • 0027893207 scopus 로고
    • Methylmercury increases intracellular concentrations of Ca++ and heavy metals in NG108-15 cells
    • [98] Hare, M.F., McGinnis, K.M., Atchison, W.D., Methylmercury increases intracellular concentrations of Ca++ and heavy metals in NG108-15 cells. J. Pharmacol. Exp. Ther. 266:3 (1993), 1626–1635.
    • (1993) J. Pharmacol. Exp. Ther. , vol.266 , Issue.3 , pp. 1626-1635
    • Hare, M.F.1    McGinnis, K.M.2    Atchison, W.D.3
  • 95
    • 74949138312 scopus 로고    scopus 로고
    • Probucol increases glutathione peroxidase-1 activity and displays long-lasting protection against methylmercury toxicity in cerebellar granule cells
    • [99] Farina, M., Campos, F., Vendrell, I., Berenguer, J., Barzi, M., Pons, S., Sunol, C., Probucol increases glutathione peroxidase-1 activity and displays long-lasting protection against methylmercury toxicity in cerebellar granule cells. Toxicol. Sci. 112:2 (2009), 416–426.
    • (2009) Toxicol. Sci. , vol.112 , Issue.2 , pp. 416-426
    • Farina, M.1    Campos, F.2    Vendrell, I.3    Berenguer, J.4    Barzi, M.5    Pons, S.6    Sunol, C.7
  • 96
    • 33750544319 scopus 로고    scopus 로고
    • Glutathione peroxidase 1 and a high cellular glutathione concentration are essential for effective organic hydroperoxide detoxification in astrocytes
    • [100] Liddell, J.R., Dringen, R., Crack, P.J., Robinson, S.R., Glutathione peroxidase 1 and a high cellular glutathione concentration are essential for effective organic hydroperoxide detoxification in astrocytes. Glia 54:8 (2006), 873–879.
    • (2006) Glia , vol.54 , Issue.8 , pp. 873-879
    • Liddell, J.R.1    Dringen, R.2    Crack, P.J.3    Robinson, S.R.4
  • 97
    • 0030201466 scopus 로고    scopus 로고
    • Intracellular Ca2+ fluctuations modulate the rate of neuronal migration
    • [101] Komuro, H., Rakic, P., Intracellular Ca2+ fluctuations modulate the rate of neuronal migration. Neuron 17:2 (1996), 275–285.
    • (1996) Neuron , vol.17 , Issue.2 , pp. 275-285
    • Komuro, H.1    Rakic, P.2
  • 98
    • 2942567727 scopus 로고    scopus 로고
    • Completion of neuronal migration regulated by loss of Ca(2+) transients
    • [102] Kumada, T., Komuro, H., Completion of neuronal migration regulated by loss of Ca(2+) transients. Proc. Natl. Acad. Sci. U. S. A. 101:22 (2004), 8479–8484.
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , Issue.22 , pp. 8479-8484
    • Kumada, T.1    Komuro, H.2
  • 99
    • 0025972360 scopus 로고
    • Multiple elevations of cytosolic-free Ca2+ in human neutrophils: initiation by adherence receptors of the integrin family
    • [103] Jaconi, M.E., Theler, J.M., Schlegel, W., Appel, R.D., Wright, S.D., Lew, P.D., Multiple elevations of cytosolic-free Ca2+ in human neutrophils: initiation by adherence receptors of the integrin family. J. Cell Biol. 112:6 (1991), 1249–1257.
    • (1991) J. Cell Biol. , vol.112 , Issue.6 , pp. 1249-1257
    • Jaconi, M.E.1    Theler, J.M.2    Schlegel, W.3    Appel, R.D.4    Wright, S.D.5    Lew, P.D.6
  • 100
    • 0025122019 scopus 로고
    • Transient increases in cytosolic free calcium appear to be required for the migration of adherent human neutrophils
    • [104] Marks, P.W., Maxfield, F.R., Transient increases in cytosolic free calcium appear to be required for the migration of adherent human neutrophils. J. Cell Biol. 110:1 (1990), 43–52.
    • (1990) J. Cell Biol. , vol.110 , Issue.1 , pp. 43-52
    • Marks, P.W.1    Maxfield, F.R.2
  • 101
    • 0028178631 scopus 로고
    • Molecular basis for Ca2+ channel diversity
    • [105] Hofmann, F., Biel, M., Flockerzi, V., Molecular basis for Ca2+ channel diversity. Annu. Rev. Neurosci. 17 (1994), 399–418.
    • (1994) Annu. Rev. Neurosci. , vol.17 , pp. 399-418
    • Hofmann, F.1    Biel, M.2    Flockerzi, V.3
  • 102
    • 0030176348 scopus 로고    scopus 로고
    • Diversity and function of presynaptic calcium channels in the brain
    • [106] Reuter, H., Diversity and function of presynaptic calcium channels in the brain. Curr. Opin. Neurobiol. 6:3 (1996), 331–337.
    • (1996) Curr. Opin. Neurobiol. , vol.6 , Issue.3 , pp. 331-337
    • Reuter, H.1
  • 103
    • 0028904492 scopus 로고
    • Pharmacological dissection of multiple types of Ca2+ channel currents in rat cerebellar granule neurons
    • [107] Randall, A., Tsien, R.W., Pharmacological dissection of multiple types of Ca2+ channel currents in rat cerebellar granule neurons. J. Neurosci. 15:4 (1995), 2995–3012.
    • (1995) J. Neurosci. , vol.15 , Issue.4 , pp. 2995-3012
    • Randall, A.1    Tsien, R.W.2
  • 104
    • 0026645942 scopus 로고
    • Selective role of N-type calcium channels in neuronal migration
    • [108] Komuro, H., Rakic, P., Selective role of N-type calcium channels in neuronal migration. Science 257:5071 (1992), 806–809.
    • (1992) Science , vol.257 , Issue.5071 , pp. 806-809
    • Komuro, H.1    Rakic, P.2
  • 105
    • 0031707773 scopus 로고    scopus 로고
    • Orchestration of neuronal migration by activity of ion channels, neurotransmitter receptors, and intracellular Ca2+ fluctuations
    • [109] Komuro, H., Rakic, P., Orchestration of neuronal migration by activity of ion channels, neurotransmitter receptors, and intracellular Ca2+ fluctuations. J. Neurobiol. 37:1 (1998), 110–130.
    • (1998) J. Neurobiol. , vol.37 , Issue.1 , pp. 110-130
    • Komuro, H.1    Rakic, P.2
  • 106
    • 0031593780 scopus 로고    scopus 로고
    • Effects of Cd2+, Pb2+ and CH3Hg+ on high voltage-activated calcium currents in pheochromocytoma (PC12) cells: potency, reversibility, interactions with extracellular Ca2+ and mechanisms of block
    • [110] Shafer, T.J., Effects of Cd2+, Pb2+ and CH3Hg+ on high voltage-activated calcium currents in pheochromocytoma (PC12) cells: potency, reversibility, interactions with extracellular Ca2+ and mechanisms of block. Toxicol. Lett. 99:3 (1998), 207–221.
    • (1998) Toxicol. Lett. , vol.99 , Issue.3 , pp. 207-221
    • Shafer, T.J.1
  • 107
    • 0025835916 scopus 로고
    • Methylmercury blocks N- and L-type Ca++ channels in nerve growth factor-differentiated pheochromocytoma (PC12) cells
    • [111] Shafer, T.J., Atchison, W.D., Methylmercury blocks N- and L-type Ca++ channels in nerve growth factor-differentiated pheochromocytoma (PC12) cells. J. Pharmacol. Exp. Ther. 258:1 (1991), 149–157.
    • (1991) J. Pharmacol. Exp. Ther. , vol.258 , Issue.1 , pp. 149-157
    • Shafer, T.J.1    Atchison, W.D.2
  • 108
    • 0037199103 scopus 로고    scopus 로고
    • Effects of prolonged exposure to nanomolar concentrations of methylmercury on voltage-sensitive sodium and calcium currents in PC12 cells
    • [112] Shafer, T.J., Meacham, C.A., Barone, S. Jr., Effects of prolonged exposure to nanomolar concentrations of methylmercury on voltage-sensitive sodium and calcium currents in PC12 cells. Brain Res. Dev. Brain Res. 136:2 (2002), 151–164.
    • (2002) Brain Res. Dev. Brain Res. , vol.136 , Issue.2 , pp. 151-164
    • Shafer, T.J.1    Meacham, C.A.2    Barone, S.3
  • 109
    • 84966325513 scopus 로고    scopus 로고
    • Methylmercury-dependent increases in Fluo4 fluorescence in neonatal rat cerebellar slices depend on granule cell migrational stage and GABAA receptor modulation
    • [113] Bradford, A.B., Mancini, J.D., Atchison, W.D., Methylmercury-dependent increases in Fluo4 fluorescence in neonatal rat cerebellar slices depend on granule cell migrational stage and GABAA receptor modulation. J. Pharmacol. Exp. Ther. 356:1 (2016), 2–12.
    • (2016) J. Pharmacol. Exp. Ther. , vol.356 , Issue.1 , pp. 2-12
    • Bradford, A.B.1    Mancini, J.D.2    Atchison, W.D.3
  • 110
    • 0029552022 scopus 로고
    • Methylmercury acts at multiple sites to block hippocampal synaptic transmission
    • [114] Yuan, Y., Atchison, W.D., Methylmercury acts at multiple sites to block hippocampal synaptic transmission. J. Pharmacol. Exp. Ther. 275:3 (1995), 1308–1316.
    • (1995) J. Pharmacol. Exp. Ther. , vol.275 , Issue.3 , pp. 1308-1316
    • Yuan, Y.1    Atchison, W.D.2
  • 111
    • 0030778973 scopus 로고    scopus 로고
    • Action of methylmercury on GABA(A) receptor-mediated inhibitory synaptic transmission is primarily responsible for its early stimulatory effects on hippocampal CA1 excitatory synaptic transmission
    • [115] Yuan, Y., Atchison, W.D., Action of methylmercury on GABA(A) receptor-mediated inhibitory synaptic transmission is primarily responsible for its early stimulatory effects on hippocampal CA1 excitatory synaptic transmission. J. Pharmacol. Exp. Ther. 282:1 (1997), 64–73.
    • (1997) J. Pharmacol. Exp. Ther. , vol.282 , Issue.1 , pp. 64-73
    • Yuan, Y.1    Atchison, W.D.2
  • 112
    • 0037930194 scopus 로고    scopus 로고
    • Methylmercury differentially affects GABA(A) receptor-mediated spontaneous IPSCs in Purkinje and granule cells of rat cerebellar slices
    • [116] Yuan, Y., Atchison, W.D., Methylmercury differentially affects GABA(A) receptor-mediated spontaneous IPSCs in Purkinje and granule cells of rat cerebellar slices. J. Physiol. 550:Pt 1 (2003), 191–204.
    • (2003) J. Physiol. , vol.550 , pp. 191-204
    • Yuan, Y.1    Atchison, W.D.2
  • 113
    • 75249106472 scopus 로고    scopus 로고
    • Bal-Price AK. mRNA expression is a relevant tool to identify developmental neurotoxicants using an in vitro approach
    • [117] Hogberg, H.T., Kinsner-Ovaskainen, A., Coecke, S., Hartung, T., Bal-Price AK. mRNA expression is a relevant tool to identify developmental neurotoxicants using an in vitro approach. Toxicol. Sci. 113:1 (2010), 95–115.
    • (2010) Toxicol. Sci. , vol.113 , Issue.1 , pp. 95-115
    • Hogberg, H.T.1    Kinsner-Ovaskainen, A.2    Coecke, S.3    Hartung, T.4
  • 114
    • 0035676977 scopus 로고    scopus 로고
    • The machinery of programmed cell death
    • [118] Zimmermann, K.C., Bonzon, C., Green, D.R., The machinery of programmed cell death. Pharmacol. Ther. 92:1 (2001), 57–70.
    • (2001) Pharmacol. Ther. , vol.92 , Issue.1 , pp. 57-70
    • Zimmermann, K.C.1    Bonzon, C.2    Green, D.R.3
  • 115
    • 84922616366 scopus 로고    scopus 로고
    • Methylmercury causes neuronal cell death through the suppression of the TrkA pathway: in vitro and in vivo effects of TrkA pathway activators
    • [119] Fujimura, M., Usuki, F., Methylmercury causes neuronal cell death through the suppression of the TrkA pathway: in vitro and in vivo effects of TrkA pathway activators. Toxicol. Appl. Pharmacol. 282:3 (2015), 259–266.
    • (2015) Toxicol. Appl. Pharmacol. , vol.282 , Issue.3 , pp. 259-266
    • Fujimura, M.1    Usuki, F.2
  • 116
    • 0029956641 scopus 로고    scopus 로고
    • Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice
    • [120] Kuida, K., Zheng, T.S., Na, S., Kuan, C., Yang, D., Karasuyama, H., Rakic, P., Flavell, R.A., Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice. Nature 384:6607 (1996), 368–372.
    • (1996) Nature , vol.384 , Issue.6607 , pp. 368-372
    • Kuida, K.1    Zheng, T.S.2    Na, S.3    Kuan, C.4    Yang, D.5    Karasuyama, H.6    Rakic, P.7    Flavell, R.A.8
  • 117
    • 26444537963 scopus 로고    scopus 로고
    • Neural stem cell differentiation is dependent upon endogenous caspase 3 activity
    • [121] Fernando, P., Brunette, S., Megeney, L.A., Neural stem cell differentiation is dependent upon endogenous caspase 3 activity. FASEB J. 19:12 (2005), 1671–1673.
    • (2005) FASEB J. , vol.19 , Issue.12 , pp. 1671-1673
    • Fernando, P.1    Brunette, S.2    Megeney, L.A.3
  • 118
    • 77951498581 scopus 로고    scopus 로고
    • New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?
    • [122] Deng, W., Aimone, J.B., Gage, F.H., New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?. Nat. Rev. Neurosci. 11:5 (2010), 339–350.
    • (2010) Nat. Rev. Neurosci. , vol.11 , Issue.5 , pp. 339-350
    • Deng, W.1    Aimone, J.B.2    Gage, F.H.3
  • 119
    • 84886087366 scopus 로고    scopus 로고
    • Neural stem cell apoptosis after low-methylmercury exposures in postnatal hippocampus produce persistent cell loss and adolescent memory deficits
    • [123] Sokolowski, K., Obiorah, M., Robinson, K., McCandlish, E., Buckley, B., DiCicco-Bloom, E., Neural stem cell apoptosis after low-methylmercury exposures in postnatal hippocampus produce persistent cell loss and adolescent memory deficits. Dev. Neurobiol. 73:12 (2013), 936–949.
    • (2013) Dev. Neurobiol. , vol.73 , Issue.12 , pp. 936-949
    • Sokolowski, K.1    Obiorah, M.2    Robinson, K.3    McCandlish, E.4    Buckley, B.5    DiCicco-Bloom, E.6
  • 120
    • 0034668745 scopus 로고    scopus 로고
    • Antioxidants J811 and 17beta-estradiol protect cerebellar granule cells from methylmercury-induced apoptotic cell death
    • [124] Dare, E., Gotz, M.E., Zhivotovsky, B., Manzo, L., Ceccatelli, S., Antioxidants J811 and 17beta-estradiol protect cerebellar granule cells from methylmercury-induced apoptotic cell death. J. Neurosci. Res. 62:4 (2000), 557–565.
    • (2000) J. Neurosci. Res. , vol.62 , Issue.4 , pp. 557-565
    • Dare, E.1    Gotz, M.E.2    Zhivotovsky, B.3    Manzo, L.4    Ceccatelli, S.5
  • 121
    • 23944441220 scopus 로고    scopus 로고
    • Very low levels of methylmercury induce cell death of cultured rat cerebellar neurons via calpain activation
    • [125] Sakaue, M., Okazaki, M., Hara, S., Very low levels of methylmercury induce cell death of cultured rat cerebellar neurons via calpain activation. Toxicology 213:1–2 (2005), 97–106.
    • (2005) Toxicology , vol.213 , Issue.1-2 , pp. 97-106
    • Sakaue, M.1    Okazaki, M.2    Hara, S.3
  • 122
    • 78650545101 scopus 로고    scopus 로고
    • Hippocampal neurons exposed to the environmental contaminants methylmercury and polychlorinated biphenyls undergo cell death via parallel activation of calpains and lysosomal proteases
    • [126] Tofighi, R., Johansson, C., Goldoni, M., Ibrahim, W.N., Gogvadze, V., Mutti, A., Ceccatelli, S., Hippocampal neurons exposed to the environmental contaminants methylmercury and polychlorinated biphenyls undergo cell death via parallel activation of calpains and lysosomal proteases. Neurotox. Res. 19:1 (2011), 183–194.
    • (2011) Neurotox. Res. , vol.19 , Issue.1 , pp. 183-194
    • Tofighi, R.1    Johansson, C.2    Goldoni, M.3    Ibrahim, W.N.4    Gogvadze, V.5    Mutti, A.6    Ceccatelli, S.7
  • 123
    • 0033956278 scopus 로고    scopus 로고
    • Calpain and caspase: can you tell the difference?
    • [127] Wang, K.K., Calpain and caspase: can you tell the difference?. Trends Neurosci. 23:1 (2000), 20–26.
    • (2000) Trends Neurosci. , vol.23 , Issue.1 , pp. 20-26
    • Wang, K.K.1
  • 124
    • 33748087835 scopus 로고    scopus 로고
    • Involvement of calpain activation in neurodegenerative processes
    • [128] Camins, A., Verdaguer, E., Folch, J., Pallas, M., Involvement of calpain activation in neurodegenerative processes. CNS Drug Rev. 12:2 (2006), 135–148.
    • (2006) CNS Drug Rev. , vol.12 , Issue.2 , pp. 135-148
    • Camins, A.1    Verdaguer, E.2    Folch, J.3    Pallas, M.4
  • 125
    • 0031281945 scopus 로고    scopus 로고
    • Calpains: intact and active?
    • [129] Johnson, G.V., Guttmann, R.P., Calpains: intact and active?. Bioessays 19:11 (1997), 1011–1018.
    • (1997) Bioessays , vol.19 , Issue.11 , pp. 1011-1018
    • Johnson, G.V.1    Guttmann, R.P.2
  • 126
    • 0036010745 scopus 로고    scopus 로고
    • Calcium homeostasis and dichlorvos induced neurotoxicity in rat brain
    • [130] Raheja, G., Gill, K.D., Calcium homeostasis and dichlorvos induced neurotoxicity in rat brain. Mol. Cell. Biochem. 232:1–2 (2002), 13–18.
    • (2002) Mol. Cell. Biochem. , vol.232 , Issue.1-2 , pp. 13-18
    • Raheja, G.1    Gill, K.D.2
  • 127
    • 0033213973 scopus 로고    scopus 로고
    • Caspase and calpain substrates: roles in synaptic plasticity and cell death
    • [131] Chan, S.L., Mattson, M.P., Caspase and calpain substrates: roles in synaptic plasticity and cell death. J. Neurosci. Res. 58:1 (1999), 167–190.
    • (1999) J. Neurosci. Res. , vol.58 , Issue.1 , pp. 167-190
    • Chan, S.L.1    Mattson, M.P.2
  • 128
    • 0031452173 scopus 로고    scopus 로고
    • Structure and physiological function of calpains
    • [132] Sorimachi, H., Ishiura, S., Suzuki, K., Structure and physiological function of calpains. Biochem. J. 328:Pt 3 (1997), 721–732.
    • (1997) Biochem. J. , vol.328 , pp. 721-732
    • Sorimachi, H.1    Ishiura, S.2    Suzuki, K.3
  • 129
    • 72149120574 scopus 로고    scopus 로고
    • The microtubule network and neuronal morphogenesis: dynamic and coordinated orchestration through multiple players
    • [133] Poulain, F.E., Sobel, A., The microtubule network and neuronal morphogenesis: dynamic and coordinated orchestration through multiple players. Mol. Cell. Neurosci. 43:1 (2010), 15–32.
    • (2010) Mol. Cell. Neurosci. , vol.43 , Issue.1 , pp. 15-32
    • Poulain, F.E.1    Sobel, A.2
  • 130
    • 33750466222 scopus 로고    scopus 로고
    • Microtubule: a common target for parkin and Parkinson's disease toxins
    • [134] Feng, J., Microtubule: a common target for parkin and Parkinson's disease toxins. Neuroscientist 12:6 (2006), 469–476.
    • (2006) Neuroscientist , vol.12 , Issue.6 , pp. 469-476
    • Feng, J.1
  • 131
    • 0020959823 scopus 로고
    • Interaction of methylmercury with microtubules in cultured cells and in vitro
    • [135] Sager, P.R., Doherty, R.A., Olmsted, J.B., Interaction of methylmercury with microtubules in cultured cells and in vitro. Exp. Cell Res. 146:1 (1983), 127–137.
    • (1983) Exp. Cell Res. , vol.146 , Issue.1 , pp. 127-137
    • Sager, P.R.1    Doherty, R.A.2    Olmsted, J.B.3
  • 132
    • 0021931945 scopus 로고
    • The effects of methyl mercury binding to microtubules
    • [136] Vogel, D.G., Margolis, R.L., Mottet, N.K., The effects of methyl mercury binding to microtubules. Toxicol. Appl. Pharmacol. 80:3 (1985), 473–486.
    • (1985) Toxicol. Appl. Pharmacol. , vol.80 , Issue.3 , pp. 473-486
    • Vogel, D.G.1    Margolis, R.L.2    Mottet, N.K.3
  • 133
    • 0024500168 scopus 로고
    • Analysis of methyl mercury binding sites on tubulin subunits and microtubules
    • [137] Vogel, D.G., Margolis, R.L., Mottet, N.K., Analysis of methyl mercury binding sites on tubulin subunits and microtubules. Pharmacol. Toxicol. 64:2 (1989), 196–201.
    • (1989) Pharmacol. Toxicol. , vol.64 , Issue.2 , pp. 196-201
    • Vogel, D.G.1    Margolis, R.L.2    Mottet, N.K.3
  • 134
    • 70449707133 scopus 로고    scopus 로고
    • Methylmercury disrupts the balance between phosphorylated and non-phosphorylated cofilin in primary cultures of mice cerebellar granule cells. A proteomic study
    • [138] Vendrell, I., Carrascal, M., Campos, F., Abian, J., Sunol, C., Methylmercury disrupts the balance between phosphorylated and non-phosphorylated cofilin in primary cultures of mice cerebellar granule cells. A proteomic study. Toxicol. Appl. Pharmacol. 242:1 (2010), 109–118.
    • (2010) Toxicol. Appl. Pharmacol. , vol.242 , Issue.1 , pp. 109-118
    • Vendrell, I.1    Carrascal, M.2    Campos, F.3    Abian, J.4    Sunol, C.5
  • 136
    • 77958000068 scopus 로고    scopus 로고
    • Effects of low level of methylmercury on proliferation of cortical progenitor cells
    • [140] Xu, M., Yan, C., Tian, Y., Yuan, X., Shen, X., Effects of low level of methylmercury on proliferation of cortical progenitor cells. Brain Res. 1359 (2010), 272–280.
    • (2010) Brain Res. , vol.1359 , pp. 272-280
    • Xu, M.1    Yan, C.2    Tian, Y.3    Yuan, X.4    Shen, X.5
  • 137
    • 84907775016 scopus 로고    scopus 로고
    • Rho family GTPases: key players in neuronal development, neuronal survival, and neurodegeneration
    • [141] Stankiewicz, T.R., Linseman, D.A., Rho family GTPases: key players in neuronal development, neuronal survival, and neurodegeneration. Front. Cell. Neurosci., 8, 2014, 314.
    • (2014) Front. Cell. Neurosci. , vol.8 , pp. 314
    • Stankiewicz, T.R.1    Linseman, D.A.2
  • 138
    • 27944479854 scopus 로고    scopus 로고
    • Rho GTPases: biochemistry and biology
    • [142] Jaffe, A.B., Hall, A., Rho GTPases: biochemistry and biology. Annu. Rev. Cell Dev. Biol. 21 (2005), 247–269.
    • (2005) Annu. Rev. Cell Dev. Biol. , vol.21 , pp. 247-269
    • Jaffe, A.B.1    Hall, A.2
  • 139
    • 58749103132 scopus 로고    scopus 로고
    • Methylmercury exposure downregulates the expression of Racl and leads to neuritic degeneration and ultimately apoptosis in cerebrocortical neurons
    • [143] Fujimura, M., Usuki, F., Sawada, M., Rostene, W., Godefroy, D., Takashima, A., Methylmercury exposure downregulates the expression of Racl and leads to neuritic degeneration and ultimately apoptosis in cerebrocortical neurons. Neurotoxicology 30:1 (2009), 16–22.
    • (2009) Neurotoxicology , vol.30 , Issue.1 , pp. 16-22
    • Fujimura, M.1    Usuki, F.2    Sawada, M.3    Rostene, W.4    Godefroy, D.5    Takashima, A.6
  • 140
    • 84897584374 scopus 로고    scopus 로고
    • Rho/ROCK pathway and neural regeneration: a potential therapeutic target for central nervous system and optic nerve damage
    • [144] Tan, H.B., Zhong, Y.S., Cheng, Y., Shen, X., Rho/ROCK pathway and neural regeneration: a potential therapeutic target for central nervous system and optic nerve damage. Int. J. Ophthalmol. 4:6 (2011), 652–657.
    • (2011) Int. J. Ophthalmol. , vol.4 , Issue.6 , pp. 652-657
    • Tan, H.B.1    Zhong, Y.S.2    Cheng, Y.3    Shen, X.4
  • 141
    • 78649636704 scopus 로고    scopus 로고
    • Inhibition of the Rho/ROCK pathway prevents neuronal degeneration in vitro and in vivo following methylmercury exposure
    • [145] Fujimura, M., Usuki, F., Kawamura, M., Izumo, S., Inhibition of the Rho/ROCK pathway prevents neuronal degeneration in vitro and in vivo following methylmercury exposure. Toxicol. Appl. Pharmacol. 250:1 (2011), 1–9.
    • (2011) Toxicol. Appl. Pharmacol. , vol.250 , Issue.1 , pp. 1-9
    • Fujimura, M.1    Usuki, F.2    Kawamura, M.3    Izumo, S.4
  • 142
    • 85046914723 scopus 로고    scopus 로고
    • Transcription factors and neural stem cell self-renewal, growth and differentiation
    • [146] Ahmed, S., Gan, H.T., Lam, C.S., Poonepalli, A., Ramasamy, S., Tay, Y., Tham, M., Yu, Y.H., Transcription factors and neural stem cell self-renewal, growth and differentiation. Cell Adh. Migr. 3:4 (2009), 412–424.
    • (2009) Cell Adh. Migr. , vol.3 , Issue.4 , pp. 412-424
    • Ahmed, S.1    Gan, H.T.2    Lam, C.S.3    Poonepalli, A.4    Ramasamy, S.5    Tay, Y.6    Tham, M.7    Yu, Y.H.8
  • 143
    • 40049084803 scopus 로고    scopus 로고
    • Methylmercury inhibits differentiation of rat neural stem cells via Notch signalling
    • [147] Tamm, C., Duckworth, J.K., Hermanson, O., Ceccatelli, S., Methylmercury inhibits differentiation of rat neural stem cells via Notch signalling. Neuroreport 19:3 (2008), 339–343.
    • (2008) Neuroreport , vol.19 , Issue.3 , pp. 339-343
    • Tamm, C.1    Duckworth, J.K.2    Hermanson, O.3    Ceccatelli, S.4
  • 144
    • 0036970570 scopus 로고    scopus 로고
    • Notch signaling inhibits PC12 cell neurite outgrowth via RBP-J-dependent and -independent mechanisms
    • [148] Levy, O.A., Lah, J.J., Levey, A.I., Notch signaling inhibits PC12 cell neurite outgrowth via RBP-J-dependent and -independent mechanisms. Dev. Neurosci. 24:1 (2002), 79–88.
    • (2002) Dev. Neurosci. , vol.24 , Issue.1 , pp. 79-88
    • Levy, O.A.1    Lah, J.J.2    Levey, A.I.3
  • 145
    • 84869465982 scopus 로고    scopus 로고
    • Janson Lang AM, Ceccatelli S: inherited effects of low-dose exposure to methylmercury in neural stem cells
    • [149] Bose, R., Onishchenko, N., Edoff, K., Janson Lang AM, Ceccatelli S: inherited effects of low-dose exposure to methylmercury in neural stem cells. Toxicol. Sci. 130:2 (2012), 383–390.
    • (2012) Toxicol. Sci. , vol.130 , Issue.2 , pp. 383-390
    • Bose, R.1    Onishchenko, N.2    Edoff, K.3
  • 146
    • 79960842301 scopus 로고    scopus 로고
    • Time-response evaluation by transcriptomics of methylmercury effects on neural differentiation of murine embryonic stem cells
    • [150] Theunissen, P.T., Pennings, J.L., Robinson, J.F., Claessen, S.M., Kleinjans, J.C., Piersma, A.H., Time-response evaluation by transcriptomics of methylmercury effects on neural differentiation of murine embryonic stem cells. Toxicol. Sci. 122:2 (2011), 437–447.
    • (2011) Toxicol. Sci. , vol.122 , Issue.2 , pp. 437-447
    • Theunissen, P.T.1    Pennings, J.L.2    Robinson, J.F.3    Claessen, S.M.4    Kleinjans, J.C.5    Piersma, A.H.6
  • 147
    • 84936997596 scopus 로고    scopus 로고
    • Low concentrations of methylmercury inhibit neural progenitor cell proliferation associated with up-regulation of glycogen synthase kinase 3beta and subsequent degradation of cyclin E in rats
    • [151] Fujimura, M., Usuki, F., Low concentrations of methylmercury inhibit neural progenitor cell proliferation associated with up-regulation of glycogen synthase kinase 3beta and subsequent degradation of cyclin E in rats. Toxicol. Appl. Pharmacol. 288:1 (2015), 19–25.
    • (2015) Toxicol. Appl. Pharmacol. , vol.288 , Issue.1 , pp. 19-25
    • Fujimura, M.1    Usuki, F.2


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